检索结果-南通市图书馆

Artificial intelligence empowers the second-observer strategy for colonoscopy:a randomized clinical trial

在线全文

学校读者我要写书评

暂无评论

Gastroenterology Report 2023年第1期11卷 216-223页

作者： Pu Wang Xiao-Gang Liu Min Kang Xue Peng Mei-Ling Shu Guan-Yu Zhou Pei-Xi Liu Fei Xiong Ming-Ming deng hong-Fen Xia Jian-Jun Li Xiao-Qi Long yan Song Liang-Ping Li Department of Gastroenterology Sichuan Provincial People’s HospitalUniversity of Electronic Science and Technology of ChinaChengduSichuanP.R.China Department of Gastroenterology The Affiliated Hospital of Southwest Medical UniversityLuzhouSichuanP.R.China Department of Gastroenterology Xinqiao HospitalThird Military Medical UniversityChongqingP.R.China Department of Gastroenterology Suining Central HospitalSuiningSichuanP.R.China

Background:In colonoscopy screening for colorectal cancer,human vision limitationsmay lead to highermiss rate of lesions;artificial intelligence(AI)assistance has been demonstrated to improve polyp ***,there still lacks direct evidence to demonstrate whether AI is superior to trainees or experienced nurses as a second observer to increase adenoma detection during *** this study,we aimed to compare the effectiveness of assistance fromAI and human observer during ***:A prospective multicenter randomized study was conducted from 2 September 2019 to 29 May 2020 at four endoscopy centers in *** patients were randomized to either computer-aided detection(CADe)-assisted group or observer-assisted *** primary outcome was adenoma per colonoscopy(APC).Secondary outcomes included polyp per colonoscopy(PPC),adenoma detection rate(ADR),and polyp detection rate(PDR).We compared continuous variables and categorical variables by using R studio(version 3.4.4).Results:A total of 1,261(636 in the CADe-assisted group and 625 in the observer-assisted group)eligible patients were ***(0.42 vs 0.35,P=0.034),PPC(1.13 vs 0.81,P<0.001),PDR(47.5%vs 37.4%,P<0.001),ADR(25.8%vs 24.0%,P=0.464),the number of detected sessile polyps(683 vs 464,P<0.001),and sessile adenomas(244 vs 182,P=0.005)were significantly higher in the CADe-assisted group than in the observer-assisted *** detections of the CADe system were lower than those of the human observer(122 vs 191,P<0.001).Conclusions:Compared with the human observer,the CADe system may improve the clinical outcome of colonoscopy and reduce disturbance to routine practice(*** No.:ChiCTR1900025235).

关键词： artificial intelligence colon cancer screening adenoma early detection computer-aided detection

Development of a LiFePO_(4)-based high power lithium secondary battery for HEVs applications

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Rare Metals 2020年第12期39卷 1457-1463页

作者： Long-Zheng deng Feng Wu Xu-Guang Gao Wei-ping Wu Beijing Key Laboratory of Environmental Science and Engineering School of Chemical Engineering and the Environment Beijing Institute of TechnologyBeijing 100081China National&Local United Engineering Laboratory for Power Battery Department of ChemistryInstitute of Functional Material ChemistryNortheast Normal UniversityChangchun 130024China

A LiFeP04-type lithium secondary battery cell of 8 Ah capacity with a high energy density and power density was developed for hybrid electric vehicle(HEV)applications by optimizing the key raw materials and process *** 8 Ah class LiFePO_(4)cell with an energy density of 77.2 Wh·kg^(-1)exhibits a power density of 2818 W·kg^(-1)at 50%SOC(state of charge).The battery shows good cyclic capability with the capacity retention of 81.1%after 1,870 cycles at 5 C charge and 10 C discharge *** is demonstrated that the cells have an excellent balance of high-power,high-energy,low temperature,and long-life performance for meeting the requirements of HEV.

关键词： Li-ion battery Lithium iron phosphate High-power Long-life Hybrid electric vehicle

Illuminating single genomic loci in live cells by reducing nuclear background fluorescence

在线全文

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2021年第5期64卷 667-677页

作者： Song Lu Dianbing Wang Yu Hou Dongge Guo Yulin deng Xian-En Zhang School of Life Sciences Beijing Institute of TechnologyBeijing 100081China National Laboratory of Biomacromolecules CAS Center for Excellence in BiomacromoleculesInstitute of BiophysicsChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China

The tagging of genomic loci in living cells provides visual evidence for the study of genomic spatial organization and gene ***/dCas9(clustered regularly interspaced short palindromic repeats/deactivated Cas9)labeling system labels genes through binding of the dCas9/sgRNA/fluorescent protein complex to repeat sequences in the target genomic ***,the existence of numerous fluorescent proteins in the nucleus usually causes a high background fluorescent *** study aims to limit the number of fluorescent modules entering the nucleus by redesigning the current CRISPR/dCas9-SunTag labeling system consisting of dCas9-SunTag-NLS(target module)and scFv-sfGFP-NLS(signal module).We removed the nuclear location sequence(NLS)of the signal module and inserted two copies of EGFP into the signal *** ratio of the fluorescent intensity of the nucleus to that of the cytoplasm(N/C ratio)was decreased by 71%,and the ratio of the signal to the background(S/B ratio)was increased by 1.6 *** system can stably label randomly selected genomic loci with as few as 9 repeat sequences.

关键词： CRISPR/dCas9 labeling background reduction low-repetitive loci live cell imaging

Hydroarylation of terminal alkynes with arylboronic acids catalyzed by low loadings of palladium

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2023年第2期34卷 165-169页

作者： Lei Xu Shiyu Li Qi Zhang Ning deng Biao Zhang Huajian Xu School of Chemistry and Chemical Engineering School of Food and Biological EngineeringInstitute of Industry&Equipment TechnologyAnhui Province Key Laboratory of Advance Catalytic Materials and Reaction EngineeringHefei University of TechnologyHefei 230009China

The hydroarylation reaction of terminal alkynes with arylboronic acids catalyzed by low(400 ppm) loadings of palladium has been developed. The reaction is broad in scope and high-yielding, even on multigram scale. It is suitable for the synthesis of alkenes labeled with deuterium, and for the late-stage modification of bioactive molecules.

关键词： Hydroarylation Low loadings Terminal alkyne Deuterium-labeled Palladium

Application of electrochemical depassivation in PRB systems to recovery Fe^0 reactivity

在线全文

学校读者我要写书评

暂无评论

Frontiers of Environmental Science & Engineering 2016年第4期10卷 33-41页

作者： Xin LU Miao LI Hao deng Pengfei LIN Mark R. MATSUMOTO Xiang LIU School of Environment Tsinghua University Beijing 100084 China CNPC Research Institute of Safety & Environmental Technology Beijing 102206 China State Key Laboratory of Petroleum and Petrochemical Pollution Control and Treatment Beijing 102206 China College of Chemical Engineering China University of Petroleum (East China) Qingdao 266580 China Department of Chemical and Environmental Engineering University of California Riverside Riverside CA 92521 USA

Permeable reactive barriers （PRBs） show remarkable Cr（VI） removal performance. However, the diminished removal rate because of mineral fouling over time is the bottleneck for application of PRBs. The present study demonstrated that electrochemical depassivation was effective for recovering the Fe^0 reactivity, and minerals can be cleaned layer by layer with no secondary ion contamination and no transformation from Cr（III） to Cr（VI）. The removal recovery rate increased with increasing electrolysis voltage before reaching the optimal electrolysis voltage, and then decreased as the electrolysis voltage further increased. The recovery effect at electrolysis voltages of 5, 10, and 15 V show the same trend as a function of electrolysis time, where recovery rate first increased and then decreased after reaching the optimal electrolysis time. The Cr（VI） removal rate significantly decreased with increasing electrolysis distance. Furthermore, Fe^0 brush meshes electrode, Fe^0 fillings, and polyvinyl chloride （PVC） meshes separators were combined to create an Electro-PRB configuration for the caisson excavation construction technique, which lays the foundation for establishment of promising Electro-PRB systems to treat Cr（VI）-contaminated groundwater.

关键词： PRB Cr(VI) Fe Passivation Electrochemical depassivation

Universal Image Steganalysis Based on Convolutional Neural Network with Global Covariance Pooling

在线全文

学校读者我要写书评

暂无评论

Journal of Computer Science & Technology 2022年第5期37卷 1134-1145页

作者： Xiao-Qing deng Bo-Lin Chen Wei-Qi Luo Da Luo Guangdong Key Laboratory of Information Security Technology Sun Yat-sen UniversityGuangzhou 510006China School of Cyberspace Security Dongguan University of TechnologyDongguan 523808China

Recently,steganalytic methods based on deep learning have achieved much better performance than traditional methods based on handcrafted ***,most existing methods based on deep learning are specially designed for one image domain(i.e.,spatial or JPEG),and they often take long time to *** make a balance between the detection performance and the training time,in this paper,we propose an effective and relatively fast steganalytic network called US-CovNet(Universal Steganalytic Covariance Network)for both{the}spatial and JPEG *** this end,we carefully design several important components of{US-CovNet}that will significantly affect the detection performance,including the high-pass filter set,the shortcut connection and the pooling{layer}.Extensive experimental results show that compared with the current best steganalytic networks(i.e.,SRNet and J-YeNet),{US-CovNet}can achieve the state-of-the-art results for detecting spatial steganography and have competitive performance for detecting JPEG *** example,the detection accuracy of US-CovNet is at least 0.56%higher than that of SRNet in the spatial *** the JPEG domain,US-CovNet performs slightly worse than J-YeNet in some cases with the degradation of less than 0.78%.However,the training time of US-CovNet is significantly reduced,which is less than 1/4 and 1/2 of SRNet and J-YeNet respectively.

关键词： steganalysis steganography convolutional neural networks global covariance pooling

Regulation of AMPK activation by extracellular matrix stiffness in pancreatic cancer

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Genes & Diseases 2024年第3期11卷 338-350页

作者： Xin Xu Yuan Fang Somaira Nowsheen Ye-Xiong Li Zhenkun Lou Min deng State Key Laboratory of Molecular Oncology and Department of Radiation Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China Department of General Surgery Shanghai General HospitalShanghai Jiaotong University School of MedicineShanghai 200080China Department of General Surgery Zhongshan HospitalFudan UniversityShanghai 200032China Department of Dermatology University of California San DiegoSan DiegoCA 92093USA Department of Oncology Mayo ClinicRochesterMN 55905USA

The adenosine monophosphate(AMP)-activated protein kinase(AMPK)sits at a cen-tral node in the regulation of energy metabolism and tumor *** is best known to sense high cellular ADP or AMP levels,which indicate the depletion of energy *** studies have shown that the low expression of phosphorylated AMPK is associated with a poor prognosis of pancreatic *** this study,we report that AMPK is also highly sensitive to extracellular matrix(ECM)*** found that AMPK is activated in cells when cultured under low ECM stiffness conditions and is functionally required for the metabolic switch induced by ECM *** regulation of AMPK requires the Hippo kinases but not LKB1/*** kinases directly phosphorylate AMPKa at Thr172 to activate AMPK at low ECM ***,we found AMPK activity is inhibited in patients with pancreatic ductal adenocarcinoma(PDAC)with high ECM stiffness and is associated with a poor survival *** activation of Hippo kinases by ROCK inhibitor Y-27632 in combination with the mitochondrial inhibitor metformin synergistically activates AMPK and dramatically inhibits PDAC ***,these findings establish a novel model for AMPK regulation by the mechanical properties of ECMs and provide a rationale for simultaneously targeting the ECM stiffness-Hippo kinases-AMPK signaling and low glucose-LKB1-AMPK signaling pathways as an effective therapeutic strategy against PDAC.

关键词： AMPKactivity Cellularmetabolic switch ECM stiffness Hippokinase signaling Pancreaticductal adenocarcinoma

不确定性的激励型需求响应对配电网可靠性的影响

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

现代电力 2020年第4期37卷 416-424页

作者：范宏邓剑上海电力大学上海市杨浦区200090

随着激励型需求响应逐渐参与到电网运行中,其在改善负荷分布以及提升配电网可靠性具有影响。在现有激励型需求响应特点的基础上,依据消费者心理学原理分别建立了不可调度(可中断负荷、紧急需求响应)和可调度(直接负荷控制)的响应模型。... 详细信息

随着激励型需求响应逐渐参与到电网运行中,其在改善负荷分布以及提升配电网可靠性具有影响。在现有激励型需求响应特点的基础上,依据消费者心理学原理分别建立了不可调度(可中断负荷、紧急需求响应)和可调度(直接负荷控制)的响应模型。以不同时间尺度为基础通过模糊C均值聚类算法将激励型需求响应资源进行分类,在此基础上考虑不可调度和可调度响应资源在不同时间尺度下的响应能力和不确定性等响应特性,建立了灵活配置的激励型需求响应参与两阶段响应调度模型,最后通过序贯蒙特卡洛模拟法对改进RBTS Bus6系统进行可靠性计算。算例验证了所提方法的有效性。

关键词： Logistic函数模糊C均值聚类激励型需求响应不确定性配电网可靠性

在线全文

学校读者我要写书评

暂无评论

基于多重分形的Karst流域地貌信息挖掘

测绘科学 2012年第4期37卷 147-150,156页

作者：陈旺梁虹邓亚东李静向尚贵州师范大学地理与环境科学学院贵阳550001 中国地质科学院岩溶地质研究所广西桂林541004

本文利用多重分形理论揭示出了DEM不同尺度下的地貌多重分形谱的变化规律。基于多重分形理论研究表明:多重分形理论构建的高程多重分形谱模型能挖掘出更全面、更精细Karst流域地貌形态信息,其中高程多重分形谱模型中的宽度定量表征出了K... 详细信息

本文利用多重分形理论揭示出了DEM不同尺度下的地貌多重分形谱的变化规律。基于多重分形理论研究表明:多重分形理论构建的高程多重分形谱模型能挖掘出更全面、更精细Karst流域地貌形态信息,其中高程多重分形谱模型中的宽度定量表征出了Karst流域地貌的起伏程度,多重分形谱最大、最小子集维数的差值定量表征了地貌形态的差异性,而且根据多重分形谱的参数随DEM分辨率变化关系并结合广义熵理论,确定了Karst地貌形态研究的数据的空间分辨率最优范围在(0-15]之间。

关键词：分形多重分形谱 Karst地貌 DEM