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Accurate prediction of biliary atresia with an integrated model using MMP-7 levels and bile acids

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World Journal of Pediatrics 2024年第8期20卷 822-833页

作者： Yi-Jiang Han shu-Qi Hu Jin-Hang Zhu Xiao Cai deng-Ming Lai Bao-hai Chen Kun Zhu Qiao Tong Xin-Rui Zhou Jia-Le deng Jin-Fa Tou Zhuo Fang Li-Zhong Du Department of Neonatal Surgery Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhouChina Department of Data and Analytics WuXi Diagnostics Innovation Research InstituteShanghaiChina Department of Information Center Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhouChina Department of Pathology Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhouChina Department of Neonatology Children’s HospitalZhejiang University School of MedicineNational Clinical Research Center for Child HealthHangzhouChina

Background Biliary atresia(BA)is a rare fatal liver disease in children,and the aim of this study was to develop a method to diagnose BA *** We determined serum levels of matrix metalloproteinase-7(MMP-7),the results of 13 liver tests,and the levels of 20 bile acids,and integrated computational models were constructed to diagnose *** Our findings demonstrated that MMP-7 expression levels,as well as the results of four liver tests and levels of ten bile acids,were significantly different between 86 BA and 59 non-BA patients(P<0.05).The computational prediction model revealed that MMP-7 levels alone had a higher predictive accuracy[area under the receiver operating characteristic curve(AUC)=0.966,95%confidence interval(CI):0.942,0.989]than liver test results and bile acid *** AUC was 0.890(95%CI 0.837,0.943)for liver test results and 0.825(95%CI 0.758,0.892)for bile acid ***,bile levels had a higher contribution to enhancing the predictive accuracy of MMP-7 levels(AUC=0.976,95%CI 0.953,1.000)than liver test *** AUC was 0.983(95%CI 0.962,1.000)for MMP-7 levels combined with liver test results and bile acid *** addition,we found that MMP-7 levels were highly correlated with gamma-glutamyl transferase levels and the liver fibrosis *** The innovative integrated models based on a large number of indicators provide a noninvasive and cost-effective approach for accurately diagnosing BA in children.

关键词： Bile aid.Biliary atresia Diagnosis Liver fibrosis Liver test MMP-7

A novel improvement strategy and a comprehensive mechanism insight for α-MnO_(2) energy storage in rechargeable aqueous zinc-ion batteries

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Carbon Energy 2024年第9期6卷 93-108页

作者： Fan Xiankai Xiang Kaixiong Zhou Wei deng Weina Zhu hai Chen Liang Chen Han School of Materials and Environmental Engineering Changsha UniversityChangshaChina College of Energy Materials and Chemistry Inner Mongonia UniversityHohhotInner MongoliaChina Liling Ceramic Institute Hunan University of TechnologyZhuzhouHunanChina

Aqueous zinc-ion batteries have been regarded as the most potential candidate to substitute lithium-ion ***,many serious challenges such as suppressing zinc dendrite growth and undesirable reactions,and achieving fully accepted mechanism also have not been ***,the commensal composite microspheres withα-MnO_(2) nano-wires and carbon nanotubes were achieved and could effectively suppress ZnSO_(4)·3Zn(OH)_(2)·nH_(2)O rampant *** electrode assembled with the microspheres delivered a high initial capacity at a current density of 0.05 A g^(-1) and maintained a significantly prominent capacity retention of 88%over 2500 ***,a novel energy-storage mechanism,in which multivalent manganese oxides play a synergistic effect,was comprehen-sively investigated by the quantitative and qualitative analysis for ZnSO_(4)·3Zn(OH)_(2)·nH_(2)*** capacity contribution of multivalent manganese oxides and the crystal structure dissection in the transformed processes were completely ***,our research could provide a novel strategy for designing improved electrode structure and a comprehensive understanding of the energy storage mechanism of α-MnO_(2) cathodes.

关键词： α-MnO_(2) aqueous zinc-ion batteries carbon nanotubes composite microspheres energy storage mechanism

Lath-like phases formed at an extremely high temperature in a Mg-RE(RE=rare earth)-Al alloy

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Rare Metals 2024年第8期43卷 3937-3945页

作者： Bo deng shu-Hui Lv Qiang Yang Dong-Yue Zhao Jun-Yuan Fan Xin Qiu School of Materials Science and Engineering Changchun University of Science and TechnologyChangchun 130022China State Key Laboratory of Rare Earth Resource Utilization Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China Chongqing Research Institute Changchun University of Science and TechnologyChongqing 401135China

Thermal stable intermetallic particles are important for the heat resistance of magnesium(Mg)*** this work,many lath-like particles formed in α-Mg grains of a Mg-8Gd-3Sm-0.7Al casting alloy when heat-treated at 873 ***-resolution high-angle annular dark field scanning transmission electron microscopy(HAADF-STEM) characterizations indicate that most of them are Mg-containing Al_(2)(Gd,Sm),with the atomic ratio of Mg:Al:(Gd,Sm) being ~1:1:1;a small part of them with relatively wider thickness are long-period stacking ordered(LPSO) phases simultaneously containing both 14H and 18R *** followed common orientation relationships with Mg matrix as those reported in previous *** addition,many Mg laths were observed in the primary blocky Al_(2)(Gd,Sm) phase at grain boundaries,where the atomic ratio of Al:(Gd,Sm) in the Al_(2)(Gd,Sm) matrix was 2:***,density functional theory(DFT) calculations illustrated the detail structure of the re-constructed Mg/Al_(2)RE interface and simultaneously deduced the underlying reason for the re-dissolution of the newly formed Mg-containing Al_(2)(Gd,Sm) plates in α-Mg matrix.

关键词： Magnesium alloy HAADF-STEM Microstructures Intermetallic particles Orientation relationships Interfaces

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顺铂前体脂质体的制备及包封率测定

中国医院药学杂志 2006年第4期26卷 416-418页

作者：马晶邓树海济南盛泽医药科技开发有限公司山东济南250100 山东大学药物制剂研究所山东济南250012

目的:对顺铂前体脂质体制备工艺及包封率测定方法进行初步研究。方法:选用山梨醇为水溶性载体,采用前体脂质体法与超声分散混合法制备顺铂前体脂质体;高效液相色谱法测得包封率。结果:制得的顺铂前体脂质体为球形双层脂质体,包封率为71... 详细信息

目的:对顺铂前体脂质体制备工艺及包封率测定方法进行初步研究。方法:选用山梨醇为水溶性载体,采用前体脂质体法与超声分散混合法制备顺铂前体脂质体;高效液相色谱法测得包封率。结果:制得的顺铂前体脂质体为球形双层脂质体,包封率为71.8%。结论:本法制备的顺铂前体脂质体,在水化前便于贮存,重新混悬时易于分散、工艺简单、可规模化生产、包封率高;高效液相色谱法测定顺铂的含量,方法简便、准确。

关键词：顺铂前体脂质体包封率高效液相色谱法

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双嘧达莫阿司匹林胃内漂浮片的研究

中国医药工业杂志 2005年第11期36卷 682-684页

作者：张军邓树海山东大学药学院药物制剂研究所山东济南250012

采用均匀设计优化双嘧达莫阿司匹林胃内漂浮片的处方工艺,用HPLC测定释放度,并观察制品的体外漂浮性。结果表明,5～7kg硬度的片剂有良好的体外漂浮,体外释药曲线符合Higuchi方程。

关键词：双嘧达莫阿司匹林漂浮片释放度高效液相色谱法

Risk Assessment of Deep-Water Horizontal X-Tree Installation

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China Ocean Engineering 2024年第2期38卷 210-220页

作者： MENG Wen-bo FU Guang-ming HUANG Yi LIU shu-jie HUANG Liang GAOYong-hai CNOOC China Limited Zhanjiang BranchZhanjiang 524057China Key Laboratory of Unconventional Oil and Gas Development Ministry of Education(China University of Petroleum(East China))Qingdao 266580China

Due to the high potential risk and many influencing factors of subsea horizontal X-tree installation,to guarantee the successful completion of sea trials of domestic subsea horizontal X-trees,this paper established a modular risk evaluation model based on a fuzzy fault ***,through the analysis of the main process oftree down and combining the Offshore&Onshore Reliability Data(OREDA)failure statistics and the operation procedure and the data provided by the job,the fault tree model of risk analysis of the tree down installation was ***,by introducing the natural language of expert comprehensive evaluation and combining fuzzy principles,quantitative analysis was carried out,and the fuzzy number was used to calculate the failure probability of a basic event and the occurrence probability of a top ***,through a sensitivity analysis of basic events,the basic events of top events significantly affected were determined,and risk control and prevention measures for the corresponding high-risk factors were proposed for subsea horizontal X-tree down installation.

关键词： subsea horizontal X-tree risk assessment fuzzy fault tree modular risk evaluation model

Stereoselective Self-Assembly of Chiral Metalla[2]Catenanes and Lemniscular Macrocycles

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CCS Chemistry 2024年第8期6卷 2000-2010页

作者： shu-Jin Bao hai-Ning Zhang Guo-Xin Jin Shanghai Key Laboratory of Molecular Catalysis and Innovative Materials State Key Laboratory of Molecular Engineering of PolymersDepartment of ChemistryFudan UniversityShanghai 200433

Designing and stereoselectively constructing chiral mechanically interlocked molecules(MIMs)is a goal that many chemists are pursuing due to their potential in the development of functional molecular machines involved in catalysis,sensing,and chiroptical ***,the synthesis of enantiopure supramolecular entities with crystallographic structures remains ***,the stereoselective self-assembly of chiral metalla[2]catenanes interlocked by two D-shaped macrocycles was realized by combining long binuclear half-sandwich organometallic Cp*Rh^(III)(Cp*=η^(5)-pentamethylcyclopentadienyl)clip and ditopic monodentate ligand incorporating L-leucine *** resulting metalla[2]catenane displayed unique co-conformational mechanical helical chirality characteristics arising from the chirality transfer of the chiral ***,decreasing the length of the binuclear Cp*Rh^(III)clip and adjusting the steric hindrance of the amino-acid side chains(L-alanine and L-phenylalanine)in the ligands resulted in two lemniscular macrocycles with left-handed(M)-twisted conformational *** the best of our knowledge,the synthesized macrocycles are the first family of homochiral abnormal lemniscate-shaped organometallic macrocycles featuring figure-eight ***[2]catenanes and macrocycles with opposite chirality were also generated by employing corresponding D-amino acid ligands,as evidenced by single-crystal X-ray diffraction,nuclear magnetic resonance,mass,and circular dichroism *** present study demonstrates that homochiral MIMs can be accessed readily using amino acid–containing ligands through rational molecular design.

关键词： stereoselective synthesis chirality metallacatenanes twisted macrocycles aminoacid residues

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苦参碱毫微粒的制备及体外释药动力学研究

中国药学杂志 2007年第2期42卷 136-139页

作者：李艳辉邓树海山东大学药学院药物制剂研究所济南250012

目的制备肝靶向性苦参碱聚氰基丙烯酸正丁酯毫微粒并进行体外形态学及释药动力学研究。方法采用乳化聚合法制备,以毫微粒包封率为考察指标,均匀设计优化处方与工艺,高效液相色谱法测定含量,透析法考察其体外释药动力学特征。结果制得的... 详细信息

目的制备肝靶向性苦参碱聚氰基丙烯酸正丁酯毫微粒并进行体外形态学及释药动力学研究。方法采用乳化聚合法制备,以毫微粒包封率为考察指标,均匀设计优化处方与工艺,高效液相色谱法测定含量,透析法考察其体外释药动力学特征。结果制得的毫微粒均匀圆整,算术平均粒径为(157·4±22·4)nm,包封率为(84·91±1·76)%,载药量为(16·98±0·35)%,体外释药具有双相动力学特征。结论该制备工艺稳定可行,可用于肝靶向苦参碱聚氰基丙烯酸正丁酯毫微粒的制备。

关键词：苦参碱毫微粒聚氰基丙烯酸正丁酯

Transparent micropatterned conductive films based on highlyordered nanowire network

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Nano Research 2024年第5期17卷 4288-4297页

作者： Xin-Ran Zhang hai-Tao deng Xu Zeng Yi-Lin Wang Peng Huang Xiao-Sheng Zhang School of Integrated Circuit Science and Engineering University of Electronic Science and Technology of ChinaChengdu 611731China

Transparent conductive films that are based on nanowire networks are essential to construct flexible,wearable,and even stretchable ***,large-scale precise micropatterning,especially with regard to the controllability of the organizing orientation of nanowires,is a critical ***,we proposed a liquid film rupture self-assembly approach for manufacturing transparent conductive films with microstructure arrays based on a highly ordered nanowire *** large-scale microstructure conductive films were fabricated through air-liquid interface self-assembly and liquid film rupture *** typical micropattern morphologies,including square,hexagon,circle,serpentine,etc.,were prepared to reveal the universal applicability of the proposed *** homogeneity and controllability of this approach were verified for multiple *** the assembly cycles increasing,the optical transmittance decreases *** addition,theoretical model analysis is carried out,and the analytical formula of the speed of the film moving with the surface tension and the density of the liquid film is ***,the feasibility of this approach for piezoresistive strain sensors is *** fabrication approach demonstrated a cost-effective and efficient method for precisely arranging nanowires,which is useful in transparent and wearable applications.

关键词： flexible electronics transparent conductive network micropatterning nanowires micro electromechanical systems(MEMS)