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Progress and review of the studies on the end-Triassic mass extinction event

Science china Earth Sciences 2005年第12期48卷 2049-2060页

作者： deng shenghui1,2. lu yuanzheng1,{2. & xu daoyi4 1. research institute of petroleum Exploration and development, beijing 100083, china 2. Key Laboratory of Oil and Gas Reservoir of Petrochina, beijing 100083, china 3. china University of Geosciences, beijing 100083, china 4. institute of Geology, china Earthquake Administration, beijing 10002., china 1. research {1. of {2. Exploration and development 100083 Beijing China 2. Key Laboratory of Oil and Gas Reservoir of Petro{1. 100083 Beijing China 3. china University of Geosciences 100083 Beijing China 4. institute of Geology China Earthquake Administration 100029 Beijing China

The mass extinction at the end-Triassic is one of the five biggest in the Phanerozoic. However,it is the least well understood among these five events, and only till last decade it became a great academic interesting subject to geologists. The evidences for this event come obviously from bivalves, brachiopods, ammonites, corals, radiolaria, ostracods and foraminifera of marine habitats, and plants and tetrapods of terrestrial realm. By contrast, for some of other groups, such as marine gastropods and marine vertebrates, no mass extinction has been recog-nized yet. The extinction event is strongly marked at specific level but shown a complicated situa-tion at generic and family levels. Dramatic changing of the environment, such as the temperature raise due to the greenhouse effect, the marine anoxic habitats caused by a sudden transgression after the regression at the end of Triassic, has been claimed to be the main cause of the extinction. Many hypotheses have been suggested to demonstrate the mechanisms of the environment changing, among which two popular ones are the bolide impact and volcanic eruption. The Triassic-Jurassic (Tr-J) boundary mass extinction event is still poorly understood because no enough data have been obtained from the Tr-J boundary successional sections of both marine and terrestrial sediments, and most of these studies were regionally restricted. The basic aspects of the event and its associated environmental conditions remain poorly characterized and the causal mechanism or mechanisms are equivocal. Some authors even doubt its occurrence. china has many successionally developed terrestrial and marine Tr-J sections. Detailed studies of these sections may be important and significant for well understanding of the event.

关键词： progress, review, end-Triassic, mass extinction, mechanism, Tr-J boundary.

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Identifying the geographical origin and processing technology of Moyao(Myrrh)on the basis of near-infrared spectroscopy combined with chemometrics

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Journal of Traditional Chinese Medicine 2024年第3期44卷 505-514页

作者： xu Ningning YAN Ganming xu Fengjie deng Linfeng QIAO Xinjiang lu Changzheng CHENG Shaomin TCM Diagnosis institute College of Traditional Chinese MedicineJiangxi University of Chinese MedicineNanchang 330004China TCM Processing institute Pharmaceutical CollegeJiangxi University of Chinese medicineNanchang 330004China School of Electronic Information and Artificial Intelligence Shaanxi University of Science and TechnologyXi'an 710021China Jiangzhong Pharmaceutical Co. Ltd.Nanchang 330096China Jiangxi Guhan Refined Chinese Herbal Pieces Co. Ltd.Nanchang330041.China

OBJECTIVE:To evaluate the quality of Moyao(Myrrh)in the identification of the geographical origin and processing of the ***:Raw Moyao(Myrrh)and two kinds of Moyao(Myrrh)processed with vinegar from three countries were identified using near-infrared(NIR)spectroscopy combined with chemometric *** component analysis(PCA)was used to reduce the dimensionality of the data and visualize the clustering of samples from different categories.A classical chemometric algorithm(PLS-DA)and two machine learning algorithms[K-nearest neighbor(KNN)and support vector machine]were used to conduct a classification analysis of the near-infrared spectra of the Moyao(Myrrh)samples,and their discriminative performance was ***:Based on the accuracy,precision,recall rate,and F1.value in each model,the results showed that the classical chemometric algorithm and the machine learning algorithm obtained positive *** all of the chemometric analyses,the NIR spectrum of Moyao(Myrrh)preprocessed by standard normal variation or Multivariate scattering correction combined with KNN achieved the highest accuracy in identifying the geographical origins,and the accuracy of identifying the processing technology established by the KNN method after first-order derivative pretreatment was the *** best accuracy of geographical origin discrimination and processing technology discrimination were 0.9853 and 0.9706 ***:NIR spectroscopy combined with chemometric technology can be an important tool for tracking the origin and processing technology of Moyao(Myrrh)and can also provide a reference for evaluations of its quality and the clinical use.

关键词： Moyao(Myrrh) near-infrared spectroscopy geographical origin processing technology

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Structural characteristics of the Tan-lu fault zone in Cenozoic basins offshore the Bohai Sea

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Science china Earth Sciences 2008年第S2期51卷 20-31页

作者： QI JiaFu1,2.ZHOU XinHuai3,deng RongJing4 & ZHANG KeXin2.1 State Key Laboratory of petroleum Resource and Prospecting,{2. petroleum University,beijing 102.49,{2. 2.Department of Earth Sciences,{2. petroleum University,beijing 102.00,{2. 3 Tianjin Branch of CNOOC china Limited,Tianjin 300451,{2. 4 beijing research Center of CNOOC china Limited,beijing10002.,{2. china Petr Univ State Key Lab Petr Resource & Prospecting Beijing 102249 Peoples R China china Petr Univ Dept Earth Sci Beijing 102200 Peoples R China CNOOC china Ltd Tianjin Branch Tianjin 300451 Peoples R China CNOOC china Ltd Beijing Res Ctr Beijing 100027 Peoples R China

The Tan-lu fault zone across the eastern margin of the Cenozoic basins offshore the Bohai Sea is a NNE-trending right-lateral strike-slip fault system developed in the Cenozoic basin cover. It cuts through NE-to NNE-striking major extensional faults that controlled the formation of Paleogene basins. Recent {1. exploration indicates that Cenozoic structural activities of the Tan-lu fault system have directly or indirectly affected oil and gas distribution offshore the Bohai Sea. As part of a deep fault zone the Tan-lu fault zone has been activated since the Oligocene,and obviously affected the tectonic evolution of offshore Bohai basins since then. The formation of Paleogene rift basins offshore the Bohai Sea has utilized the pre-existing structural elements of the Tan-lu fault zone that developed in the late Mesozoic.

关键词： strike-slip fault extensional structure Tan-lu fault zone Bohaiwan basin

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Carbon isotope composition and correlation across the Cambrian-Ordovician boundary in Kalpin Region of the Tarim Basin, china

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Science china Earth Sciences 2008年第9期51卷 1317-1329页

作者： JING XiuChun deng {1. ZHAO ZongJu lu {2. ZHANG ShiBen School of the Earth Sciences and Resources China University of GeosciencesBeijing 100083China research {1. of {2. Exploration and development Beijing 100083China

Biostratigraphically constrained sequences at the Wushi Yingshan and Kalpin Cement Plant sections (Kalpin Region; Tarim Basin) were densely sampled for geochemical studies. Carbonates across the Cambrian-Ordovician boundary of both sections mainly record negative carbon isotope values. Stable isotope curves show four negative and four positive excursions appearing alternately at the Wushi Yingshan section and five negative alternating with five positive excursions at the Kalpin Cement Plant section. The carbon isotope logs of these two sections are correlated with the international Cambrian-Ordovician boundary key sections: (1. Dayangcha section in{1., (2. Green Point section in Canada, (3) Black mountain section in Australia and (4) Lowson Cove section in USA. These correlations suggest that the Cambrian-Ordovician boundary of the Wushi Yingshan section and the Kalpin Cement Plant section can be placed within a particular horizon that also corresponds to the observed biostratigraphic units.

关键词： Cambrian-Ordovician boundary carbon isotopes conodonts Tarim Basin

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Bioinformatics Analysis of the Relationship between Dilated Cardiomyopathy and Chronic Heart Failure

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Journal of Biosciences and Medicines 2024年第8期12卷 333-346页

作者： Lanqing Yu Haidong Zhou Bailu {1. Jiaochang Wei Mei Zhang Chongyao xu Guiyun Wei Junxiu Zhou Jun Huang Qi lu Shaowu Ye Graduate School Youjiang Medical University for Nationalities Baise China Clinical Medical College Affiliated Hospital of Youjiang Medical University for Nationalities Baise China Department of Internal Medicine The Peoples Hospital of Wuzhou Wuzhou China Pharmaceutical College Guangxi Medical University Nanning China Department of Pharmacy Guangxi Zhuang Autonomous Region Maternal and Child Health Hospital Nanning China Department of Pharmacy Baise Maternal and Child Hospital Baise China Orthopedic Trauma Napo Peoples Hospital Baise China Department of Internal Medicine Wuzhou Gongren Hospital Wuzhou China

Objective: To screen and analyze the differentially expressed genes between dilated cardiomyopathy (DCM) and chronic heart failure (CHF) based on bioinformatics methods. Methods: The Gene Expression Omnibus (GEO) database was used for data retrieval, and the chip data GSE3585 was downloaded, which was the original data of DCM and normal control group. At the same time, the chip data GSE76701.was downloaded, which was the original data of CHF and control group. Differentially expressed mRNAs (DEmRNAs) were screened by R language limma package, the data were standardized, and the common differentially expressed genes were screened. GO function and KEGG pathway enrichment analysis were performed on the common differentially expressed genes. String1..0 online tool was used for data analysis to obtain differentially expressed genes, and the results were imported into Cytoscape 3.9.1.software. The results were imported into Cytoscape 3.9.1.software, and the common expression gene module was obtained by MOCDE algorithm. Nine Hub genes were obtained by 1. algorithms such as MCC. Results: A total of {1.8 differentially expressed genes were screened. GO analysis showed that differentially expressed genes were mainly concentrated in 9 different physiological and pathological processes. KEGG analysis showed that the main signaling pathways involved in differentially expressed genes were {1. and 9 key differentially expressed genes were predicted: NPPB, NPPA, MYH6, FRZB, ASPN, SFRP4, RPS4Y1. DDX3Y. Conclusion: This study preliminarily explored the molecular mechanism of DCM and CHF, and obtained the common differentially expressed genes of the two diseases. Further experimental studies are needed to verify the correlation between gene expression and clinicopathological features. Provide new ideas for clinical drug treatment research.

关键词： Dilated Cardiomyopathy Chronic Heart Failure Bioinformatics Analysis Differentially Expressed Genes

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S-doped mesoporous graphene modified separator for high performance lithium-sulfur batteries

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Materials Reports(Energy) 2024年第3期4卷 60-68页

作者： Xinlong Ma Chenggen xu Yin Yang Dong Sun Kai Zhao Changbo {1. Peng Jin Yiting Chong Sirawit Pruksawan Zhihua Xiao Fuke Wang State Key Laboratory of Heavy Oil Processing China University of PetroleumBeijingChangping102249China State Key Laboratory of Coking Coal Exploitation and Comprehensive Utilization China Pingmei Shenma GroupPingdingshan 467000China institute of Materials {1. and Engineering(IMRE) Agency for ScienceTechnology and Research(A*STAR)2 Fusionopolis WayInnovis#08-03138634Republic of Singapore

Due to their low cost,environmental friendliness and high energy density,the lithium-sulfur batteries(LSB)have been regarded as a promising alternative for the next generation of rechargeable battery ***,the practical application of LSB is seriously hampered by its short cycle life and high self-charge owing to the apparent shuttle effect of soluble lithium *** MgSO_(4)@MgO composite as both template and dopant,template-guided S-doped mesoporous graphene(SMG)is prepared via the fluidized-bed chemical vapor deposition *** the polypropylene(PP)modifier,SMG with high specific surface area,abundant mesoporous structures and moderate S doping content offers a wealth of physical and chemical adsorptive sites and reduced interfacial contact resistance,thereby restraining the serious shuttle effects of lithium ***,the LSB configured with mesoporous graphene(MG)as S host material and SMG as a separator modifier exhibits an enhanced electrochemical performance with a high average capacity of 955.64 mA h g^(-1. at 1. and a small capacity decay rate of 0.1.9%per ***,the density functional theory(DFT)calculation models have been rationally constructed and demonstrated that the doped S atoms in SMG possess higher binding energy to lithium polysulfides than that in MG,indicating that the SMG/PP separator can effectively capture soluble lithium polysulfides via chemical binding *** work would provide valuable insight into developing a versatile carbon-based separator modifier for LSB.

关键词： Fluidized-bed chemical vapor deposition Mesoporous graphene S doping Separator modification Lithium-sulfur battery

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Solvothermal Synthesis, Structural Characterization and Properties of Two New Layered Lanthanide Sulfates

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Chemical research in Chinese Universities 2013年第5期29卷 831-836页

作者： lu Yun ZHANG {1. xu Yan State Key Laboratory of Materials-oriented Chemical Engineering College of Chemistry and Chemical Engineering Nanjing University of Technology Nanjing 210009 P. R. China

Two new layered lanthanide sulfates, [C1.H1.N2.[Pr2.SO4）4（H2.）2.（1. and [H5O2.[Sm（SO4）2.H2.）3]（2. were synthesized via solvothermal reaction and structurally characterized by single-crystal X-ray diffraction（XRD）, infrared（IR） spectroscopy, thermal analysis, fluorescent spectra and inductively coupled plasma（ICP）. Crystal data for compound 1. triclinic, Pi space group, a=0.8052.4） nm, b=0.9438（4） nm, c=1.4990（7） nm, α=79.450（5）°, β= 83.703（5）°, γ=74.048（5）°, V=1.0746（9） nm3, Z=2. for compound 2. monoclinie, P2./c space group, a=0.6599（1.） nm, b=1.8940（3） nm, c=0.8765（1.） nm, β=96.596（2.°, V=1.0883（3） nm3, Z=4. Structure analysis indicates that both the compounds exhibit a 2. corrugated layer structure, with protonated 4,4＇-bipyridine cations and water dimmers （H5O2.＋ located between the inorganic layers of compounds pounds 1.and 2.were further investigated. 1.and 2. respectively. luminescent properties of com-

关键词： Solvothermal synthesis Open-framework Lanthanide sulfate Layered structure luminescence

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W/O/W佐剂添加两种免疫增强剂对口蹄疫灭活疫苗的影响

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中国兽医科学 2024年第3期54卷 300-307页

作者：周宇杰卢宇许泽玉唐健中钱莺娟邓碧华南京农业大学动物医学院教育部动物健康与食品安全国际合作联合实验室江苏省外国专家工作室江苏南京210095 江苏省农业科学院动物免疫工程研究所江苏南京210014 南京农业大学动物医学院江苏南京210095 兽用生物制品(泰州)国泰技术创新中心江苏泰州225300 江苏大学药学院江苏镇江212013

为进一步提高口蹄疫灭活疫苗的免疫效果,本研究在水包油包水(W/O/W)佐剂配方上添加免疫增强剂,一种是天然化合物维生素E(VE),另一种是人工合成的咪喹莫特衍生物(IMQ-Chol)。每种免疫增强剂设低中高三种不同剂量,加入到基础配方中制备成... 详细信息

为进一步提高口蹄疫灭活疫苗的免疫效果,本研究在水包油包水(W/O/W)佐剂配方上添加免疫增强剂,一种是天然化合物维生素E(VE),另一种是人工合成的咪喹莫特衍生物(IMQ-Chol)。每种免疫增强剂设低中高三种不同剂量,加入到基础配方中制备成不同的佐剂,然后与口蹄疫灭活病毒进行配伍。观察各组疫苗的外观并检测其稳定性、黏度、粒径和多分散系数(PDI)以确定其理化性质;称量小鼠体重、检测血常规、血液生化和组织学变化来评估免疫增强剂的安全性;检测小鼠血清中的特异性抗体、抗体亚型、细胞因子水平以及小鼠脾T淋巴细胞的分化情况,评价免疫增强剂对疫苗免疫效果的影响。结果显示,配制的疫苗均为乳白色W/O/W乳液,37℃放置9周疫苗未出现分层现象,黏度均在1. cp以下,粒径在2.0 nm~370 nm之间,PDI在0.34~0.42.间;不同剂量的免疫增强剂对小鼠体重没有影响(P>0.05),血常规、血液生化及组织学切片结果表明两种免疫增强剂的生物安全性良好;添加VE或IMQ-Chol的免疫组与基础配方免疫组相比,特异性抗体水平均显著提高(P1.;其中,添加高剂量VE的免疫组和添加低剂量IMQ-Cho的免疫组不仅特异性抗体水平显著提高(P1.,Th1.相关分子(Ig G2.、IFN-γ、IL-1.0}和Th2.相关分子(Ig G1.IL-4、IL-6)的分泌水平也有提升(P4^(+)T细胞的比例分别为75.2.和77.3%,高于基础配方组的69.6%,且CD4^(+)/CD8^(+)比值也高于基础配方组(P<0.05)。以上结果表明,VE和IMQ-Chol这两种免疫增强剂在不影响疫苗的理化特性的同时都具有良好的安全性,并且添加高剂量的VE或低剂量的IMQ-Chol更能有效地提高口蹄疫灭活疫苗的免疫效果。

关键词：口蹄疫 W/O/W佐剂免疫增强剂维生素E 咪喹莫特

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Two New Piperazine Templated Lanthanide Sulfates with 2. Corrugated Layered Crystal Structures

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Chemical research in Chinese Universities 2013年第1期29卷 10-14页

作者： ZHANG deng FAN Xin-rong {1. Yun xu Yan State Key Laboratory of Materials-oriented Chemical Engineering College of Chemistry and Chemical Engineering Nanjing University of Technology Nanjing 210009 P. R. China

Two new piperazine templated lanthanide sulfates （C4N2.I2.1.5[Ln（SO4）3（H2.）]H2.[Ln=Gd（1., Tb（2.] have been synthesized solvothermally and structurally characterized by single crystal X-ray diffraction（XRD）... 详细信息

Two new piperazine templated lanthanide sulfates （C4N2.I2.1.5[Ln（SO4）3（H2.）]H2.[Ln=Gd（1）, Tb（2.] have been synthesized solvothermally and structurally characterized by single crystal X-ray diffraction（XRD）, infrared（IR） spectroscopy, thermal analysis, fluorescent spectra and inductively coupled plasma（ICP）. Single crystal X-ray diffraction reveals that both compounds 1 and 2.crystallized in the monoclinic crystal system, with space group P2./c and cell dimensions： a=0.64468（19） nm, b=2.9979（9） nm, c=0.9818（3） nm, fl=101.2.1（4）, V=l.8608（10） nm3, Z=4 for compound 1; a=0.642.9（19） nm, b=3.0010（9） rim, c=0.9812.3） nm, fl=101.2.9（4）, V=1.8560（10） nm3, Z=4 for compound 2. Compounds 1 and 2.are isomorphous and have similar 2. corrugated inorganic frameworks fabricated via the connection of single chains and $2.4 groups, while fully protonated piperazine cations and water molecules are located between the inorganic layers. The solid state luminescent properties of compound 2.were investigated and it displayed a typical luminescent property of Tb3＋ with excitation wavelength at 371 nm.

关键词： Solvothermal synthesis Lanthanide sulfate Layered structure luminescence

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骨髓增生异常综合征与急性髓系白血病之间免疫浸润相关基因的筛选及验证

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中国组织工程研究 2024年第13期28卷 2082-2089页

作者：邓发滑胡华丽王斯奇许建霞禄婷婷黄海韦四喜贵州医科大学医学检验学院临床生化教研室贵州省贵阳市550004 贵州医科大学附属医院临床检验中心贵州省贵阳市550004

背景:骨髓增生异常综合征具有较高的急性髓系白血病转化风险,有研究表明免疫浸润在二者之间发挥重要作用,但免疫细胞浸润与相关差异表达基因的调控关系仍需更多研究证实。目的:通过生物信息学分析方法,寻找与骨髓增生异常综合征和急性... 详细信息

背景:骨髓增生异常综合征具有较高的急性髓系白血病转化风险,有研究表明免疫浸润在二者之间发挥重要作用,但免疫细胞浸润与相关差异表达基因的调控关系仍需更多研究证实。目的:通过生物信息学分析方法,寻找与骨髓增生异常综合征和急性髓系白血病具有预后意义的差异表达基因,探讨差异基因与免疫浸润细胞调控在疾病发生发展中的可能作用及机制。方法:利用GEO数据集筛选差异表达基因用于生物信息学分析,对差异表达基因进行DO、GO、KEGG和GSEA分析。利用TCGA预后数据库绘制差异表达基因的K-M曲线,并对预后相关的差异基因进行受试者工作特征曲线分析判断基因的临床诊断性能。最后,采用CIBERSORT分析预后相关关键基因与免疫浸润细胞分布之间的相关性,利用RT-qPCR检测健康对照、骨髓增生异常综合征及急性髓系白血病患者外周血样本对筛选出的关键基因进行初步验证。结果与结论:①在骨髓增生异常综合征和急性髓系白血病之间共获得1.0个差异表达基因,其中1.个基因表达上调,1.4个基因表达下调;②DO、GO、KEGG及GSEA分析结果提示差异表达基因可能通过调节免疫应答促进骨髓增生异常综合征向急性髓系白血病发展,CIBERSORT分析显示骨髓增生异常综合征与急性髓系白血病之间存在免疫浸润差异,其中CD4+T细胞、单核细胞、中性粒细胞、M1.噬细胞在急性髓系白血病患者中分布降低,而炎症抑制细胞M2.噬细胞在急性髓系白血病患者中分布增加,可能与急性髓系白血病免疫抑制有关;③利用K-M曲线及受试者工作特征曲线从1.0个差异基因中筛选出4个与免疫和预后相关且具有较好诊断性能的基因:MANSC1.FLT3、BMX及CXCR2.④RT-qPCR检测结果显示MANSC1.BMX及CXCR2.急性髓系白血病患者中低表达,而FLT3在急性髓系白血病患者中高表达。结果表明,MANSC1.FLT3、BMX及CXCR2.骨髓增生异常综合征与急性髓系白血病患者间差异表达,不仅与患者预后显著相关,还可能通过调节患者的免疫浸润影响骨髓增生异常综合征及急性髓系白血病的发生和进展,它们可作为骨髓增生异常综合征向急性髓系白血病转化的潜在生物标志物和治疗靶点,为骨髓增生异常综合征“转白”的临床诊疗研究提供新的方向。

关键词：骨髓增生异常综合征急性髓系白血病免疫浸润预后生物信息学

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