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冰碰载荷下船体板弹塑性动力响应分析

中国舰船研究 2020年第6期15卷 155-161页

作者：蔡伟朱凌武汉理工大学高性能船舶技术教育部重点实验室湖北武汉430063 武汉理工大学交通学院湖北武汉430063 高新船舶与深海开发装备协同创新中心上海200240

[目的]北极航道在远洋运输中发挥着越来越重要的作用。极地船舶在北极航行过程中不可避免地会与浮冰发生碰撞,从而使结构产生塑性变形损伤,严重影响船舶的航行安全。为了研究浮冰碰撞载荷作用下船体板所产生的塑性变形损伤和能量吸收情... 详细信息

[目的]北极航道在远洋运输中发挥着越来越重要的作用。极地船舶在北极航行过程中不可避免地会与浮冰发生碰撞,从而使结构产生塑性变形损伤,严重影响船舶的航行安全。为了研究浮冰碰撞载荷作用下船体板所产生的塑性变形损伤和能量吸收情况,开展楔形冰与船体板碰撞模型实验研究。[方法]首先,分析船体板的塑性变形损伤以及冰体破碎失效情况;然后,总结并对比现有不同冰体材料模型下冰撞刚性墙的计算结果,揭示不同冰材料模型下计算结果的差异;最后,采用数值模拟方法研究冰碰撞载荷作用下固支矩形板的塑性变形和碰撞力时间历程,并与模型实验结果进行对比验证。[结果]结果显示,不同冰体材料模型的数值模拟结果其差异性和离散性较大;采用了各向同性弹脆性冰数值材料的计算模型其数值计算结果与实验结果吻合较好;在碰撞条件相同冰体与刚体碰撞时,冰体碰撞下船体板的最终塑性变形值和能量吸收值比刚体碰撞下的小。[结论]研究成果可为极地船舶结构安全评估方法提供参考建议。

关键词：极地船舶浮冰碰撞塑性变形能量吸收

Stimulated-Brillouin-scattering-based arbitrarily phase coded microwave waveform transmitter with anti-dispersion transmission

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Chinese Optics Letters 2022年第8期20卷 69-74页

作者： Sha zhu Kunpeng Zhai wei Li Ning Hua zhu College of Microelectronics Faculty of Information TechnologyBeijing University of TechnologyBeijing 100124China State Key Laboratory on Integrated Optoelectronics Institute of SemiconductorsChinese Academy of SciencesBeijing 100083China School of Electronic Electrical and Communication EngineeringCenter of Materials Science and Optoelectronics EngineeringUniversity of Chinese Academy of SciencesBeijing 100049China

We focus on photonic generation and transmission of microwave signals in this *** on dual-pumped stimulated Brillouin scattering,a single-sideband(SSB)optical signal with high sideband rejection ratio is *** with a phase-modulated optical carrier,an arbitrarily phase coded microwave signal is generated after photoelectric *** SSB modulation can eliminate the fiber-dispersion-induced power dispersion naturally,and the phase modulation of the optical carrier can achieve arbitrary phase encoding and suppress background *** proposed scheme can achieve both generation and anti-dispersion transmission of arbitrarily phase coded signals simultaneously,which is suitable for one-to-multi long-distance radar networking.

关键词： microwave photonics phase coded signal anti-dispersion transmission optical signal processing

~·OH对聚二甲基硅氧烷乳液辐射效应的影响(英文)

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物理化学学报 2005年第8期21卷 873-877页

作者：彭静朱轶才翟茂林乔金樑魏根拴北京大学化学与分子工程学院应用化学研究所北京100871

通过凝胶和溶胶分析与分子量测定的方法,研究了不同体系下,"OH对PDMS乳液γ辐射效应的影响.结果表明,"OH不仅可引发聚二甲基硅氧烷的分子间交联,也能促进其降解.对于纯PDMS乳液,在所研究的剂量范围内,"OH对其辐射交联行为影响较小.但若... 详细信息

通过凝胶和溶胶分析与分子量测定的方法,研究了不同体系下,"OH对PDMS乳液γ辐射效应的影响.结果表明,"OH不仅可引发聚二甲基硅氧烷的分子间交联,也能促进其降解.对于纯PDMS乳液,在所研究的剂量范围内,"OH对其辐射交联行为影响较小.但若体系中加入H2O2、KIO4和N2O这些提高"OH生成产额的添加剂时,"OH对PDMS的促降解作用会随着吸收剂量增加而表现更明显,导致凝胶含量与纯乳液辐照情况相比下降较多.即使加入交联剂-三羟甲基丙烷三甲基丙烯酸酯(TMPTMA),在过量的"OH存在下,当吸收剂量大于40kGy以上时,TMPTMA不仅没有提高交联度,反而会与"OH协同,使PDMS的凝胶含量下降更显著,同时产生更多的小分子聚合物,并使PDMS的平均分子量分布变窄.这可能是由于交联剂首先与"OH作用,形成的产物会加快PDMS的降解.

关键词： OH自由基聚二甲基硅氧烷(PDMS)乳液辐射交联辐射降解交联剂

Genetic variation and molecular profiling of congenital malformations of the female genital tract based on whole-genome sequencing

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世界儿科杂志（英文版） 2024年第11期20卷 1179-1195页

作者： Jun-Jun qiu Xing-Yu Chang Ning Zhang Luo-Pei Guo Shuai Wang wei-Yue Gu Yi-Meng Yin Zhi-Wen Shi Ke-Qin Hua Obstetrics and Gynecology Hospital Fudan UniversityShanghai 200011China Shanghai Key Laboratory of Female Reproductive Endocrine-Related Diseases 413 Zhaozhou RoadShanghai 200011China Data and Analysis Center for Genetic Diseases Chigene Translational Medicine Research CenterBeijing 100032China Translational Research Institute of Brain and Brain-Like Intelligence School of MedicineShanghai Fourth People's HospitalTongji UniversityShanghai 200434China

Background Congenital malformations of the female genital tract(CM-FGT)are characterized by abnormal development of the fallopian tubes,uterus,and vagina,often accompanied by malformations in the urinary system,bones and ***,no definitive pathogenic genes and molecular genetic causes have been identified.Methods We present the largest whole-genome sequencing study of CM-FGT to date,analyzing 590 individuals in China:95 patients,442 case-controls,and 53 familial controls.Results Among the patients,5.3％carried known CM-FGT-related *** and case-control analyses in two dimensions of coding and non-coding regulatory regions revealed seven novel de novo copy number variations,12 rare single-nucleotide variations,and 10 rare 3'untranslated region(UTR)mutations in genes related to CM-FGT,particularly highlighting ASH1L as a pathogenic ***-cell sequencing data showed that the majority of CM-FGT-related risk genes are spatiotemporally specifically expressed early in uterus development.Conclusions In conclusion,this study identified novel variants related to CM-FGT,particularly highlighting ASH1L as a pathogenic *** findings provide insights into the genetic variants underlying CM-FGT,with single-cell sequencing data revealing spatiotemporal specific expression patterns of key risk genes early in uterine *** study significantly advances the understanding of CM-FGT etiology and genetic landscape,offering new opportunities for prenatal screening.

关键词： Copy number variant Congenital malformations of the female genital tract Single nucleotide variants Whole-genome sequencing

Boosting Electrocatalytic Urea Production via Promoting Asymmetric C–N Coupling

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CCS Chemistry 2023年第11期5卷 2617-2627页

作者： Mengyi qiu Xiaorong zhu Shuowen Bo Kai Cheng Nihan He Kaizhi Gu Dezhong Song Chen Chen Xiaoxiao wei Dongdong Wang Yingying Liu Shuang Li Xiaojin Tu Yafei Li Qinghua Liu Conggang Li Shuangyin Wang State Key Laboratory of Chemo/Bio-Sensing and Chemometrics College of Chemistry and Chemical EngineeringHunan UniversityChangsha 410082 College of Chemistry and Materials Science Nanjing Normal UniversityNanjing 210023 National Synchrotron Radiation Laboratory University of Science and Technology of ChinaHefei 230022 Key Laboratory of Magnetic Resonance in Biological Systems State Key Laboratory of Magnetic Resonance and Atomic and Molecular PhysicsNational Center for Magnetic Resonance in Wuhan Collaborative Innovation Center of Chemistry for Life SciencesWuhan Institute of Physics and MathematicsChinese Academy of SciencesWuhan 430064 Institute for Advanced Study Central South UniversityChangsha 410083

Electrocatalytic C–N coupling shows great potential in direct and sustainable urea ***,the mechanism of interaction between catalytic sites and intermediate species is currently unclear,and exploring corresponding strategies to boost urea synthesis is ***,we demonstrated that a multihole structure could preserve the Cu^(+)component of Cu_(2)O spheres under electrochemical reduction *** in situ formed Cu^(0)–Cu^(+)site thermodynamically and kinetically promoted the asymmetric coupling process of^(*)CO and^(*)NO,thereby boosting the urea *** impressive urea yield rates of 29.2 and 114.0 mmol h^(−1)g^(−1)were realized for electrochemical coupling of CO_(2)with nitrate and nitrite,*** multihole-Cu_(2)O exhibits both superior activity and long-term stability compared to the electrocatalysts with a reconstructed Cu^(0)-dominated *** work provides insights into the identification and design of the active site for C–N coupling and urea synthesis.

关键词： asymmetric coupling C-N bond urea synthesis electrocatalysis active site

The tumor-enriched small molecule gambogic amide suppresses glioma by targeting WDR1-dependent cytoskeleton remodeling

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Signal Transduction and Targeted Therapy 2023年第12期8卷 5904-5918页

作者： Jiaorong Qu Bojun qiu Yuxin Zhang Yan Hu Zhixing Wang Zhiang Guan Yiming Qin Tongtong Sui Fan Wu Boyang Li wei Han Xiaozhong Peng Department of Molecular Biology and Biochemistry Institute of Basic Medical SciencesMedical Primate Research CenterNeuroscience CenterChinese Academy of Medical SciencesSchool of Basic MedicinePeking Union Medical CollegeBeijing 100005China State Key Laboratory of Common Mechanism Research for Major Diseases BeijingChina Department of Molecular Neuropathology Beijing Neurosurgical InstituteCapital Medical UniversityBeijing 100070China Department of Neurosurgery Beijing Tiantan HospitalCapital Medical UniversityBeijingChina State Key Laboratory of Respiratory Health and Multimorbidity BeijingChina National Human Diseases Animal Model Resource Center Beijing Engineering Research Center for Experimental Animal Models of Human Critical DiseasesInstitute of Laboratory Animal ScienceChinese Academy of Medical Sciences&Peking Union Medical CollegeBeijing 100021China

Glioma is the most prevalent brain tumor,presenting with limited treatment options,while patients with malignant glioma and glioblastoma(GBM)have poor *** physical obstacle to drug delivery imposed by the blood‒brain barrier(BBB)and glioma stem cells(GSCs),which are widely recognized as crucial elements contributing to the unsatisfactory clinical *** this study,we found a small molecule,gambogic amide(GA-amide),exhibited the ability to effectively penetrate the blood-brain barrier(BBB)and displayed a notable enrichment within the tumor ***,GA-amide exhibited significant efficacy in inhibiting tumor growth across various in vivo glioma models,encompassing transgenic and primary patient-derived xenograft(PDX)*** further performed a genome-wide clustered regularly interspaced short palindromic repeats(CRISPR)knockout screen to determine the druggable target of *** the combination of the cellular thermal shift assay(CETSA),the drug affinity responsive target stability(DARTS)approach,molecular docking simulation and surface plasmon resonance(SPR)analysis,WD repeat domain 1(WDR1)was identified as the direct binding target of *** direct interaction with WDR1,GA-amide promoted the formation of a complex involving WDR1,MYH9 and Cofilin,which accelerate the depolymerization of F-actin to inhibit the invasion of patient-derived glioma cells(PDCs)and induce PDC apoptosis via the mitochondrial apoptotic *** conclusion,our study not only identified GA-amide as an effective and safe agent for treating glioma but also shed light on the underlying mechanisms of GA-amide from the perspective of cytoskeletal homeostasis.

关键词： glioma invasion homeostasis

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习近平建设清洁美丽世界思想研究

上海经济研究 2019年第9期31卷 17-26页

作者：朱秋上海商学院习近平新时代中国特色社会主义思想研究所

经济全球化所带来的环境污染已经构成人类社会发展的一个最大威胁。习近平总书记站在人类命运共同体的高度,以大国领袖的远见卓识,不断思考"建设一个什么样的世界、如何建设这个世界"等关乎人类未来发展的重大课题,并在不同场合对建设... 详细信息

经济全球化所带来的环境污染已经构成人类社会发展的一个最大威胁。习近平总书记站在人类命运共同体的高度,以大国领袖的远见卓识,不断思考"建设一个什么样的世界、如何建设这个世界"等关乎人类未来发展的重大课题,并在不同场合对建设清洁美丽世界做了重要阐述,形成了科学完整、内涵丰富、意义深远的思想体系,为解决人类社会未来发展所面临的全球性环境问题提供了中国智慧、中国方案、中国力量。习近平建设清洁美丽世界思想可以概括为:以习近平生态文明建设思想为引领;推动构建人类命运共同体;实现人类社会绿色、低碳、循环、可持续发展。习近平建设清洁美丽世界思想加深了对保护和发展生产力的认识,回答了当今世界所面临的重大问题,开阔了国际安全的视野,扩展了中国共产党人的初心和使命,为后发国家的经济发展提供了战略指南。

关键词：习近平清洁美丽世界人类命运共同体生态文明环境

Design of a photonic crystal fiber polarization beam splitter with simple structure and ultra-wide bandwidth

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Chinese Physics B 2023年第10期32卷 476-482页

作者：魏云鹏苑金辉屈玉玮邱石周娴颜玢玢王葵如桑新柱余重秀 State Key Laboratory of Information Photonics and Optical Communications Beijing University of Posts and TelecommunicationsBeijing 100876China Research Center for Convergence Networks and Ubiquitous Services University of Science&Technology BeijingBeijing 100083China

A novel polarization beam splitter(PBS)based on dual-core photonic crystal fiber(DC-PCF)is proposed in this *** proposed DC-PCF PBS contains two kinds of lattices and three kinds of air holes to form the asymmetrical elliptic dual-core *** using the full-vector finite element method,the propagation characteristics of the proposed DC-PCF PBS are *** simulation results show that the bandwidth of the proposed DC-PCF PBS can reach to 340 nm,which covers the S+C+L+U communication bands,the shortest splitting length is 1.97 mm,and the maximum extinction ratio appears near wavelength 1550 ***,the insertion loss of the proposed DC-PCF PBS is very *** is believed that the proposed DC-PCF PBS has important applications in the field of all-optical communication and network.

关键词： dual-core photonic crystal fiber polarization beam splitter extinction ratio bandwidth

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超导材料辐照效应的研究进展

材料导报 2020年第15期34卷 15116-15125页

作者：朱红梅李佐光邱长军毛哲华秦经刚南华大学机械工程学院中科院等离子体物理研究所

超导材料由于具有一系列的优异特性如零电阻效应、迈斯纳效应、约瑟夫森效应等,已逐渐应用在信息能源、电力交通、科学仪器、医疗技术、国防军事等重要领域,有力推动了国民经济和人类社会的发展。目前,超导材料在强磁场、强辐射、超低... 详细信息

超导材料由于具有一系列的优异特性如零电阻效应、迈斯纳效应、约瑟夫森效应等,已逐渐应用在信息能源、电力交通、科学仪器、医疗技术、国防军事等重要领域,有力推动了国民经济和人类社会的发展。目前,超导材料在强磁场、强辐射、超低温等极端环境下的辐照效应是国内外研究者们普遍关注的热点。在高能粒子轰击作用下,超导材料晶格中的原子发生一系列的碰撞,从而产生大量的辐照缺陷(如离位峰、贫原子区、空位、间隙原子、位错、空洞)、缺陷团以及新的析出相,这些对其超导性能(临界温度TC、临界磁场HC、临界电流IC以及临界电流密度JC等)存在显著影响。本文全面综述了不同超导材料辐照效应的国内外研究进展。按临界温度TC分类,超导材料可分为低温超导材料(TC25 K,主要有铋系、钇系、MgB2以及铁基超导材料)。重点综述了辐照源(包括中子、离子(He、B、C、O、Ne、Si、Ar、Ti、Ni、Xe、Au、Pb等)、质子、电子以及射线(γ、χ射线))、辐照条件(能量、剂量、温度)、超导材料的初始状态、掺杂(MgO、B、Sn、Ag等)等因素对其超导性能的影响。大量研究表明,超导材料经辐照后可引入缺陷,磁通钉扎强度和密度增大,临界电流密度JC得到改善;此外,增加超导材料中的载流子或改善晶体的有序化可提高其临界温度TC。最后,针对当前超导材料亟待解决的一些关键问题,提出了通过优化材料体系及其制备工艺、热处理、掺杂以及数值模拟与实验相结合等方式改善其辐照效应的技术途径,为超导材料的研究开发和商业化应用提供思路。

关键词：超导材料辐照效应缺陷超导性能