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Magnetic resonance imaging evaluation and nuclear receptor binding SET domain protein 1 mutation in the Sotos syndrome with attention-deficit/hyperactivity disorder

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World Journal of Clinical Cases 2025年第2期13卷 5-9页

作者： wei zhu Shanghai XiRong Information Science and Technology Co. LtdNational Science and Technology ParkSchool of Life Sciences and TechnologyTongji UniversityShanghai 200092China

Sotos syndrome is characterized by overgrowth features and is caused by alterations in the nuclear receptor binding SET domain protein 1 ***/hyperactivity disorder(ADHD)is considered a neurodevelopment and psychiatric disorder in *** characteristics and clinical presentation could play an important role in the diagnosis of Sotos syndrome and *** resonance imaging(MRI)has been used to assess medical images in Sotos syndrome and *** images process is considered to display in MRI while wavelet fusion has been used to integrate distinct images for achieving more complete information in single image in this *** the future,genetic mechanisms and artificial intelligence related to medical images could be used in the clinical diagnosis of Sotos syndrome and ADHD.

关键词： Sotos syndrome Attention-deficit/hyperactivity disorder Genetic mutation Magnetic resonance imaging Wavelet fusion

Sequence-activated chemiluminescence probes: programmable illumination for high-contrast in vivo sensing and imaging

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Science China Chemistry 2025年第01期 26-34页

作者： Yutao Zhang Juan Li wei-Hong zhu Zhiqian Guo Shanghai Key Laboratory of Functional Materials Chemistry Joint International Research Laboratory of Precision Chemistry and Molecular Engineering Institute of Fine Chemicals School of Chemistry and Molecular Engineering East China University of Science and Technology State Key Laboratory of Bioreactor Engineering Shanghai Frontier Science Research Base of Optogenetic Techniques for Cell MetabolismEast China University of Science & Technology

Sequence-activated chemiluminescence(CL) technique offers a unique approach to detecting specific biomolecules or cellular events with high sensitivity and spatial resolution. The fundamental principle behind sequence-activated CL probes involves tailoring highly-controllable CL signals in response to specific sequences or events of interest, thus enabling high-contrast signals under complex physiological conditions. This sequential activation could be triggered by enzymes, reactive oxygen species(ROS), biothiols or changes in the microenvironment. These unique sequence-activated CL probes bestow several advantages, including minimal background, deep-tissue penetration, and the ability of non-invasive or minimally invasive detection. The sequence-activated CL techniques represent a significant advancement in molecular imaging and diagnostics. In this mini-review, we focus on the latest developments in sequential CL probes, addressing the technical challenges and discussing the future trajectory by harnessing CL signaling and molecular recognition.

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Spatial transcriptomics combined with single-nucleus RNA sequencing reveals glial cell heterogeneity in the human spinal cord

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Neural Regeneration Research 2025年第11期20卷 3302-3316页

作者： Yali Chen Yiyong wei Jin Liu Tao zhu Cheng Zhou Donghang Zhang Department of Anesthesiology West China HospitalSichuan UniversityChengduSichuan ProvinceChina Laboratory of Anesthesia and Critical Care Medicine National-Local Joint Engineering Research Center of Translational Medicine of AnesthesiologyWest China HospitalSichuan UniversityChengduSichuan ProvinceChina Department of Anesthesiology Longgang District Maternity&Child Healthcare Hospital of Shenzhen City(Longgang Maternity and Child Institute of Shantou University Medical College)ShenzhenGuangdong ProvinceChina Department of Anesthesiology Affiliated Hospital of Zunyi Medical UniversityZunyiGuizhou ProvinceChina

Glial cells play crucial roles in regulating physiological and pathological functions,including sensation,the response to infection and acute injury,and chronic neurodegenerative *** cells include astrocytes,microglia,and oligodendrocytes in the central nervous system,and satellite glial cells and Schwann cells in the peripheral nervous *** the greater understanding of glial cell types and functional heterogeneity achieved through single-cell and single-nucleus RNA sequencing in animal models,few studies have investigated the transcriptomic profiles of glial cells in the human spinal ***,we used high-throughput single-nucleus RNA sequencing and spatial transcriptomics to map the cellular and molecular heterogeneity of astrocytes,microglia,and oligodendrocytes in the human spinal *** explore the conservation and divergence across species,we compared these findings with those from *** the human spinal cord,astrocytes,microglia,and oligodendrocytes were each divided into six distinct transcriptomic *** the mouse spinal cord,astrocytes,microglia,and oligodendrocytes were divided into five,four,and five distinct transcriptomic subclusters,*** comparative results revealed substantial heterogeneity in all glial cell types between humans and ***,we detected sex differences in gene expression in human spinal cord glial ***,in all astrocyte subtypes,the levels of NEAT1 and CHI3L1 were higher in males than in females,whereas the levels of CST3 were lower in males than in *** all microglial subtypes,all differentially expressed genes were located on the sex *** addition to sex-specific gene differences,the levels of MT-ND4,MT2A,MT-ATP6,MT-CO3,MT-ND2,MT-ND3,and MT-CO_(2) in all spinal cord oligodendrocyte subtypes were higher in females than in ***,the present dataset extensively characterizes glial cell heterogeneity and offers a valuable resource for explo

关键词： astrocyte glial cell human microglia oligodendrocyte sex differentiation single-nucleus RNA sequencing spatial transcriptomics species variation spinal cord

Stochastic averaging of quasi partially integrable Hamiltonian systems under fractional Gaussian noise

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2017年第9期18卷 704-717页

作者： Qiang-feng LU mao-lin deng wei-qiu zhu Department of Mechanics Zhefiang University Hangzhou 310077 China State Key Laboratory of Fluid Power and Mechatronic Systems Zhejiang University Hangzhou 310027 China Key Laboratory of Soft Machines and Smart Devices of Zhejiang Province Zhejiang University Hangzhou 310027 China

A stochastic averaging method for predicting the response of quasi partially integrable and non-resonant Hamiltoniansystems to fractional Gaussian noise （fGla） with the Hurst index 1/2〈H〈l is proposed. The averaged stochastic differential equa-tions （SDEs） for the first integrals of the associated Hamiltonian system are derived. The dimension of averaged SDEs is less thanthat of the original system. The stationary probability density and statistics of the original system are obtained approximately fromsolving the averaged SDEs numerically. Two systems are worked out to illustrate the proposed stochastic averaging method. It isshown that the results obtained by using the proposed stochastic averaging method and those from digital simulation of originalsystem agree well, and the computational time for the former results is less than that for the latter ones.

关键词： Fractional Brownian motion (fBm) Fractional Gaussian noise (fGn) Quasi partially integrable Hamiltonian system Stochastic averaging method Stationary response

MET receptor tyrosine kinase promotes the generation of functional synapses in adult cortical circuits

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Neural Regeneration Research 2025年第5期20卷 1431-1444页

作者： Yuehua Cui Xiaokuang Ma Jing wei Chang Chen Neha Shakir Hitesch Guirram Zhiyu Dai Trent Anderson Deveroux Ferguson Shenfeng qiu Basic Medical Sciences University of Arizona College of Medicine-PhoenixPhoenixAZUSA Department of Medicine University of Arizona College of Medicine-PhoenixPhoenixAZUSA

Loss of synapse and functional connectivity in brain circuits is associated with aging and neurodegeneration,however,few molecular mechanisms are known to intrinsically promote synaptogenesis or enhance synapse *** have previously shown that MET receptor tyrosine kinase in the developing cortical circuits promotes dendritic growth and dendritic spine *** investigate whether enhancing MET in adult cortex has synapse regenerating potential,we created a knockin mouse line,in which the human MET gene expression and signaling can be turned on in adult(10–12 months)cortical neurons through doxycycline-containing *** found that similar to the developing brain,turning on MET signaling in the adult cortex activates small GTPases and increases spine density in prefrontal projection *** findings are further corroborated by increased synaptic activity and transient generation of immature silent *** MET signaling resulted in an increasedα-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid/N-methyl-Daspartate(AMPA/NMDA)receptor current ratio,indicative of enhanced synaptic function and *** data reveal that enhancing MET signaling could be an interventional approach to promote synaptogenesis and preserve functional connectivity in the adult *** findings may have implications for regenerative therapy in aging and neurodegeneration conditions.

关键词： aging circuit connectivity cortical circuits molecular mechanisms neural regeneration neurodegeneration synapses

Enhanced electrochemical oxidation of phenol by introducing ferric ions and UV radiation

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Journal of Environmental Sciences 2008年第11期20卷 1386-1391页

作者： mao, Xuhui wei, lin HONG, Song zhu, Hua lin, An GAN, Fuxing School of Resource and Environmental Science Environmental Engineering Department Wuhan University Wuhan 430079 China

The mineralization of phenol in aerated electrochemical oxidation has been *** results show that a cathodic Fenton process can occur when the Ti-0.3Mo-0.8Ni alloy material is used as cathode in solution containing ferric or ferrous ions; moreover,the reinforcement of cathodic Fenton process on the total organic carbon (TOC) removal rate of phenol is quite *** the metallic ions investigated,the ferric ion is the best catalyst for the electrochemical mineralization of phenol at initial...

关键词： mineralization phenol electrochemical oxidation cathodic Fenton process UV radiation

Feedback maximization of reliability of MDOF quasi integrable-Hamiltonian systems under combined harmonic and white noise excitations

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Journal of Zhejiang University-Science A(Applied Physics & Engineering) 2009年第9期10卷 1245-1251页

作者： lin-cong CHEN Rong-hua HUAN wei-qiu zhu Department of Mechanics State Key Laboratory of Fluid Power Transmission and Control Zhejiang University Hangzhou 310027 China

We studied the feedback maximization of reliability of multi-degree-of-freedom （MDOF） quasi integrable-Hamiltonian systems under combined harmonic and white noise excitations. First, the partially averaged Ito equations are derived by using the stochastic averaging method for quasi integrable-Hamiltonian systems under combined harmonic and white noise excitations. Then, the dynamical programming equation and its boundary and final time conditions for the control problems of maximizing the reliability is established from the partially averaged equations by using the dynamical programming principle. The nonlinear stochastic optimal control for maximizing the reliability is determined from the dynamical programming equation and control constrains. The reliability function of optimally controlled systems is obtained by solving the final dynamical programming equation. Finally, the application of the proposed procedure and effectiveness of the control strategy are illustrated by using an example.

关键词： Stochastic optimal control Dynamical programming Quasi integrable-Hamiltonian system Stochastic averaging Combined harmonic and white noise excitation Reliability

A Triphenylphosphonium Functionalized AIE Conjugated Macrocyclic Tetramal&mide for Mitochondrial-targeting Bioimaging

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Chinese Journal of Chemistry 2022年第1期40卷 39-45页

作者： wei Zeng mao-Hua lin ling-Yun zhu Mei-Jin lin Key Laboratory of Molecule Synthesis and Function Discovery College of ChemistryFuzhou UniversityFuzhouFujian 350116China College of Materials Science and Engineering Fuzhou UniversityFuzhouFujian 350116China

Developme nt of subcellular orga nelle-targeted bioimagi ng probes is of great imports nee in the field of early detection of diseases and exploring the behaviors of subcellular ***,we present a triphenyIphosphonium functionalized conjugated macrocyclic tetramaleimide(TPP-CMT)as a mitochondrial-targeting bioimaging *** core of TPP-CMT is obtained by connecting two pyrenes and two benzenes through four *** unique structure endows TPP-CMT with exceptional far red/near-i nfirared aggregati on-induced emissi on(FR/NIR-AIE)***-CMT is an excelle nt fluoresce nt emitter in most solve nts and eve n in solid *** qua ntum yield of TPP-CMT was higher tha n 27% when dissolved in comm on middle-polarity orga nic solve nt and this value remained at 28.2% in its solid *** in troducti on of four triphe ny Iphosph onium on maleimide positions endows TPP-CMT with mitochondrial-targeting *** to the FR/NIR-AIE characteristics and the mitochondri-al-targeti ng ability,this well-desig ned fluoresce nt probe was successfully employed for mitochondrial targeti ng bioimaging of HeLa and HepG2 cells.

关键词： Fluorescent probes Macrocycles Photophysics FR/NIR-AIE Mitochondrial-targeting bioimaging

Deformation characteristics and thresholds of the Tanjiawan landslide in the Three Gorges Reservoir Area,China

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Journal of Mountain Science 2022年第5期19卷 1370-1385页

作者： ZHANG Fu-ling deng mao-lin YI Qing-lin LU Shu-qiang ZHENG wei-jun HUANG Hai-feng zhu Xing Hubei Geological Disaster Prevention and Control Engineering Technology Research Center China Three Gorges UniversityYichang 443002China College of Civil Engineering&Architecture China Three Gorges UniversityYichang 443002China State Key Laboratory of Geohazard Prevention and Geoenvironment Protection Chengdu University of TechnologyChengdu 610059China Natural Resources and Planning Bureau ofZigui County Yichang 443002China

Since the first impoundment of the Three Gorges Reservoir(TGR)in China in 2003,more than 5000 landslides including potential landslides were *** this paper,a deep-seated active landslide in TGR area was *** years’monitoring data and field investigations from 2006 to 2020 were used to analyze the deformation characteristics,influencing factors,and meteohydrological *** landslide showed a none-overall periodic movement pattern featuring acceleration during long-duration rainfall and rapid transition to constant creep after rainfall *** secondary sliding masses,No.1 and No.2,were defined via field *** reservoir has no impact on the deformation whereas long-duration-low-intensity rainfall is the main *** present,the cumulative displacements of the main sliding mass range from 0.9 to 3.2 m,and the deformation during the rainy season is gradually *** boundary of this landslide was formed,and the boundary of No.2 sliding mass became *** probability of the failure of sliding mass No.2 is very high under the conditions of continuous *** 15-day antecedent rainfall combined with 4-day cumulative rainfall could be the rainfall threshold which could be associated with the groundwater level S1 of 294 m above sea level for forecasting large deformation of Tanjiawan landslide.

关键词： Three Gorges Reservoir Deformation characteristics Deep-seated landslide Rainfall threshold Groundwater threshold