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Experimental remolding on the caprock's 3D strain field of the Indosinian-Yanshanian epoch in Tongling deposit concentrating area

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Science china Earth Sciences 2005年第7期48卷 863-874页

作者： deng jun1,huang dinghua2.wang qingfei1,wan li1,sun zhongshi3,yang liqiang1 & GAO bangfei1 1. state key laboratory of geological processes and mineral resources,china university of geosciences,beijing 100083,china 2. Faculty of Earth Sciences,china university of geosciences,Wuhan 430074,china 3. Department of Earth Sciences,Jilin university,Changchun 130061,china state {1. {2. of geological processes and mineral resources China University of Geosciences Beijing 100083 China Faculty of Earth Sciences China University of Geosciences Wuhan 430074 China Department of Earth Sciences Jilin University Changchun 130061 China

Based on field observations and rheology analysis, we perform one analogue experiment and remold the 3D structural frame of Tongling deposit concentrating area firstly. Then we disassemble and dialyze the 3D structures of the model using the methods of "slicing" and "stripping". A series of sliced planes vertical to the fold hinges show similar landscapes of that in the drill hole profiles. Meanwhile, layer stripping analysis indicates that the deformation features of each layer in the model are qualitatively analogical to those obtained from field observations. Through contrasting the 3D structure between the experimental model and the field phenomena, we verify the following 3D deformation features of the caprock in this area: (1. the Tongling area mainly consists of three series of NE S-typed fold groups; (2. in the uniform stress field, the incoherent folds universally develop in different positions, along different axes as well as in different strata; (3) the faults propagate upward which are mostly inter-bedded detachment faults, while the fold amplitudes decrease while going deeper; and (4) the folds and cleavages are highly developed in the Silurian System indicating that the deformation effect of the Indosin-ian-Yanshanian structural layer terminates at this layer, which suggests that the Silurian System is the crucial layer for the inversion between brittle and plastic deformation domains and the underlying strata are subject to the control of another deformation system with distinct properties.

关键词： Tongling deposit concentrating area Indosinian-Yanshanian epoch 3D structural frame of the caprock analogue experiment slicing and stripping analysis structural model.

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Transport network and flow mechanism of shallow ore-bearing magma in Tongling ore cluster area

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Science china Earth Sciences 2006年第4期49卷 397-407页

作者： deng jun1,2, wang qingfei1,2 , huang dinghua3 , wan li4, yang liqiang1,2 & GAO bangfei1,2 1. state key laboratory of geological processes and mineral resources, china university of geosciences, beijing 100083, china 2. key laboratory of lithosphere Tectonics and lithoprobing Technology of Ministry of Education, china university of Geo- sciences, beijing 100083, china 3. Faculty of Earth Sciences, china university of geosciences, Wuhan 430074, china 4. School of Mathematics and Information Science, Guangzhou university, Guangzhou 510405, china 1. state {1. {2. of geological processes and mineral resources China University of Geosciences Beijing 100083 China 2. {1. laboratory of {2.thosphere Tectonics and {2.thoprobing Technology of Ministry of Education China University of Geosciences Beijing 100083 China 3. Faculty of Earth Sciences China University of Geosciences Wuhan 430074 China 4. School of Mathematics and Information Science Guangzhou University Guangzhou 510405 China

Abundant studies revealed that shallow intrusions of the Yanshanian epoch resulted in the mass mineralization of the Tong{1.ng region. Various evidences showed there existed a concealed magma chamber at ?1. km depth in the middle part of this region during Yanshanian epoch, from which the ore-forming magma was generated and then transported to the superficial layer. Yet the transport network and flow mechanism of the shallow ore-bearing magma, the {2. problem associ- ated with ore-forming process, was relatively {1.ttle focused on. Integrate analysis of structural me- chanics, statistical fractal and geological facts suggested that NE trending high-angle fold-related thrust faults and the tessellated basement ones served as the main pathways for the shallow magma’s transporting, moreover, the saddle void spaces among adjacent strata in the folds upon this fault system provided the place for magma’s emplacement. So the folds in the upper part and faults in the lower part of the upper crust constituted the fluid’s transport and emplacement network. During the deformation of geologic body with multi-layer structure, the layers in the upper part tended to fold when received the jacking stress from the lower part, while the lower one inc{1.ned to fault undergoing loads of the upper part. And the producing probabi{1.ty of this structure assemblage was highly in- creased in the condition, such as in the Tong{1.ng area, that the mechanic rigidity of the lower layers was stronger than that of the upper ones. For the pre-existence of fluid-conducting network, the top magma with high volatile in the magma chamber transported rapidly to the superficial layer in dyking pattern, located in the void spaces of folds, filled and reconstructed them. The sudden drop of pres- sure caused the fluid unmixing from the magma and mass ore-forming elements concentration. Pulse activity of the dyking may be the principal reason why magmatic bodies in the Tong{1.ng area were spatially-temporally con

关键词： Tongling, structural network, magma intrusion, fractal, dyke.

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Adsorption and adhesion of blood proteins and fibroblasts on multi-wall carbon nanotubes

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Science china({1.fe Sciences) 2009年第5期52卷 479-482页

作者： li Dejun1, YUAN {2., yang Ying1, deng XiangYun1, Lü XiaoYing2. huang Yan2. CAO Zheng2. liU Hao3 & sun Xueliang3 1 College of Physics and Electronic Information Science, Tianjin Normal university, Tianjin 300074, china 2.state {12. laboratory of Bioelectronics, Southeast university, Nanjing 2.0096, china 3 Department of Mechanical & Materials Engineering, university of Western Ontario, London, ON, Canada College of Physics and Electronic Information Science Tianjin Normal University Tianjin 300074 China state {1. {2. of Bioelectronics Southeast University Nanjing 210096 China Department of Mechanical & Materials Engineering University of Western Ontario London ON Canada

This article concerns the investigation of blood protein adsorption on carbon paper and multi-wall carbon nanotubes (MWCNTs). Mouse fibroblast cell adhesion and growth on MWCNTs was also studied. The results showed that fibrinogen adsorption on carbon paper was much lower than that on MWCNTs, which means that platelets readily aggregate on the surface of MWCNTs. Mouse fibroblast cells implanted on MWCNTs tended to grow more prolifically than those implanted on carbon paper. The cell concentration observed on MWCNTs increased from 1.{1.1.5/mL for a single day culture to {1.1.5/mL for a 7-day culture. No toxicity reaction was observed during the culturing period. These results indicated that MWCNTs possessed excellent tissue compatibility.

关键词： multi-wall carbon nanotubes cell adhesion protein adsorption toxicity tissue compatibility

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Manipulating d-d orbital hybridization induced by Mo-doped Co_(9)S_(8) nanorod arrays for high-efficiency water electrolysis

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Journal of Energy Chemistry 2024年第6期93卷 592-600,I0015页

作者： Xue Zhou Jing li Guangyao Zhou Weiran {1. Yucan Zhang {2. yang Huan Pang Mingyi Zhang Dongmei sun Yawen Tang lin Xu Jiangsu key {1. of New Power Batteries Jiangsu Collaborative Innovation Centre of Biomedical Functional MaterialsSchool of Chemistry and Materials ScienceNanjing Normal UniversityNanjing 210023JiangsuChina 'College of Science Jinling Institute of TechnologyNanjing 211169JiangsuChina state {1. {2. of Multiphase Complex Systems Institute of Process EngineeringChinese Academy of SciencesBeijing 100190China Nanjing IPE Institute of Green Manufacturing Industry Nanjing 211100JiangsuChina School of Chemistry and Chemical Engineering Yangzhou UniversityYangzhou 225009JiangsuChina key {1. for Photonic and Electronic Bandgap Materials Ministry of EducationSchool of Physics and Electronic EngineeringHarbin Normal UniversityHarbin 150025HeilongjiangChina

Precisely refining the electronic structure of electrocatalysts represents a powerful approach to further optimize the electrocatalytic ***,we demonstrate an ingenious d-d orbital hybridization concept to construct Mo-doped Co_(9)S_(8) nanorod arrays aligned on carbon cloth(CC)substrate(abbreviated as Mo-Co_(9)S_(8)@CC hereafter)as a high-efficiency bifunctional electrocatalyst toward water *** has experimentally and theoretically validated that the 4d-3d orbital coupling between Mo dopant and Co site can effectively optimize the H_(2.O activation energy and lower H^(*)adsorption energy barrier,thereby leading to enhanced hydrogen evolution reaction(HER)and oxygen evolution reaction(OER)*** to the unique electronic and geometrical advantages,the optimized Mo-Co_(9)S_(8)@CC with appropriate Mo content exhibits outstanding bifunctional performance in alkaline solution,with the overpotentials of 75 and 2.4 mV for the delivery of a current density of 1. mA cm^(-2.,small Tafel slopes of 53.8 and 39.9 mV dec~(-1.and long-term stabilities for at least 32.and 30 h for HER and OER,*** impressively,a water splitting electrolylzer assembled by the self-supported Mo-Co_(9)S_(8)@CC electrode requires a low cell voltage of 1.53 V at 1. mA cm^(-2.and shows excellent stability and splendid reversibility,demonstrating a huge potential for affordable and scalable electrochemical H_(2. *** innovational orbital hybridization strategy for electronic regulation herein provides an inspirable avenue for developing progressive electrocatalysts toward new energy systems.

关键词： d-d orbital hybridization Transition metal sulfides Nanorods arrays Water electrolysis

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Status of aquatic organisms resources and their environments in {1.tze River system(2.1.-2.2.)⋆

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Aquaculture and Fisheries 2024年第5期9卷 833-850页

作者： Haile yang {1. Shen Yongfeng He Huiwu Tian Lei Gao Jinming Wu Zhigang Mei Nian Wei {1.n wang Tingbing Zhu Feifei Hu Jin{1.ng Gong Hongchun Du Xinbin Duan Huatang deng Daoqun wang Fengyue Zhu Yunfeng {1. Fan Wu Huijun Ru Yan Zhang junyi {1. jun{1.n yang Yuntao Zhou Dongdong Fang Yinping wang Danqing {1.n Yanping yang Peijie {1. Silei {1.u Jian yang Ping Zhuang Sikai wang Tao Zhang Gang yang Wenbo yang {1.lai Yuan Kun Cao Shuo Xu Huiyuan {1.u Zhiqiang {1.ang Chongrui wang Hong {1. Xiping Yuan Xin yang Yilong Fu Yanping Zhang Haixin Zhang Zhiying Tao Sheng wang Xiaoping Gao Binsong Jin Kemao {1. Guojie wang Shenglong Jian Yingqin {1. Chenjiang Xue Chunyun Lei Shaowei Xue Yi sun Bin Zhu Ke Shao Xingkun Hu Meihua Xiong jun Du Bin He Tao Yan Yingying huang Yuanchao Zou Biwen Xie Yongming wang Bin {1. Fei {1.u Yaoyao Zhang Fei Fan Zhijian wang Jing huang Haoran Gu Hailong Ge Yan Dan Yan {1. Shuqiao wang Chuang Zhang Lu Zhou Xue wang Sheng Zeng Yan Xiang Xugang He Jianhui Qin Chengxing Xia Jie Hou Yifu Shi {1.fang Gao Zhiqiang Zhu Hongbao Shen Yun Du Xuejun Duan Jiawu Xiong Deguo yang Shaoping {1.u Zhaohui Ni Hui Zhang Kai {1.u Feng Zhao Yingren {1. Jianwei wang Qiwei Wei yangtze River Fisheries Research Institute Chinese Academy of Fishery SciencesWuhan430223China Institute of Hydrobiology Chinese Academy of SciencesWuhan430072China Fishery Resource and Environment Research Center Chinese Academy of Fishery SciencesBeijing100141China key {1. of Freshwater Fisheries and Germplasm {2. Utilization Ministry of Agriculture and Rural AffairsFreshwater Fisheries Research CenterChinese Academy of Fishery SciencesWuxi214081China East china Sea Fisheries Research Institute Chinese Academy of Fishery SciencesShanghai200090China Institute of Fisheries Engineering Chinese Academy of Fishery SciencesBeijing100141China Hunan Fisheries Science Institute Changsha410153China Jiangxi Fisheries Research Institute Nanchang330039China Jiujiang Academy of Fishery Sciences Jiujiang332000China School of life Sciences Nanchang UniversityNanchang330031China Qinghai Provincial Fishery Technology Extension Center Xining810012China Yunnan Academy of Fishery Sciences Kunming650111China Institute of Hydroecology Ministry of Water Resources and Chinese Academy of SciencesWuhan430079China Fisheries Institute Sichuan Academy of Agricultural SciencesChengdu611731China School of life Sciences Neijiang Normal UniversityNeijiang641100China School of life Sciences Southwest UniversityChongqing400715China Chongqing Fishery Sciences Research Institute Chongqing401120China Guizhou Fisheries Research Institute Guiyang550025China College of Fisheries Huazhong Agricultural UniversityWuhan430072China Hubei Fisheries Science Research Institute Wuhan430070China Shaanxi Fisheries Research Institute Xi’an710086China Innovation Academy for Precision Measurement Science and Technology Chinese Academy of SciencesWuhan430077China Nanjing Institute of Geography and limnology Chinese Academy of SciencesNanjing210008China Central South Inventory and Planning Institute of state Forestry and Grassland Administration Changsha410014China

The yangtze River is the mother river of *** promote the aquatic ecosystem protection of the great river,the Project of yangtze Fisheries {2. and Environment Investigation(2.17-2.2.)supported by the Ministry of Agriculture and Rural Affairs,*** carried out by 2. institutes and universities that located in the yangtze River basin surveys the status of(1)fish species composition and spatial distribution,(2.current fish abundance,(3)endangered fishes,(4)yangtze finless porpoise,(5)aquatic eco-environments,(6)water-level fluctuation areas,(7)capture fisheries and recreational fisheries of the yangtze River mainstream and 10 of its main tributaries,including Yalong River,Heng River,Min River(including Dadu River),Chishui River,Tuo River,Jialing River,Wu River,Han River,Dongting Lake and Poyang *** results showed that there were 443 fish species(belonging to 163 genus,37 families,and 18 orders)before 2.17,but only 32. fish species(including 15 new recorded exotic species)were recorded in the project of *** them,Cyprinus carpio,Carassius auratus,Hypophthalmichthys molitrix,Pelteobagrus fulvidraco,Coilia brachygnathus,Silurus asotus,Saurogobio dabryi,Ctenopharyngodon idellus,Pelteobagrus nitidus,Hemiculter leucisculus,Siniperca chuatsi,Coreius heterodon,Culter alburnus,Parabramis pekinensis,and Aristichthys nobilis were the dominant species across the whole yangtze River *** is estimated that there were 886 million individuals weighing 12..8 million kg,merely equivalent to 2..3%of the {2. in 1950s,30.9%of the {2. in 1960s,or 58.7%of the {2. in *** the new list of protected fishes that recorded in the yangtze River system,only 15 of 2. were collected in this project of *** gladius has been affirmed to be Extinct by International Union for Conservation of Nature(IUCN).The wild individuals of Tenualosa reevesii and Luciobrama macrocephalus have disappeared for many years and maybe have been extinct

关键词： Fishes yangtze finless porpoise resources Aquatic ecosystem Fisheries Background investigation yangtze river system

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Structural Analysis of 83-kb Genomic DNA from Thellungiella halophila:Sequence Features and Microcolinearity between Salt Cress and Arabidopsis thaliana

Structural Analysis of 83-kb Genomic DNA from Thellungiella ...

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植物分子生物学与现代农业——2.1.全国植物生物学研讨会

作者： Zhiyong deng1,3,Yin li 1,3,Ran Xia2.3,Weiquan {2.1,Xiahe huang2.ling Zhang1,Shengli Zhang2.,Cuiping yang1,Yiyue Zhang1,2.Mingsheng Chen2.and Qi Xie1,2.4* 1 state key laboratory for Biocontrol,sun Yat-sen(Zhongshan) university,135 Xinggang Road W, Guangzhou 5102.5,{12. 2.National Center for Plant Genomics(beijing),state key laboratory of Plant Genomics,Institute of Genetics and Developmental Biology,Chinese Academy of Sciences,Datun Road,beijing 100101, {12.

Salt cress(Thellungiella halophila) has become a desirable plant model for molecular analysis of the mechanisms of salt *** of its physiological action and expressed EST has resulted in better ***,less is known about ...

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XELOX(capecitabine plus oxaliplatin)plus bevacizumab(anti-VEGF-A antibody)with or without adoptive cell immunotherapy in the treatment of patients with previously untreated metastatic colorectal cancer:a multicenter,open-label,randomized,controlled,phase 3 trial

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Signal Transduction and Targeted Therapy 2024年第5期9卷 2104-2113页

作者： Qiu-Zhong Pan Jing-Jing Zhao liang liu Dong-Sheng Zhang li-Ping wang Wen-Wei Hu De-Sheng Weng Xiang Xu Yi-Zhuo li Yan Tang Wei-Hong Zhang Jie-Yao li Xiao Zheng Qi-Jing wang Yong-Qiang li Tong Xiang li Zhou Shuang-Ning yang Chen Wu Rong-Xing huang Jia He Wei-Jiao Du Lu-{12. Chen Yue-Na Wu Bin Xu Qiong Shen Yi Zhang Jing-Ting Jiang Xiu-Bao Ren Jian-Chuan Xia state {1. {2. of Oncology in South china Guangdong Provincial Clinical Research Center for CancerCollaborative Innovation Center for Cancer MedicineSun Yat-Sen University Cancer CenterGuangzhouGuangdong 510060PR China Department of Biotherapy Sun Yat-Sen University Cancer CenterGuangzhouGuangdong 510060PR China Tianjin Medical university Cancer Institute and Hospital National Clinical Research Center for CancerTianjin 300060PR China key {1. of Cancer Immunology and Biotherapy Tianjin 300060PR China Department of Biotherapy/Immunology Tianjin Medical University Cancer Institute and HospitalTianjin 300060PR China Department of Medical Oncology Sun Yat-sen University Cancer CenterGuangzhou 510060PR China Department of Oncology the First Affiliated Hospital of Zhengzhou UniversityZhengzhou 450052PR China Department of Tumor Biological Treatment the Third Affiliated Hospital of Soochow UniversityChangzhouJiangsu 213003PR China Jiangsu Engineering Research Center for Tumor Immunotherapy ChangzhouJiangsu 213003PR China Institute for Cell Therapy of Soochow university ChangzhouJiangsu 213003PR China Department of Stem Cell&Regenerative Medicine State Key Laboratory of TraumaBurn and Combined InjuryDaping HospitalArmy Medical UniversityChongqing 400042PR China Imaging Diagnosis and Interventional Center Sun Yat-sen University Cancer CenterGuangzhouGuangdong 510060PR China

Fluoropyrimidine-based combination chemotherapy plus targeted therapy is the standard initial treatment for unresectable metastatic colorectal cancer(mCRC),but the prognosis remains *** phase 3 trial(***:NCT039501.4)assessed the efficacy and adverse events(AEs)of the combination of PD-1.blockade-activated DC-CIK(PD1.T)cells with XELOX plus bevacizumab as a first-line therapy in patients with mCRC.A total of {1.{1.participants were enrolled and randomly assigned in a 1.1.ratio to receive either first-line XELOX plus bevacizumab(the control group,n=1.{1.or the same regimen plus autologous PD1.T cell immunotherapy(the immunotherapy group,n=1.0)every {1. days for up to 6 cycles,followed by maintenance treatment with capecitabine and *** main endpoint of the trial was progression-free survival(PFS).The median follow-up was 1..5 *** PFS was 1..8 months(95%CI,1..6-1..0)for the immunotherapy group compared with 9.9 months(8.0-1..8)for the control group(hazard ratio[HR],0.60[95%CI,0.40-0.88];p=0.009).Median overall survival(OS)was not reached for the immunotherapy group and {1..6 months(95%CI,1..3-3{1.8)for the control group(HR,0.57[95%CI,0.33-0.98];p=0.043).Grade 3 or higher AEs occurred in {1..0%of patients in the immunotherapy group and {1..5%in the control groups,with no toxicity-associated deaths *** addition of PD1.T cells to first-line XELOX plus bevacizumab demonstrates significant clinical improvement of PFS and OS with well tolerability in patients with previously untreated mCRC.

关键词： PD1 immunotherapy bevacizumab

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淫羊藿质量影响因素及质控对策分析

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中国中药杂志 2018年第5期43卷 1062-1070页

作者：邓爱平方文韬周青罡杨洪军王凌南铁贵康利平郭兰萍黄璐琦詹志来中国中医科学院中药资源中心道地药材国家重点实验室培育基地北京100700 广东药科大学中药学院广东广州510006 安徽中医药大学药学院安徽合肥230012 江西汇仁药业股份有限公司江西南昌330052 中国中医科学院中药研究所北京100700

淫羊藿为常用强阳补肾药，临床用药历史悠久。淫羊藿多基原、多产地、难鉴别的特点是淫羊藿质量控制中应重点关注的问题，淫羊藿苷的不稳定性是淫羊藿高不合格率的主要原因。针对淫羊藿质量控制难的问题，该文提出以下几点建议：寻找合... 详细信息

淫羊藿为常用强阳补肾药，临床用药历史悠久。淫羊藿多基原、多产地、难鉴别的特点是淫羊藿质量控制中应重点关注的问题，淫羊藿苷的不稳定性是淫羊藿高不合格率的主要原因。针对淫羊藿质量控制难的问题，该文提出以下几点建议：寻找合适的质量控制指标是解决目前淫羊藿质量控制问题的前提。针对淫羊藿资源紧张的问题，建议将药用部位恢复为“干燥地上部分”。此外应加强淫羊藿药材规范化种植，做到种质可控，产地可控，采收可控，加工可控，保证淫羊藿质量。在干燥方法上建议将“晒干或阴干”改为“干燥”，即烘干、晒干、阴干均可。其次对不同品种、不同产地、不同采收期、不同加工方法的淫羊藿进行系统的质量分析，完善淫羊藿质量评价方法，以期为淫羊藿质量控制提供新的思路，为重新制定淫羊藿限量标准提供参考依据。

关键词：淫羊藿研究现状质量影响因素

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CEPC Technical Design Report

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Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai yang Bai Vipul Bairathi Csaba Balazs Phi{1.p Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Big{1.etti Shalva Bilanishvi{1. deng Bing{1.n Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapag{1.a Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Ca{1.bbi junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen Hua-Xing Chen Huirun Chen Jinhui Chen Ji-Yuan Chen Kai Chen Ma{1. Chen Mingjun Chen Mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen Wei Chen Xiang Chen Xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen Yukai Chen Ze{1.n Chen Zi{1.n Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu Xiaotong Chu Zi{1.ang Chu Gug{1.elmo Coloretti Andreas Crivel{1.n Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi {1.ng-Yun Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Fi{1.ppis Christophe De La Taille Francesca De Mori Chiara De Sio E{1.sa Del Core Shuangxue deng Wei-Tian deng Zhi deng Ziyan deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong Jianin AGH university of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui university HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu university Institute of ScienceVaranasi Bandirma Onyedi Eylul university Bandirma Beihang university Beijing beijing Computational Science Research Center Beijing beijing Conveyi LTD Beijing beijing Glass Research Institute Co. LtdBeijing beijing Institute of Technology Beijing beijing Normal {1. Beijing Brown university ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad university Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo university Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central china Normal {1. WuhanHubei Central South university ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan china academy of engineering physics MianyangSichuan china building materials academy Beijing china Center of Advanced Science and Technology Beijing china Institute of Atomic Energy Beijing china Ji{1.ang {2. HangzhouZhejiang china Nuclear Instrument CO. LTDBeijing china university of geosciences Beijing china university of geosciences WuhanHubei china {1. of Mining and Technology XuzhouJiangsu china West Normal {1. NanchongSichuan Chongqing university Department of PhysicsChongqing Chulalongkorn university Bangkok City university of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell university IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu {1. DalianLiaoning Dalian {1. of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East china {1. Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by {1.,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV linac,a 1.1.GeV Damping Ring,a Booster capable of achieving energies up to 1.0 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 1.0 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×1.^(34)cm^(-2.s^(-1.per interaction point(IP),resulting in an integrated luminosity of 1. ab^(-1.for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,2.1.)and the Conceptual Design Report(CDR,2.1.),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2.2.-2.2.,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2.30s.

关键词： initiated exceeding precise

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中药Ⅰ号方对阿尔兹海默病的多靶位治疗作用

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中国比较医学杂志 2013年第5期23卷 26-29页

作者：梁良刘羽曹子青杨亚军朱华黄澜盛树力秦川邓巍北京协和医学院中国医学科学院医学实验动物研究所病理室卫生部人类疾病比较医学重点实验室国家中医药管理局人类疾病动物模型三级实验室北京100021 山西省曲沃县西街本草中药研究所山西曲沃043400

目的应用高通量抗体芯片技术(KinexTM Antibody Microarray)来研究中药I号方(PN-1.对阿尔兹海默病的治疗作用。方法将阿尔兹海默病模型小鼠分为两组,其中对照组4只,每天给予双蒸水灌胃,给药组8只每天给予中药提取物灌胃,给药3个月后,利... 详细信息

目的应用高通量抗体芯片技术(KinexTM Antibody Microarray)来研究中药I号方(PN-1.对阿尔兹海默病的治疗作用。方法将阿尔兹海默病模型小鼠分为两组,其中对照组4只,每天给予双蒸水灌胃,给药组8只每天给予中药提取物灌胃,给药3个月后,利用KinexTMAntibody Microarray筛选出两组的差异表达蛋白,然后用Ingenuity Pathway Analysis(IPA)及查阅文献找到其中与阿尔兹海默病相关的蛋白分子。结果给予中药I号方(PN-1.的阿尔兹海默病小鼠与空白对照小鼠比较,差异表达蛋白其中与阿尔兹海默病相关,且存在变化的为:p-tau(T52.)、COX2.caspase6和caspase9下降;bcl-xl和CaMK4升高。结论中药Ⅰ号方(PN-1.能从抗tau蛋白高磷酸化、抗炎、抑制凋亡和提高记忆力等多靶位改善阿尔兹海默病模型小鼠的病理生理表现,可能成为治疗阿尔兹海默病的有效药物。

关键词：阿尔兹海默病模型小鼠中药Ⅰ号方多靶位

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