检索结果-南通市图书馆

A draft sequence of the rice (Oryza sativa ssp. indica) genome

Chinese Science Bulletin 2001年第23期46卷 1937-1942页

作者： YU jun, HU Songnian, wang jun,li Songgang WONG Ka-Shu Gane, liU Bin,deng Yajun, DAI li, ZHOU Yan,ZHANG Xiuqing, CAO Mengliang, liU Jing,sun Jiandong , TANG Jiabin, CHEN Yanjiong,huang Xiaobing, liN Wei, YE Chen, TONG Wei,CONG lijuan, GENG Jianing, HAN Yujun, li lin,li Wei, HU Guangqiang, huang Xiangang,li Wenjie, li Jian, liU Zhanwei, li Long,liU Jianping, Ql Qiuhui, liU Jinsong, li li,wang Xuegang, LU Hong, WU Tingling,ZHU Miao, Nl Peixiang, HAN Hua, DONG Wei,REN Xiaoyu, FENG Xiaoli, GUI Peng,li Xianran, wang Hao, XU Xin, ZHAI Wenxue,XU Zhao, ZHANG Jinsong, HE Sijie,ZHANG Jianguo, XU Jichen, ZHANG Kunlin,ZHENG Xianwu, DONG Jianhai, ZENG wanyong,TAO lin, CHEN Xuewei, HE jun, liU Daofeng,TIAN Wei, TIAN Chaoguang, XIA Hongai,li Gang, gao Hui, li Ping, CHEN Wei ,wang Xudong, ZHANG Yong, HU Jianfei,wang Jing, liU Song, yang Jian,ZHANG Guangyu, XIONG Yuqing, li Zhijie,MAO Long, ZHOU Chengshu, ZHU Zhen,CHEN Runsheng, HAO Bailin,ZHENG Weimou, CHEN Shouyi, QUO Wei,li Guojie, liU Siqi, huang Guyang,TAO Ming, wang Jian, ZHU lihuang,YUAN Longping& yang Huanmingbeijing Genomics Institute/Center of Genomics & Bioinformatics, Chinese Academy of Sciences, beijing 101300, china Hangzhou Genomics Institute/Institute of Bioinformatics of Zhejiang university/key laboratory of Bioinformatics of Zhejiang Province, Hangzhou 310007, china Institute of Genetics, Chinese Academy of Sciences, beijing 100101, china National Hybrid Rice R & D Center, Changsha 410125, china laboratory of Bioinformatics, Institute of Biophysics, Chinese Academy of Sciences, beijing 100101, china College of life Sciences, Peking university, beijing 100871, china Institute of Theoretical Physics, Chinese Academy of Sciences, beijing 1Q0080, china Digital china Ltd., beijing 100080, china Institute of Computing Technology, Chinese Academy of Sciences, beijing 100080, china Medical College, Xi’an Jiaotong university, Xi’an 710061, chinaThese authors contributed equally to this work.Corresponding author.Corresponden beijing Genomics Institute/Center of Genomics & Bioinformatics Chinese Academy of Sciences Beijing China Hangzhou Genomics Institute/Institute of Bioinformatics of Zhejiang university/{1. laboratory of Bioinformatics of Zhejiang Province Hangzhou China College of life Sciences Peking University Beijing China Medical College Xi’an Jiaotong University Xi’an China Institute of Genetics Chinese Academy of Sciences Beijing China laboratory of Bioinformatics Institute of Biophysics Chinese Academy of Sciences Beijing China National Hybrid Rice R & D Center Changsha China Institute of Theoretical Physics Chinese Academy of Sciences Beijing China Digital china Ltd. Beijing China Institute of Computing Technology Chinese Academy of Sciences Beijing China

The sequence of the rice genome holds fundamental information for its biology, including physiology, genetics, development, and evolution, as well as information on many beneficial phenotypes of economic significance. Using a "whole genome shotgun" approach, we have pro-duced a draft rice genome sequence of Oryza sativa ssp. in-dica, the major crop rice subspecies in china and many other regions of Asia. The draft genome sequence is constructed from over 4.3 mil{1.on successful sequencing traces with an accumulative total length of 221..9 Mb. The initial assembly of the non-redundant sequences reached 409.76 Mb in length, based on 3.30 mil{1.on successful sequencing traces with a total length of 1.97.4 Mb from an indica variant cultivar 93-1., giving an estimated coverage of 95.29% of the rice genome with an average base accuracy of higher than 99%. The coverage of the draft sequence, the randomness of the sequence distribution, and the consistency of BIG-ASSEM-BLER, a custom-designed software package

关键词： rice genome draft sequences.

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

淫羊藿质量影响因素及质控对策分析

引用

中国中药杂志 2018年第5期43卷 1062-1070页

作者：邓爱平方文韬周青罡杨洪军王凌南铁贵康利平郭兰萍黄璐琦詹志来中国中医科学院中药资源中心道地药材国家重点实验室培育基地北京100700 广东药科大学中药学院广东广州510006 安徽中医药大学药学院安徽合肥230012 江西汇仁药业股份有限公司江西南昌330052 中国中医科学院中药研究所北京100700

淫羊藿为常用强阳补肾药，临床用药历史悠久。淫羊藿多基原、多产地、难鉴别的特点是淫羊藿质量控制中应重点关注的问题，淫羊藿苷的不稳定性是淫羊藿高不合格率的主要原因。针对淫羊藿质量控制难的问题，该文提出以下几点建议：寻找合... 详细信息

淫羊藿为常用强阳补肾药，临床用药历史悠久。淫羊藿多基原、多产地、难鉴别的特点是淫羊藿质量控制中应重点关注的问题，淫羊藿苷的不稳定性是淫羊藿高不合格率的主要原因。针对淫羊藿质量控制难的问题，该文提出以下几点建议：寻找合适的质量控制指标是解决目前淫羊藿质量控制问题的前提。针对淫羊藿资源紧张的问题，建议将药用部位恢复为“干燥地上部分”。此外应加强淫羊藿药材规范化种植，做到种质可控，产地可控，采收可控，加工可控，保证淫羊藿质量。在干燥方法上建议将“晒干或阴干”改为“干燥”，即烘干、晒干、阴干均可。其次对不同品种、不同产地、不同采收期、不同加工方法的淫羊藿进行系统的质量分析，完善淫羊藿质量评价方法，以期为淫羊藿质量控制提供新的思路，为重新制定淫羊藿限量标准提供参考依据。

关键词：淫羊藿研究现状质量影响因素

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

CEPC Technical Design Report

引用

Radiation Detection Technology and Methods 2024年第1期8卷 I0003-I0016,1-1091页

作者： Waleed Abdallah Tiago Carlos Adorno de Freitas Konstantin Afanaciev Shakeel Ahmad Ijaz Ahmed Xiaocong Ai Abid Aleem Wolfgang Altmannshofer Fabio Alves Weiming An Rui An Daniele Paolo Anderle Stefan Antusch Yasuo Arai Andrej Arbuzov Abdesslam Arhrib Mustafa Ashry Sha Bai Yu Bai yang Bai Vipul Bairathi Csaba Balazs Phi{1.p Bambade Yong Ban Tripamo Bandyopadhyay Shou-Shan Bao Desmond P.Barber Ayse Bat Varvara Batozskaya Subash Chandra Behera Alexander Belyaev Michele Bertucci Xiao-jun Bi Yuanjie Bi Tianjian Bian Fabrizio Bianchi Thomas Biekotter Michela Big{1.etti Shalva Bilanishvi{1. deng Bing{1.n Denis Bodrov Anton Bogomyagkov Serge Bondarenko Stewart Boogert Maarten Boonekamp Marcello Borri Angelo Bosotti Vincent Boudry Mohammed Boukidi Igor Boyko Ivanka Bozovic Giuseppe Bozzi Jean-Claude Brient Anastasiia Budzinskaya Masroor Bukhari Vladimir Bytev Giacomo Cacciapag{1.a Hua Cai Wenyong Cai Wujun Cai Yijian Cai Yizhou Cai Yuchen Cai Haiying Cai Huacheng Cai Lorenzo Ca{1.bbi junsong Cang Guofu Cao Jianshe Cao Antoine Chance Xuejun Chang Yue Chang Zhe Chang Xinyuan Chang Wei Chao Auttakit Chatrabhuti Yimin Che Yuzhi Che Bin Chen Danping Chen Fuqing Chen Fusan Chen Gang Chen Guoming Chen Hua-Xing Chen Huirun Chen Jinhui Chen Ji-Yuan Chen Kai Chen Ma{1. Chen Mingjun Chen Mingshui Chen Ning Chen Shanhong Chen Shanzhen Chen Shao-Long Chen Shaomin Chen Shiqiang Chen Tianlu Chen Wei Chen Xiang Chen Xiaoyu Chen Xin Chen Xun Chen Xurong Chen Ye Chen Ying Chen Yukai Chen Ze{1.n Chen Zi{1.n Chen Gang Chen Boping Chen Chunhui Chen Hok Chuen Cheng Huajie Cheng Shan Cheng Tongguang Cheng Yunlong Chi Pietro Chimenti Wen Han Chiu Guk Cho Ming-Chung Chu Xiaotong Chu Zi{1.ang Chu Gug{1.elmo Coloretti Andreas Crivel{1.n Hanhua Cui Xiaohao Cui Zhaoyuan Cui Brunella D'Anzi {1.ng-Yun Dai Xinchen Dai Xuwen Dai Antonio De Maria Nicola De Fi{1.ppis Christophe De La Taille Francesca De Mori Chiara De Sio E{1.sa Del Core Shuangxue deng Wei-Tian deng Zhi deng Ziyan deng Bhupal Dev Tang Dewen Biagio Di Micco Ran Ding Siqin Dingl Yadong Ding Haiyi Dong Jianin AGH university of Science and Technology Faculty of Physics and Applied Computer ScienceKrakow Anhui university HefeiAnhui Applied Physics Department Federal Urdu University of ArtsScience and TechnologyIslamabad Banaras Hindu university Institute of ScienceVaranasi Bandirma Onyedi Eylul university Bandirma Beihang university Beijing beijing Computational Science Research Center Beijing beijing Conveyi LTD Beijing beijing Glass Research Institute Co. LtdBeijing beijing Institute of Technology Beijing beijing Normal {1. Beijing Brown university ProvidenceRI Budker Institute of Nuclear Physics Novosibirsk Cadi Ayyad university Laboratory of Fundamental and Applied PhysicsPolydisciplinary FacultyMarrakech Cairo university Giza Center for Theory and Computation National Tsing Hua UniversityHsinchu Central china Normal {1. WuhanHubei Central South university ChangshaHunan Centro de Fisica Teorica de Particulas Universidade Tecnica de LisboaLisboa Chengdu KaitengSifang Digital Radio&TV Equipment Co. LtdChengduSichuan china academy of engineering physics MianyangSichuan china building materials academy Beijing china Center of Advanced Science and Technology Beijing china Institute of Atomic Energy Beijing china Ji{1.ang university HangzhouZhejiang china Nuclear Instrument CO. LTDBeijing china university of geosciences Beijing china university of geosciences WuhanHubei china {1. of Mining and Technology XuzhouJiangsu china West Normal {1. NanchongSichuan Chongqing university Department of PhysicsChongqing Chulalongkorn university Bangkok City university of Hong Kong Department of PhysicsHong Kong Cockcroft Institute Daresbury Cornell university IthacaNY CPPM(AMU/IPhU&CNRS/INP) Marseille Dalian Minzu {1. DalianLiaoning Dalian {1. of Technology Department of PhysicsDalian Deutsches Elektronen-Synchrotron DESY Hamburg Dzhelepov laboratory of Nuclear Problems of Joint Institute for Nuclear Research(DLNP JINR) Dubna East china {1. Of Science And Technol

The Circular Electron Positron Collider(CEPC)is a large scientific project initiated and hosted by {1.,fostered through extensive collaboration with international *** complex comprises four accelerators:a 30 GeV linac,a 1.1.GeV Damping Ring,a Booster capable of achieving energies up to 1.0 GeV,and a Collider operating at varying energy modes(Z,W,H,and tt).The linac and Damping Ring are situated on the surface,while the subterranean Booster and Collider are housed in a 1.0 km circumference underground tunnel,strategically accommodating future expansion with provisions for a potential Super Proton Proton Collider(SPPC).The CEPC primarily serves as a Higgs *** its baseline design with synchrotron radiation(SR)power of 30 MW per beam,it can achieve a luminosity of 5×1.^(34)cm^(-2)s^(-1.per interaction point(IP),resulting in an integrated luminosity of 1. ab^(-1.for two IPs over a decade,producing 2.6 million Higgs *** the SR power to 50 MW per beam expands the CEPC's capability to generate 4.3 million Higgs bosons,facilitating precise measurements of Higgs coupling at sub-percent levels,exceeding the precision expected from the HL-LHC by an order of *** Technical Design Report(TDR)follows the Preliminary Conceptual Design Report(Pre-CDR,201.)and the Conceptual Design Report(CDR,201.),comprehensively detailing the machine's layout,performance metrics,physical design and analysis,technical systems design,R&D and prototyping efforts,and associated civil engineering ***,it includes a cost estimate and a preliminary construction timeline,establishing a framework for forthcoming engineering design phase and site selection *** is anticipated to begin around 2027-2028,pending government approval,with an estimated duration of 8 *** commencement of experiments and data collection could potentially be initiated in the mid-2030s.

关键词： initiated exceeding precise

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Fabrication of multi-shell coated silicon nanoparticles via in-situ electroless deposition as high performance anodes for lithium ion batteries

引用

Journal of Energy Chemistry 2020年第9期29卷 160-168,I0005页

作者： Wen-Feng Ren jun-Tao {1. Shao-Jian Zhang Ai-{1.ng {1.n You-Hu Chen Zhen-Guang gao Yao Zhou {1. deng {1.ng huang Shi-Gang sun state {1. laboratory of Physical Chemistry of Solid Surfaces iChEM(Collaborative Innovation Center of Chemistry for Energy Materials)College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005FujianChina College of Energy Xiamen UniversityXiamen 361005FujianChina

Si-based materials have been extensively studied because of their high theoretical capacity,low working potential,and abundant reserves,but serious initial irreversible capacity loss and poor cyclic performance resulting from large volume change of Si during lithiation and delithiation processes restrict their widespread ***,we report the preparation of multi-shell coated Si(DS-Si)nanocomposites by in-situ electroless deposition method using Si granules as the active materials and copper sulfate as Cu *** ratio of Si and Cu was readily tuned by varying the concentration of copper *** multi-shell(Cu@CuxSi/SiO2)coating on Si surface promotes the formation of robust and dense SEI films and the transportation of ***,the obtained DS-Si composites exhibit an initial coulombic efficiency of 86.2%,a capacity of 1.36 mAh g^-1.after 1.0 discharge-charge cycles at 840 mA g^-1.and an average charge capacity of 1.93 mAh g^-1.at 4200 mA g^-*** study provides a low-cost and large-scale approach to the preparation of nanostructured Si-metal composites anodes with good electrochemical performance for lithium ion batteries.

关键词： Silicon nanoparticles Multi-shell coating Electroless deposition Anode materials lithium ion batteries

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

7种十字花科绿肥作物对干旱胁迫的生理应答及抗旱性评价

引用

植物营养与肥料学报 2024年第9期30卷 1833-1844页

作者：孙艳妮王佳蓉韩高海唐云丽魏奭杰贾振鹏秦璐杨璐曹卫东黄冬琳高亚军王朝辉张达斌西北农林科技大学资源环境学院陕西杨凌712100 永寿县农业技术推广中心陕西永寿713400 中国农业科学院油料作物研究所/农业农村部油料作物生物学与遗传育种重点开放实验湖北武汉430062 中国农业科学院农业资源与农业区划研究所北京100081 农业农村部西北植物营养与农业环境重点实验室陕西杨凌712100 作物抗逆与高效生产全国重点实验室陕西杨凌712100

【目的】研究干旱胁迫对十字花科绿肥作物生育期生长及生理特性的影响,为筛选适宜的十字花科绿肥作物品种提供理论依据和关键技术参数,助力我国旱地农业绿色发展。【方法】以7种十字花科绿肥为研究对象,通过室内盆栽试验模拟干旱胁迫环... 详细信息

【目的】研究干旱胁迫对十字花科绿肥作物生育期生长及生理特性的影响,为筛选适宜的十字花科绿肥作物品种提供理论依据和关键技术参数,助力我国旱地农业绿色发展。【方法】以7种十字花科绿肥为研究对象,通过室内盆栽试验模拟干旱胁迫环境,分析正常灌水(田间持水量80%)和干旱胁迫(田间持水量40%)条件下7种十字花科绿肥作物生育期内生长指标、光合特性和生理特征的变化规律,并通过主成分分析法对其抗旱性进行综合评价,最终筛选出抗旱能力突出的十字花科绿肥作物品种。【结果】1.与正常灌水相比,干旱胁迫处理下各绿肥作物叶片的净光合速率和蒸腾速率均下降(P2)干旱胁迫条件下,绿肥作物发芽率、根长和生物量分别平均比正常灌水降低6.1.,1.7%(P238%(P3)干旱胁迫条件下,秦优1.号叶片过氧化氢酶活性显著增加26%,秦优1.号、青杂1.号叶片超氧化物歧化酶活性显著增加,7种绿肥叶片过氧化物酶活性均呈升高趋势(P>0.05);4)干旱胁迫会引起中绿油2号、紫芥、秦优1.号和中油肥1.叶片脯氨酸含量显著增加,紫芥、中绿油1.、中绿油2号丙二醛含量显著降低;5)主成分分析结果表明,生物量和叶片丙二醛含量、过氧化氢酶及过氧化物酶活性可作为评估十字花科绿肥抗旱性的首选抗旱指标,中绿油1.在供试7种十字花科绿肥的抗旱能力方面综合评分最高,抗旱能力较强。【结论】中绿油1.因其叶片较高的抗氧化能力、渗透调节能力及较长根系长度,在干旱胁迫条件下综合抗旱能力突出,可作为抗旱型十字花科绿肥品种在黄土高原地区推广应用。

关键词：干旱胁迫十字花科绿肥光合特性生理特征主成分分析

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

基于白光中子源的^(1.7)Au中子辐射俘获截面测量及共振参数分析

引用

物理学报 2024年第7期73卷 104-113页

作者：罗淏天张奇玮栾广源王晓宇邹翀任杰阮锡超贺国珠鲍杰孙琪黄翰雄王朝辉吴鸿毅顾旻皓余滔解立坤陈永浩安琪白怀勇鲍煜曹平陈昊磊陈琪萍陈裕凯陈朕崔增琪樊瑞睿封常青高可庆韩长材韩子杰何泳成洪杨黄蔚玲黄锡汝季筱璐吉旭阳蒋伟江浩雨姜智杰敬罕涛康玲康明涛李波李超李嘉雯李论李强李晓李样刘荣刘树彬刘星言穆奇丽宁常军齐斌斌任智洲宋英鹏宋朝晖孙虹孙康孙晓阳孙志嘉谭志新唐洪庆唐靖宇唐新懿田斌斌王丽娇王鹏程王琦王涛峰文杰温中伟吴青彪吴晓光吴煊羊奕伟易晗于莉于永积张国辉张林浩张显鹏张玉亮张志永赵豫斌周路平周祖英朱丹阳朱科军朱鹏朱兴华中国原子能科学研究院核数据重点实验室北京102413 中国科学院高能物理研究所北京100049 散裂中子源科学中心东莞523803 核探测与核电子学国家重点实验室北京100049 中国科学技术大学近代物理系核探测与核电子学国家重点实验室合肥230026 北京大学物理学院核物理与核技术国家重点实验室北京100871 中国工程物理研究院核物理与化学研究所绵阳621900 西北核技术研究院西安710024 中国科学院大学北京100049 中国科学技术大学工程与应用物理系合肥230026 北京航空航天大学物理学院北京100083 华能山东石岛湾核电有限公司荣成264312

中子辐射俘获反应在反应堆运行、核装置设计及核天体物理研究中起重要的作用.4πBaF_(2)探测装置有着高时间分辨能力、低中子灵敏度、高探测效率等优点,适合开展中子辐射俘获反应截面数据的测量.中国原子能科学研究院核数据重点实验室... 详细信息

中子辐射俘获反应在反应堆运行、核装置设计及核天体物理研究中起重要的作用.4πBaF_(2)探测装置有着高时间分辨能力、低中子灵敏度、高探测效率等优点,适合开展中子辐射俘获反应截面数据的测量.中国原子能科学研究院核数据重点实验室建立了伽马全吸收装置(Gamma total absorption facility,GTAF),该装置用28块六棱BaF_(2)晶体和1.块五棱BaF_(2)晶体构成了外径25 cm,内径1. cm的球壳,覆盖了95.2%的立体角.利用GTAF在中国散裂中子源Back-n束线上,测量了1.7Au(n,γ)的反应截面数据.测量数据通过能量筛选、PSD方法、晶体多重性筛选进行了初步本底扣除,随后结合对^(nat)C及空样品的测量数据对本底进行了分析及扣除,获得了1.7Au俘获反应的产额,利用SAMMY程序拟合得到了^(1.7)Au在1.1.0 e V的共振能量、中子共振宽度和伽马共振宽度参数.实验测量结果与ENDF/B-VIII.0数据库符合良好,其共振参数存在一定差异,分析原因可能与GTAF能量分辨率、Back-n的中子能谱测量精度、以及实验本底扣除方法相关,这也是下一步工作的重点.

关键词：中子辐射俘获截面共振参数白光中子源伽马全吸收装置

来源：

维普期刊数据库博看期刊

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Connexin 43-modified bone marrow stromal cells reverse the imatinib resistance of K562 cells via Ca^(2+)-dependent gap junction intercellular communication

引用

Chinese Medical Journal 2023年第2期136卷 194-206页

作者： Xiaoping li Yunshuo Xiao Xiaoqi {1. Ruihao huang Rui {1. Yi deng jun Rao Qiangguo gao Shijie yang Xi Zhang Department of Hematology 920th Hospital of Joint Logistic Support Force of People’s LiberationKunmingYunnan 650000China Medical Center of Hematology Xinqiao HospitalState Key Laboratory of TraumaBurn and Combined InjuryArmy Medical UniversityChongqing 400037China Department of Cell Biology College of Basic Medicine Army Medical UniversityChongqing 400038China Jinfeng laboratory Chongqing 401329China

Background: Imatinib mesylate (IM) resistance is an emerging problem for chronic myeloid leukemia (CML). Previous studies found that connexin 43 (Cx43) deficiency in the hematopoietic microenvironment (HM) protects minimal residual disease (MRD), but the mechanism remains unknown. Methods: Immunohistochemistry assays were employed to compare the expression of Cx43 and hypoxia-inducible factor 1. (HIF-1.) in bone marrow (BM) biopsies of CML patients and healthy donors. A coculture system of K562 cells and several Cx43-modified bone marrow stromal cells (BMSCs) was established under IM treatment. Proliferation, cell cycle, apoptosis, and other indicators of K562 cells in different groups were detected to investigate the function and possible mechanism of Cx43. We assessed the Ca^(2+)-related pathway by Western blotting. Tumor-bearing models were also established to validate the causal role of Cx43 in reversing IM resistance. Results: Low levels of Cx43 in BMs were observed in CML patients, and Cx43 expression was negatively correlated with HIF-1.. We also observed that K562 cells cocultured with BMSCs transfected with adenovirus-short hairpin RNA of Cx43 (BMSCs-shCx43) had a lower apoptosis rate and that their cell cycle was blocked in G0/G1.phase, while the result was the opposite in the Cx43-overexpression setting. Cx43 mediates gap junction intercellular communication (GJIC) through direct contact, and Ca ^(2+ )is the key factor mediating the downstream apoptotic pathway. In animal experiments, mice bearing K562, and BMSCs-Cx43 had the smallest tumor volume and spleen, which was consistent with the in vitro experiments. Conclusions: Cx43 deficiency exists in CML patients, promoting the generation of MRD and inducing drug resistance. Enhancing Cx43 expression and GJIC function in the HM may be a novel strategy to reverse drug resistance and promote IM efficacy.

关键词： Bone marrow microenvironment Connexin 43(Cx43) Gap junction intercellular communication Hypoxia Imatinib resistance

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Combination of anti-PD-1.antibody with P-GEMOX as apotentially effective immunochemotherapy for advancednatural killer/T cell lymphoma

引用

Signal Transduction and Targeted Therapy 2021年第1期6卷 184-192页

作者： jun Cai Panpan {1.u Huiqiang huang Yajun {1. Shuyun Ma Hui Zhou Xiaopeng Tian Yuchen Zhang Yan gao Yi Xia Xuanye Zhang Hang yang {1.rong {1. Qingqing Cai state {1. laboratory of Oncology in South china Collaborative Innovation Center of Cancer MedicineSun Yat-sen University Cancer CenterGuangzhou 510060P.R.China Department of Medical Oncology Sun Yat-sen University Cancer CenterGuangzhou 510060P.R.China Department of Lymphoma and Hematology Hunan Cancer HospitalChangsha 410013P.R.China Department of Lymphoma and Hematology The Affiliated Cancer Hospital of Xiangya School of MedicineCentral South UniversityChangsha 410013P.R.China

Advanced natural killer/T cell lymphoma(NKTL)has demonstrated poor prognosis with currently available ***,we report the efficacy of anti-programmed death 1.PD-1.antibody with the P-GEMOX(pegaspargase,gemcitabine,and oxaliplatin)regimen in advanced *** patients underwent six 21.day cycles of anti-PD-1.antibody(day 1.,pegaspargase 2000 U/m^(2)(day 1.,gemcitabine 1.g/m^(2)(days 1.and 8)and oxaliplatin 1.0 mg/m^(2)(day 1.,followed by anti-PD-1.antibody maintenance every 3 *** death-ligand 1.PD-L1.expression and genetic alterations were determined in paraffin-embedded pretreatment tissue samples using immunohistochemistry and next-generation sequencing(NGS)*** were assessed using ^(1.)F-fluorodeoxyglucose positron emission tomography(^(1.)FDG-PET)and computed tomography or magnetic resonance *** patients exhibited significant responses,comprising of seven complete remissions and one partial remission(overall response rate:88.9%).After a median follow-up of 1..6 months,6/9 patients(66.7%)remained in complete *** most common grade 3/4 adverse events were anemia(33.3%),neutropenia(33.3%),and thrombocytopenia(33.3%);all of which were manageable and *** produced a high response rate in patients with positive PD-L1.expression(5/6,83.3%).NGS analysis suggested that STAT3/JAK3/PD-L1.alterations and ARID1. mutation were associated with immunochemotherapy *** in DDX3X and alteration in epigenetic modifiers of KMT2D,TET2,and BCORL1.might indicate a poor response to *** conclusion,the anti-PD-1.antibody plus P-GEMOX regimen demonstrated promising efficacy in advanced ***-L1.expression combined with specific genetic alterations could be used as potential biomarkers to predict therapeutic responses to immunochemotherapy.

关键词： alterations killer lymphoma

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Differential transcriptomic landscapes of multiple organs from SARS-CoV-2 early infected rhesus macaques

引用

Protein & Cell 2022年第12期13卷 920-939页

作者： Chun-Chun gao Man li Wei deng Chun-Hui Ma Yu-Sheng Chen Yong-Qiao sun Tingfu Du Qian-Lan liu Wen-Jie li Bing Zhang lihong sun Si-Meng liu Fengli li Feifei Qi Yajin Qu Xinyang Ge Jiangning liu Peng wang Yamei Niu Zhiyong liang Yong-liang Zhao Bo huang Xiao-Zhong Peng Ying yang Chuan Qin Wei-Min Tong Yun-Gui yang CAS key {1. of Genomic and Precision Medicine Collaborative Innovation Center of Genetics and DevelopmentCollege of Future TechnologyBeijing Institute of GenomicsChinese Academy of SciencesBeijing 100101China china National Center for Bioinformation Beijing 100101China Sino-Danish College University of Chinese Academy of SciencesBeijing 101408China Department of Pathology Beijing Ditan HospitalCapital Medical UniversityBeijing 100000China Department of Pathology Institute of Basic Medical SciencesMolecular Pathology Research CenterChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100005China NHC key {1. of Human Disease Comparative Medicine Beijing Key Laboratory for Animal Models of Emerging and Remerging Infectious DiseasesInstitute of Laboratory Animal ScienceChinese Academy of Medical Sciences and Comparative Medicine CenterPeking Union Medical CollegeBeijing 100021China Institute of Stem Cell and Regeneration Chinese Academy of SciencesBeijing 100101China Institute of Medical Biology Chinese Academy of Medical Sciences and Peking Union Medical CollegeKunming 650031China Center for Experimental Animal Research Institute of Basic Medical Sciences Chinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100005China Department of Pathology Peking Union Medical College HospitalMolecular Pathology Research CenterChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100005China Department of Immunology&National key {1. of Medical Molecular Biology Institute of Basic Medical SciencesChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100005China Clinical Immunology Center Chinese Academy of Medical SciencesBeijing 100005China Department of Biochemistry&Molecular Biology Tongji Medical CollegeHuazhong University of Science&TechnologyWuhan 430030China state {1. laboratory of Medical Molecular Biology Department of Molecular Biology and BiochemistryInstitute of Basic Med

SARS-CoV-2 infection causes complicated clinical manifestations with variable multi-organ injuries,how-ever,the underlying mechanism,in particular immune responses in different organs,remains *** this study,comprehensive transcriptomic alterations of 1. tissues from rhesus macaque infected with SARS-CoV-2 were *** to normal controls,SARS-CoV-2 infection resulted in dysregulation of genes involving diverse functions in various examined tissues/organs,with drastic transcriptomic changes in cerebral cortex and right ***,cerebral cortex exhibited a hyperinflammatory state evidenced by sig-nificant upregulation of inflammation response-related ***,expressions of coagulation,angio-genesis and fibrosis factors were also up-regulated in cerebral *** on our findings,neuropilin 1.NRP1.,a receptor of SARS-CoV-2,was significantly elevated in cerebral cortex post infection,accompanied by active immune response releasing inflammatory factors and signal transmission among tissues,which enhanced infection of the central nervous system(CNS)in a positive feedback way,leading to viral ***,our study depicts a multi-tissue/organ tran-scriptomic landscapes of rhesus macaque with early infection of SARS-CoV-2,and provides important insights into the mechanistic basis for COVID-1.-asso-ciated clinical complications.

关键词： SARS-CoV-2 NRP1 inflammation central nervous system viral encephalitis rhesus macaque

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

The histone methyltransferase EZH2 primes the early differentiation of follicular helper T cells during acute viral infection

引用

Cellular & Molecular Immunology 2020年第3期17卷 247-260页

作者： Xiangyu Chen Guoshuai Cao Jialin Wu Xinxin wang Zhiwei Pan Jianbao gao Qin Tian lifan Xu Zhirong li Yaxing Hao Qizhao huang Pengcheng wang Minglu Xiao Luoyingzi Xie Shupei Tang Zhenyu liu li Hu Jianfang Tang Ran He li wang Xinyuan Zhou Yuzhang Wu Mengjie Chen Beicheng sun Bo Zhu jun huang lilin Ye Institute of Immunology PLAThird Military Medical University400038 ChongqingChina Institute for Molecular Engineering University of ChicagoChicagoIL 60637USA Institute of Cancer Xinqiao HospitalThird Military Medical University400038 ChongqingChina Cancer Center The General Hospital of Western Theater CommandChengduChina Section of Genetic Medicine Department of MedicineUniversity of ChicagoChicagoIL 60637USA Department of Hepatobiliary Surgery The Affiliated Drum Tower Hospital of Nanjing University Medical SchoolNanjing 210009 JiangsuChina

Epigenetic modifications to histones dictate the differentiation of naïve CD4^(+) T cells into different subsets of effector T helper(TH)*** histone methyltransferase enhancer of zeste homolog 2(EZH2)has been implicated in the mechanism regulating the differentiation of TH1.TH2 and regulatory T(Treg)***,whether and how EZH2 regulates follicular helper T(TFH)cell differentiation remain *** a mouse model of acute lymphocytic choriomeningitis virus(LCMV)infection,we observed abundant EZH2 expression and associated H3K27me3 modifications preferentially in the early committed virus-specific TFH cells compared to those in TH1.*** of EZH2 in LCMV-specific CD4^(+) T cells leads to a selective impairment of early TFH cell fate commitment,but not late TFH differentiation or memory TFH ***,EZH2 specifically stabilizes the chromatin accessibility of a cluster of genes that are important for TFH fate commitment,particularly B cell lymphoma 6(Bcl6),and thus directs TFH cell ***,we identified the chromatin-modifying enzyme EZH2 as a novel regulator of early TFH differentiation during acute viral infection.

关键词： EZH2 infection acute

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：