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Experimental remolding on the caprock's 3D strain field of the Indosinian-Yanshanian epoch in Tongling deposit concentrating area

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Science china Earth Sciences 2005年第7期48卷 863-874页

作者： deng jun1,huang dinghua2,wang qingfei1,wan li1,sun zhongshi3.yang liqiang1 & gao bangfei1 1. state key laboratory of geological processes and mineral resources,china university of geosciences,beijing 100083.china 2. Faculty of Earth Sciences,china university of geosciences,Wuhan 430074,china 3. Department of Earth Sciences,Jilin university,Changchun 130061,china state {1. laboratory of geological processes and mineral resources China University of Geosciences Beijing 100083 China Faculty of Earth Sciences China University of Geosciences Wuhan 430074 China Department of Earth Sciences Jilin University Changchun 130061 China

Based on field observations and rheology analysis, we perform one analogue experiment and remold the 3D structural frame of Tongling deposit concentrating area firstly. Then we disassemble and dialyze the 3D structures of the model using the methods of "slicing" and "stripping". A series of sliced planes vertical to the fold hinges show similar landscapes of that in the drill hole profiles. Meanwhile, layer stripping analysis indicates that the deformation features of each layer in the model are qualitatively analogical to those obtained from field observations. Through contrasting the 3D structure between the experimental model and the field phenomena, we verify the following 3D deformation features of the caprock in this area: (1. the Tongling area mainly consists of three series of NE S-typed fold groups; (2) in the uniform stress field, the incoherent folds universally develop in different positions, along different axes as well as in different strata; (3) the faults propagate upward which are mostly inter-bedded detachment faults, while the fold amplitudes decrease while going deeper; and (4) the folds and cleavages are highly developed in the Silurian System indicating that the deformation effect of the Indosin-ian-Yanshanian structural layer terminates at this layer, which suggests that the Silurian System is the crucial layer for the inversion between brittle and plastic deformation domains and the underlying strata are subject to the control of another deformation system with distinct properties.

关键词： Tongling deposit concentrating area Indosinian-Yanshanian epoch 3D structural frame of the caprock analogue experiment slicing and stripping analysis structural model.

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Transport network and flow mechanism of shallow ore-bearing magma in Tongling ore cluster area

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Science china Earth Sciences 2006年第4期49卷 397-407页

作者： deng jun1,2, wang qingfei1,2 , huang dinghua3 , wan li4, yang liqiang1,2 & gao bangfei1,2 1. state key laboratory of geological processes and mineral resources, china university of geosciences, beijing 100083, china 2. key laboratory of lithosphere Tectonics and lithoprobing Technology of Ministry of Education, china university of Geo- sciences, beijing 100083, china 3. Faculty of Earth Sciences, china university of geosciences, Wuhan 430074, china 4. School of Mathematics and Information Science, Guangzhou university, Guangzhou 510405, china state {1. laboratory of geological processes and mineral resources China University of Geosciences Beijing China key {1. of lithosphere Tectonics and lithoprobing Technology of Ministry of Education China University of Geosciences Beijing China Faculty of Earth Sciences China University of Geosciences Wuhan China School of Mathematics and Information Science Guangzhou University Guangzhou China

Abundant studies revealed that shallow intrusions of the Yanshanian epoch resulted in the mass mineralization of the Tong{1.ng region. Various evidences showed there existed a concealed magma chamber at ?1. km depth in the middle part of this region during Yanshanian epoch, from which the ore-forming magma was generated and then transported to the superficial layer. Yet the transport network and flow mechanism of the shallow ore-bearing magma, the key problem associ- ated with ore-forming process, was relatively {1.ttle focused on. Integrate analysis of structural me- chanics, statistical fractal and geological facts suggested that NE trending high-angle fold-related thrust faults and the tessellated basement ones served as the main pathways for the shallow magma’s transporting, moreover, the saddle void spaces among adjacent strata in the folds upon this fault system provided the place for magma’s emplacement. So the folds in the upper part and faults in the lower part of the upper crust constituted the fluid’s transport and emplacement network. During the deformation of geologic body with multi-layer structure, the layers in the upper part tended to fold when received the jacking stress from the lower part, while the lower one inc{1.ned to fault undergoing loads of the upper part. And the producing probabi{1.ty of this structure assemblage was highly in- creased in the condition, such as in the Tong{1.ng area, that the mechanic rigidity of the lower layers was stronger than that of the upper ones. For the pre-existence of fluid-conducting network, the top magma with high volatile in the magma chamber transported rapidly to the superficial layer in dyking pattern, located in the void spaces of folds, filled and reconstructed them. The sudden drop of pres- sure caused the fluid unmixing from the magma and mass ore-forming elements concentration. Pulse activity of the dyking may be the principal reason why magmatic bodies in the Tong{1.ng area were spatially-temporally con

关键词： Tongling, structural network, magma intrusion, fractal, dyke.

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Surface engineering of P2-type cathode material targeting long-cycling and high-rate sodium-ion batteries

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Journal of Energy Chemistry 2024年第10期97卷 444-452,I0009页

作者： jun Xiao {1. Xiao Shijian wang Zefu huang Jiayi li Cheng Gong Guilai Zhang Bing sun Hong gao Huiqiao li Xin Guo Yong wang Hao liu Guoxiu wang Centre for Clean Energy Technology School of Mathematical and Physical SciencesFaculty of ScienceUniversity of Technology SydneyBroadwaySydneyNew South Wales 2007Australia Joint International laboratory on Environmental and Energy Frontier Materials School of Environmental and Chemical EngineeringShanghai UniversityShanghai 200444China state {1. laboratory of Materials Processing and Die and Mould Technology School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074HubeiChina

The widespread interest in layered P2-type Mn-based cathode materials for sodium-ion batteries(SIBs)stems from their cost-effectiveness and abundant ***,the inferior cycle stability and mediocre rate performance impede their further development in practical ***,we devised a wet chemical precipitation method to deposit an amorphous aluminum phosphate(AlPO_(4),denoted as AP)protective layer onto the surface of P2-type Na_(0.55)Ni_(0.1.Co_(0.7)Mn_(0.8)O_(2)(NCM@AP).The resulting NCM@5AP electrode,with a 5 wt%coating,exhibits extended cycle life(capacity retention of78.4%after 200 cycles at 1.0 mA g^(-1.)and superior rate performance(98 mA h g^(-1.at 500 mA g^(-1.)compared to pristine ***,our investigation provides comprehensive insights into the phase stability and active Na^(+)ion kinetics in the NCM@5AP composite electrode,shedding light on the underlying mechanisms responsible for the enhanced performance observed in the coated electrode.

关键词： Layered metal oxides Sodium-ion batteries P2-type structure Surface engineering

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Scientific Advances and Weather Services of the china Meteorological Administration’s National Forecasting Systems during the {1. 2022 Winter Olympics

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Advances in Atmospheric Sciences 2024年第5期41卷 767-776页

作者： Guo deng Xueshun SHEN jun DU Jiandong GONG Hua TONG liantang deng Zhifang XU Jing CHEN Jian sun Yong wang Jiangkai HU Jianjie wang Mingxuan CHEN Huiling YUAN Yutao ZHANG Hongqi li Yuanzhe wang li gao li SHENG Da li li li Hao wang Ying ZHAO Yinglin li Zhili liU Wenhua GUO china Meteorological Administration Earth System Mode{1.ng and Prediction Centre Beijing 100081China state {1. laboratory of Severe Weather China Meteorological AdministrationBeijing 100081China key {1. of Earth System Modeling and Prediction China Meteorological AdministrationBeijing 100081China National Meteorological Center China Meteorological AdministrationBeijing 100081China Environmental Modeling Center/NCEP/NWS/NOAA College ParkMD 20740USA Nanjing university of Information Science and Technology Nanjing 210044China Institute of Urban Meteorology China Meteorological AdministrationBeijing 100089China School of Atmospheric Sciences and key {1. of Mesoscale Severe Weather/Ministry of Education Nanjing UniversityNanjing 210023China Tsinghua university Beijing 100084China

Since the beijing 2022 Winter Olympics was the first Winter Olympics in history held in continental winter monsoon c{1.mate conditions across complex terrain areas,there is a deficiency of relevant research,operational... 详细信息

Since the beijing 2022 Winter Olympics was the first Winter Olympics in history held in continental winter monsoon climate conditions across complex terrain areas,there is a deficiency of relevant research,operational techniques,and *** made providing meteorological services for this event particularly *** china Meteorological Administration(CMA)Earth System Modeling and Prediction Centre,achieved breakthroughs in research on short-and medium-term deterministic and ensemble numerical *** key technologies crucial for precise winter weather services during the Winter Olympics were developed.A comprehensive framework,known as the Operational System for High-Precision Weather Forecasting for the Winter Olympics,was *** of these advancements represent the highest level of capabilities currently available in *** meteorological service provided to the beijing 2022 Games also exceeded previous Winter Olympic Games in both variety and *** included achievements such as the“100-meter level,minute level”downscaled spatiotemporal resolution and forecasts spanning 1 to 15 *** 30 new technologies and over 60 kinds of products that align with the requirements of the Winter Olympics Organizing Committee were developed,and many of these techniques have since been integrated into the CMA’s operational national forecasting *** accomplishments were facilitated by a dedicated weather forecasting and research initiative,in conjunction with the preexisting real-time operational forecasting systems of the *** program represents one of the five subprograms of the WMO’s high-impact weather forecasting demonstration project(SMART2022),and continues to play an important role in their Regional Association(RA)II Research Development Project(Hangzhou RDP).Therefore,the research accomplishments and meteorological service experiences from this program will be carried forward into forthcoming highimpact weather

关键词： beijing Winter Olympic Games CMA national forecasting system data assimilation ensemble forecast bias correction and downscaling machine learning-based fusion methods

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Tislelizumab in previously treated,locally advanced unresectable/metastatic microsatellite instability-high/mismatch repair-deficient solid tumors

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Chinese Journal of Cancer Research 2024年第3期36卷 257-269页

作者： Jian li Ye Xu Aimin Zang Yunong {1. Quanli {1. Yanqiao Zhang Dong wang Jianming Xu Ying Yuan Haiping Jiang Jieer Ying Chunmei Shi Yanhong deng Jing wang Tianshu liu Yi huang Xiaoping Qian Yueyin Pan Ying Cheng Sheng Hu Jin wang Mengyue Shi Ke wang Han Hu lin Shen state {1. laboratory of Holistic Integrative Management of Gastrointestinal Cancers Beijing Key Laboratory of Carcinogenesis and Translational ResearchDepartment of Gastrointestinal OncologyPeking University Cancer Hospital&InstituteBeijing 100142China Department of Oncology Fudan University Shanghai Cancer CenterShanghai 200032China Department of Medical Oncology Affiliated Hospital of Hebei UniversityBaoding 071000China key {1. of Carcinogenesis and Translational Research(Ministry of Education/beijing) Department of GynecologyPeking University Cancer Hospital&InstituteBeijing 100142China Department of Immunotherapy Henan Cancer HospitalZhengzhou 450001China Department of Gastrointestinal Oncology Affiliated Cancer Hospital of Harbin Medical UniversityHarbin 150086China Department of Gastrointestinal Oncology Chongqing University Cancer HospitalChongqing 400030China Department of Gastrointestinal Oncology the Fifth Medical CenterChinese PLA General HospitalBeijing 100048China Department of Medical Oncology the Second Affiliated HospitalZhejiang University School of MedicineHangzhou 310009China Department of Medical Oncology the First Affiliated HospitalZhejiang University School of MedicineHangzhou 310003China Department of Medical Oncology Cancer Hospital of the University of Chinese Academy of SciencesHangzhou 310022China Department of Medical Oncology Fujian Medical University Union HospitalFuzhou 350001China Department of Oncology the Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhou 510655China Department of Medical Oncology Hunan Cancer HospitalChangsha 410013China Department of Medical Oncology Zhongshan HospitalFudan UniversityShanghai 200032China Department of Immunotherapy Hubei Cancer HospitalWuhan 430079China Department of Medical Oncology the Affiliated Hospital of Nanjing University Medical SchoolNanjing 210008China Department of Medical Oncology Anhui Provincial HospitalHefei 230001China Department of Medical Oncology Jilin Cancer Hospital

Objective:The open-label,phase II RATIONALE-209 study evaluated tislelizumab(anti-programmed cell death protein 1.antibody)as a tissue-agnostic monotherapy for microsatellite instability-high(MSI-H)/mismatch repair-deficient(dMMR)***:Adults with previously treated,locally advanced unresectable or metastatic MSI-H/dMMR solid tumors were *** received tislelizumab 200 mg intravenously every 3 *** response rate(ORR;primary endpoint),duration of response(DoR),and progression-free survival(PFS)were assessed by independent review committee(Response Evaluation Criteria in Solid Tumors v1.1..Results:Eighty patients were enrolled and treated;75(93.8%)patients had measurable disease at *** had metastatic disease and received at least one prior therapy for advanced/metastatic disease(n=79;98.8%).At primary analysis(data cutoff July 8,2021.median follow-up 1..2 months),overall ORR[46.7%;95%confidence interval(95%CI),35.1.58.6;one-sided P1.and ORR across tumor-specific subgroups[colorectal(n=46):39.1.(95%CI,25.1.54.6);gastric/gastroesophageal junction(n=9):55.6%(95%CI,21.2−86.3);others(n=20):60.0%(95%CI,36.1.80.9)]were significantly greater with tislelizumab vs.a prespecified historical control ORR of 1.%;five(6.7%)patients had complete *** DoR,PFS,and overall survival were not reached with long-term follow-up(data cutoff December 5,2022;median follow-up 28.9 months).Tislelizumab was well tolerated with no unexpected safety ***-related adverse events(TRAEs)of grade≥3 occurred in 53.8%of patients;7.5%of patients discontinued treatment due to ***:Tislelizumab demonstrated a significant ORR improvement in patients with previously treated,locally advanced unresectable or metastatic MSI-H/dMMR tumors and was generally well tolerated.

关键词： Biomarkers DNA mismatch repair immune checkpoint inhibitors microsatellite instability phase II clinical trials programmed cell death 1.receptor

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Associations of sleeping patterns and isotemporal substitution of other behavior with the prevalence of CKD in Chinese adults

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Frontiers of Medicine 2024年第2期18卷 303-314页

作者： Yi Ding Xiaoli Xu Zhuojun Xin Qiuyu Cao Jiaojiao huang Xianglin Wu Yanan Huo Qin wan Yingfen Qin Ruying Hu lixin Shi Qing Su Xuefeng Yu li Yan Guijun Qin Xulei Tang Gang Chen Min Xu Tiange wang Zhiyun Zhao Zhengnan gao Guixia wang Feixia Shen Zuojie Luo li Chen Qiang li Zhen Ye Yinfei Zhang Chao liu Youmin wang Tao yang Huacong deng Lulu Chen Tianshu Zeng Jiajun Zhao Yiming Mu Shengli Wu Yuhong Chen Jieli Lu Weiqing wang Guang Ning Yu Xu Yufang Bi Mian li Department of Endocrine and Metabolic Diseases Shanghai Institute of Endocrine and Metabolic DiseasesRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai200025China Shanghai National Clinical Research Center for Metabolic Diseases Key Laboratory for Endocrine and Metabolic Diseases of the National Health Commission of ChinaShanghai Key Laboratory for Endocrine TumorState Key Laboratory of Medical GenomicsRuijin HospitalShanghai Jiao Tong University School of MedicineShanghai200025China Jiangxi Provincial People’s Hospital Affiliated to Nanchang UniversityNanchang330000China Department of Endocrinology The Affiliated Hospital of Southwest Medical UniversityLuzhou646000China Department of Endocrinology The First Affiliated Hospital of Guangxi Medical UniversityNanning530000China Zhejiang Provincial Center for Disease Control and Prevention Hangzhou310000China Department of Endocrinology Affiliated Hospital of Guiyang Medical UniversityGuiyang550000China Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai200000China Tongji Hospital Tongji Medical CollegeHuazhong University of Science and TechnologyWuhan430000China sun Yat-sen Memorial Hospital Sun Yat-sen UniversityGuangzhou510000China Department of Endocrinology The First Affiliated Hospital of Zhengzhou UniversityZhengzhou450000China Department of Endocrinology The First Hospital of Lanzhou UniversityLanzhou730000China Fujian Provincial Hospital Fujian Medical UniversityFuzhou350000China Dalian Municipal Central Hospital Affiliated of Dalian Medical UniversityDalian116000China Department of Endocrinology The First Hospital of Jilin UniversityChangchun130000China Department of Endocrinology The First Affiliated Hospital of Wenzhou Medical UniversityWenzhou325000China Qilu Hospital of Shandong university Jinan250000China Department of Endocrinology The Second Affiliated Hospital of Harbin Medical UniversityHarbin150000China Department of Endocrinology Cen

Studies have found a U-shaped relationship between sleep duration and chronic kidney disease(CKD)risk,but limited research evaluated the association of reallocating excessive sleep to other behavior with *** included 1.4538 participants from the nationwide cohort of the Risk Evaluation of Cancers in Chinese Diabetic Individuals:A Longitudinal Study,with self-reported time of daily-life *** isotemporal substitution models,we found that substituting 1.h of sleeping with sitting,walking,or moderate-to-vigorous physical activity was associated with a lower CKD ***-time physical activity displacement was associated with a greater prevalence reduction than occupational physical activity in working *** stratified analysis,a lower CKD prevalence related to substitution toward physical activity was found in long *** pronounced correlations were observed in long sleepers with diabetes than in those with prediabetes,and they benefited from other behavior substitutions toward a more active *** U-shaped association between sleep duration and CKD prevalence implied the potential effects of insufficient and excessive sleep on the kidneys,in which the pernicious link with oversleep could be reversed by time reallocation to physical *** divergence in the predicted effect on CKD following time reallocation to behavior of different domains and intensities and in subpopulations with diverse metabolic statuses underlined the importance of optimizing sleeping patterns and adjusting integral behavioral composition.

关键词： sleep physical activity chronic kidney disease isotemporal substitution behavioral pattern

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sTREM-1.as promising prognostic biomarker for acute-on-chronic liver failure and mortality in patients with acute decompensation of cirrhosis

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World Journal of Gastroenterology 2024年第9期30卷 1177-1188页

作者： Song-Man Yu Hai li Guo-Hong {1. Xian-Bo wang Xin Zheng Jin-jun Chen Zhong-Ji Meng Yu-Bao Zheng Yan-Hang gao Zhi-Ping Qian Feng liu Xiao-Bo Lu Yu Shi Jia Shang Ruo-Chan Chen Yan huang Department of Infectious Diseases Xiangya HospitalCentral South UniversityChangsha 410000Hunan ProvinceChina Department of Gastroenterology Renji HospitalShanghai Jiao Tong University School of MedicineShanghai 200127China Department of Infectious Diseases Southwest HospitalThird Military Medical University(Army Medical University)Chongqing 400038China Center of Integrative Medicine Beijing Ditan HospitalCapital Medical UniversityBeijing 100020China Department of Infectious Diseases Institute of Infection and ImmunologyUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430020Hubei ProvinceChina Department of Infectious Diseases Nanfang HospitalSouthern Medical UniversityGuangzhou 510515Guangdong ProvinceChina Department of Infectious Disease Taihe HospitalHubei University of MedicineShiyan 442009Hubei ProvinceChina Department of Infectious Diseases The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630Guangdong ProvinceChina Department of Hepatology The First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina Department of liver Intensive Care Unit Shanghai Public Health Clinical CentreFudan UniversityShanghai 200093China Tianjin Institute of Hepatology Nankai University Second People's HospitalTianjin 300192China Infectious Disease Center The First Affiliated Hospital of Xinjiang Medical UniversityUrumqi 830054Xinjiang Uygur Autonomous RegionChina The state {1. laboratory for Diagnosis and Treatment of Infectious Diseases The First Affiliated Hospital of School of MedicineZhejiang UniversityHangzhou 310003Zhejiang ProvineChina Department of Infectious Diseases Henan Provincial People's HospitalZhengzhou 463599Henan ProvineChina Department of Infectious Diseases Hunan Key Laboratory of Viral HepatitisXiangya HospitalCentral South UniversityChangsha 110051Hunan ProvineChina

BACKGROUND Acute decompensation(AD)of cirrhosis is associated with high short-term mortality,mainly due to the development of acute-on-chronic liver failure(ACLF).Thus,there is a need for biomarkers for early and accurate identification of AD patients with high risk of development of ACLF and *** triggering receptor expressed on myeloid cells-1.sTREM-1.is released from activated innate immune cells and correlated with various inflammatory *** To explore the prognostic value of sTREM-1.in patients with AD of *** A multicenter prospective cohort of 442 patients with cirrhosis hospitalized for AD was divided into a study cohort(n=309)and validation cohort(n=1.3).Demographic and clinical data were collected,and serum sTREM-1.was measured at *** enrolled patients were followed-up for at least 1.*** In patients with AD and cirrhosis,serum sTREM-1.was an independent prognosis predictor for 1.year survival and correlated with liver,coagulation,cerebral and kidney failure.A new prognostic model of AD(P-AD)incorporating sTREM-1.blood urea nitrogen(BUN),total bilirubin(TBil),international normalized ratio(INR)and hepatic encephalopathy grades was established and performed better than the model for end-stage liver disease(MELD),MELD-sodium(MELD-Na),chronic liver failure-consortium(CliF-C)ACLF and CliF-C AD ***,sTREM-1.was increased in ACLF and predicted the development of ACLF during first 28-d *** ACLF risk score incorporating serum sTREM-1.BUN,INR,TBil and aspartate aminotransferase levels was established and significantly superior to MELD,MELD-Na,CliF-C ACLF,CliF-C AD and P-AD in predicting risk of ACLF *** Serum sTREM-1.is a promising prognostic biomarker for ACLF development and mortality in patients with AD of cirrhosis.

关键词： Soluble triggering receptor expressed on myeloid cell-1 Acute decompensation Cirrhosis Acute-on-chronic liver failure Prognostic biomarker

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Characterization of acute-on-chronic liver diseases: A multicenter prospective cohort study

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World Journal of Hepatology 2024年第5期16卷 809-821页

作者： Yuan-Yao Zhang Sen Luo Hai li Shu-Ning sun Xian-Bo wang Xin Zheng Yan huang Bei-ling li Yan-Hang gao Zhi-Ping Qian Feng liu Xiao-Bo Lu jun-Ping liu Hao-Tang Ren Yu-Bao Zheng Hua-Dong Yan Guo-Hong deng liang Qiao Yan Zhang Wen-Yi Gu Xiao-Mei Xiang Yi Zhou Yi-Xin Hou Qun Zhang Yan Xiong Cong-Cong Zou jun Chen Ze-Bing huang Xiu-Hua Jiang Ting-Ting Qi Yuan-Yuan Chen Na gao Chun-Yan liu Wei Yuan Xue Mei Jing li Tao li Rong-Jiong Zheng Xin-Yi Zhou jun Zhao Zhong-Ji Meng Department of Infectious Disease Institute of Biomedical ResearchRegulatory Mechanism and Targeted Therapy for Liver Cancer Shiyan Key LaboratoryHubei provincial Clinical Research Center for Precise Diagnosis and Treatment of Liver CancerTaihe HospitalHubei University of MedicineShiyan 442000Hubei ProvinceChina Department of Gastroenterology Renji HospitalSchool of MedicineShanghai Jiao Tong UniversityShanghai 200120China Department of Infectious Diseases Southwest HospitalThe Third Military Medical University(Army Medical University)Chongqing 400000China Center of Integrative Medicine Beijing Ditan HospitalCapital Medical UniversityBeijing 100020China Department of Infectious Diseases Institute of Infection and ImmunologyUnion HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430020Hubei ProvinceChina Department of Infectious Diseases Hunan Key Laboratory of Viral HepatitisXiangya HospitalCentral South UniversityChangsha 110051Hunan ProvinceChina Hepatology Unit Department of Infectious DiseasesNanfang HospitalSouthern Medical UniversityGuangzhou 510515Guangdong ProvinceChina Department of Hepatology The First Hospital of Jilin UniversityChangchun 130021Jilin ProvinceChina Department of liver Intensive Care Unit Shanghai Public Health Clinical CentreFudan UniversityShanghai 200093China Tianjin Institute of Hepatology Nankai University Second People's HospitalTianjin 300192China Infectious Disease Center The First Affiliated Hospital of Xinjiang Medical UniversityUrumqi 830054Xinjiang Uygur Autonomous RegionChina Department of Infectious Diseases and Hepatology The Second Hospital of Shandong UniversityJinan 250000Shandong ProvinceChina state {1. laboratory for Diagnosis and Treatment of Infectious Diseases Collaborative Innovation Center for Diagnosis and Treatment of Infectious DiseaseThe First Affiliated HospitalZhejiang University School of MedicineHangzhou 310000Zhejiang ProvinceChina Department of Infectious Diseases The Thir

BACKGROUND Acute-on-chronic liver disease(AoCLD)accounts for the majority of patients hospitalized in the Department of Hepatology or Infectious *** To explore the characterization of AoCLD to provide theoretical guidance for the accurate diagnosis and prognosis of *** Patients with AoCLD from the Chinese Acute-on-Chronic liver Failure(ACLF)study cohort were included in this *** clinical characteristics and outcomes,and the 90-d survival rate associated with each clinical type of AoCLD were analyzed,using the Kaplan-Meier method and the log-rank *** A total of 3375 patients with AoCLD were enrolled,including 1.79(49.7%)patients with liver cirrhosis acute decompensation(LC-AD),850(25.2%)patients with ACLF,577(1..1.)patients with chronic hepatitis acute exacer-bation(CHAE),and 269(8.0%)patients with liver cirrhosis active phase(LC-A).The most common cause of chronic liver disease(CLD)was HBV infection(71.4%).The most common precipitants of AoCLD was bacterial infection(22.8%).The 90-d mortality rates of each clinical subtype of AoCLD were 43.4%(232/535)for type-C ACLF,36.0%(36/1.0)for type-B ACLF,27.0%(58/21.)for type-A ACLF,9.0%(1.1.1.79)for LC-AD,3.0%(8/269)for LC-A,and 1.2%(7/577)for *** HBV infection is the main cause of CLD,and bacterial infection is the main precipitant of *** most common clinical type of AoCLD is *** diagnosis and timely intervention are needed to reduce the mortality of patients with LC-AD or ACLF.

关键词： Acute-on-chronic liver disease Acute-on-chronic liver failure liver cirrhosis Clinical features Prognosis

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Study of the response of 1.B-doped MCP to wide-energy range neutrons from eV to MeV

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Nuclear Science and Techniques 2024年第8期35卷 132-141页

作者： Qiang li li‑Jiao wang Xiang‑Biao Qiu Jing‑Wen li Wei Xu Tao li Ze‑Bin lin Chang‑jun Ning Yong‑Hao Chen Rui‑Rui Fan Kang sun Jing‑Yu Tang Rong Zhang Han‑Tao Jing Bo Mei Qi An Hao‑Fan Bai Jiang‑Bo Bai Jie Bao Ping Cao Qi‑Ping Chen Zhen Chen Zeng‑Qi Cui An‑Chuan Fan Chang‑Qing Feng Fan‑Zhen Feng Ke‑Qing gao Min‑Hao Gu Chang‑Cai Han Zi‑Jie Han Guo‑Zhu He Yong‑Cheng He yang Hong Yi‑Wei Hu Han‑Xiong huang Wei‑Hua Jia Hao‑Yu Jiang Wei Jiang Zhi‑Jie Jiang Zheng‑Yao Jin ling Kang Bo li Chao li Gong li Jia‑Wen li Xiao li yang li Jie liu Rong liu Shu‑Bin liu Guang‑Yuan Luan Bin‑Bin Qi Jie Ren Zhi‑Zhou Ren Xi‑Chao Ruan Zhao‑Hui Song Zhi‑Xin Tan Sheng‑Da Tang Peng‑Cheng wang Zhao‑Hui wang Zhong‑Wei Wen Xiao‑Guang Wu Xuan Wu li‑Kun Xie Yi‑Wei yang Han Yi Yong‑Ji Yu Guo‑Hui Zhang lin‑Hao Zhang Mo‑Han Zhang Qi‑Wei Zhang Xian‑Peng Zhang Yu‑liang Zhang Yue Zhang Zhi‑Yong Zhang Mao‑Yuan Zhao Lu‑Ping Zhou Zhi‑Hao Zhou Ke‑jun Zhu Institute of High Energy Physics Chinese Academy of Sciences(CAS)Beijing 100049China Spallation Neutron Source Science Center Dongguan 523803China state {1. laboratory of Particle Detection and Electronics Institute of High Energy PhysicsChinese Academy of SciencesBeijing 100049China Dongguan Songshan Lake Future School Dongguan 523808China North Night Vision Science&Technology(Nanjing)Research Institute Co.Ltd. Nanjing 211106China Sino‑French Institute of Nuclear Engineering and Technology Sun Yat-sen UniversityZhuhai 519082China School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230027China state {1. laboratory of Particle Detection and Electronics University of Science and Technology of ChinaHefei 230026China Department of Modern Physics University of Science and Technology of ChinaHefei 230026China state {1. laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China Institute of Nuclear Physics and Chemistry China Academy of Engineering PhysicsMianyang 621900China key {1. of Nuclear Data China Institute of Atomic EnergyBeijing 102413China USTC Archaeometry Lab University of Science and Technology of ChinaHefei 230026China Northwest Institute of Nuclear Technology Xi’an 710024China university of Chinese Academy of Sciences Beijing 100049China

Neutron-sensitive microchannel plates(nMCPs)have applications in neutron detection,including energy spectrum measurements,neutron-induced cross sections,and neutron imaging.1.B-doped MCPs(B-MCPs)have attracted significant attention owing to their potential for exhibiting a high neutron detection efficiency over a large neutron energy *** spatial and temporal resolutions are useful for neutron energy-resolved ***,their practical applications still face many technical *** this study,a B-MCP with 1. mol%1.B was tested for its response to wide-energy neutrons from eV to MeV at the Back-n white neutron source at the china Spallation Neutron *** neutron detection efficiency was calibrated at 1.eV,which is approximately 300 times that of an ordinary MCP and indicates the success of 1. B *** factors that caused the reduction in the detection efficiency were simulated and *** neutron energy spectrum obtained using B-MCP was compared with that obtained by other measurement methods,and showed very good consistency for neutron energies below tens of *** response is more complicated at higher neutron energy,at which point the elastic and nonelastic reactions of all nuclides of B-MCP gradually become *** is beneficial for the detection of neutrons,as it compensates for the detection efficiency of B-MCP for high-energy neutrons.

关键词： Neutron radiation image 1.B-doped MCP Neutron response Wide-energy range neutrons

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A draft sequence of the rice (Oryza sativa ssp. indica) genome

引用

Chinese Science Bulletin 2001年第23期46卷 1937-1942页

作者： YU jun, HU Songnian, wang jun,li Songgang WONG Ka-Shu Gane, liU Bin,deng Yajun, DAI li, ZHOU Yan,ZHANG Xiuqing, CAO Mengliang, liU Jing,sun Jiandong , TANG Jiabin, CHEN Yanjiong,huang Xiaobing, liN Wei, YE Chen, TONG Wei,CONG lijuan, GENG Jianing, HAN Yujun, li lin,li Wei, HU Guangqiang, huang Xiangang,li Wenjie, li Jian, liU Zhanwei, li Long,liU Jianping, Ql Qiuhui, liU Jinsong, li li,wang Xuegang, LU Hong, WU Tingling,ZHU Miao, Nl Peixiang, HAN Hua, DONG Wei,REN Xiaoyu, FENG Xiaoli, GUI Peng,li Xianran, wang Hao, XU Xin, ZHAI Wenxue,XU Zhao, ZHANG Jinsong, HE Sijie,ZHANG Jianguo, XU Jichen, ZHANG Kunlin,ZHENG Xianwu, DONG Jianhai, ZENG wanyong,TAO lin, CHEN Xuewei, HE jun, liU Daofeng,TIAN Wei, TIAN Chaoguang, XIA Hongai,li Gang, gao Hui, li Ping, CHEN Wei ,wang Xudong, ZHANG Yong, HU Jianfei,wang Jing, liU Song, yang Jian,ZHANG Guangyu, XIONG Yuqing, li Zhijie,MAO Long, ZHOU Chengshu, ZHU Zhen,CHEN Runsheng, HAO Bailin,ZHENG Weimou, CHEN Shouyi, QUO Wei,li Guojie, liU Siqi, huang Guyang,TAO Ming, wang Jian, ZHU lihuang,YUAN Longping& yang Huanmingbeijing Genomics Institute/Center of Genomics & Bioinformatics, Chinese Academy of Sciences, beijing 101300, china Hangzhou Genomics Institute/Institute of Bioinformatics of Zhejiang university/key laboratory of Bioinformatics of Zhejiang Province, Hangzhou 310007, china Institute of Genetics, Chinese Academy of Sciences, beijing 100101, china National Hybrid Rice R & D Center, Changsha 410125, china laboratory of Bioinformatics, Institute of Biophysics, Chinese Academy of Sciences, beijing 100101, china College of life Sciences, Peking university, beijing 100871, china Institute of Theoretical Physics, Chinese Academy of Sciences, beijing 1Q0080, china Digital china Ltd., beijing 100080, china Institute of Computing Technology, Chinese Academy of Sciences, beijing 100080, china Medical College, Xi’an Jiaotong university, Xi’an 710061, chinaThese authors contributed equally to this work.Corresponding author.Corresponden beijing Genomics Institute/Center of Genomics & Bioinformatics Chinese Academy of Sciences Beijing China Hangzhou Genomics Institute/Institute of Bioinformatics of Zhejiang university/{1. laboratory of Bioinformatics of Zhejiang Province Hangzhou China College of life Sciences Peking University Beijing China Medical College Xi’an Jiaotong University Xi’an China Institute of Genetics Chinese Academy of Sciences Beijing China laboratory of Bioinformatics Institute of Biophysics Chinese Academy of Sciences Beijing China National Hybrid Rice R & D Center Changsha China Institute of Theoretical Physics Chinese Academy of Sciences Beijing China Digital china Ltd. Beijing China Institute of Computing Technology Chinese Academy of Sciences Beijing China

The sequence of the rice genome holds fundamental information for its biology, including physiology, genetics, development, and evolution, as well as information on many beneficial phenotypes of economic significance. Using a "whole genome shotgun" approach, we have pro-duced a draft rice genome sequence of Oryza sativa ssp. in-dica, the major crop rice subspecies in china and many other regions of Asia. The draft genome sequence is constructed from over 4.3 mil{1.on successful sequencing traces with an accumulative total length of 221..9 Mb. The initial assembly of the non-redundant sequences reached 409.76 Mb in length, based on 3.30 mil{1.on successful sequencing traces with a total length of 1.97.4 Mb from an indica variant cultivar 93-1., giving an estimated coverage of 95.29% of the rice genome with an average base accuracy of higher than 99%. The coverage of the draft sequence, the randomness of the sequence distribution, and the consistency of BIG-ASSEM-BLER, a custom-designed software package

关键词： rice genome draft sequences.

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