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A Measuring Solution for Mechanical Characteristics of MO Disks

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Wuhan University Journal of Natural Sciences 2001年第4期6卷 769-774页

作者： Pei Xian-deng Wang Hai-wei Xie chang-sheng Liu Ben-xi National Storage System Laboratory Huazhong Univ. of Sci. and Technol. Wuhan 430074 China

Mechanical characteristics of MO disk are vital for the designer of the drives and the manufacturers who provide the mass-product MO disks. So measuring mechanical characteristics is very significant. We compares the existing measuring methods and gives some novel measuring methods we adopted in details. The measuring system based upon these methods was introduced too. Some typical measuring results are also shown in this paper.

关键词： MO disk mechanical characteristics precision grating track counting laser triangulation method

Induction of membraneless organelles as a strategy for HIV-1 post-nuclear entry steps

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Journal of Molecular Cell Biology 2023年第2期15卷 1-2页

作者： sheng Zhou Hongyu deng CAS Key Laboratory of Infection and Immunity Institute of BiophysicsChinese Academy of SciencesBeĳing 100101China University of Chinese Academy of Sciences Beĳing 100049China CAS Center for Excellence in Biomacromolecules Institute of BiophysicsChinese Academy of SciencesBeĳing 100101China

As intracellular parasites,viruses must modulate the environment of host cells to facilitate viral genome replication and virion *** strategy is to establish specialized,membrane-associated subcellular structures to concentrate viral and cellular components and mediate viral replication *** strategy is utilized by many positive-strand RNA viruses such as coronaviruses,hepatitis C virus,and Zika virus,and they re-organize host endo-membranes to form double-membrane vesicles for viral genome replication(Wolff et al.,2020).

关键词： al. steps utilized

伯氏疟原虫K173对哌喹抗性培育的初步观察

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国际医学寄生虫病杂志 2013年第2期40卷 89-91页

作者：高岩邓长生王琪陈颖裴晶陈沛泉宋健平广州中医药大学青蒿研究中心广州510405 广州中医药大学科技产业园有限公司广州251044 广州市医药职业学校广州341145

目的培育伯氏疟原虫K173哌喹抗性株。方法参照大剂量复燃法进行抗哌喹虫株的培育，每5代用Peters4天抑制试验检测90％有效剂量（90% effective dose，ED90）并计算抗性指数（resistance index,I）I90。结合Anekin等抗性培育资料，比较... 详细信息

目的培育伯氏疟原虫K173哌喹抗性株。方法参照大剂量复燃法进行抗哌喹虫株的培育，每5代用Peters4天抑制试验检测90％有效剂量（90% effective dose，ED90）并计算抗性指数（resistance index,I）I90。结合Anekin等抗性培育资料，比较哌喹和磷酸哌喹的抗药性。结果实验历时7个多月，培育至30代．哌喹抗性株抗性指数I90为22．9，属于中度抗性。Artekin资料中，培育至第30代，磷酸哌喹抗性株抗性指数I90为371．1。属于重度抗性；Artequick药效学资料中，培育至第30代，哌喹抗性株抗性指数190为27．6．属于中度抗性。结论哌喹较易产生抗药性，但其抗性比磷酸哌喹轻，抗性产生时间也较磷酸哌喹迟。

关键词：哌喹磷酸哌喹抗药性伯氏疟原虫K173

Impulse feature extraction method for machinery fault detection using fusion sparse coding and online dictionary learning

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Chinese Journal of Aeronautics 2015年第2期28卷 488-498页

作者： deng Sen Jing Bo sheng sheng Huang Yifeng Zhou Hongliang Aeronautics and Astronautics Engineering College Air Force Engineering University Unit 94371 of People's Liberation Army

Impulse components in vibration signals are important fault features of complex machines. Sparse coding （SC） algorithm has been introduced as an impulse feature extraction method, but it could not guarantee a satisfactory performance in processing vibration signals with heavy background noises. In this paper, a method based on fusion sparse coding （FSC） and online dictionary learning is proposed to extract impulses efficiently. Firstly, fusion scheme of different sparse coding algorithms is presented to ensure higher reconstruction accuracy. Then, an improved online dictionary learning method using FSC scheme is established to obtain redundant dictionary and it can capture specific features of training samples and reconstruct the sparse approximation of vibration signals. Simulation shows that this method has a good performance in solving sparse coefficients and training redundant dictionary compared with other methods. Lastly, the proposed method is further applied to processing aircraft engine rotor vibration signals. Compared with other feature extraction approaches, our method can extract impulse features accurately and efficiently from heavy noisy vibration signal, which has significant supports for machinery fault detection and diagnosis.

关键词： Dictionary learning Fault detection Impulse feature extraction Information fusion Sparse coding

On orders in number fields: Picard groups, ring class fields and applications

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Science China Mathematics 2015年第8期58卷 1627-1638页

作者： LV chang deng YingPu Key Laboratory of Mathematics Mechanization NCMIS Academy of Mathematics and Systems ScienceChinese Academy of Sciences

We focus on orders in arbitrary number fields, consider their Picard groups and finally obtain ring class fields corresponding to them. The Galois group of the ring class field is isomorphic to the Picard *** an application, we give criteria of the integral solvability of the diophantine equation p = x2+ ny2 over a class of imaginary quadratic fields where p is a prime element.

关键词： orders Picard groups ring class fields integral points

经典名方真武汤对大鼠血液指标和组织病理的影响

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中国实验方剂学杂志 2022年第5期28卷 86-94页

作者：郑绍琴秦凯华张首亚郭诗媛陈颖谊王兆佳刘敏艾英徐勤周玖瑶邓长生宋健平广州中医药大学青蒿研究中心广州510405 广州中医药大学科技产业园有限公司广州510445 成都中医药大学成都610072

目的:观察经典名方真武汤长期应用对大鼠血液指标和组织病理的安全性影响。方法:采用SD大鼠进行灌胃给药30 d毒性实验。按体质量和性别随机分为4组,每组32只,雌雄各半,分别为真武汤低、中、高剂量(生药16,24,36 g·kg^(-1))3个剂量组(... 详细信息

目的:观察经典名方真武汤长期应用对大鼠血液指标和组织病理的安全性影响。方法:采用SD大鼠进行灌胃给药30 d毒性实验。按体质量和性别随机分为4组,每组32只,雌雄各半,分别为真武汤低、中、高剂量(生药16,24,36 g·kg^(-1))3个剂量组(等效于真武汤临床剂量的20,30,45倍)及1个空白组(纯净水);每天上午灌胃给药1次,连续给药30 d,停药后观察14 d;每周测量体质量和摄食量1次,并根据所称体质量更换给药量;实验期间每天进行1次一般观察;分别于给药前1 d(D_(-1)),给药后4 h(D_(0)),给药第15天(D_(14)),给药结束(D_(29))和恢复期结束(D_(43))测量大鼠心电图1次;于给药结束(D_(30))和恢复期结束(D_(44))对部分大鼠(每次64只)进行血液和各组织病理学检查。结果:与空白组比较,真武汤高剂量组(D_(8)~D_(35)),中剂量组(D_(13)~D_(35)),低剂量组(D_(15)~D_(33))部分大鼠出现脱毛现象,主要脱毛部位出现在项颈部。与空白组比较,真武汤中、高剂量组雌性大鼠给药D_(7)体质量明显降低(P<0.05);真武汤低剂量组在给药D_(21)和D_(29)大鼠体质量明显降低(P<0.05);真武汤中、高剂量组在给药D_(7)~D_(29)大鼠体质量有不同程度的降低(P<0.05)。与空白组比较,给药第1周,真武汤低、中、高剂量组大鼠摄食量明显减少(P<0.05);雄性大给药第1,2周,真武汤中、高剂量组大鼠摄食量和给药第4周高剂量组大鼠摄食量明显减少(P<0.05)。与空白组比较,雌性大鼠在给药D_(14),真武汤中、高剂量组大鼠心率明显加快(P<0.05);雄性大鼠在给药D_(14)和D_(29),真武汤低、中、高剂量组大鼠心率明显加快(P<0.05);雄性大鼠在给药D_(14)和D_(29),真武汤中剂量组大鼠P波时间延长(P<0.05);雌性大鼠在给药D_(14)天,真武汤中、高剂量组大鼠QRS间期延长(P<0.05);雌性大鼠在给药D_(14)天,真武汤高剂量组大鼠S波波幅明显降低(P<0.05);雄性大鼠在给药D_(14)和D_(29),真武汤中、高剂量组大鼠S波波幅明显降低(P<0.05)。实验显示低、中、高剂量真武汤对SD大鼠灌胃给药30 d毒性实验,可导致大鼠脱毛,体质量下降,饮食不佳,心率加快,心率不齐,对血液学检测(血常规、凝血四项和血生化)指标影响不明显,病理检查亦无明显变化。结论:真武汤有正性肌力作用,临床45倍量无明显毒性作用,但要注意预防室性早搏的发生。

关键词：真武汤毒性试验安全性评价经典名方长期毒性组织病理

Advances in plastid transformation for metabolic engineering in higher plants

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aBIOTECH 2022年第3期3卷 224-232页

作者： sheng Yang Yi deng shengchun Li State Key Laboratory of Biocatalysis and Enzyme Engineering School of Life SciencesHubei UniversityWuhan430062China

The plastid(chloroplast)genome of higher plants is an appealing target for metabolic engineering via genetic *** the bacterial-type plastid genome is small compared with the nuclear genome,it can accommodate large quantities of foreign genes that precisely integrate through homologous *** complex metabolic pathways in plants often requires simultaneous and concerted expression of multiple transgenes,the possibility of stacking several transgenes in synthetic operons makes the transplastomic approach *** potential for extraordinarily high-level transgene expression,absence of epigenetic gene silencing and transgene containment due to the exclusion of plastids from pollen transmission in most angiosperm species further add to the attractiveness of plastid transformation *** minireview describes recent advances in expanding the toolboxes for plastid genome engineering,and highlights selected high-value metabolites produced using transplastomic plants,including artemisinin,astaxanthin and paclitaxel.

关键词： Plastid transformation Metabolic engineering Multiple transgenes High-level expression

Effects of Deformation Rate on the Unbinding Pathway of the MMP8-Aggrecan_IGD Complex in Cartilage

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Computer Modeling in Engineering & Sciences 2019年第8期120卷 305-318页

作者： deng Li Shuwei chang Department of Civil Engineering National Taiwan UniversityTaipei 10617Taiwan

Mechanical force plays a critical role in the remodeling and degradation of cartilage *** cartilage tissue generates,absorbs,and transmits mechanical force,enabling specific biological processes in our body.A moderate intensity mechanical force is necessary for cartilage tissue remodeling and the adaptation of biomechanical properties,but a high intensity mechanical force can lead to pathological degradation of cartilage ***,the molecular mechanism of cartilage degradation is still *** use full atomistic simulations with SMD simulations to investigate whether the magnitude of mechanical force affects the unbinding pathway of the MMP8-Aggrecan_IGD *** find that when the pulling velocity is slow,the mechanical force required to unbind the Aggrecan_IGD from MMP8 is higher,and a three-step unbinding pathway is *** the other hand,when the pulling velocity is fast,the mechanical force required to unbind the Aggrecan_IGD from MMP8 is lower,and a two-step unbinding pathway is *** results help us to understand how the magnitude of the mechanical force affects the unbinding pathway of the enzyme-ligand complex in cartilage tissue at the molecular level.

关键词： Mechanical force steered molecular dynamics(SMD) unbinding pathway potential of mean force(PMF)

Microscopic sand production simulation and visual sanding pattern description in weakly consolidated sandstone reservoirs

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Petroleum Science 2022年第1期19卷 279-295页

作者： chang-Yin Dong Bo Zhou Fan-sheng Huang Lei Zhang Yi-Zhong Zhao Yang Song Jun-Yu deng Key Laboratory of Unconventional Oil&Gas Development Ministry of EducationQingdao266580ShandongPR China School of Petroleum Engineering China University of Petroleum(East China)Qingdao266580ShandongPR China Research Institute of Petroleum Engineering Technology Shengli BranchSINOPECDongying257000ShandongPR China Research Ltd.of Engineering Technology CNPCTianjin345000PR China

To visually describe the sanding pattern,this study constructs a new particle-scale microstructure model of weakly consolidated formation,and develop the corresponding methodology to simulate the sanding process and predict sand cavity *** microstructure model is a particle-objective model,which focuses on the random sedimentation of every sand *** the microstructure,every particle has its own size,sphericity and inclination *** is used to simulate the actual structure of cemented granular materials,which considers the heterogeneity and randomness of reservoir properties,provides the initial status for subsequent sanding *** the particle detachment criteria,the microscopic simulation of sanding can be visually implemented to investigate the pattern and cavity shapes caused by sand *** results indicate that sanding always starts initially from the borehole border,and then extends along the weakly consolidated plane,showing obvious characteristic of *** typical microscopic sanding patterns,concerning pore liquefaction,pseudo wormhole and continuous collapse,are proposed to illustrate the sanding mechanism in weakly consolidated *** nonuniformity of sanding performance depends on the heterogeneous distribution of reservoir properties,such as rock strength and particle ***,the three sanding patterns are verified by visually experimental *** proposed integrated methodology is capable of predicting and describing the sanding cavity shape of an oil well after long-term sanding production,and providing the focus objective of future sand control measure.

关键词： Weakly consolidated reservoir Particle-scale microstructure model Microcosmic sanding process simulation Visual sanding cavity description Sanding prediction Sand control optimization