检索结果-南通市图书馆

Osteocyte pericellular and perilacunar matrices as markers of bone-implant mechanical integrity

BIOCELL 2022年第10期46卷 2209-2216页

作者： ReMY GAUTHIER HeLÈNE FOLLET ANA-MARIA TRUNFIO-SFARGHIU delphine farlay NINA ATTIK SYLVAIN MEILLE JeRÔME CHEVALIER DAVID MITTON Universite de Lyon CNRSINSA de LyonUniversite Claude Bernard Lyon 1MATEISUMR5510VilleurbanneF-69621France Universite de Lyon Universite Claude Bernard Lyon 1INSERMLYOS UMR 1033LyonF-69008France Universite de Lyon INSA-LyonCNRS UMR5259LaMCoSVilleurbanneF-69621France Universite de Lyon Universite Claude Bernard Lyon 1UMR CNRS 5615Laboratoire des Multimateriaux et InterfacesVilleurbanneF-69622France Universite de Lyon Universite Claude Bernard Lyon 1Faculte d’OdontologieLyonF-69008France Universite de Lyon Universite Gustave EiffelUniv Claude Bernard Lyon 1LBMC UMR_T 9406LyonF-69622France

To develop durable bone healing strategies through improved control of bone repair,it is of critical importance to understand the mechanisms of bone mechanical integrity when in contact with biomaterials and *** mechanical integrity is defined here as the adaptation of structural properties of remodeled bone in regard to an applied mechanical ***,the authors present why future investigations in bone repair and regeneration should emphasize on the matrix surrounding the *** are mechanosensitive cells considered as the orchestrators of bone remodeling,which is the biological process involved in bone *** bone cells are trapped in an interconnected porous network,the lacunocanalicular network,which is embedded in a bone mineralized extracellular *** a consequence of an applied mechanical loading,the bone deformation results in the deformation of this lacunocanalicular network inducing a shift in interstitial fluid pressure and velocity,thus resulting in osteocyte *** material environment surrounding each osteocyte,the so called perilacunar and pericellular matrices properties,define its *** this mechanical stimulation pathway is well known,the laws used to predict bone remodeling are based on strains developing at a tissue scale,suggesting that these strains are related to the shift in fluid pressure and velocity at the lacunocanalicular *** this relationship has been validated through observation in healthy bone,the fluid behavior at the bone-implant interface is more *** presence of the implant modifies fluid behavior,so that for the same strain at a tissue scale,the shift in fluid pressure and velocity will be different than in a healthy bone *** that context,new markers for bone mechanical integrity,considering fluid behavior,have to be *** viewpoint exposed by the authors indicates that the properties of the pericellular and the perilacunar

关键词： Bone mechanical integrity Osteocytes Pericellular Perilacunar Mechanosensitivity

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：