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Enhanced generation of nondegenerate photon pairs in nonlinear metasurfaces

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Advanced Photonics 2021年第5期3卷 22-27页

作者： Matthew Parry Andrea Mazzanti Alexander Poddubny Giuseppe della valle Dragomir N.Neshev Andrey A.Sukhorukov Australia National University Research School of PhysicsCanberraAustralia ARC Centre of Excellence for Transformative Meta-Optical Systems CanberraAustralia Politecnico di Milano Dipartimento di FisicaMilanItaly ITMO University Department of PhysicsSaint PetersburgRussia Ioffe Institute Saint PetersburgRussia Consiglio Nazionale delle Ricerche Istituto di Fotonica e NanotecnologieMilanItaly

We predict theoretically a regime of photon-pair generation driven by the interplay of multiple bound states in the continuum resonances in nonlinear *** nondegenerate photon-pair generation is derived from the hyperbolic topology of the transverse phase matching and can enable orders-of-magnitude enhancement of the photon rate and spectral brightness,as compared to the degenerate *** show through comprehensive simulations that the entanglement of the photon pairs can be tuned by varying the pump polarization,which can underpin future advances and applications of ultracompact quantum light sources.

关键词： optics photonics light metasurface spontaneous parametric down-conversion entanglement

术前自体血采集预防髋关节置换术后血栓性疾病的作用

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中国骨伤 2013年第1期26卷 38-40页

作者：鲁宁杨阳 Alejandro González della valle Eduardo A.Salvati 昆明医学院第二附属医院骨科云南昆明650101 康奈尔大学附属纽约特种外科医院骨科美国纽约10021

目的:研究术前自体血采集对预防髋关节置换术后血栓性疾病的有效性。方法:收集2007年1月年至2010年3月收集在纽约特种外科医院(Hosptal for Special Surgery,HSS)医院行全髋关节置换术912例患者的临床资料,其中男428例,女484例。排除标... 详细信息

目的:研究术前自体血采集对预防髋关节置换术后血栓性疾病的有效性。方法:收集2007年1月年至2010年3月收集在纽约特种外科医院(Hosptal for Special Surgery,HSS)医院行全髋关节置换术912例患者的临床资料,其中男428例,女484例。排除标准为有出血体质及不能行硬膜外麻醉的患者。患者年龄24～93岁,平均(65.28±11.90)岁。骨性关节炎835例(91.3%),股骨头坏死32例(3.6%),髋关节发育不良20例(2.3%),类风湿性关节炎20例(2.2%),其他诊断5例(0.6%)。手术采用硬膜外低压麻醉(平均动脉压维持在45～55mmHg),手术采用后外侧切口,尽量减少股静脉扭曲的时间,反复冲洗和吸引出股骨髓腔内容物。当处理髋臼侧的时候,下肢处于中立位置。处理股骨侧髓腔之前1～2min,静脉给予肝素(10～15U/kg)。所有患者随访至少3个月,无一例失访。结果:752例术前进行了自体血捐献,160例没有捐献自体血。共11例发生血栓性疾病,占患者总数的1.3%,其中5例术前捐献自体血,6例术前未捐献自体血,两者血栓性疾病发病率差异有统计学意义(P=0.021)。所有血栓患者中8例确诊为深静脉血栓形成,发生率为0.8%;所有血栓患者中有症状并且诊断为肺栓塞的3例,发生率为0.5%,无致命性的肺栓塞PE。结论:髋关节置换术前捐献自体血能降低术后血栓性疾病的发生率。

关键词：关节成形术,置换,髋静脉血栓形成肺栓塞

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多重血栓预防方案在髋关节置换中的应用

实用医学杂志 2013年第14期29卷 2325-2327页

作者：鲁宁杨阳 Alejandro González della valle Eduardo A.Salvati 昆明医学院第二附属医院骨科 650101 美国康奈尔大学附属纽约特种外科医院骨科 10021

目的:评价多重血栓预防方案在髋关节置换运用的有效性和安全性。方法:收集从2006年1月到2010年5月在纽约特种外科医院(Hospital for Special Surgery,HSS)行全髋关节置换手术患者共993例,其中男473例,女529例。通过针对血栓形成的各种... 详细信息

目的:评价多重血栓预防方案在髋关节置换运用的有效性和安全性。方法:收集从2006年1月到2010年5月在纽约特种外科医院(Hospital for Special Surgery,HSS)行全髋关节置换手术患者共993例,其中男473例,女529例。通过针对血栓形成的各种原因和不同时相,采用多重血栓预防方案。结果:13例发生血栓性疾病(VTE),发生率1.3%。确诊为DVT的10例,发生率为1%。诊断为PE的有3例,发生率为0.3%。没有一个为致命性的PE。接受阿司匹林的患者中7例发生VTE,占接受阿司匹林治疗患者的0.9%,其中下肢深静脉血栓4例,有症状的肺栓塞3例;接受华法林的患者中6个发生VTE,占接受华法林治疗患者的2%,其中下肢深静脉血栓5,有症状肺栓塞1例。结论:人工髋关节置换患者采用此多重血栓预防方案,血栓(包括深静脉血栓和肺栓塞)的发生率很低,安全可靠,抗凝药口服与此相关的并发症也很低。

关键词：多重预防髋关节置换血栓性疾病

Clinical and economic impact of infliximab one-hour infusion protocol in patients with inflammatory bowel diseases:A multicenter study

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2017年第2期8卷 131-136页

作者： Anna Viola Giuseppe Costantino Antonino Carlo Privitera Fabrizio Bossa Angelo Lauria Laurino Grossi Maria Beatrice Principi Nicola della valle Maria Cappello Gastroenterology and Hepatology Section Dipartimento Biomedico di Medicina Interna e Specialistica University of Palermo IBD Unit Dipartimento di Medicina Interna e Terapia Medica University of Messina IBD and PelvicF loor Unit Azienda Ospedaliera per l’Emergenza Ospedale Cannizzaro Gastroenterology Section Casa Sollievo della Sofferenza S. Giovanni Rotondo Gastroenterology and Endoscopy Unit A.O.Bianchi-Melacrino-Morelli Fisiopatologia Digestiva Ospedale Spirito Santo Gastroenterology Section Gastroenterologia

AIM To assess the impact of short infliximab(IFX) infusion on hospital resource utilization and *** All inflammatory bowel diseases(IBD) patients who received IFX 1 h infusion from March 2007 to September 2014 in eight centers from Southern Italy were included in the analysis. Demographic, clinical and infusion related data were collected. The potential benefits related to the short infusion protocol were assessed both in terms of time saving and increased infusion unit capacity. In addition, indirect patient-related cost savings were *** One hundred and twenty-five patients were recruited(64 with ulcerative colitis and 61 with Crohn's disease). Median duration of disease was of 53 mo and mean age of pts at diagnosis was of 34 years(SD: ± 13). Adverse infusion reactions were reported in less than 4% both before and after short infusion. The total number of infusions across the selected centers was of 2501(30.5% short infusions). In the analyzed cohort, 1143 h were saved(762 in the infusion and 381 in observation phases) through the rapid IFX infusion protocol. This time saving(-15% compared to the standard protocol in infusion phase) represents, from the hospital perspective, an opportunity to optimize infusion unit capacity by allocating the saved time in alternative cost-effective treatments. This is the case of opportunity cost that represents the value of forgone benefit which could be obtained from a resource in its next-best alternative use. Hence, an extra hour of infusion in the case of standard 2-h IFX represents a loss in opportunity to provide other cost effective services. The analysis showed that the short infusion increased the infusion units capacity up to 50% on days when the IFX infusions were scheduled(infusion phase). Furthermore, the analysis showed that the short IFX infusion protocol leads to time savings also in the post-infusion phase(observation) leading to a time saving of 10% on average among the analyzed centers. F

关键词： Infliximab One-hour infusion Cost savings Economic impact Multicenter study

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全髋关节置换术中小剂量肝素的应用研究

中华关节外科杂志（电子版） 2013年第4期7卷 30-32页

作者：鲁宁杨阳 González della valle A Salvati EA 昆明医学院第二附属医院骨科云南650101 美国康奈尔大学附属纽约特种外科医院骨科 10021

目的研究全髋关节置换术中使用小剂量肝素的有效性和安全性。方法在纽约特种外科医院的行全髋关节置换的患者共993例，从2006年1月到2010年5月。其中男473例，女529例，均排除了患有血小板减少症、出血体质以及不能行硬膜外麻醉的患者... 详细信息

目的研究全髋关节置换术中使用小剂量肝素的有效性和安全性。方法在纽约特种外科医院的行全髋关节置换的患者共993例，从2006年1月到2010年5月。其中男473例，女529例，均排除了患有血小板减少症、出血体质以及不能行硬膜外麻醉的患者。手术采用硬膜外低压麻醉（平均动脉压维持在45～55mmHg），行后外侧切口，尽量减少股静脉扭曲的时间，反复冲洗和吸引出股骨髓腔内容物。当处理髋臼侧的时候，下肢处于中立位置。处理股骨侧髓腔之前2—3min，静脉给予肝素（10—15U／kg）。结果此组患者平均手术时间83分钟（35～268min），平均失血量183ml（50—1400m1）。术后随访3个月。本组患者共有13例发生血栓性疾病，占患者总数的1．3％。所有血栓患者中确诊为DVT的有10例，发生率为1％。没有一例患者发生切口血肿及主要出血并发症。随访期间没有一例患者死亡。结论全髋关节术中给予肝素血栓发生率低，术后无相关的出血并发生。

关键词：关节成形术,置换,髋肝素,低分子量血栓形成

From chronic liver disorders to hepatocellular carcinoma: Molecular and genetic pathways

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World Journal of Gastrointestinal Oncology 2010年第6期2卷 259-264页

作者： Enzo Ierardi Rosa Rosania Mariangela Zotti Floriana Giorgio Simonetta Prencipe Nicola della valle Vincenzo De Francesco Carmine Panella Section of Gastroenterology Department of Medical Sciences University of Foggia

Hepatocarcinogenesis is a process attributed to progressive genomic changes that alter the hepatocellular phenotype producing cellular intermediates that evolve into hepatocellular carcinoma (HCC). During the preneoplastic phase, the liver is often the site of chronic hepatitis and/or cirrhosis, and these conditions induce liver regeneration with accelerated hepatocyte cycling in an organ that is otherwise proliferatively at rest. Hepatocyte regeneration is accelerated by upregulation of mitogenic pathways involving molecular and genetic mechanisms. Hepatic growth factors, inhibitors and triggers may also play a role. This process leads to the production of monoclonal populations of aberrant and dysplastic hepatocytes that have telomerase reexpression, microsatellite instability, and occasionally structural aberrations in genes and chromosomes. Development of dysplastic hepatocytes in foci and nodules and the emergence of HCC are associated with the accumulation of irreversible structural alterations in genes and chromosomes even if the genomic basis of the malignant phenotype is largely heterogeneous. Therefore, a malignant hepatocyte phenotype may be produced by changes in genes acting through different regulatory pathways, thus producing several molecular variants of HCC. On these bases, a key point for future research will be to determine whether the deletions are specific, due to particular loci in the minimally deleted regions of affected chromosome arms, or whether they are nonspecific with loss of large portions of chromosomes or entire chromosome arms leading to passive deletion of loci. The final aim is the possibility of identifying a step where carcinogenetic processes could be terminated.

关键词： Hepatocarcinoma Chronic liver disorders Genetic pathways Molecular pathways Hepatic growth factors Augmenter liver regeneration

Loculated pericardial hematoma diagnosed with point-of-care ultrasound

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World Journal of Emergency Medicine 2024年第3期15卷 241-242页

作者： Joaquín valle Alonso Esther Montoro Leandro Noblia Emergency Department Royal Bournemouth HospitalBournemouth 14450UK Emergency Department Hospital Santa LuciaCartagena 30202Spain

Pericardial hematoma is a rare but potentially lifethreatening consequence following cardiac surgery that requires prompt recognition and *** can present with symptoms such as chest pain,dyspnea,tachycardia,and hypotension,which may mimic other post-operative *** pericardial hematoma compressing the atria might be difficult to *** and hematoma are more common in patients receiving early anticoagulant therapy.A focused cardiac ultrasound (Fo CUS) plays a pivotal role in the diagnosis,revealing the presence of pericardial effusion and signs of cardiac *** aim of this report was to provide a prompt diagnosis of loculated pericardial hematoma via Fo CUS in the emergency department (ED).

关键词： hematoma diagnosis cardiac

多种转谷氨酰胺酶在人结肠的表达差异:溃疡性结肠炎中受损角化细胞转谷氨酰胺酶的表达

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世界核心医学期刊文摘（胃肠病学分册） 2005年第8期1卷 41-42页

作者： D’Argenio G Calvani M della valle N G.Peluso 李翔 National Cance r Institute-G Pascale FoundationDepartment of Experimental Oncology Naples Italy.Prof

Background and aims: Ulcerative colitis (UC) is characterised by refractory in flammatory ulceration and damage to the *** mechanisms underlying impaired healing have yet to be defined. As transglutaminase expression resulting in mat rix protein cross linking is associated with increased wound healing in a rat mo del of colitis, we hypothesised that different types of transglutaminase might a lso play a role in UC. Patients end methods: Endoscopic and histological indices were studied in 26 patients with UC (10 active and 16 inactive) and in 20 norma l controls undergoing colonoscopy. Transglutaminase activity was evaluated in pl asma (factor XIIIa) by a radioenzymatic metho- d. Factor XIIIa, tissue and keratinocyte transglutaminase protein content, and mRNA expression in the colon were evaluated by western blot analysis and semiqu antitative reverse transcription-polymerase chain reaction (RT-PCR),respectively. Colon ic location of transglutaminases and their reaction products, the -(γ-glutamy l)lysine bonds, was evaluated by immunohistochemistry using specific monoclonal ***: Transglutaminase activity was significantly lower in the pla sma of patients with active UC (4.2 (2.4) mU/ml;p< 0.05 v controls) than in thos e with inactive UC and controls(10.6 (2.2) and 12.1 (1.7) mU/ml). As shown by we stern blot,protein levels of tissue transglutaminase and factor XIIIa were uncha nged in active UC compared with inactive disease and controls, while the keratin ocyte form was reduced in active UC. Tissue transglutaminase and factor XIIIa im munostaining was strongly present in damaged areas colocalising with isopeptide bonds. In contrast, the keratinocyte form was almost absent in active UC and loc alised in the upper part of the crypts in normal subjects. RT-PCR showed upregu lation of tissue transglutaminase mRNA in active UC (320%compared with controls ) while keratinocyte transglutaminase gene expression was downregulated in activ e UC. Conclusion

关键词：溃疡性结肠炎结肠镜检角化细胞转谷氨酰胺酶大鼠结肠炎模型炎性溃疡活动型组织形态学肠隐窝组织型

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多重方法预防髋膝关节置换术后的血栓性疾病

中华关节外科杂志（电子版） 2011年第2期5卷 53-57页

作者： Alejandro González della valle Francis Jeshira Reynoso Judith Ben Ari Eduardo Salvati 鲁宁纽约特种外科医院骨科纽约10021 康奈尔大学威尔医学院骨科 Woodhull医院中心内科昆明医学院第二附属医院骨科 650101

髋、膝关节置换术后有较高的发生血栓性疾病的危险。我们研究了一种多重预防方法,于1995年在纽约特种外科医院(Hospital for Special Surgery,HSS)开始运用。它包括术前对患者患血栓性疾病(VTE)的风险进行评估,然后根据评估结果在术前... 详细信息

髋、膝关节置换术后有较高的发生血栓性疾病的危险。我们研究了一种多重预防方法,于1995年在纽约特种外科医院(Hospital for Special Surgery,HSS)开始运用。它包括术前对患者患血栓性疾病(VTE)的风险进行评估,然后根据评估结果在术前、术中、术后应用一系列安全有效的预防措施,以降低术后血栓和出血的风险。这些措施包括术前停用促凝血药物及患者的自体血采集;使用硬膜外低压麻醉,在全髋关节置换手术(THA)中股骨侧处理之前,静脉给予肝素;术后使用充气加压装置,患肢穿戴弹力袜并强有力地主动背伸和跖屈踝关节,同时尽早下床活动,以降低血液淤滞。如果这些措施能够很好地实施,对于术前没有VTE诱发因素且术后能早期活动的患者,不需要术后使用强效的抗凝药物,从而减少常规使用抗凝药物导致的并发症发病率和死亡率以及医疗费用。此方法已在近万例髋、膝关节置换术患者中应用,结果显示血栓、出血发生率以及总死亡率均很低。

关键词：血栓性疾病人工关节置换术