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GC/MS-based differential metabolic profiling of human peptic ulcer disease to study Helicobacter pylori-induced metabolic perturbations

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BIOCELL 2021年第5期45卷 1299-1311页

作者： GAGANJOT GUPTA deepak bansal ANSHULA SHARMA TAWSEEF AHMAD ATUL SACHDEV AJAZ AHMAD HAMED A.EL-SEREHY BALJINDER KAUR Department of Biotechnology Punjabi UniversityPatiala147002India Department of General Medicine Government Medical College and HospitalChandigarh160047India Department of Clinical Pharmacy College of PharmacyKing Saud UniversityRiyadh11451Saudi Arabia Department of Zoology College of ScienceKing Saud UniversityRiyadh11451Saudi Arabia

Helicobacter pylori infection has been significantly linked to Peptic Ulcer Disease and Gastric Cancer.Metabolomic fingerprinting may offer a principal way of early diagnosis and to understand the molecular mechanism of H.pylori-induced pathogenicity.The rationale of the study is to explore the underlying distinct metabolic mechanisms of H.pylori-induced PUD and to identify potential biomarkers for disease diagnosis and associated risks using Gas chromatography/mass spectrometry.GC/MS-based analytical method was used to compare metabolic profiles of healthy controls(N=20)and peptic ulcer patients(N=45).Acquired metabolomic data were analyzed by constructing a diagnostic model using principal component analysis and a non-parametric two-tailed paired Wilcoxon analysis to identify disease-specific metabolic biomarkers.A total of 75 low-molecular-weight endogenous metabolites were detected during comparative metabolomic analysis of PUD vs.healthy gut tissues,among which 16 metabolites are being proposed to be diagnostic markers of Human PUD.Perturbations related to amino acids,carbohydrates,fatty acids,organic acids,and sterol metabolism were significantly revealed during this differential metabolomic profiling.Results convincingly suggest that metabolic profiles can contribute immensely in early diagnosis of the disease and understanding molecular mechanisms of disease progression for predicting novel drug targets for prophylactic and anaphylactic measures.

关键词： Peptic ulcer disease Gastric cancer Helicobacter pylori Metabolic profiling Perturbations Stomach ulcers

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Expert opinion on the preoperative medical optimization of adults with diabetes undergoing metabolic surgery

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World Journal of Diabetes 2021年第10期12卷 1587-1621页

作者： Saptarshi Bhattacharya Sanjay Kalra Nitin Kapoor Rajiv Singla Deep Dutta Sameer Aggarwal deepak Khandelwal Vineet Surana Atul Dhingra Viny Kantroo Sachin Chittawar Nilakshi Deka Vivek Bindal Puja Dutta Endocrinology Max Superspeciality HospitalNew Delhi 110092India Endocrinology Bharti HospitalKarnal 132001HaryanaIndia Endocrinology Christian Medical CollegeVellore 632004Tamil NaduIndia Endocrinology Kalpavriksh Super Speciality CenterNew Delhi 110075India Endocrinology CEDAR Superspecialty ClinicNew Delhi 110075India Endocrinology Apex Plus Superspeciality HospitalRohtak 124001HaryanaIndia Endocrinology Maharaja Agrasen HospitalNew Delhi 110026India Endocrinology Manipal HospitalsNew Delhi 110075India Endocrinology Gangaram Bansal Super Speciality HospitalSri Ganganagar 335001RajasthanIndia Respiratory Medicine&Critical Care Indraprastha Apollo HospitalsSarita ViharNew Delhi 110076India Endocrinology Gandhi Medical CollegeBhopal 462001Madhya PardeshIndia Endocrinology Apollo HospitalsGuwahati 781005AssamIndia Minimal Access Metabolic and Bariatric surgeryMax Superspeciality HospitalPatparganjNew Delhi 110092India Nutrition Max Superspeciality HospitalPatparganjNew Delhi 110092India

Diabetes mellitus(DM)and obesity are interrelated in a complex manner,and their coexistence predisposes patients to a plethora of medical problems.Metabolic surgery has evolved as a promising therapeutic option for both conditions.It is recommended that patients,particularly those of Asian origin,maintain a lower body mass index threshold in the presence of uncontrolled DM.However,several comorbidities often accompany these chronic diseases and need to be addressed for successful surgical outcome.Laparoscopic Roux-en-Y gastric bypass(RYGB)and laparoscopic sleeve gastrectomy(LSG)are the most commonly used bariatric procedures worldwide.The bariatric benefits of RYGB and LSG are similar,but emerging evidence indicates that RYGB is more effective than LSG in improving glycemic control and induces higher rates of long-term DM remission.Several scoring systems have been formulated that are utilized to predict the chances of remission.A glycemic target of glycated hemoglobin<7%is a reasonable goal before surgery.Cardiovascular,pulmonary,gastrointestinal,hepatic,renal,endocrine,nutritional,and psychological optimization of surgical candidates improves perioperative and long-term outcomes.Various guidelines for preoperative care of individuals with obesity have been formulated,but very few specifically focus on the concerns arising from the presence of concomitant DM.It is hoped that this statement will lead to the standardization of presurgical management of individuals with DM undergoing metabolic surgery.

关键词： Diabetes Obesity Metabolic surgery Bariatric surgery Remission of diabetes

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