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Role of relevant immune-modulators and cytokines in hepatocellular carcinoma and premalignant hepatic lesions

World Journal of Gastroenterology 2018年第11期24卷 1228-1238页

作者： Abdel-Rahman N Zekri Somaya El deeb Abeer A Bahnassy Abeer M Badr Mona S Abdellateif Gamal Esmat Hosny Salama Marwa Mohanad Ahmed Esam El-dien Shimaa Rabah Assmaa Abd Elkader Molecular Virology and Immunology Unit Department of Cancer BiologyNational Cancer InstituteCairo University Department of Zoology Faculty of ScienceCairo University Department of Pathology National Cancer InstituteCairo University Medical Biochemistry and Molecular Biology Department of Cancer BiologyNational Cancer InstituteCairo University Department of Hepatology and Tropical Medicine Faculty of MedicineCairo University Department of Biochemistry Misr University for Science and Technology

AIM To assess the levels of different immune modulators in patients with hepatocellular carcinoma(HCC),in relation to other hepatic *** Eighty-eight patients were included in the current study and represented patients with HCC(20),liver cirrhosis(28) and chronic hepatitis(CH;25),and normal controls(NC;15).Peripheral blood was isolated for immunophenotyping of active myeloid dendritic cells(m DCs;CD1 c and CD40),mature inactive myeloid cells(CD1 c and HLA),active plasmacytoid cells(p DCs;CD303 and CD40),mature inactive p DCs(CD30 and HLA),active natural killer(NK) cells(CD56 and CD161),active NK cells(CD56 and CD314) and inactive NK cells(CD56 and CD158) was done by flow *** levels of interleukin(IL)-2,IL-10,IL-12,IL-1β,interferon(IFN)-α,IFN-γ and tumor necrosis factor(TNF)-αR2 were assessed by *** Active m DCs(CD1 C+/CD40+) and inactive m DCs(CD1 c+/HLA+) were significantly decreased in HCC patients in relation to NC(P < 0.001).CD40+ expression on active p DCs was decreased in HCC patients(P < 0.001),and its level was not significantly changed among other *** p DCs(CD303+/HLA+),inactive NKs(CD56+/CD158+) and active NKs(CD56+/CD161+) were not statistically changed among the four groups studied;however,the latter was increased in CH(P < 0.05).NKG2 D was statistically decreased in HCC,CH and cirrhosis(P < 0.001),and it was not expressed in 63%(12/20) of HCC *** was significant decrease of IL-2,IFN-α and IFN-γ(P < 0.001),and a significant increase in IL-10,IL-1β,and TNF-αR2(P <0.01,P < 0.001 and P < 0.001;respectively) in HCC *** was inverted correlation between IL-12 and IL-1β in HCC(r =-0.565,P < 0.01),with a strong correlation between p DCs(CD303+/CD40+) and NKs(CD56+/CD161+;r = 0.512,P < 0.05) as well as inactive m DCs(CD1 c+/HLA+) and inactive NK cells(CD56+/CD158+;r = 0.945,P < 0.001).CONCLUSION NKG2 D,CD40,IL-2 and IL-10 are important modulators in the development and progression of HCC.

关键词： Hepatocellular carcinoma Hepatitis C virus NKG2D CD40 interleukin-2 interleukin-10 myeloid dendritic cells plasmacytoid cells natural killer cell Cytokines

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The Role of Serum Trace Elements and Oxidative Stress in Egyptian Breast Cancer Patients

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Advances in Breast Cancer Research 2016年第1期5卷 37-47页

作者： Mona Mohamed K. El-deeb Heba G. El-Sheredy Ayman Farouk Mohammed Department of Chemical Pathology Medical Research Institute Alexandria University Alexandria Egypt Department of Cancer Management and Research Medical Research Institute Alexandria University Alexandria Egypt Department of Surgery Medical Research Institute Alexandria University Alexandria Egypt

Background: Oxidative stress is considered to be involved in the pathophysiology of all cancers. Studies indicated that the levels of oxidative stress markers increased in breast cancer. Trace metals are essential to normal human homeostasis. When present in an abnormal expression, they contribute in many pathological processes. Some trace metals are claimed to be carcinogenic and capable of inducing a toxic effect through the formation of free radicles and acting as cofactors in the oxidative damage of biological macromolecules and DNA. Objective: Our aim was to investigate the serum levels of some trace elements (Copper, Zinc and Cadmium), the total oxidative and anti-oxidative capacity (TOC and TAC) in patients with breast cancer in comparison to patients with benign breast tumours. Patients and Methods: The present study included 65 females. The participates were divided into 2 main groups: control group which consisted of 20 apparently healthy female;the patient groups which divided into 3 groups: group B included 15 patients with benign breast tumours, group N consisted of 15 newly diagnosed breast cancer patients and group M included 15 patients with metastatic breast cancer. Results: The mean serum levels of Copper, Zinc, and Cadmium were significantly higher in the three patients groups (B, N and M) than the control group. Similarly, serum uric acid (UA) and (TAC) levels showed significant higher level in both breast cancer groups as compared to the benign group. However TOC levels showed only significantly higher level in metastatic group. Conclusions: The present study suggested elevated TAC, UA and TOC in breast cancer patients. The increased levels of trace elements could lead to formation of free radicals or other reactive oxygen species. The serum profile of these trace metals may be helpful in predicting prognosis of breast cancer.

关键词： Trace Elements Oxidative Capacity Breast Cancer Antioxidants

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Insulin Requirements and Management in Trans-Catheter vs. Surgical Aortic Valve Replacement

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Open Journal of Thoracic Surgery 2019年第3期9卷 17-30页

作者： Yunyan Qu Liyu Xing Nazanene H. Esfandiari George M. deeb Roma Gianchandani Department of Internal Medicine Michigan Medicine University of Michigan Ann Abor MI USA Department of Cardiac Surgery Michigan Medicine University of Michigan Ann Abor MI USA

Objective: Trans-catheter Aortic Valve Replacement/Aortic Valve Implantation (TAVR) are increasingly performed today. We compared insulin requirements between TAVR and Surgical Aortic Valve Replacement (SAVR) patients with and without diabetes mellitus (DM) to determine optimal glucose management strategies during the perioperative period (POP). Methods: Charts of consecutive patients undergoing aortic procedures were retrospectively reviewed for glucose ranges, insulin requirements and routes of insulin administration (subcutaneous vs. intravenous) for patients with and without DM to maintain BG Results: Patients with SAVRs without DM and A1C Conclusions: TAVR patients have different insulin requirements compared to SAVRs (p < 0.05). This information helps build a glucose management algorithm for a procedure which is increasingly performed.

关键词： Aortic Stenosis Diabetes Mellitus Trans-Catheter Aortic Valve Replacement Surgical Aortic Valve Replacement Blood Glucose Management

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带状疱疹后神经痛危险因素Meta分析

带状疱疹后神经痛危险因素Meta分析

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作者：斯威特（ALA’A SUWAIT deeb AL SUWAIT）南昌大学

学位级别：硕士

带状疱疹后神经痛通常定义为皮损愈合持续1个月及以上的疼痛,具有持续性且疼痛性质多样,严重影响患者生活质量。为了减少带状疱疹后神经痛的发生,本文将通过检索中国知网、万方、百度学术、Pub Med等多个文献资料库相关文献,分析致带状... 详细信息

带状疱疹后神经痛通常定义为皮损愈合持续1个月及以上的疼痛,具有持续性且疼痛性质多样,严重影响患者生活质量。为了减少带状疱疹后神经痛的发生,本文将通过检索中国知网、万方、百度学术、Pub Med等多个文献资料库相关文献,分析致带状疱症后神经痛的危险因素,为减少带状疱疹神经痛的发生奠定一定的理论依据。通过针对不同因素的独立Meta分析得出,带状疱疹临床症状的严重程度和带状疱疹后神经痛的发生率呈正相关,具体因素包括皮肤损伤面积（OR:6.45,95%CI:1.78-24.05）,急性期疱疹疼痛程度（OR:6.08,95%CI:3.25-11.85）,前驱痛（OR:4.05,95%CI:2.48-6.98）、患病时的情绪状态（OR:5.88,95%CI:3.02-11.25）,患者年龄（OR:5.68,95%CI:4.55-7.83）、患者性别（OR:1.32,95%CI:1.01-1.94）。其他因素有早期接受小剂量的激素治疗、自身有基础疾病、发热、初次接受治疗的时长和接受抗病毒治疗等,其中除了早期接受小剂量的激素治疗、基础疾病及初次接受治疗的时长有表现相关性,其他因素与带状疱疹后神经痛的发生的相关性较小。

关键词：带状疱疹后神经痛危险因素 Meta分析

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Efficiency of Advanced Membrane Wastewater Treatment Plant towards Removal of Aspirin, Salicylic Acid, Paracetamol and p-Aminophenol

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Journal of Environmental Science and Engineering 2011年第2期5卷 121-137页

作者： M. Khamis R. Karaman F. Ayyash A. Qtait O. deeb A. Manssra Department of Chemistry and Chemical Technology Faculty of Science and Technology Al-Quds University Jerusalem 20002Palestine Faculty of Pharmacy Al-Quds University Jerusalem 20002 Palestine

The efficiency of membrane separation technology for wastewater treatment was employed to check its efficiency in removing pharmaceuticals, their degradation products and their metabolites from wastewater. Aspirin and paracetamol were found to degrade in wastewater furnishing salicylic acid and p-aminophenol, respectively. The kinetics for the degradation reactions of both drugs were investigated in wastewater environment and both have shown first order kinetics with rate constants 0.845 × 10^-8 Ms^-1 and 1.0 × 10^-8 Ms^-1 at room temperature, respectively. These values are an order of magnitude larger than those obtained in pure water under the same conditions. The over all performance of the plant has shown complete removal of these compounds from spiked wastewater within the detection limit of the analytical method. The most effective components for removing those drugs within the plant were activated carbon and clay micelle filters. The adsorption isotherms for these compounds have been studied using both activated carbon and newly developed adsober named clay-micelle complex. All studied isotherms were found to fit Langmuir isotherm. The Langmuir constant and the adsorption capacity were evaluated and discussed.

关键词： Pharmaceuticals wastewater membrane technology ultra-filtration reverse osmoses adsorption isotherms.

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A CLASS OF HARMONIC STARLIKE FUNCTIONS WITH RESPECT TO SYMMETRIC POINTS ASSOCIATED WITH WRIGHT GENERALIZED HYPERGEOMETRIC FUNCTION

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Analysis in Theory and Applications 2012年第4期28卷 363-376页

作者： M.K. Aouf R.M. El-Ashwah A. Shamandy S.M. El-deeb Mansoura University

Making use of Wright operator we introduce a new class of complex-valued harmonic functions with respect to symmetric points which are orientation preserving, univalent and starlike. We obtain coefficient conditions, ... 详细信息

关键词： harmonic univalent Wright operator symmetric point

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Extracellular Biosynthesis of AgNPs by the Bacterium <i>Proteus mirabilis</i>and Its Toxic Effect on Some Aspects of Animal Physiology

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Advances in Nanoparticles 2014年第3期3卷 83-91页

作者： Mohammad S. Al-Harbi Bahig A. El-deeb Nasser Mostafa Sayed A. M. Amer Department of Biology Faculty of Science Taif University Taif Saudi Arabia Department of Biology Faculty of Science Taif University Taif Saudi Arabia Department of Botany Faculty of Science Sohag University Sohag Egypt Department of Biology Faculty of Science Taif University Taif Saudi Arabia Department of Zoology Faculty of Science Cairo University Giza Egypt Department of Chemistry Faculty of Science Taif University Taif Saudi Arabia Department of Chemistry Faculty of Science Suez Canal University Ismailia Egypt

The development of a reliable green chemistry process for the biogenic synthesis of nanomaterials is an important aspect of current nanotechnology research. Silver nanoparticles (AgNPs) have been used as antimicrobial and disinfectant agents. However, there is limited information about its toxicity. Therefore, this study focused on the biosynthesis of AgNPs by the bacterium Proteus mirabilis and on determining its preliminary toxic effect on some aspects of animal physiology. A green method for the synthesis of AgNPs using culture supernatant of Proteus mirabilis has been developed in this study and the synthesized AgNPs were characterized by several techniques. The AgNPs showed a maximum absorbance at 445 nm on ultraviolet-visible spectra. The presence of proteins was identified by Fourier transform-infrared spectroscopy. The reduction of Ag+ to elemental silver was characterized by X-ray spectroscopy analysis. The transmission electron micrograph revealed the formation of polydispersed nanoparticles of 5 - 45 nm. The AgNPs were evaluated for their toxic effect on pregnant female albino rat. The result showed that liver enzymes (AST and ALP) were decreased significantly in the group treated with AgNPs. Mean corpuscular hemoglobin concentration also showed significant increase.

关键词： AgNPs P. mirabilis TEM X-Ray Liver Enzymes Blood Parameters

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RESPONSE OF BT RESISTANT STRAINS OF COTTON LEAF WORM TO SOME CHEMICAL INSECTICIDES

RESPONSE OF BT RESISTANT STRAINS OF COTTON LEAF WORM TO SOME...

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The ⅩⅤth International Plant Protection Congress

作者： Mohamed El-Said EL-ZEMAITY W.M.EL.deeb Y.A.OSMAN A.I.HUESSIN Fac.of agriculture - Ain Shams Univ.P.O.Box 68 Hadayek Shoubra 11241 Cairo Egypt Central of Pesticides Laboratory Agriculture Research Center Faculty of Science Mansora University Central of Pesticides Laboratory Agriculture Research Center

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Exploring MIA-QSARs for farnesyltransferase inhibitory effect of antimalarial compounds refined by docking simulations

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Journal of Biophysical Chemistry 2012年第1期3卷 58-71页

作者： Omar deeb Sherin Alfalah Matheus P. Freitas Elaine F. F. da Cunha Teodorico C. Ramalho Faculty of Pharmacy Al-Quds University Jerusalem Palestine

Two series of farnesyltransferase (FTase) inhibitors were grouped and their antimalarial activi-ties modeled by means of multivariate image analysis applied to quantitative structure-activity relationship (MIA-QSAR). A reliable model was achieved, with r2 for calibration, external prediction and leave-one-out cross-validation of 0.96, 0.87 and 0.83, respectively. Therefore, biological activities of congeners can be estimated using the QSAR model. The bioactivities of new compounds based on the miscellany of substructures of the two classes of FTase inhibitors were predicted using the MIA-QSAR model and the most promising ones were submitted to ADME (absorption, distribution, metabolism and excretion) and docking evaluation. Despite the smaller interaction energy of the two most promising, predicted compounds in comparison to the two most active compounds of the data set, one of the proposed structures did not violate any Lipinski’s rule of five. Therefore, it is either a potential drug or may drive synthesis of similar, improved compounds.

关键词： ADMET Docking Farnesyltransferase Inhibitors Malaria Multivariate Image Analysis-QSAR

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颌骨纤维异常增殖症

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国际口腔医学杂志 1981年第1期 31-34页

作者： deeb M E 李富康

在文献上已报告的关于纤维骨性病变的一些病例有诸多模糊和不统一的名称。骨骼上特别是颌骨上的纤维骨性病变的诊断在临床学家和病理学家都存在颇多问题。

关键词：骨性病变骨瘤病例纤维瘤结缔组织肿瘤纤维异常增殖症板状骨

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