检索结果-南通市图书馆

Differential diagnosis between autism spectrum disorder and other developmental disorders with emphasis on the preschool period

在线全文

学校读者我要写书评

暂无评论

世界儿科杂志:英文版 2023年第8期19卷 715-726页

作者： Taynara Amancio de lima Patricia Aparecida Zuanetti Marina Estima Neiva Nunes Ana Paula andrade Hamad department of Neurosciences and Behavioral Sciences Ribeirão Preto Medical SchoolUniversity of São PauloAv.Bandeirantes3900Monte AlegreRibeirão PretoSP14049-900Brazil University Hospital Ribeirão Preto Medical SchoolUniversity of São Paulo(HCFMRP-USP)Ribeirão PretoSPBrazil

Background Neurodevelopmental disorders are a heterogeneous group of conditions that manifest as delays or deviations in the acquisition of expected developmental milestones and behavioral *** spectrum disorder(ASD)is a neurodevelopmental disorder characterized by deficits in communication and social interaction and by repetitive and restricted patterns of behavior,interests and *** aim of this review is to discuss the clinical features of the differential diagnoses of ASD that are prevalent among preschoolers,focusing on their similarities and *** sources The international medical literature search was conducted using PubMed and was revised regarding the subject using single and/or combined keywords as follows:differential diagnosis,preschoolers,diagnostic challenge,attention deficit hyperactivity disorder,intellectual disability,high abilities/giftedness,childhood apraxia of speech,social communication disorder,Landau–Kleffner syndrome,stereotyped movement disorder and excessive screen *** We describe conditions commonly found in clinical practice,taking ASD as a *** addressed converging and divergent aspects of behavior,cognition,communication,language,speech,socialization,and stereotypes for the diagnosis of ASD and other disorders identified as potential differential or comorbid *** The ranking and characterization of symptoms appear to be essential for better understanding the underlying common ground between children with developmental disorders and children with ASD,thus properly diagnosing and directing social,professional,or medication *** detailed discussion adds to the literature since,although ASD differential diagnoses are frequently mentioned and discussed in textbooks and journal articles,they rarely occupy a prominent place as we aimed herein.

关键词： Autism spectrum disorder Clinical features Differential diagnosis Neurodevelopmental disorders Preschool

Highly Sensitive Poly-N-isopropylacrylamide Microgel-based Electrochemical Biosensor for the detection of SARS-COV-2 Spike Protein

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Biomedical and Environmental Sciences 2023年第3期36卷 269-278页

作者： CHEN Hao HOU Zhi Yuan CHEN Die LI Ting WANG Yi Ming de lima marcel. andrade YANG Ying GUO Zhen Zhong department of Anaesthesiology Tongji HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430030HubeiChina Hubei Province Key Laboratory of Occupational Hazard Identification and Control Wuhan University of Science and TechnologyWuhan 430065HubeiChina department of Pharmacy Medical CollegeWuhan University of Science and Technology Wuhan 430065HubeiChina School of Public Health Medical CollegeWuhan University of Science and Technology Wuhan 430065HubeiChina School of Life Sciences Keele UniversityStaffordshire ST55BGUK School of Pharmacy and Bioengineering Keele UniversityStaffordshire ST47QBUK

Objective Late 2019 witnessed the outbreak and widespread transmission of coronavirus disease 2019(COVID-19),a new,highly contagious disease caused by novel severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).Consequently,considerable attention has been paid to the development of new diagnostic tools for the early detection of *** In this study,a new poly-N-isopropylacrylamide microgel-based electrochemical sensor was explored to detect the SARS-CoV-2 spike protein(S protein)in human *** microgel was composed of a copolymer of N-isopropylacrylamide and acrylic acid,and gold nanoparticles were encapsulated within the microgel through facile and economical *** electrochemical performance of the sensor was evaluated through differential pulse *** Under optimal experimental conditions,the linear range of the sensor was 10-13-10-9 mg/m L,whereas the detection limit was 9.55 fg/***,the S protein was instilled in artificial saliva as the infected human saliva model,and the sensing platform showed satisfactory detection *** The sensing platform exhibited excellent specificity and sensitivity in detecting spike protein,indicating its potential application for the time-saving and inexpensive detection of SARS-CoV-2.

关键词： Microgel SARS-CoV-2 Spike protein detection

Chitosan and Carboxymethylchitosan as High Turbidity Water Biocoagulants

在线全文

学校读者我要写书评

暂无评论

Journal of Renewable Materials 2020年第11期8卷 1489-1504页

作者： Raimundo N.lima Júnior João L.I.O.Almeida Jones de andrade Flávia O.M.S.Abreu Natural Sciences Program State University of Ceará-UECEFortalezaCE 60714-903Brazil Physical-Chemistry department Institute of ChemistryFederal University of Rio Grande do Sul-UFRGSPorto AlegreRS 91501-970Brazil

Biocoagulants emerges as a promising technology in water treatment,in order to exploit renewable and biodegradable *** present work aims to study the coagulant action of chitosan and carboxymethylchitosan on water with very high turbidity(above 300 NTU),contrasting the physicochemical results with those obtained for aluminum *** was produced by the Williamson’s ethers synthesis and characterized by potentiometric titration,FTIR and 1 *** coagulant tests were performed using synthetic water in a Jar-test equipment,through the induction of high and low velocity gradients,followed by *** results showed turbidity and color removal efficiencies above 99%for the biocoagulants,by applying dosages much lower than those used for aluminum sulphate;the volume of sedimentable solids obtained at the end of the water treatment process was much lower when chitosan and carboxymethylchitosan were used as coagulants(reduction of 25%when compared to aluminum sulphate).In summary,carboxymethylchitosan is a non-toxic,renewable,biodegradable material with high efficiency as a coagulant for waters with very high turbidity,showing promise for in natura applications.

关键词： Chitosan carboxymethylchitosan biocoagulants colloids and interfaces

Dynamics in the emergence of dormant and non-dormant herbaceous species from the soil seed bank from a Brazilian dry forest

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Plant Ecology 2020年第3期13卷 256-265页

作者： José Djalma de Souza Bruno Ayron de Souza Aguiar Danielle Melo dos Santos Vanessa Kelly Rodrigues de Araujo Júlia Arruda Simões Juliana Ramos de andrade Elcida de lima Araújo departamento de Biologia Universidade Federal Rural de PernambucoRecifePernambucoBrazil2Universidade Federal de Pernambuco-Centro Acadêmico de VitóriaPernambucoBrazil

Aims In dry tropical forests,herbaceous species may have dormancy mechanisms and form persistent and transient seed banks in the *** acquired,these mechanisms are efficient for the establishment and survival of these herbs,especially in forests with unpredictable climates,such as the ***,our objective was to verify whether the studied herbaceous species adopt the physical dormancy mechanism and how these natural barriers are overcome,to understand the temporal dynamics existing in the soil seed bank from a Brazilian dry tropical *** Seeds of five native herbaceous species from the Caatinga forests were selected and submitted to pre-germinative treatments for verifying the presence of physical *** collected soil samples in the rainy and dry seasons for four consecutive years and monitored the emergence of the selected herbaceous in the *** verified the differences in germination and seed bank emergence in the soil by generalized linear *** Findings The presence and absence of physical dormancy were observed in seeds from Caatinga herbaceous *** found intraspecific and interspecific differences in the herbaceous emergence from soil seed banks between years and climatic *** perennial herbs,consecutive lack of emergence between seasons and years was frequent,which suggests a direct relationship with the mechanism of physical dormancy and the environmental conditions necessary to overcome integument *** these species,seed dimorphism and dormancy may confer additional advantages to their ***,presenting intermediate levels of physical dormancy in an annual species may be an evolutionary adjustment to rainfall *** contrast,we found that the annual herb without dormancy is more sensitive to seasonal and interannual climate changes,as evidenced by the increase and significant reduction of its emergence in the soil seed *** differences acquired evoluti

关键词： establishment herbaceous species physical dormancy seed bank seed germination semiarid

Can coffee help fighting the drug problem? Preliminary results of a Brazilian youth drug study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Acta Pharmacologica Sinica 2000年第12期 4-15页

作者： Gladis B FLORES,Fernanda andrade,Darcy R lima Research Coordinator Brazilian Youth Drug Study (BYDS) Research Assistant BYDS General Coordinator BYDS Professor of Clinical Pharmacology at Neurology Institute Federal University of Rio de Janeiro Brazil & Associate Director for Medicinal Plants Studies Institute for Coffee Studies Vanderbilt University Medical Center Nashville TN USA

INTRODUCTION At different times and at different places many plants have been domesticated, and the development of agriculture was an intensification by man of his food extractive process. Simultaneous to the agricultural development, the selection of psychotropic plants has always been one of the most tempting and determined activities of mankind in its history. Behaviorally active drugs have captured and control human behaviour in susceptible individuals. Nowadays the most consumed plants worldwide are legal ones such as coffee and tobacco and illegal ones such as cocaine, opium and cannabis. And little is known about

关键词： coffee caffeine chlorogenic acid al-cohol drinking depression drugs opioid receptors lim-bic system

Synthesis of highly fluorescent carbon dots from lemon and onion juices for determination of riboflavin in multivitamin/mineral supplements

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Pharmaceutical Analysis 2019年第3期9卷 209-216页

作者： Severino S. Monte-Filho Stefani I.E. andrade marcel. B. lima Mario C.U. Araujo Universidade Federal da Paraíba CCEN Departamento de Química P.O. Box 5093 Zip Code 58051-970 Joao Pessoa PB Brazil Universidade Federal Rural de Pernambuco-Unidade Acad^emica de Serra Talhada UAST Zip Code 56909-535 Serra Talhada PE Brazil

In this work, lemon and onion biomasses commonly found in street markets are for the first time used to develop a facile, fast and low-cost one-step microwave-assisted carbonization method for synthesis of highly fluorescent carbon dots (CDs). The structure and optical properties of CDs were investigated by TEM, XRD, XRF, UV-Vis, FTIR, and fluorescence spectroscopy. CDs displayed satisfactory optical pro-prieties, a high quantum yield of 23.6%, and excellent water solubility, and the particle size was 4.23-8.22 nm with an average diameter of 6.15 nm. An efficient fluorescent resonance energy transfer (FRET) between the CDs and riboflavin was achieved with CDs acting as donor and riboflavin as acceptor. A linear relationship between FRET and the riboflavin concentration from 0.10 to 3.0 μg/mL was observed, allowing the development of an accurate and fast analytical method to determine this vitamin in multivitamin/mineral supplements. despite the potential interferences in these supplements, CDs were selective for riboflavin under optimized conditions. A paired t-test at a 95% confidence level indicated no statistically significant difference between the proposed and the reference methods. Recovery test presented values ranged from 96.0% to 101.4%. The limit of detection and relative standard deviation were estimated at 1.0 ng/mL and determination of riboflavin.

关键词： Carbon dots Microwave-assisted carbonization Lemon-onion juice Riboflavin Multivitamin/mineral supplements Fluorescence

Sagittal abdominal diameter as a marker of visceral obesity in older primary care patients

在线全文

学校读者我要写书评

暂无评论

Journal of Geriatric Cardiology 2020年第5期17卷 279-283页

作者： Maria Auxiliadora Nogueira Saad Antonio José Lagoeiro Jorge Diane Xavier deávila Wolney de andrade Martins Márcia Maria Sales dos Santos Luciana Thurler Tedeschi Ismar lima Cavalcanti Maria Luiza Garcia Rosa Rubens Antunes da Cruz Filho Fluminense Federal University NiteróiRio de Janeiro StateBrazil

Background Longevity,combined with a higher prevalence of obesity,particularly visceral obesity,has been associated with an increased risk of cardiovascular *** resistance(IR)is an important link between visceral obesity and cardiovascular *** important association has been found between sagittal abdominal diameter,visceral obesity and *** objective of this study is to evaluate sagittal abdominal diameter as a marker of visceral obesity and correlate it with IR in older primary health care *** A cross-sectional study was performed with 389 patients over 60 years of age(70.6±6.9),of whom 74%were *** clinical,anthropometric and metabolic profiles were assessed and their fasting serum insulin level was used to calculate the homeostasis model assessment insulin resistance(HOMA-IR).Sagittal abdominal diameter was measured in the supine position at the midpoint between the iliac crest and the last rib with abdominal *** Sagittal abdominal diameter was significantly correlated with anthropometric measures of general and visceral obesity and with HOMA-IR in both *** was no change in the association between sagittal abdominal diameter and HOMA-IR after adjusting for age,sex,diabetes and *** It is feasible to use sagittal abdominal diameter in older primary care patients as a tool to evaluate visceral obesity,which is an indicator of cardiovascular risk.

关键词： Cardiovascular risk Insulin resistance Primary health care Sagittal abdominal diameter

Identification and characterization of resistance and pathogenicity of Enterococcus *** samples of donor breast milk

在线全文

学校读者我要写书评

暂无评论

World Journal of Clinical Pediatrics 2020年第3期9卷 53-62页

作者： Luana andrade Mendes Santana Nivea Nara Novais andrade Lucas Santana Coelho da Silva Caline Novais Teixeira Oliveira Breno Bittencourt de Brito Fabricio Freire de Melo Claudio lima Souza Lucas Miranda Marques Marcio Vasconcelos Oliveira Oliveira Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil

BACKGROUND Breast milk is the primary source of nutrition for *** babies frequently need nutritional support from Human Milk *** bacterial species of the genus Enterococcus are part of the microbiota of healthy donors,they may contaminate samples of pumped breast *** To identify and characterize the bacterial virulence and resistance in samples isolated from the nipple-areolar region,hands,and breast milk aliquots from donors at the Human Milk Bank of Municipal Hospital EsauMatos in the city of Vitória da Conquista,Bahia State,*** The personal hygiene and sanitation of donors were analyzed with the aim of identifying possible reasons for contamination of pumped *** samples as well as aliquots of unpasteurized and pasteurized milk from 30 participants were *** Enterococcus *** underwent a disk diffusion susceptibility test and molecular biology techniques to determine resistance and virulence *** Enterococcus *** identified in 30%of donors(n=9),and 11 specimens were *** to tetracycline was highly prevalent,being detectable in 63%of the isolates(n=7)and followed by intermediate sensitivity to ciprofloxacin,observed in 27%of the specimens(n=3).The efaA gene was found in 63%(n=7)of the isolates,while the ace gene was detected in 27%(n=3).CONCLUSION This study illustrates the importance of microbiological monitoring by Human Milk Banks and the need for alternatives to prevent the presence of Enterococcus *** hospital settings.

关键词： Enterococcus spp. Breast milk Virulence Human milk Pasteurization Antimicrobial resistanc

Self-reported participation restrictions in normal hearing individuals in thyroid ontogeny: Evidence of subclinical changes

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Otology 2019年第1期14卷 6-11页

作者： Caio Le?nidas Oliveira de andrade Gabriela Carvalho Machado Luan Paulo Franco Magalh?es Elen Pereira de Jesus Elaine Alves Matias Taíse lima de Oliveira Cerqueira Hélida Braga de Oliveira Luciene da Cruz Fernandes Helton Estrela Ramos Crésio de Arag?o Dantas Alves Postgraduate Program in Interactive Processes of Organs and Systems Institute of Health Science–Federal University of Bahia department of Life Sciences University of the State of Bahia Social Services Sister Dulce Institute of Health Science–Federal University of Bahia department of Speech Therapy Institute of Health Science–Federal University of Bahia department of Bioregulation Health & Sciences Institute Federal University Bahia (UFBA) Medical School Institute of Health Science–Federal University of Bahia

Purpose: To verify evidence of subclinical alterations through self-reported participation restrictions in normal hearing individuals and congenital hypothyroidism ***: An analytical, quantitative, cross-sectional exploratory study with a 1:1 ratio, consisting of a convenience sample of 86 normal hearing individuals with(n = 42) and without(n = 44) congenital hypothyroidism diagnosis. All participants underwent tonal and speech audiometry, immitance and distortion product otoacoustic emissions. The researchers excluded people with hearing loss, genetic syndromes and metabolic diseases. The instrument used for evaluate of self-reported participation restrictions was the HHIE-adapted questionnaire, composed of 25 questions, 12 of which were social domain and 13 emotional domain. Student's ttest and chi-square test were used for statistical analysis at a significance level of 5%.Results: There was a significant(p derate(40.5%)and higher prevalence of association with clinical factors and adherence to ***: The findings indicate that self-reported participation restrictions in normal hearing individuals with congenital hypothyroidism was more significant than in the non-exposed group, suggesting evidence of subclinical auditory abnormalities in this population.

关键词： Hearing Hearing loss Auditory perception Congenital hypothyroidism Surveys and questionnaires