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与在适应证外和未经测试的情况下使用药物洗脱支架相关的预后及并发症

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世界核心医学期刊文摘(心脏病学分册) 2007年第9期 12-13页

作者： Beohar N. davidson c.j. Kip K.E. 罗亮 Department of cardiology Northwestern Memorial Hospital 251 E Huron St Feinberg 8-790A Chicago IL 60610 United States

背景:有关在已核准适应证以外情况下使用药物洗脱支架的资料有限。目的:观察在经皮冠状动脉介入(PcI)适应证外(再狭窄、血管桥病变、长病变、血管大小超过推荐使用范围)和未经测试(左主干、开口处、分叉处或完全闭塞病变)的情况下使用... 详细信息

背景:有关在已核准适应证以外情况下使用药物洗脱支架的资料有限。目的:观察在经皮冠状动脉介入(PcI)适应证外(再狭窄、血管桥病变、长病变、血管大小超过推荐使用范围)和未经测试(左主干、开口处、分叉处或完全闭塞病变)的情况下使用药物洗脱支架的频

关键词：药物洗脱支架患者血运重建靶血管使用者适应证 PcI 预后

Status and prospects for symmetric organic redox flow batteries

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journal of Energy chemistry 2025年第1期100卷 125-143页

作者： Md Al Raihan c.Adam Dyker Department of chemistry University of New Brunswick

As environmental concerns from fossil fuel consumption intensify, large-scale energy storage becomes imperative for the integration of renewable sources like wind, hydro, and solar with the electrical *** flow batteries, particularly those employing organic molecules, are positioned as a key technology for this purpose. This review explores the growing field of symmetric organic redox flow batteries(ORFBs) within this context. Unlike traditional asymmetric designs based on unique active materials for each electrode, symmetric ORFBs involve a single bipolar species for both electrodes. This review highlights the benefits of a symmetric design, and categorizes five distinct classes of organic bipolar molecules used in both aqueous and non-aqueous solvents. By providing a comprehensive overview of their cell cycling and performance characteristics, the strengths and weaknesses of the diverse categories of bipolar molecules are highlighted for both solvent systems, as are opportunities for future development. This should guide new research directions and advance the development of practical symmetric ORFBs.

关键词： Redox flow battery Symmetric battery Organic battery Aqueous electrolyte Non-aqueous electrolyte

A functional tacrolimus-releasing nerve wrap for enhancing nerve regeneration following surgical nerve repair

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Neural Regeneration Research 2025年第1期20卷 291-304页

作者： Simeon c.Daeschler Katelyn j.W.So Konstantin Feinberg Marina Manoraj jenny cheung jennifer Zhang Kaveh Mirmoeini jPaul Santerre Tessa Gordon Gregory HBorschel SickKids Research Institute Neuroscience and Mental Health ProgramTorontoONCanada Institute of Biomaterials and Biomedical Engineering University of TorontoTorontoONCanada Indiana University School of Medicine IndianapolisINUSA Division of Plastic and Reconstructive Surgery the Hospital for Sick ChildrenTorontoONCanada Translational Biology and Engineering Program Ted Rogers Centre for Heart ResearchInstitute of Biomedical EngineeringFaculty of DentistryUniversity of TorontoTorontoONCanada

Axonal regeneration following surgical nerve repair is slow and often incomplete,resulting in poor functional recovery which sometimes contributes to lifelong ***,there are no FDA-approved therapies available to promote nerve *** accelerates axonal regeneration,but systemic side effects presently outweigh its potential benefits for peripheral nerve *** authors describe herein a biodegradable polyurethane-based drug delivery system for the sustained local release of tacrolimus at the nerve repair site,with suitable properties for scalable production and clinical application,aiming to promote nerve regeneration and functional recovery with minimal systemic drug *** is encapsulated into co-axially electrospun polycarbonate-urethane nanofibers to generate an implantable nerve wrap that releases therapeutic doses of bioactive tacrolimus over 31 *** and drug loading are adjustable for applications in small and large caliber nerves,and the wrap degrades within 120 days into biocompatible *** released from the nerve wrap promotes axon elongation in vitro and accelerates nerve regeneration and functional recovery in preclinical nerve repair models while off-target systemic drug exposure is reduced by 80%compared with systemic *** its surgical suitability and preclinical efficacy and safety,this system may provide a readily translatable approach to support axonal regeneration and recovery in patients undergoing nerve surgery.

关键词： biodegradable local drug delivery nerve injury nerve regeneration nerve wrap tacrolimus

直接血管成形术中行冠状动脉内血栓抽吸切除术对ST段抬高型前壁心肌梗死患者左室重构的影响

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世界核心医学期刊文摘（心脏病学分册） 2006年第11期2卷 47-47页

作者： De Luca L. Sardella G. davidson c.j. 杜媛 Department of cardiovascular and Respiratory Sciences La Sapienza University Policlinico Umberto I Viale del Policlinico 155 00100 Rome Italy Dr.

Objective: To evaluate prospectively the impact on left ventricular(LV) remodelling of an intracoronary aspiration thrombectomy device as adjunctive therapy in primary percutaneous coronary intervention(PcI) in patients with anterior ST elevation myocardial infarction(STEMI). Methods: 76 consecutive patients with anterior STEMI(65.3(11.2) years, 48 men) were randomly assigned to intracoronary thrombectomy and stent placement(n=38) or to conventional stenting(n=38) of the infarct related artery. Each patient underwent transthoracic echocardiography immediately after PcI and at six months. At the time of echocardiographic control, major adverse cardiovascular events(MAcE) in terms of death, new onset of myocardial infarction, and hospitalisation for heart failure were also evaluated. Results: After a successful primary PcI, patients in the thrombectomy group achieved a higher rate of post-procedure myocardial blush grade 3(36.8%v 13.1%, p=0.03) and effective ST segment resolution at 90 minutes(81.6%v 55.3%, p=0.02). Six months after the index intervention, 19 patients(26.8%) developed LV dilatation, defined as an increase in end diastolic volume(EDV) ≥20%: 15 in the conventional group and four in the thrombectomy group(p=0.006). Accordingly, at six months patients treated conventionally had significantly higher end systolic volumes(82(7.7) ml v 75.3(4.9) ml, pctomy. No differences in cumulative MAcE were observed(10.5%in the conventional group v 8.6%in the thrombectomy group, not significant). conclusion: compared with conventional stenting, adjunctive aspiration thrombectomy in successful primary PcI seems to be associated with a significantly lower incidence of LV remodelling at six months in patients with anterior STEMI.

关键词：前壁心肌梗死 ST段抬高左室重构血管成形术切除术梗死相关动脉经胸超声心动图收缩末容积舒

Study on the early surface films formed on Mg-Y molten alloy in different atmospheres

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journal of Magnesium and Alloys 2015年第3期3卷 173-179页

作者： A.R.Mirak c.j.davidson j.A.Taylor cAST cRc School of Mechanical and Mining EngineeringThe University of QueenslandBrisbaneQLD 4072Australia cAST cRc CSIRO Materials Science and EngineeringP.O.Box 883KenmoreQLD 4069Australia

In the present study,the non-isothermal early stages of surface oxidation of liquid Mg-1%Y alloy during casting were studied under UPH argon,dry air,and air mixed with protective fluorine-bearing *** chemistry and morphology of the surface films were characterized by SEM and EDX *** results indicate a layer of smooth and tightly coherent oxidation film composed of MgO and Y_(2)O_(3) formed on the molten Mg-Y alloy surface with 40-60 nm thickness under dry air.A dendritic/cellular microstructure is clearly visible with Y-rich second phases gathered in surface of the melt and precipitated along the grain/cell boundaries under all gas *** fluorine-bearing gas mixtures,the surface film was a mixed oxide and fluoride and more even;a flat and folded morphology can be seen under SF6 with oxide as dominated phase and under 1,1,1,2-tetra-fluoroethane,a smooth and compact surface film uniformly covering the inner surface of the bubble with equal oxide and fluoride thickness,which results in a film without any major ***_(2) phase appears to be the key characteristic of a good protective film.

关键词： Mg-Y alloy SEM EDX Early surface film Oxidation Fluoridation

Molecular mechanisms of liver ischemia reperfusion injury:Insights from transgenic knockout models

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World journal of Gastroenterology 2013年第11期19卷 1683-1698页

作者： Gourab Datta Barry j Fuller Brian R davidson Liver Transplantation and Hepatobiliary Unit Division of Surgery and Interventional ScienceRoyal Free CampusUniversity College LondonRoyal Free Hampstead NHS Trust HospitalLondon NW 2QGUnited Kingdom

Ischemia reperfusion injury is a major obstacle in liver resection and liver transplantation *** the mechanisms of liver ischemia reperfusion injury(IRI) and developing strategies to counteract this injury will therefore reduce acute complications in hepatic resection and transplantation,as well as expanding the potential pool of usable donor *** initial liver injury is initiated by reactive oxygen species which cause direct cellular injury and also activate a cascade of molecular mediators leading to microvascular changes,increased apoptosis and acute inflammatory changes with increased hepatocyte *** adaptive pathways are activated during reperfusion that reduce the reperfusion *** involves a complex interplay between neutrophils,natural killer T-cells cells,cD4+ T cell subtypes,cytokines,nitric oxide synthases,haem oxygenase-1,survival kinases such as the signal transducer and activator of transcription,Phosphatidylinositol 3-kinases/Akt and nuclear factor κβ *** animals,particularly genetic knockout models,have become a powerful tool at elucidating mechanisms of liver ischaemia reperfusion injury and are complementary to pharmacological *** disruption of the protein at the genetic level is more specific and maintained than pharmacological inhibitors or stimulants of the same *** article reviews the evidence from knockout models of liver IRI about the cellular and molecular mechanisms underlying liver IRI.

关键词： Liver Ischemia/reperfusion Transgenic Knockout Nitric oxide synthase Haem oxygenase Mitogen-activated protein kinase T cell receptor

Inflammasome links traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease

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Neural Regeneration Research 2025年第6期20卷 1644-1664页

作者： Gabriela Seplovich Yazan Bouchi juan Pablo de Rivero Vaccari jennifer c.Munoz Pareja Andrew Reisner Laura Blackwell Yehia Mechref Kevin K.Wang j.Adrian Tyndall Binu Tharakan Firas Kobeissy Department of Surgery Morehouse School of MedicineAtlantaGAUSA Department of Neurobiology Center for NeurotraumaMultiomics&Biomarkers(CNMB)Neuroscience InstituteMorehouse School of MedicineAtlantaGAUSA Department of Neurological Surgery and the Miami Project to cure Paralysis University of Miami Miller School of MedicineMiamiFLUSA Division of Pediatric critical care Department of PediatricsUniversity of Miami Miller School of MedicineMiamiFLUSA Department of Pediatrics Emory UniversityAtlantaGAUSA Department of Neurosurgery Children’s Healthcare of AtlantaAtlantaGAUSA Department of chemistry and Biochemistry Texas Tech UniversityLubbockTXUSA Morehouse School of Medicine AtlantaGAUSA

Traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease are three distinct neurological disorders that share common pathophysiological mechanisms involving neuroinflammation. One sequela of neuroinflammation includes the pathologic hyperphosphorylation of tau protein, an endogenous microtubule-associated protein that protects the integrity of neuronal cytoskeletons. Tau hyperphosphorylation results in protein misfolding and subsequent accumulation of tau tangles forming neurotoxic aggregates. These misfolded proteins are characteristic of traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease and can lead to downstream neuroinflammatory processes, including assembly and activation of the inflammasome complex. Inflammasomes refer to a family of multimeric protein units that, upon activation, release a cascade of signaling molecules resulting in caspase-induced cell death and inflammation mediated by the release of interleukin-1β cytokine. One specific inflammasome, the NOD-like receptor protein 3, has been proposed to be a key regulator of tau phosphorylation where it has been shown that prolonged NOD-like receptor protein 3 activation acts as a causal factor in pathological tau accumulation and spreading. This review begins by describing the epidemiology and pathophysiology of traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease. Next, we highlight neuroinflammation as an overriding theme and discuss the role of the NOD-like receptor protein 3 inflammasome in the formation of tau deposits and how such tauopathic entities spread throughout the brain. We then propose a novel framework linking traumatic brain injury, chronic traumatic encephalopathy, and Alzheimer's disease as inflammasomedependent pathologies that exist along a temporal continuum. Finally, we discuss potential therapeutic targets that may intercept this pathway and ultimately minimize long-term neurological decline.

关键词： Alzheimer's disease caspase-1 chronic traumatic encephalopathy inflammasomes neurodegeneration neuroinflammation NLRP1 NLRP3 pyroptosis tauopathy traumatic brain injury

challenges in developing therapeutic strategies for mild neonatal encephalopathy

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Neural Regeneration Research 2022年第2期17卷 277-282页

作者： Alice McDouall Guido Wassink Laura Bennet Alistair j.Gunn joanne O.davidson Department of Physiology The University of AucklandAucklandNew Zealand

There is increasing evidence that infants with mild neonatal encephalopathy(NE) have significant risks of mortality, brain injury and adverse neurodevelopmental outcomes. In the era of therapeutic hypothermia, infants need to be diagnosed within 6 hours of birth, corresponding with the window of opportunity for treatment of moderate to severe NE, compared to the retrospective grading over 2 to 3 days, typically with imaging and formal electroencephalographic assessment in the pre-hypothermia era. This shift in diagnosis may have increased the apparent prevalence of brain damage and poor neurological outcomes seen in infants with mild NE in the era of hypothermia. Abnormal short term outcomes observed in infants with mild NE include seizures, abnormal neurologic examination at discharge, abnormal brain magnetic resonance imaging and difficulty feeding. At 2 to 3 years of age, mild NE has been associated with an increased risk of autism, language and cognitive deficits. There are no approved treatment strategies for these infants as they were not included in the initial randomized controlled trials for therapeutic hypothermia. However, there is already therapeutic creep, with many centers treating infants with mild NE despite the limited evidence for its safety and efficacy. The optimal duration of treatment and therapeutic window of opportunity for effective treatment need to be specifically established for mild NE as the evolution of injury is likely to be slower, based on preclinical data. Randomized controlled trials of therapeutic hypothermia for infants with mild NE are urgently required to establish the safety and efficacy of treatment. This review will examine the evidence for adverse outcomes after mild NE and dissect some of the challenges in developing therapeutic strategies for mild NE, before analyzing the evidence for therapeutic hypothermia and other strategies for treatment of these infants.

关键词： asphyxia electroencephalogram erythropoietin mild hypoxic ischemic encephalopathy neonatal encephalopathy neurological examination neuroprotection Sarnat score therapeutic hypothermia

Magnetic resonance studies of a gas-solids fluidised bed:jet-jet and jet-wall interactions

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Particuology 2010年第6期8卷 617-622页

作者： Meenal Pore Daniel j.Holland Thusara c.chandrasekera christoph R.Müller Andrew j.Sederman john S.Dennis Lynn F.Gladden john F.davidson Department of chemical Engineering and Biotechnology University of CambridgePembroke StreetCambridgeCB2 3RAUK Department of Mechanical and Process Engineering ETH ZurichSonneggstrasse 38092 ZurichSwitzerland

Magnetic resonance imaging （MRI） gave images of air jets from orifices in the distributor plate of a bed of poppy seeds. Attention focused on two features：（1） The interaction between nearby vertical jets from two, three or four orifices; （2） Wall effects, where one or more orifices created vertical jets near the vertical wall of the cylinder containing the particle bed. The results show that nearby jets are mutually attracted. Likewise a jet near a wall bends out of the vertical, towards the wall, For multiple adjacent jets, the jet lengths show dependence on orifice layout： the lengths are in reasonable agreement with published measurements, by other methods, for single jets. The MRI gives three-dimensional images of the single jets and of multiple jets, separate or merging.

关键词： Fluidised bed MRI jets Distributor design