检索结果-南通市图书馆

mRNA vaccines:a new era in vaccine development

Oncology Research 2024年第10期32卷 1543-1564页

作者： SHUBHRA CHANDRA JENNIFER C.WILSON david good MING Q.WEI School of Pharmacy&Medical Sciences Gold Coast campusGriffith UniversityBrisbaneQLD-4222Australia Menzies Health Institute Queensland(MHIQ) Gold Coast CampusGriffith UniversityBrisbaneQLD-4215Australia School of Allied Health Australian Catholic UniversityBrisbaneQLD-4014Australia

The advent of RNA therapy,particularly through the development of mRNA cancer vaccines,has ushered in a new era in the field of *** article provides a concise overview of the key principles,recent advancements,and potential implications of mRNA cancer vaccines as a groundbreaking modality in cancer *** cancer vaccines represent a revolutionary approach to combatting cancer by leveraging the body’s innate immune *** vaccines are designed to deliver specific mRNA sequences encoding cancer-associated antigens,prompting the immune system to recognize and mount a targeted response against malignant *** personalized and adaptive nature of mRNA vaccines holds immense potential for addressing the heterogeneity of cancer and tailoring treatments to individual *** breakthroughs in the development of mRNA vaccines,exemplified by the success of COVID-19 vaccines,have accelerated their application in *** mRNA platform’s versatility allows for the rapid adaptation of vaccine candidates to various cancer types,presenting an agile and promising avenue for therapeutic *** trials of mRNA cancer vaccines have demonstrated encouraging results in terms of safety,immunogenicity,and *** candidates,such as BioNTech’s BNT111 and Moderna’s mRNA-4157,have exhibited promising outcomes in targeting melanoma and solid tumors,*** successes underscore the potential of mRNA vaccines to elicit robust and durable anti-cancer immune *** the field holds great promise,challenges such as manufacturing complexities and cost considerations need to be addressed for widespread *** development of scalable and cost-effective manufacturing processes,along with ongoing clinical research,will be pivotal in realizing the full potential of mRNA cancer ***,mRNA cancer vaccines represent a cutting-edge therapeutic approach that holds the promise of transforming cancer treatment.

关键词： Cancer immunotherapy Immune checkpoint Preventive&therapeutic vaccine Delivery system mRNA

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

In silico Proteome-wide Amino aCid and Elemental Composition (PACE) Analysis of Expression Proteomics Data Provides A Fingerprint of Dominant Metabolic Processes

引用

Genomics, Proteomics & Bioinformatics 2013年第4期11卷 219-229页

作者： david M. good Anwer Mamdoh Harshavardhan Budamgunta Roman A. Zubarev Division of Physiological Chemistry I Department of Medical Biochemistry and Biophysics Karolinska InstituteSE17177 Stockholm Sweden Science for Life Laboratory SE17121 Solna Sweden

Proteome-wide Amino aCid and Elemental composition （PACE） analysis is a novel and informative way of interrogating the proteome. The PACE approach consists of in silico decompo- sition of proteins detected and quantified in a proteomics experiment into 20 amino acids and five elements （C, H, N, O and S）, with protein abundances converted to relative abundances of amino acids and elements. The method is robust and very sensitive; it provides statistically reliable differ- entiation between very similar proteomes. In addition, PACE provides novel insights into prote- ome-wide metabolic processes, occurring, e.g., during cell starvation. For instance, both Escherichia coli and Synechocystis down-regulate sulfur-rich proteins upon sulfur deprivation, but E. coli preferentially down-regulates cysteine-rich proteins while Synechocystis mainly down- regulates methionine-rich proteins. Due to its relative simplicity, flexibility, generality and wide applicability, PACE analysis has the potential of becoming a standard analytical tool in proteomics.

关键词： Shotgun proteomics Mass spectrometry LC-MS/MS Data reduction Cyanobacterium Arginine deprivation

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Development of test scenarios and bicyclist surrogate for the evaluation of bicyclist automatic emergency braking systems

引用

Journal of Intelligent and Connected Vehicles 2018年第1期1卷 15-27页

作者： Qiang Yi Stanley Chien Lingxi Li Wensen Niu Yaobin Chen david good Chi-Chih Chen Rini Sherony Department of Electrical and Computer Engineering Indiana University-Purdue UniversityIndianapolisIndianaUSA School of Public and Environmental Affairs Indiana UniversityBloomingtonIndianaUSA Department of Electrical and Computer Engineering Ohio State UniversityColumbusOhioUSA Toyota Collaborative Safety Research Center Ann ArborMichiganUSA

Purpose–To support the standardized evaluation of bicyclist automatic emergency braking(AEB)systems,test scenarios,test procedures and test system hardware and software tools have been investigated and developed by the Transportation Active Safety Institute(TASI)at Indiana University-Purdue University *** paper aims to focus on the development of test scenarios and bicyclist surrogate for evaluating vehicle–bicyclist AEB ***/methodology/approach–The harmonized general estimates system(GES)/FARS 2010-2011 crash data and TASI 110-car naturalistic driving data(NDD)are used to determine the crash geometries and environmental factors of crash scenarios including lighting conditions,vehicle speeds,bicyclist speeds,etc.A surrogate bicyclist including a bicycle rider and a bicycle surrogate is designed to match the visual and radar characteristics of bicyclists in the USA.A bicycle target is designed with both leg pedaling and wheel rotation to produce proper micro-Doppler features and generate realistic motion for camera-based AEB ***–Based on the analysis of the harmonized GES/FARS crash data,five crash scenarios are recommended for performance testing of bicyclist AEB *** with TASI 110-car naturalistic driving data,the crash environmental factors including lighting conditions,obscuring objects,vehicle speed and bicyclist speed are *** surrogate bicyclist was designed to represent the visual and radar characteristics of the real bicyclists in the *** height of the bicycle rider mannequin is 173 cm,representing the weighted height of 50th percentile US male and female *** size and shape of the surrogate bicycle were determined as 26-inch wheel and mountain/road bicycle frame,*** leg pedaling motion and wheel rotation are suggested to produce proper micro-Doppler features and support the camera-based AEB ***/value–The results have demonstrated that the developed scenarios,

关键词： Bicyclist Surrogate bicyclist Automatic emergency braking(AEB) Crash scenarios Crash testing Naturalistic driving Radar cross section(RCS) Micro-Doppler

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Direct-to-indirect mapping for optimal low-thrust trajectories

引用

Astrodynamics 2024年第1期8卷 27-46页

作者： david Ottesen Ryan P.Russell Department of Aerospace Engineering and Engineering Mechanics The University of Texas at AustinAustinTexas78712USA

Optimal,many-revolution spacecraft trajectories are challenging to solve.A connection is made for a class of models between optimal direct and indirect *** transfers that minimize thrust-acceleration-squared,primer vector theory maps direct,many-impulsive-maneuver trajectories to the indirect,continuous-thrust-acceleration *** mapping algorithm is independent of how the direct solution is obtained and requires only a solver for a boundary value problem and its partial derivatives.A Lambert solver is used for the two-body problem in this *** mapping is simple because the impulsive maneuvers and co-states share the same linear space around an optimal *** numerical results,the direct coast-impulse solutions are demonstrated to converge to the indirect continuous solutions as the number of impulses and segments *** two-body design space is explored with a set of three many-revolution,many-segment examples changing semimajor axis,eccentricity,and *** first two examples involve a small change to either semimajor axis or eccentricity,and the third example is a transfer to geosynchronous *** a single processor,the optimization runtime is seconds to minutes for revolution counts of 10 to 100,and on the order of one hour for examples with up to 500 *** of these thrust-acceleration-squared solutions are good candidates to start a homotopy to a higher-fidelity minimization problem with practical constraints.

关键词： direct optimization indirect optimization impulsive maneuvers Lambert's problem two-body dynamics primer vectortheory

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Utilization of pH-driven methods to fortify nanoemulsions with multiple polyphenols

引用

Food Science and Human Wellness 2024年第4期13卷 1943-1950页

作者： Hualu Zhou Bingjing Zheng david Julian McClements Department of Food Science and Technology College of Agricultural and Environmental SciencesUniversity of GeorgiaGriffinGA 30223USA Biopolymers and Colloids Laboratory Department of Food ScienceUniversity of MassachusettsAmherstMA 01003USA Department of Food Science&Bioengineering Zhejiang Gongshang UniversityHangzhou 310018China

Simple but effective methods are required to incorporate multiple bioactive polyphenols into delivery systems to increase their dispersibility,stability and *** developed and tested three p Hdriven protocols for creating nanoemulsions loaded with multiple lipophilic *** protocols differed in how the different polyphenols were incorporated into the *** impact of these three methods on the formation,properties,and gastrointestinal fate of nanoemulsions loaded with curcumin,resveratrol,and quercetin was *** three methods produced nanoemulsions with similar initial particle properties:droplet diameters(0.15,0.16,and 0.15μm)and zeta-potentials(–59,–58,and–58 m V),***,the average encapsulation efficiencies(82%,88%,and 61%),gastrointestinal stabilities(83%,97%,and 29%)and bioaccessibilities(77%,90%,and 73%)for curcumin,resveratrol,and quercetin were somewhat *** particular,more quercetin degradation occurred using the approach that held it under alkaline conditions for extended *** general,the p H-driven method provides researchers with a versatile approach of incorporating multiple polyphenols with different characteristics into functional food and beverages using a simple and inexpensive method.

关键词： Polyphenols pH-Driven encapsulation Nanoemulsions Gastrointestinal fate Functional foods

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

针灸在澳大利亚中医诊所的应用

引用

中医药导报 2017年第12期23卷 1-3,15页

作者：田丹枫石建美 david A·good 刘师序王玥许可魏明谦夏惠琴昆士兰医学科学院孟席斯健康研究所/格里菲斯大学黄金海岸校区澳大利亚昆士兰州4222 山东中医药大学山东济南250002 澳大利亚天主教大学物理治疗学院/巴尼奥校区澳大利亚昆士兰州4014 布里斯本中医药针灸中心澳大利亚昆士兰州4014

目的:分析澳大利亚中医诊所针灸的应用、疾病种类及初诊患者针灸治疗情况。方法:收集澳大利亚布里斯本中医药针灸中心2009年1月1日至2014年12月31日共6年的757例初诊门诊病例,用Excel表格和SPSS20.0统计分析。结果:6年间中医诊所就诊并... 详细信息

目的:分析澳大利亚中医诊所针灸的应用、疾病种类及初诊患者针灸治疗情况。方法:收集澳大利亚布里斯本中医药针灸中心2009年1月1日至2014年12月31日共6年的757例初诊门诊病例,用Excel表格和SPSS20.0统计分析。结果:6年间中医诊所就诊并针灸治疗的患者数量呈不断上升趋势,中年患者为主要就诊人群(40~59岁占35.54%),女性患者多于男性患者(男∶女为58.04∶100)。针灸门诊接收的疾病种类较丰富,其中疼痛类疾病占大多数(59.18%)。结论:澳大利亚居民对针灸的接受度有所提高,患者以中年为主,病种以疼痛类疾病居多。此外,针灸治疗的疾病种类繁多,应当挖掘针灸更广泛的潜力,以促进针灸在澳大利亚的发展。

关键词：针灸澳大利亚中医诊所病种分布统计分析

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Simplified prediction models for acoustic installation effects of train-mounted equipment

引用

Railway Engineering Science 2024年第2期32卷 125-143页

作者： david Thompson Dong Zhao Giacomo Squicciarini Institute of Sound and Vibration Research University of SouthamptonSouthampton SO171BJUK

Acoustic models of railway vehicles in standstill and pass-by conditions can be used as part of a virtual certification process for new *** each piece of auxiliary equipment,the sound power measured on a test bench is combined with meas-ured or predicted transfer *** is important,however,to allow for installation effects due to shielding by fairings or the train *** the current work,fast-running analytical models are developed to determine these installation *** model for roof-mounted sources takes account of diffraction at the corner of the train body or fairing,using a barrier *** equipment mounted under the train,the acoustic propagation from the sides of the source is based on free-field Green’s *** bottom surfaces are assumed to radiate initially into a cavity under the train,which is modelled with a simple diffuse field *** sound emitted from the gaps at the side of the cavity is then assumed to propagate to the receivers according to free-field Green’s *** show good agreement with a 2.5D boundary element model and with *** uncertainty and parametric uncertainty are *** largest variability occurs due to the height and impedance of the ground,especially for a low *** leads to standard deviations of up to 4 dB at low *** the roof-mounted sources,uncertainty over the location of the corner used in the equivalent barrier model can also lead to large standard deviations.

关键词： Train noise Auxiliary equipment Acoustic installation effects Virtual certification Uncertainty

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Quantification of perfluorinated compounds in atmospheric particulate shows potential connection with environmental event

引用

Journal of Environmental Sciences 2024年第2期136卷 237-247页

作者： Hua Tang Ying Wang Shengling Si Hongli Li david Da Yong Chen National Institute of Metrology 18 BeisanhuandongluChaoyang DistrictBeijing 100029China School of Chemistry and Materials Science Nanjing Normal UniversityNanjing 210023China Si Chuan Zhong Ce Biao Wu Technology Co.Ltd. Sichuan 610052China Department of Chemistry University of British ColumbiaVancouver V6T 1Z1BCCanada

A method of quantification of perfluorinated compounds(PFCs)from atmospheric particulate matter(APM)is described.A single step pretreatment method,selective pressurized liquid extraction(SPLE),was developed to reduce the high matrix background and avoid contamination from commonly used multiple sample pretreatment *** effective sorbent was selected to purify the PFCs during SPLE,followed by liquid chromatography-tandem mass spectrometry(LC–MS/MS),for quantification of *** affecting the SPLE efficiency,including temperature,static extraction time,and number of extraction cycles used,were *** optimum conditions were found to be 120℃,10 min,and 3 cycles,***-MS/MS method was developed to obtain the optimal sensitivity specific to *** method detection limits(MDLs)were 0.006 to 0.48 ng/g for the PFCs studied and the linear response range was from 0.1 to 100 ng/*** ensure accurate values were obtained,each step of the experiment was evaluated and controlled to prevent *** optimized method was tested by performing spiking experiments in natural particulate matter matrices and good rates of recovery and reproducibility were obtained for all target ***,the method was successfully used to measure 16 PFCs in the APM samples collected in Beijing over five years from 2015 to *** is observed that some PFCs follow the trend of total PFC changes,and can be attributed to the environment influencing events and policy enforcement,while others don't seem to change as much with time of the year or from year to year.

关键词： Selective pressurized liquid extraction Liquid chromatography-mass spectrometry Perfluorinated compounds Atmospheric particulate matter Pollution control

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Assessment of groundwater quantity, quality, and associated health risk of the Tano river basin, Ghana

引用

Acta Geochimica 2024年第2期43卷 325-353页

作者： Adwoba Kua-Manza Edjah Bruce Banoeng-Yakubo Anthony Ewusi Enoch Sakyi-Yeboah david Saka Clara Turetta Giulio Cozzi david Atta-Peters Larry Pax Chegbeleh Water Resources Research Centre Ghana Atomic Energy CommissionAccraGhana Earth Science Department University of GhanaLegonAccraGhana Geological Engineering Department University of Mines and TechnologyTarkwaGhana Department of Statistics University of GhanaAccraLegonGhana Institute of Polar Sciences National Research Council of ItalyVeniceItaly

In the Tano River Basin,groundwater serves as a crucial resource;however,its quantity and quality with regard to trace elements and microbiological loadings remain poorly understood due to the lack of groundwater logs and limited water *** study presents a comprehensive analysis of the Tano River Basin,focusing on three key ***,it investigated the aquifer hydraulic parameters and the results showed signiﬁcant spatial variations in borehole depths,yields,transmissivity,hydraulic conductivity,and speciﬁc *** boreholes were concentrated in the northeastern and southeastern zones,while geological formations,particu-larly the Apollonian Formation,exhibit a strong inﬂuence on borehole *** study identiﬁed areas with high transmissivity and hydraulic conductivity in the southern and eastern regions,suggesting good groundwater avail-ability and suitability for sustainable water ***-ondly,the research investigated the groundwater quality and observed that the majority of borehole samples fall within WHO(Guidelines for Drinking-water Quality,Environmental Health Criteria,Geneva,2011,***://***)***,some samples have pH levels below the standards,although the groundwater generally qualiﬁes as *** study further explores hydrochemical facies and health risk assessment,highlighting the dominance of Ca–HCO3 water *** element analysis reveals minimal health risks from most elements,with chromium(Cr)as the primary contributor to chronic health ***,this study has provided a key insights into the Tano River Basin’s hydrogeology and associated health *** outcome of this research has contributed to the broader understanding of hydrogeologi-cal dynamics and the importance of managing groundwater resources sustainably in complex geological environments.

关键词： Groundwater Unsupervised machine learning technique Hydrochemistry Aquifer hydraulic parameter Health risk

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Travel for Inspiration--A new place could inspire a new idea

引用

空中英语教室（高级版．彭蒙惠英语） 2024年第9期 34-35,49,50页

作者： david Schonthal 不详

Here's good news for entrepreneurs,innovators and anyone else seeking to get their creative juices flowing:Japan and Korea just announced the availability of digital nomad visas for those seeking a months'long change ... 详细信息

关键词： seeking creative Korea

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：