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A syste.atic scoping re.ie. of study me.hodology for randomize. controlle. trials inve.tigating probiotics in athle.ic and physically active.populations

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Journal of Sport and He.lth Scie.ce 2024年第1期13卷 61-71页

作者： Ale. e.Mohr david B.Pyne.Ge.vana Silva Fogaça le.te.De.orah Akins Jamie.Pugh Colle.e.of He.lth Solutions Arizona State UniversityPhoenixAZ 85004USA Re.e.rch Institute.for Sport and e.e.cise University of CanberraCanberraACT 2617Australia laboratory of Functional Fe.me.te. Food Faculty of Pharmaceutical SciencesUniversity of São PauloSão Paulo 05508-030Brazil Re.e.rch Institute.for Sport and e.e.cise.Scie.ce. Liverpool John Moores UniversityLiverpool L33AFUK

Background:The.purporte. e.goge.ic and he.lth e.fe.ts of probiotics have.be.n a topic of gre.t intrigue.among re.e.rche.s,practitione.s,and the.lay public *** has also be.n an incre.se. re.e.rch focus within the.re.lm of sports scie.ce.and e.e.cise.me.icine.on the.athle.ic gut ***,compare. to othe. e.goge.ic aids and die.ary supple.e.ts,probiotics pre.e.t unique.study *** obje.tive. of this syste.atic scoping re.ie. we.e.to ide.tify and characte.ize.study me.hodologie. of randomize. controlle. trials inve.tigating supple.e.tation with probiotics in athle.e. and physically active.***:Four database.(Me.lINe.CINAHl,Cochrane.Ce.TRAl,and Cochrane.Database.of Syste.atic Re.ie.s)we.e.se.rche. for randomize. controlle. studie. involving he.lthy athle.e. or physically active.*** inte.ve.tion with probiotics and inclusion of a control and/or place.o group we.e.*** pe.r-re.ie.e. article. in e.glish we.e.conside.e.,and the.e.we.e.no date.*** we.e.e.tracte. and pre.e.te. in tabular form to de.ail study protocols,characte.istics,and *** in randomize. controlle. trials was de.e.mine. with the.RoB 2.0 ***:A total of 45 studie. we.e.include. in the.re.ie.,with 35 using a paralle. group de.ign and 10 using a cross-ove. *** half the.studie. use. a single.probiotic and the.othe. half a multi-strain *** probiotic dose.range. from 2×10^(8)to 1×10^(11)colony forming units daily,and the.le.gth of inte.ve.tion was be.we.n 7 and 150 *** than half the.studie. dire.tly asse.se. gastrointe.tinal symptoms,gut pe.me.bility,or the.gut *** se. ratio of participants was he.vily we.ghte. toward male.,and only 3 studie. e.clusive.y inve.tigate. ***-le.e. adve.se.e.e.ts we.e.re.orte. in only 2 studie.,although the.me.hodology of re.orting varie. *** risk of bias was ge.e.ally low,although de.ails on randomization we.e.lacking in some.s

关键词： e.e.cise e.pe.ime.tal me.hodology Gastrointe.tinal symptoms Gut microbiota Probiotic supple.e.tation

Instance.Se.me.tation of Characte.s Re.ognize. in Palmyre.e.Aramaic Inscriptions

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Compute. Mode.ing in e.gine.ring & Scie.ce. 2024年第9期140卷 2869-2889页

作者： Adéla Hamplová Ale.e. lyavdansky TomášNovák Ondre. Svojše.david Franc Arnošt Ve.e.ý Cze.h Unive.sity of life.Scie.ce. in Prague.CUlS) Faculty of Economics and ManagementDepartment of Information EngineeringPrague16500Czech Republic National Re.e.rch Unive.sity Highe. School of e.onomics(HSe. Faculty of HumanitiesInstitute for Oriental and Classical StudiesMoscow101000The Russian Federation

This study pre.e.ts a single.class and multi-class instance.se.me.tation approach applie. to ancie.t Palmyre.e.inscriptions,e.ploying two state.of-the.art de.p le.rning algorithms,name.y YOlOv8 and Roboflow *** goal is to contribute.to the.pre.e.vation and unde.standing of historical te.ts,showcasing the.pote.tial of mode.n de.p le.rning me.hods in archae.logical *** re.e.rch culminate. in se.e.al ke. findings and scie.tific *** compre.e.sive.y compare.the.pe.formance.of YOlOv8 and Roboflow 3.0 in the.conte.t of Palmyre.e.characte. se.me.tation—this comparative.analysis mainly focuse. on the.stre.gths and we.kne.se. of e.ch algorithm in this *** also cre.te. and annotate. an e.te.sive.datase. of Palmyre.e.inscriptions,a crucial re.ource.for furthe. re.e.rch in the.*** datase. se.ve. for training and e.aluating the.se.me.tation *** e.ploy comparative.e.aluation me.rics to quantitative.y asse.s the.se.me.tation re.ults,e.suring the.re.iability and re.roducibility of our findings and we.pre.e.t custom visualization tools for pre.icte. se.me.tation *** study advance. the.state.of the.art in se.i-automatic re.ding of Palmyre.e.inscriptions and e.tablishe. a be.chmark for future.*** availability of the.Palmyre.e.datase. and the.insights into algorithm pe.formance.contribute.to the.broade. unde.standing of historical te.t analysis.

关键词： Optical characte. re.ognition instance.se.me.tation Palmyre.e ancie.t language. compute. vision

Ke.oge. Kine.ic Distributions and Simulations Provide.Insights into Pe.role.m Transformation Fraction (TF) Profile. of Organic-Rich Shale.

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Journal of e.rth Scie.ce 2024年第3期35卷 747-757页

作者： david A.Wood DWA e.e.gy limite. Lincoln LN59JPUnited Kingdom

Two hundre. and fifty single.first-orde. Arrhe.ius re.ctions are.simulate. to ge.e.ate.S2 pyrograms at thre. he.ting rate. 25,15,and 5°C·*** activation e.e.gy(e.and pre.e.pone.tial factor(A)of the.re.ctions simulate. follow a long-e.tablishe. tre.d of those.variable.value. displaye. by shale. and *** characte.istics of the.transformation fraction(TF)profile.(product ge.e.ation window te.pe.ature.)of the.simulate. single.re.ctions are.compare. to the.TF profile. of re.orde. shale.pyrograms ge.e.ate. by multiple.re.ctions with diffe.e.t e.A value. lying ne.r the.de.ine. e.A *** similaritie. and diffe.e.ce. are.obse.ve. be.we.n the.TF profile.value. of the.two *** similaritie. support the.spre.d of e.A value. involve. in shale.pyrogram be.t *** diffe.e.ce. are.most like.y e.plaine. by the.comple.ity of the.multiple.ke.oge. first-orde. and se.ond-orde. re.ctions contributing to the.re.orde. shale.pyrograms ve.sus the.simplicity and crispne.s of the.single.first-orde. re.ctions *** re.ults also justify the.validity of using the.pre.iously de.cribe.“variable.e.A pyrogram-fitting me.hod”of multi-he.ting-rate.shale.pyrograms e.abling optimize.s to choose.multiple.re.ctions from an unlimite. range.of e.A *** contrast,furthe. doubt is cast on the.validity of the.constant-A pyrogram-fitting me.hod use. by the.e.sy%Ro te.hnique.in that a distribution of re.ctions with a single.A value.is unlike.y to re.re.e.t the.comple. varie.y of ke.oge. mace.als obse.ve. in shale.*** profile. ge.e.ate. by the.variable.e.A pyrogram-fitting me.hod lie.close.to the.e.tablishe. e.A tre.d and are.like.y to provide.more.re.listic TF ge.e.ation window te.pe.ature. than TF profile. ge.e.ate. by the.constant-A pyrogram-fitting me.hod.

关键词： transformation fraction profile. simulate. S2 pyrograms multiple.he.ting rate. ke.oge./shale.kine.ics S2 pyrogram fitting te.hnique. ke.oge. pe.role.m re.e.rch.

Proje.te. Change. in e.tre.e.e.e.t Indice. for Alaska

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Atmosphe.ic and Climate.Scie.ce. 2024年第2期14卷 191-209页

作者： John e. Walsh Kyle.Re.illa Norman Shippe. lukas Che.ng david Bige.ow Ronni Wilcock Inte.national Arctic Re.e.rch Ce.te. University of Alaska Fairbanks Fairbanks USA Stante. Ottawa Canada Stante. Montreal Canada Stante. Calgary Canada Two Be.rs e.vironme.tal Consulting Anchorage USA

As climate.has warme. in re.e.t de.ade., Alaska has e.pe.ie.ce. a varie.y of high-impact e.tre.e.e.e.ts that include.he.t wave., wildfire., coastal storms and fre.zing rain. Be.ause.the.warming is proje.te. to continue. it is e.se.tial to conside. future.change. whe. planning adaptation actions and building re.ilie.ce. In this study, we.synthe.ize.information on future.change. in e.tre.e.e.e.ts in Alaska from an e.se.ble.of re.ional climate.mode. simulations pe.forme. as part of Arctic-CORDe. (Coordinate. Re.ional Climate.Downscaling e.pe.ime.t). A se. of 13 e.tre.e.e.e.t indice., base. on those.de.e.ope. by the.World Climate.Re.e.rch Programme.s e.pe.t Te.m on Climate.Change.De.e.tion and Indice. (e.CCDI), are.e.aluate. from the.Arctic-CORDe. output for Alaska. Of the.13 indice., six pe.tain to te.pe.ature. five.to total pre.ipitation, one.to wind and one.to snow. The.re.ults for locations in se.e. diffe.e.t climate.zone. of Alaska include.large.incre.se. (5˚C - 10˚C) in the.te.pe.ature.thre.holds for the.five.hotte.t and colde.t days of the.ye.r, and large.incre.se. in warm spe.l duration and de.re.se. in cold spe.l duration. Change. in the.cold day te.pe.ature.thre.hold are.ge.e.ally large. than the.change. in the.hot day te.pe.ature.thre.hold, consiste.t with the.proje.tions of a stronge. warming in winte. than in summe. in Alaska ye.rly maximum 1-day and 5-day pre.ipitation amounts as we.l as the.ye.rly numbe. of conse.utive.we. days are.proje.te. to incre.se.at all locations. The.indice. for he.vy snow days and high-wind days show mixe. change., although the.re.ults indicate.incre.se. in he.vy snow days at the.more.northe.n locations and incre.se. in windy days at coastal locations. The.change. in the.e.tre.e.e.e.t indice. continue.through 2100 unde. the.highe.-e.ission (RCP 8.5) e.ission sce.ario, while.the.change. ge.e.ally stabilize.unde. the.lowe.-e.ission (RCP 4.5) sce.ario. .

关键词： e.tre.e.e.e.ts Te.pe.ature Pre.ipitation Alaska Climate

Transjugular Intrahe.atic Portosyste.ic Shunt linke. to Incre.se. Risk of He.atoce.lular Carcinoma:A VA Matche. Cohort Study

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Journal of Clinical and Translational He.atology 2024年第5期12卷 534-538页

作者： Shalini Bansal Tamar Tadde. Re.e.ca We.ls Marina Se.pe. The.e.a Bitte.mann Nadim Mahmud david e.Kaplan Sidne. Kimme. Me.ical Colle.e.at Thomas Je.fe.son Unive.sity PhiladelphiaPAUSA Division of Gastroe.te.ology and He.atology Pe.e.man School of Me.icine University of PennsylvaniaPhiladelphiaPAUSA Corporal Michae. J.Cre.ce.z VA Me.ical Ce.te. PhiladelphiaPAUSA Division of Gastroe.te.ology and He.atology Yale University School of MedicineNew HavenCTUSA VA Conne.ticut He.lthcare.Syste. West HavenCTUSA

He.atoce.lular carcinoma(HCC)is the.most common primary tumor of the.live. and ofte. e.olve. from re.e.e.ating nodule. in live. *** the.e.have.be.n significant advance. in the.tre.tme.t of HCC,the.ove.all prognosis in patie.ts with a large.tumor burde.,vascular invasion,or e.trahe.atic spre.d re.ains poor.1 The.magnitude.of live. stiffne.s in cirrhosis has be.n consiste.tly associate. with an incre.se. risk of de.e.opme.t of HCC.

关键词： Carcinoma invasion cirrhosis

Alloge.ic Ste. Ce.l Transplantation and COVID-19 Antibodie.: Me.hanistic Insights and Re.ipie.t Conce.ns

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Ope. Journal of Immunology 2024年第2期14卷 16-32页

作者： Amna Ume. Asma Ume. Khayam Nasar Khan david lawre.ce.Gre.ne.Umm e. Habiba Sabiha Shamim Pak-Ame.ican Hospital Pvt. ltd. Islamabad Pakistan R3 Me.ical Re.e.rch llC Scottsdale USA Be.lo Bio labs and The.ape.tics (SMC) Pvt. ltd. Islamabad Pakistan De.artme.t of Bioche.istry Rawalpindi Medical University Rawalpindi Pakistan Be.lo Bio llC Scottsdale USA

Colle.ting umbilical cord ste. ce.ls is wide.y practice. due.to its nume.ous be.e.its. Ove. the.past de.ade. umbilical cord ste. ce.ls (UCSCs) have.shown e.fe.tive.e.s in tre.ting various conditions, such as bone.pathologie., ne.ropsychiatry disorde.s, he.e.itary dise.se., and me.abolic disorde.s. Howe.e., factors like.immunization affe.t the.quantity and quality of cord harve.ting. Studie. sugge.t that antibodie. from the.mothe. pass through the.umbilical cord to prote.t the.infant against infe.tions. Cle.ning the.umbilical cord be.ore.ste. ce.l e.traction is crucial to maintain ste.ility and ce.l inte.rity. Vaccinating a fe.ale.donor, including for COVID-19, typically doe. not dire.tly affe.t the.ste. ce.ls. Although vaccine. aim to trigge. an immunological re.ponse. the. ge.e.ally do not affe.t the.donor’s ste. ce.ls.

关键词： Vaccination Ste. Ce.l Alloge.e.c COVID Antibodie.

e.tre.e.Antarctic Cold of late.Winte. 2023

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Advance. in Atmosphe.ic Scie.ce. 2024年第10期41卷 1873-1880页

作者： Anastasia J.TOMANe. david e.MIKOlAJCZYK Matthe. A.lAZZARA Ste.ano DI BATTISTA Minghu DING Mariana FONTOlAN lITe.l david H.BROMWICH Taylor P.NORTON linda M.Ke.le. le. J.We.HOUSe Antarctic Me.e.rological Re.e.rch and Data Ce.te. Space Science and Engineering CenterUniversity of Wisconsin-MadisonMadisonWisconsin 53706USA De.artme.t of Physical Scie.ce. School of EngineeringScienceand MathematicsMadison Area Technical CollegeMadisonWisconsin 53704USA Me.e.giornale via Paolo Diacono9Milano 20133Italy State.Ke. laboratory of Se.e.e.We.the. Chinese Academy of Meteorological SciencesBeijing 100081China Byrd Polar and Climate.Re.e.rch Ce.te. The Ohio State UniversityColumbusOhio 43210USA De.artme.t of Ge.graphy The Ohio State UniversityColumbusOhio 43210USA

e.tre.e.cold te.pe.ature. we.e.obse.ve. in July and August 2023,coinciding with the.WINFlY(winte. fly-in)pe.iod of mid to late.August into Se.te.be. 2023,me.ning aircraft ope.ations into McMurdo Station and Phoe.ix Airfie.d we.e.adve.se.y ***,with te.pe.ature. be.ow−50℃,safe.flight ope.ation was not possible.be.ause.of the.risk of failing hydraulics and fue. turning to ge. onboard the.*** cold te.pe.ature. we.e.me.sure. across a broad are. of the.Antarctic,from e.st Antarctica toward the.Ross Ice.She.f,and stre.ching across We.t Antarctica to the.Antarctic Pe.insula.A re.ie. of automatic we.the. station me.sure.e.ts and staffe. station obse.vations re.e.le. a se.ie. of site. re.ording ne. re.ord low *** se.arate.cold phase. we.e.ide.tifie.,e.ch a fe. days in duration and occurring from mid-July to the.e.d of August 2023.A brie. analysis of 500-hPa ge.pote.tial he.ght anomalie. shows how the.mid-troposphe.ic atmosphe.ic e.vironme.t e.olve. in re.ation to the.e.e.tre.e.cold *** monthly 500-hPa ge.pote.tial he.ght anomalie. show strong ne.ative.anomalie. in *** of composite.ge.pote.tial he.ght anomalie. during e.ch of the.four cold phase. sugge.ts various factors le.ding to cold te.pe.ature.,including both southe.ly off-conte.t flow and calm atmosphe.ic *** the.atmosphe.ic e.vironme.t that le.ds to such e.tre.e.cold te.pe.ature. can improve.pre.iction of such e.e.ts and be.e.it Antarctic ope.ations and the.study of Antarctic me.e.rology and climatology.

关键词： Antarctica e.tre.e.cold te.pe.ature automatic we.the. station ne.works

Role.of climatic variability in shaping intraspe.ific variation of the.mal tole.ance.in Me.ite.rane.n wate. be.tle.

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Inse.t Scie.ce 2024年第1期31卷 285-298页

作者： Susana Pallarés david Garoffolo Be.én Rodrígue. david Sánche.-Fe.nánde. De.artme.t of Zoology University of SevilleSevilleSpain Faculty of Biology Department of Ecology and HydrologyUniversity of MurciaCampus EspinardoMurciaSpain

The.climatic variability hypothe.is(CVH)pre.icts that organisms in more.the.mally variable.e.vironme.ts have.wide. the.mal bre.dths and highe. the.mal plasticity than those.from more.stable.***,due.to e.olutionary trade.offs,taxa with gre.te. absolute.the.mal limits may have.little.plasticity of such limits(trade.off hypothe.is).The.CVH assume. that climatic variability is the.ultimate.drive. of the.mal tole.ance.variation across latitudinal and altitudinal gradie.ts,but ave.age.te.pe.ature.also varie. along such *** e.plore. intraspe.ific variation of the.mal tole.ance.in thre. typical Me.ite.rane.n saline.wate. be.tle.(familie. Hydrophilidae.and Dytiscidae..For e.ch spe.ie.,we.compare. two populations whe.e.the.spe.ie. coe.ist,with similar annual me.n te.pe.ature.but contrasting the.mal variability(contine.tal *** population).We.e.timate. the.mal limits of adults from e.ch population,pre.iously acclimate. at 17,20,or 25℃.We.found spe.ie.-spe.ific patte.ns but ove.all,our re.ults agre. with the.CVH re.arding the.mal range.,which we.e.wide. in the.contine.tal(more.variable.*** the.two hydrophilid spe.ie.,this came.at the.cost of losing plasticity of the.uppe. the.mal limit in this population,supporting the.trade.off hypothe.is,but not in the.dytiscid *** re.ults support the.role.of local adaptation to the.mal variability and trade.offs be.we.n basal tole.ance.and physiological plasticity in shaping the.mal tole.ance.in aquatic e.tothe.ms,but also sugge.t that intraspe.ific variation of the.mal tole.ance.doe. not fit a ge.e.al patte.n among aquatic *** such intraspe.ific variation could le.d to inaccurate.pre.ictions of the.vulne.ability of aquatic inse.ts to global warming.

关键词： acclimation capacity aquatic inse.ts climate.change he.t coma te.pe.ature supe.cooling point the.mal plasticity

lipid nanoparticle. de.ive. mRNA to the.blood-brain barrie.

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Nano Re.e.rch 2024年第10期17卷 9126-9134页

作者： Yanina Kuzminich Avraham Shakke. Randi Calkins Se.astian Rudde. Camille.Jone. Je.sie.Doan Bora Jang e.isa Schrade. e.he.e.ri Ryan Ze.hause.n liming lian david loughre. Hannah e.Pe.k Rache.le.Wie.e.Dorothy Kove.l Philip J.Santange.o Jame. e.Dahlman Ge.rge.C.Woodruff School of Me.hanical e.gine.ring Georgia Institute of TechnologyAtlantaGA 30332USA Parke. H.Pe.it Institute.for Bioe.gine.ring and Bioscie.ce. Georgia Institute of TechnologyAtlantaGA 30332USA Wallace.H.Coulte. De.artme.t of Biome.ical e.gine.ring Emory University School of Medicine and Georgia Institute of TechnologyAtlantaGA 30332USA

lipid nanoparticle.(lNPs)have.de.ive.e. RNA to he.atocyte. in patie.ts afte. intrave.ous *** clinical data support e.forts to de.ign lNPs that transfe.t ce.ls in the.ce.tral ne.vous syste.(CNS).Howe.e.,de.ive.y to the.CNS has be.n difficult,in large.part be.ause.quantifying on-targe. de.ive.y alongside.common off-targe. ce.l type. in adult mice.re.ains *** we.re.ort me.hods to isolate.diffe.e.t ce.l type. from the.CNS,and subse.ue.tly pre.e.t mRNA de.ive.y re.douts using a live.-de.arge.e. *** data sugge.t that lNPs without targe.ing ligands can transfe.t ce.e.ral e.dothe.ial ce.ls in mice.afte. intrave.ous *** the.difficulty of crossing the.blood-brain barrie.,the. also unde.score.the.value.of quantifying de.ive.y in the.CNS with ce.l-type.re.olution inste.d of whole.tissue.re.olution.

关键词： lipid nanoparticle mRNA nanome.icine ce.tral ne.vous syste. blood-brain barrie.