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Utilization of RNA sequencing to investigate olfactory dysfunction in chronic rhinosinusitis without nasal polyps:A pilot study

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World Journal of Otorhinolaryngology-Head and Neck Surgery 2024年第1期10卷 29-36页

作者： Jorge A.Gutierrez III Jeremy l.Barth Rodney J.Schlosser Thomas S.Edwards Timothy l.smith Zachary M.Soler Department of Otolaryngology-Head and Neck Surgery Medical University of South CarolinaCharlestonSouth CarolinaUSA Department of Regenerative Medicine&Cell Biology Medical University of South CarolinaCharlestonSouth CarolinaUSA Department of Otolaryngology-Head and Neck Surgery Oregon Health&Science UniversityPortlandOregonUSA

Objectives:Prior research on olfactory dysfunction in chronic rhinosinusitis(CRS)has focused on patients with polyps and suggests that direct inflammation of the olfactory cleft mucosa plays a contributory *** purpose of this study was to evaluate gene expression in superior turbinate mucosal specimens,comparing normosmic and dysosmic CRS patients without polyps(CRSsNP).Methods:Tissue samples were obtained from the superior turbinates of patients with CRSsNP at the time of endoscopic sinus *** subsequently underwent RNA sequencing and functional analysis to investigate biological pathways associated with differentially expressed genes between dysosmic(n=7)and normosmic(n=4)***:Differential gene expression analysis comparing dysosmic and normosmic CRSsNP patients showed upregulation of 563 genes and downregulation of 327 *** stringent criteria for multiple comparisons,one upregulated gene(Immediate Early Response 3[IER3])had an false discovery rate(FDR)correction adjustedP value considered statistically significant(Pld change 2.69).Reactome functional analysis revealed eight biological pathways significantly different between dysosmic and normosmic patients(Pluding Il-4 and Il-13 signaling,Il-10 signaling,and rhodopsin-like ***:RNA sequencing of the superior turbinates in patients with CRSsNP can provide valuable information regarding biological pathways and genes involved in olfactory *** study supports literature suggesting that Type 2 inflammation may play a role in olfactory dysfunction in at least some patients with *** study also prompts questions regarding the role of Il-10,rhodopsin-like receptors,andIER3 in the pathogenesis of olfactory dysfunction.

关键词： chronic rhinosinusitis without nasal polyps olfactory dysfunction RNA sequencing

A new view of the local Universe

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Science China(Physics,Mechanics & Astronomy) 2024年第3期67卷 167-168页

作者： lister Staveley-smith International Centre for Radio Astronomy Research(ICRAR) University of Western AustraliaCrawley WA 6009Australia ARC Centre of Excellence for All Sky Astrophysics(ASTRO 3D) Crawley WA 6009Australia

The distribution and kinematics of gas in and around dark matter halos, the formation of stellar populations from the gravitational collapse of gas clouds, and the interaction of stars and their remnants with interste... 详细信息

关键词： galaxies stars galactic

Competitive interactions and coexistence of sympatric flagship carnivores in Asia

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Integrative Zoology 2024年第2期19卷 183-199页

作者： Zhilin lI Jiayu lU Xiaoyi SHI li’an DUO James l.D.smith Tianming WANG Tianjin Key laboratory of Conservation and Utilization of Animal Diversity College of Life SciencesTianjin Normal UniversityTianjinChina Department of Fisheries Wildlife and Conservation BiologyUniversity of MinnesotaSt.PaulMinnesotaUSA Ministry of Education Key laboratory for Biodiversity Science and Engineering College of Life SciencesBeijing Normal UniversityBeijingChina National Forestry and Grassland Administration Key laboratory for Conservation Ecology of Northeast Tiger and leopard BeijingChina

Understanding the competition and coexistence of flagship carnivores is key to creating strategies for their conservation in the face of global carnivore *** studies exploring the dynamics and competition between tigers(Panthera tigris)and leopards(***)span decades,there is a lack of understanding regarding the factors that influence their coexistence mechanisms on a broad scale,as well as the drivers determining their exploitative and interference *** gathered a comprehensive list of research papers among which 36 papers explored the interspecific interactions between tigers and leopards and tested the influence of biotic and abiotic factors on the coexistence mechanisms along three dimensions using multiple response variables regression models;we also tested the influence of ecological drivers determining the exploitative or interference competition between tigers and *** and ungulate density were the most important predictors in regulating the coexistence *** and leopards exhibited more positive relations/higher overlaps as elevation increased in the spatial *** addition,they showed a higher dietary overlap in the prey-rich *** determined that interference competition between tigers and leopards was less frequently observed in habitats with dense tree cover and homogeneous vegetation ***,studies with multiple metrics would promote the detection of interference *** study provides new insight into the competitive interactions and coexistence mechanisms of tigers and leopards on a broad ***-makers and managers should pay more attention to the factors of elevation,prey abundance,and habitat structures for the conservation of tigers and leopards.

关键词： carnivores coexistence mechanisms competitive interactions exploitative competition interference competition

Harnessing endothelial cells and vascularization strategies for nerve regeneration

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Neural Regeneration Research 2024年第11期19卷 2337-2338页

作者： Papon Muangsanit Poppy smith Virology and Cell Technology Research Team National Center for Genetic Engineering and Biotechnology(BIOTEC)National Science and Technology Development Agency(NSTDA)PathumthaniThailand UCl Centre for Nerve Engineering UCLLondonUK Department of Pharmacology UCL School of PharmacyUCLLondonUK

Peripheral nerves are essential components of the human body’s communication system,transmitting signals between the central nervous system and various body *** resulting from trauma or disease can result in debilitating sensory and motor *** injuries,particularly those resulting in significant gaps in the nerve tissue,pose a formidable challenge for clinicians and *** their limitations,including limited availability and donor site morbidity,nerve autografts remain the clinical gold standard for treating nerve injuries.

关键词： injuries nerves donor

Multiple sclerosis is at a checkpoint: advancing the program

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Neural Regeneration Research 2025年第3期20卷 811-812页

作者： Brandon C.smith Jessica l.Williams Department of Neurosciences Lerner Research InstituteCleveland ClinicClevelandOHUSA Department of Biological Geologicaland Environmental SciencesCleveland State UniversityClevelandOHUSA

Multiple sclerosis(MS) is a chronic inflammatory and demyelinating disease of the central nervous system(CNS). Patients with MS experience sensory and motor function loss due to myelin and/or axon damage perpetuated b... 详细信息

关键词： Hauser sclerosis damage

Electrobiocorrosion by microbes without outer-surface cytochromes

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mlife 2024年第1期3卷 110-118页

作者： Dawn E.Holmes Trevor l.Woodard Jessica A.smith Florin Musat Derek R.lovley Department of Microbiology University of Massachusetts AmherstAmherstMassachusettsUSA Department of Physical and Biological Science Western New England UniversitySpringfieldMassachusettsUSA Department of Biomolecular Sciences Central Connecticut State UniversityNew BritainConnecticutUSA Department of Biology Section for MicrobiologyAarhus UniversityAarhusDenmark Department of Molecular Biology and Biotechnology Facuity of Biology and GeologyBabes-Bolyai UniversityCluj-NapocaRomania

Anaerobic microbial corrosion of iron-containing metals causes extensive economic *** microbes are capable of direct metal-to-microbe electron transfer(electrobiocorrosion),but the prevalence of electrobiocorrosion among diverse methanogens and acetogens is poorly understood because of a lack of tools for their genetic *** studies have suggested that respiration with 316l stainless steel as the electron donor is indicative of electrobiocorrosion,because,unlike pure Fe^(0),316l stainless steel does not abiotically generate H_(2) as an intermediary electron ***,we report that all of the methanogens(Methanosarcina vacuolata,Methanothrix soehngenii,and Methanobacterium strain IM1)and acetogens(Sporomusa ovata and Clostridium ljungdahli)evaluated respired with pure Fe^(0)as the electron donor,but only ***,***,and *** were capable of stainless steel *** electrobiocorrosive methanogens re-quired acetate as an additional energy source in order to produce methane from stainless *** of *** and *** demonstrated how acetogens can provide acetate to methanogens during *** only was Meth-anobacterium strain IM1 not capable of electrobiocorrosion,but it also did not accept electrons from Geobacter metal-lireducens,an effective electron-donating partner for direct interspecies electron transfer to all methanogens that can directly accept electrons from Fe^(0).The finding that ***,***,and *** are capable of electrobiocorrosion,despite a lack of the outer-surface c-type cytochromes previously found to be important in other electrobiocorrosive microbes,demonstrates that there are multiple microbial strategies for making electrical contact with Fe^(0).

关键词： acetogen corrosion Fe^(0) methanogen stainless steel

喀麦隆初级汉语综合课教学设计 ——以喀麦隆Bilingual Grammar School Molyko为例

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喀麦隆初级汉语综合课教学设计 ——以喀麦隆Bilingual Grammar S...

作者： AGBOR smith FOMBO 重庆交通大学

学位级别：硕士

本文主要探讨了喀麦隆“Bilingual Grammar School Molyko”初级汉语综合课的教学设计与实践。通过对该校汉语学习情况的调查研究,以及对综合课教学设计的深入分析,评估和反思,为喀麦隆中学汉语教学提供理论依据和实践指导。本研究具有... 详细信息

本文主要探讨了喀麦隆“Bilingual Grammar School Molyko”初级汉语综合课的教学设计与实践。通过对该校汉语学习情况的调查研究,以及对综合课教学设计的深入分析,评估和反思,为喀麦隆中学汉语教学提供理论依据和实践指导。本研究具有重要的学术和实际意义,既丰富了国际汉语教育理论,又为汉语教师在非洲国家的教学实践提供了具体参考。在第二章中,研究对喀麦隆“Bilingual Grammar School Molyko”中学汉语学习情况进行了详尽调查。调查采用问卷、访谈等方法,收集了学生、教师和学校管理者的多维度数据。分析结果显示,该校学生对汉语学习具有较高兴趣,但在学习过程中也面临诸多挑战,如语言环境缺乏、学习资源不足和教学方法单一等问题。这些问题的存在,不仅制约了学生的汉语学习效果,也影响了汉语教学的进一步发展。第三章聚焦于“Bilingual Grammar School Molyko”中学生综合课的教学设计。根据调查结果和教学实践经验,结合汉语国际教育的理论和方法,设计了一套适合喀麦隆中学生的汉语综合课教学方案。该方案从教学目标、课程设置、教学内容、教学方法和评价体系等方面进行了系统规划。教学目标明确,注重听、说、读、写四项技能的全面发展;课程设置合理,既有基础知识的传授,又有文化素养的培养;教学内容丰富,涵盖语言知识、文化知识和交际能力的培养;教学方法多样,采用任务型教学、情景教学等方法,提高学生的学习兴趣和参与度;评价体系完善,既有形成性评价,又有终结性评价,全面监测学生的学习效果。第四章对“Bilingual Grammar School Molyko”初级中文综合课的教学设计进行了评估与反思。评估采用质性和量性相结合的方法,通过课堂观察、学生测试、教师访谈等途径,全面分析了教学设计的实施效果。评估结果表明,该教学设计在提高学生汉语水平和学习兴趣方面取得了一定成效,但也存在一些不足,如教学资源有限、师资力量不足、教学方法需要进一步改进等。基于评估结果,研究提出了一系列改进建议,如增加教学资源投入、加强教师培训、改进教学方法等,为后续的教学实践提供了有益参考。本研究通过对喀麦隆“Bilingual Grammar School Molyko”初级汉语综合课教学设计的调查、分析和反思,不仅丰富了国际汉语教育理论,也为喀麦隆中学汉语教学实践提供了重要参考。研究结果显示,科学合理的教学设计对提高学生汉语学习效果具有重要作用,但同时也需要持续关注和解决实际教学中存在的问题,才能真正实现汉语教育的长远发展。本论文的研究方法具有一定创新性,通过综合运用问卷调查、访谈、课堂观察和教学评估等多种方法,获取了详实的数据,确保了研究结果的可靠性和科学性。研究不仅对喀麦隆汉语教学具有重要指导意义,也对其他非洲国家的汉语教育实践具有参考价值。希望本研究能够为喀麦隆及其他非洲国家的汉语教学提供有益借鉴,推动国际汉语教育事业的发展。

关键词：喀麦隆中学汉语教学教学设计你好喀麦隆

COVID-19 vaccination produces exercise-responsive SARS-CoV-2 specific T-cells regardless of infection history

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Journal of Sport and Health Science 2024年第1期13卷 99-107页

作者： Kyle A.smith Tiffany M.Zúñiga Forrest l.Baker Helena Batatinha Charles R.Pedlar Shane C.Burgess Michael P.Gustafson Emmanuel Katsanis Richard J.Simpson School of Nutritional Sciences and Wellness The University of ArizonaTucsonAZ 85721USA Department of Pediatrics The University of ArizonaTucsonAZ 85724USA Faculty of Sport Allied Health and Performance ScienceSt.Mary's UniversityTwickenham TW14SXUK Institute of Sport Exercise and Health University College LondonLondon WC1E 7HUUK Department of Animal and Comparative Biomedical Sciences The University of ArizonaTucsonAZ 85721USA The University of Arizona Cancer Center The University of ArizonaTucsonAZ 85719USA laboratory Medicine and Pathology Mayo Clinic ArizonaPhoenixAZ 85054USA Department of Immunobiology The University of ArizonaTucsonAZ 85724USA Department of Medicine The University of ArizonaTucsonAZ 85724USA Department of Pathology The University of ArizonaTucsonAZ 85724USA

Background:The mobilization and redistribution of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)specific T-cells and neutralizing antibodies(nAbs)during exercise is purported to increase immune surveillance and protect against severe coronavirus disease 2019(COVID-19).We sought to determine if COVID-19 vaccination would elicit exercise-responsive SARS-CoV-2 T-cells and transiently alter nAb ***:Eighteen healthy participants completed a 20-min bout of graded cycling exercise before and/or after receiving a COVID-19 *** major leukocyte subtypes were enumerated before,during,and after exercise by flow cytometry,and immune responses to SARS-CoV-2 were determined using whole blood peptide stimulation assays,T-cell receptor(TCR)-βsequencing,and SARS-CoV-2 nAb ***:COVID-19 vaccination had no effect on the mobilization or egress of major leukocyte subsets in response to intensity-controlled graded ***,non-infected participants had a significantly reduced mobilization of CD4+and CD8+naive T-cells,as well as CD4+central memory T-cells,after vaccination(synthetic immunity group);this was not seen after vaccination in those with prior SARS-CoV-2 infection(hybrid immunity group).Acute exercise after vaccination robustly mobilized SARS-CoV-2 specific T-cells to blood in an intensity-dependent *** groups mobilized T-cells that reacted to spike protein;however,only the hybrid immunity group mobilized T-cells that reacted to membrane and nucleocapsid *** increased significantly during exercise only in the hybrid immunity ***:These data indicate that acute exercise mobilizes SARS-CoV-2 specific T-cells that recognize spike protein and increases the redistribution of nAbs in individuals with hybrid immunity.

关键词： Anti-viral COVID-19 Exercise immunology SARS-CoV-2 T-Cells Vaccine

Aboveground carbon sequestration of Cunninghamia lanceolata forests:Magnitude and drivers

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Forest Ecosystems 2024年第1期11卷 32-41页

作者： Chen Wang Shuguang liu Yu Zhu Andrew R.smith Ying Ning Deming Deng National Engineering laboratory for Applied Technology of Forestry&Ecology in South China Central South University of Forestry and TechnologyChangsha 410004China Technology Innovation Center for Ecological Conservation and Restoration in Dongting lake Basin Ministry of Natural ResourcesChangsha 410007China College of life Science and Technology Central South University of Forestry and TechnologyChangsha 410004China School of Ecology and Environment Hainan UniversityHaikou 570228China School of Natural Sciences Bangor UniversityGwyneddLL572UWUK College of Forestry Central South University of Forestry and TechnologyChangsha 410004China Hunan Prospecting Designing&Research General Institute for Agriculture Forestry&IndustryChangsha 410007China

Understanding the spatial variation,temporal changes,and their underlying driving forces of carbon sequestration in various forests is of great importance for understanding the carbon cycle and carbon management *** carbon density and sequestration in various Cunninghamia lanceolata forests,extensively cultivated for timber production in subtropical China,vary with biodiversity,forest structure,environment,and cultural factors remain poorly explored,presenting a critical knowledge gap for realizing carbon sequestration supply potential through *** on a large-scale database of 449 permanent forest inventory plots,we quantified the spatial-temporal heterogeneity of aboveground carbon densities and carbon accumulation rates in Cunninghamia lanceolate forests in Hunan Province,China,and attributed the contributions of stand structure,environmental,and management factors to the heterogeneity using quantile age-sequence analysis,partial least squares path modeling(PlS-PM),and hot-spot *** results showed lower values of carbon density and sequestration on average,in comparison with other forests in the same climate zone(i.e.,subtropics),with pronounced spatial and temporal ***,quantile regression analysis using carbon accumulation rates along an age sequence showed large differences in carbon sequestration rates among underperformed and outperformed forests(0.50 and 1.80 Mg·ha^(-1)·yr^(-1)).PlS-PM demonstrated that maximum DBH and stand density were the main crucial drivers of aboveground carbon density from young to mature ***,species diversity and geotopographic factors were the significant factors causing the large discrepancy in aboveground carbon density change between low-and high-carbon-bearing *** analysis revealed the importance of culture attributes in shaping the geospatial patterns of carbon *** work highlighted that retaining largesized DBH trees and increasing shade-t

关键词： Carbon density Carbon accumulation rate Forest age Spatial variation Cultural influence