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Bhlhe40 protects cochlear hair cell-like HEI-OC1 cells against H_(2)O_(2) ‑triggered oxidative injury

BIOCELL 2024年第6期48卷 991-999页

作者： LITING WEN XIAOXIA ZENG PEIXIONG CHEN dapeng zhao YANGYANG LI XIANHAI ZENG Department of Otorhinolaryngology Longgang Otorhinolaryngology Hospital and Shenzhen Key Laboratory of OtorhinolaryngologyShenzhen Institute of OtorhinolaryngologyShenzhenChina

Background:Cochlear hair cell injury is a common pathological feature of hearing *** basic helix-loop-helix family,member e40(Bhlhe40),a gene belonging to the basic helix-loop-helix(bHLH)family,exhibits strong transcriptional repression ***:Oxidative damage,in House Ear Institute-Organ of Corti 1(HEI-OC1)cells,was caused using hydrogen peroxide(H2O2).The Ad-Bhlhe40 particles were constructed to overexpress Bhlhe40 in HEI-OC1 *** assays including cell counting kit-8(CCK-8),terminal deoxynucleotidyl transferase-mediated dUTP nick end-labeling assay(TUNEL),ﬂow cytometry,immunoﬂuorescence,and corresponding commercial kits were employed to investigate the impacts of Bhlhe40 on cell viability,apoptosis,oxidative stress levels,mitochondrial membrane potential and cellular ***,a dual-luciferase reporter assay was performed to conﬁrm the targeting of the histone deacetylases 2(Hdac2)by ***:The results revealed that Bhlhe40 was downregulated in H_(2)O_(2)-treated HEI-OC1 cells,but its overexpression improved cell viability and mitigated H_(2)O_(2)-induced oxidative injury in HEI-OC1 cells with increase of superoxide dismutase(SOD),catalase(CAT)and glutathione peroxidase(GPx)activities and decrease of reactive oxygen species(ROS)***,overexpression of Bhlhe40 suppressed H_(2)O_(2)-triggered cell senescence,as evidenced by the fact that the upregulation of P53,P21,and P16 in HEI-OC1 cells treated with H2O2 were all alleviated by Bhlhe40 *** we further veriﬁed that overexpression of Bhlhe40 could inhibit the expression of Hdac2,which may be related to the repression of Hdac2 ***:This study suggests that Bhlhe40 plays a protective role against senescence and oxidative damage in cochlear hair cells exposed to H2O2.

关键词： Bhlhe40 Oxidative injury Cochlear hair cell Histone deacetylases 2

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Crack mystery of the damaging Kumamoto earthquakes

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Science Bulletin 2016年第11期61卷 868-870页

作者： dapeng zhao Xin Liu Department of Geophysics Tohoku University College of Marine Geosciences Ocean University of China

The 2016 Kumamoto earthquake(M 7.3 in the Japan Meteorological Agency(JMA)scale)sequence wrote a new chapter of active seismotectonics and subduction dynamics in the Japan *** earthquake sequence,

关键词：地震序列破坏性日本气象厅裂缝活动构造 Moto 动力学上地壳

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Temperature increase impacts personality traits in aquatic non-native species： Implications for biological invasion under climate change

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Current Zoology 2015年第6期61卷 966-971页

作者： dapeng zhao Peishan FENG Tianjin Key Laboratory of Animal and Plant Resistance College of Life Sciences Tianjin Normal University Tianjin 300387 China

Climate change, such as elevated temperatures, may facilitate biological invasion. Aquatic animal systems are more vulnerable to biological invasion when the temperature rises. Animal personality also plays an important role in the possibility of successful establishment of invasive species. However, it is still unclear how personality traits of invasive species will respond to global warming. This study focuses on juveniles of red swamp crawfish Procambarus clarkii, an invasive poikilothermic species with wide distribution throughout the world, and explores how slight temperature increases influence three personality traits （ac- tivity, boldness and aggressiveness） ofP. clarkii. For each personality, individual variation is to be presented in condition of the same temperature. Individual personality values can significantly increase with the subtle rising of water temperature. Significant correlations among activity, boldness and aggressiveness are found at any temperature stage, and such relationships are main- tained at a similar level in the face of different temperatures. It is most likely that significant expressions of personality traits may be an ecological compensation strategy to offset increased metabolic costs when faced with small temperature increases. Aggres- sion syndromes are formed due to stable linkages between personality traits, in order to acquire allopatric resources efficiently and establish a new population in this species

关键词： Animal personality Biological invasion Climate change Crawfish Invasive species

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Postconflict behavior among female Sichuan snub-nosed monkeys Rhinopithecus roxellana within one-male units in the Qinling Mountains,China

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Current Zoology 2010年第2期56卷 222-226页

作者： Jian ZHANG dapeng zhao Baoguo LI College of Life Sciences Northwest University Xi＇an 710069 China Institute of Zoology Shaanxi Academy of Sciences Xi＇an 710069 China Institute of Zoology Chinese Academy of Sciences Beijing 100101 China

For group-living primates, the information on postconflict management is crucial for understanding primate competition and cooperation. However, such information is poorly known for snub-nosed monkeys, especially for wild populations. In this study, from September 2007 to June 2008, we investigated postconflict behavior among adult females Sichuan snub-nosed monkeys Rhinopithecus roxellana within one-male units in a wild, provisioned group in the Qinling Mountains of China by means of the time-rule method and the PC-MC method. We obtained a total of 81 PC-MC pairs and each individual was involved in only 0.004 aggressive behavior per observation hour. The first affiliative behavior was more likely to occur within the first minute after a conflict. The postconflict affiliative behaviors most often seen were contact-sit, embrace and grooming. The affiliative contacts between adult females occur due to selective attraction, i.e. reconciliation. The pattern of postconflict affiliation demonstrates that the R. roxellana belongs to a tolerant species.

关键词： Sichuan snub-nosed monkey Rhinopithecus roxellana Female Postconflict behavior Reconciliation

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基于文字与文献研究的“亭”风景审美探源

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天津大学学报（社会科学版） 2024年第3期26卷 270-278页

作者：吴静子冯倩瑶赵大鹏天津大学建筑学院天津300072 天津市城市规划设计研究院天津300201

“亭”作为中国古代典型的风景建筑,它的发展与演变体现出中国古代风景审美的精髓与特质,并反映出中国“人与自然和谐共生”这种审美理念从萌芽到质变再到巅峰发展的完整过程。文章通过统计分析先秦至宋代文献中与“亭”相关的文字、语... 详细信息

“亭”作为中国古代典型的风景建筑,它的发展与演变体现出中国古代风景审美的精髓与特质,并反映出中国“人与自然和谐共生”这种审美理念从萌芽到质变再到巅峰发展的完整过程。文章通过统计分析先秦至宋代文献中与“亭”相关的文字、语词与词义,发现“亭”自魏晋时期开始体现出风景建筑的特征,隋唐至宋代发展更为兴盛。通过研究以揭示蕴含于其中的风景审美内容与风景审美方式,以期更深刻地认识中国古代的风景审美理念,为实践中国古代风景审美文化的现代化转译提供理论支撑。

关键词：亭语词风景审美风景建筑亭名

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Sex differences in anogenital distances and digit ratios in wild David＇s rock squirrels Sciurotamias davidianus

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Current Zoology 2014年第2期60卷 180-185页

作者： dapeng zhao Zhuoyue CHEN Baoguo LI Tianjin Key Laboratory of Animal and Plant Resistance College of Life Sciences Tianjin Normal University Tianjin 300387China College of Life Sciences Northwest University Xi'an 710069 China

The prenatal hormonal environment plays an important role in organizing sex differences in the morphology, physiology and behavior of humans as well as other vertebrates. Currently, all related research on rodents has been focused on Myomorpha. This study presents data on sex differences in the anogenital distance （AGD） and the ratio of the second to the fourth digit length （2D：4D） from 44 wild David＇s rock squirrels Sciurotamias davidianus captured from the Qinling Mountains, China. This was the first study of a species from Sciuromorpha. The AGD as well as body mass are sexually dimorphic. There are no sex differences or lateral asymmetry in 2D：4D. Significant correlation was not found between AGD and 2D：4D for any paw. The findings indicate that 2D：4D may not be fixed or influenced by the prenatal steroidal environment in David＇s rock squirrels [Current Zoology 60 （2）： 180-185, 2014].

关键词： Anogenital distance 2D:4D Seiurotamias davidianus Sex dimorphism

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Hand preference during bimanual coordinated task in northern pig-tailed macaques Macaca leonina

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Current Zoology 2016年第4期62卷 385-391页

作者： dapeng zhao Yuan WANG Xueyan WEI Tianjin Key Laboratory of Animal and Plant Resistance College of Life Sciences Tianjin Normal University Tianjin 300387 Wildlife Institute Beijing Forestry University Eco-Bridge Continental Beijing 100083 China

In humans, handedness is one defining characteristic regardless of cultures and ethnicity. Population-level right handedness is considered to be related with the evolution of left hemisphere for manual control and language. In order to further understand evolutionary origins of human cerebral lateralization and its behavioral adaptation, standardized measures on hand preference are required to make reliable comparison in nonhuman primate species. In this study, we present the first evidence on hand preference during bimanual coordinated tasks in northern pig-tailed ma- caques Macaca leonina. The classical TUBE task was applied to examine hand preference among nine individuals from Tianjin Zoo of China. We recorded and made analysis on both frequency and bout data on manual laterality. The results consistently show that subjects displayed strong indi- vidual hand preferences, whereas no significant group-level handedness was found. There were no sex and age significant differences on both direction and strength of hand preference. The M. leonina preferred to use the index finger to extract the baited food inside the tube. Our findings fill the knowledge gap on primate handedness, and efficiently affirm the robustness of the TUBE task as one efficient measure of hand preference in primates.

关键词： bimanual coordination hand preference Macaca leonina primate evolution.

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Do deposed adult male Sichuan snub-nosed monkeys Rhinopithecus roxellana roam as solitary bachelors or continue to interact with former band members?

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Current Zoology 2009年第3期55卷 235-237页

作者： dapeng zhao Baoguo LI College of Life Sciences Northwest University Xi＇an 710069 China

Dispersal patterns exhibited by group-living animals play an important role in individual reproductive success and survival, as well as population and social dynamics （Greenwood, 1980; Isbell and van Vuren, 1996; Kappeler and van Schaik, 2002）. Dispersing individuals may emigrate voluntarily, or they may be forcibly evicted by other individuals （Pusey and Packer, 1987; Clobert et al. , 2001 ）. One cause of individual dispersal is when an extra-group male compels another male to leave a group of females. This phenomenon has been well documented in primates, especially Old World monkey species （ e.g. Colobus vellerosus ： Saj and Sicotte, 2005 ; Erythrocebus patas ： Ohsawa, 2003 ; Macaca fascicularis ： van Noordwiik and van Schaik, 2001）.

关键词： Deposed males All male groups One-male groups Behavioral strategy

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Seismic tomography of the Moon

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Chinese Science Bulletin 2008年第24期53卷 3897-3907页

作者： zhao dapeng LEI JianShe LIU Lucy Department of Geophysics Tohoku University Sendai 980-8578 Japan Institute of Crustal Dynamics China Earthquake Administration Beijing 100085 China

We attempted to determine the first three-dimensional P and S wave velocity and Poisson's ratio structures of the lunar crust and mantle down to 1000 km depth under the near-side of the Moon by applying seismic tomography to the moonquake arrival-time data recorded by the Apollo seismic network operated during 1969 to *** results show that significant lateral heterogeneities may exist in the lunar *** there is no plate tectonics in the Moon,the lateral heterogeneities may be produced at the early stage of the Moon formation and evolution,and they have been preserved till *** seems to be a correlation between the distribution of deep moonquakes and lateral velocity variations in the lunar lower mantle,suggesting that the occurrence of deep moonquakes may be affected by the lunar structural heterogeneity in addition to the tidal *** this is an experimental work and the result is still preliminary,it indicates that tomographic imaging of the lunar interior is feasible.

关键词：地震层析成像月亮地震数据内部构造月震

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Sex-specific participation in inter-group conflicts within a multilevel society:the first evidence at the individual level

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Integrative Zoology 2013年第4期8卷 441-454页

作者： dapeng zhao Zhuoyue CHEN Baoguo LI Teresa ROMERO Tianjin Key Laboratory of Animal and Plant Resistance College of Life SciencesTianjin Normal UniversityTianjinChina College of Life Sciences Northwest UniversityXi’anChina Institute of Zoology Shaanxi Academy of SciencesXi’anChina Department of Cognitive and Behavioral Science Graduate School of Arts and SciencesUniversity of TokyoTokyoJapan Japan Society for the Promotion of Science ChiyodaTokyoJapan

Inter-group conflicts are common among many group-living animals and involve potentially complex motivations and *** living in multilevel societies offer a good opportunity to study inter-group *** study is the first to explore the function of sex-specific participation during inter-group conflicts within a multilevel society at the individual *** Sichuan snub-nosed monkey(Rhinopithecus roxellana)is an endangered seasonal breeding species living in a multilevel *** Sep 2007 to May 2008 we recorded 290 inter-group conflicts of a free-ranging provisioned band of *** in the Qinling Mountains of China to investigate the function of individual aggression during inter-group *** findings show that adult males were the main participants in inter-group conflicts,while females took part in them only *** male participation rate during the mating season,when adult females were estrous,was significantly higher than that during the non-mating ***,males directed their aggression to other males,and directed more intense aggression towards bachelor males than towards other resident *** both sexes,the participation rate as initiators was higher in the winter than that in the spring;and there was a significant positive correlation between group size and the participation rate as *** results suggest that inter-group aggression in Sichuan snub-nosed monkeys is linked to both mate defense and resource defense.

关键词： inter-group conflict mate defense multilevel society resource defense Rhinopithecus roxellana

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