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氧气对飞秒激光泵浦的氮气分子无腔激光效应的淬灭作用（特邀）（英文）

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光子学报 2020年第11期 177-184页

作者：桂杰玉周冬杰张翔卢琦罗雨梁青青 danylo rostyslav HOUARD Aurélien MYSYROWICZ André 刘一上海理工大学光电信息与计算机工程学院上海市现代光学系统重点实验室巴黎综合理工学院应用光学实验室

关键词：非线性光学空气激光超快光谱技术淬灭效应飞秒脉冲

Multiple-Photon Resonance Enabled Quantum Interference in Emission Spectroscopy of N_(2)^(+)

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Ultrafast Science 2024年第2期4卷 1-7页

作者： Xiang Zhang Qi Lu YaLei Zhu Jing Zhao rostyslav danylo Liang Xu Mingwei Lei Hongbing Jiang Chengyin Wu Zhedong Zhang Aurélien Houard Vladimir Tikhonchuk AndréMysyrowicz Qihuang Gong Songlin Zhuang Zengxiu Zhao Yi Liu Shanghai Key Lab of Modern Optical System University of Shanghai for Science and Technology.516Jungong Road200093 ShanghaiChina Department of Physics National University of Defense TechnologyChangsha 410073China Laboratoire d'Optique Appliquee ENSTA ParisEcole Polytechnique CNRSInstitut Polytechnique de Paris828 Boulevard des Marechaux91762 Palaiseau CedexFrance State Key Laboratory for Mesoscopic Physics School of PhysicsPeking UniversityBejing 100871China Department of Physics City University of Hong KongKowloonHong Kong SAR Centre Lasers Intenses et Applications University of Bordeaux-CNRS-CEA351 Cours de la Liberation33405 Talence Cedex France Extreme Light Infrastructure ERIC ELI Beamlines Facility25241 Doln BrezanyCzech Republic CAS Center for Excellence in Ultra-intense Laser Science Shanghai 201800China

Quantum interference occurs frequently in the interaction of laser radiation with materials,leading to a series of fascinating effects such as lasing without inversion,electromagnetically induced transparency,Fano resonance,*** quantum interference effects are mostly enabled by single-photon resonance with transitions in the matter,regardless of how many optical frequencies are ***,we report on quantum interference driven by multiple photons in the emission spectroscopy of nitrogen ions that are resonantly pumped by ultrafast infrared laser *** the spectral domain,Fano resonance is observed in the emission spectrum,where a laser-assisted dynamic Stark effect creates the *** the time domain,the fast-evolving emission is measured,revealing the nature of free-induction decay arising from quantum radiation and molecular *** findings clarify the mechanism of coherent emission of nitrogen ions pumped with mid-infrared pump laser and are found to be *** present work opens a route to explore the important role of quantum interference during the interaction of intense laser pulses with materials near multiple photon resonance.

关键词： pumped pump Quantum

Histone H1/MBP hydrolysing antibodies - novel potential marker in diagnosis of disease severity in systematic lupus erythematosus patients

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Health 2010年第10期2卷 1204-1207页

作者： Valentyna Chopyak Yaroslav Tolstiak Iryna Magoryvska rostyslav Bilyy rostyslav Bilyy Natalya Korniy Yuriy Kit rostyslav Stoika Lviv Medical Institute danylo Halytsky Lviv National Medical University Institute of Cell Biology

Recently we have shown the presence of catalytically active IgGs, capable to cleave histone H1 and bovine myelin basic protein (MBP), in blood serum of SLE patients. Here we present data that demonstrate the correlation between a) proteolytic activity towards histone H1 and MBP of IgG-antibodies from blood serum of SLE patients and b) disease severity level in these patients. IgGs were isolated from blood serum by chromatography on protein G-sepharose. Commercial preparations of bovine myelin basic proteins (MBP) and calf thymus histone H1 were used as substrates. Analysis of the proteolytic activity showed that 16 of 38 lgG-preparations (42,1%) obtained from blood serum of SLE patients were capable of cleaving both histone H1 and MBP with different efficiency. It was revealed that the presence in blood serum of lgGs possessing proteolytic activity towards both histone H1 and bMBP closely correlates with manifestation of the disease severity in SLE patients.

关键词： System Lupus Erythematosus Proteolytic Activity IgG-Antibodies Disease Severity

Nemeth-Kellner Lymphoma Is a Valid Experimental Model in Testing Chemical Agents for Anti-Lymphoproliferative Activity

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Open Journal of Blood Diseases 2013年第3期3卷 1-6页

作者： Maxim D. Lootsik Maksym M. Lutsyk rostyslav S. Stoika Department of Histology Cytology and Embryology Danylo Halytsky National Medical University Lviv Ukraine. Institute of Cell Biology National Academy of Sciences of Ukraine Lviv Ukraine nstitute of Cell Biology National Academy of Sciences of Ukraine Lviv Ukraine

Scheme of detection and investigation of antitumor activity of chemical substances by use of experimental murine Nemeth-Kellner lymphoma (NK/Ly) are described. It includes monitoring of growth of NK/Ly ascites by everyday weighting of animals in course of intraperitoneal application of tested substance in 24 or 48 hours after inoculation of 107 tumor cells. The inhibitory effect became distinct on the 6th-8th day of experiment, and 3 types of response were observed: 1) complete suppression of ascites development, corresponding to high antitumor activity of tested substance;2) partial suppression of ascites growth (weak antitumor activity);3) insignificant effect on ascites growth (lack of activity, at least towards hematoblastoses). As compared with leukemia L1210 or P388 lymphoma NK/Ly provides more distinct daily increment of body weight due to tumor growth. Clinical pattern of tumor development was supported by cytomorphological investigations of tumor cells which included: 1) cells count in ascites;2) measuring cell dimensions and ratio of enlarged cells in a population (diameter over 17 μm in case of NK/Ly);3) quantitative evaluation of tumor cells damage by smears count after staining with azure-eosin, bromophenol blue and hematoxylin. In case of complete suppression of ascites growth the cytological investigation was conducted by delayed application of tested agent to animals with the developed ascites. After treatment with vinblastine or doxorubicin NK/Ly cells represent a convenient object for fractionation of cell population, as demonstrated by separation of giant and small tumor cell subpopulations.

关键词： Nemeth-Kellner Lymphoma Antitumor Substances Screening