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Hepatitis B cure:Current situation and prospects

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World Journal of Hepatology 2024年第6期16卷 900-911页

作者： Ya-Ping Li Chen-Rui Liu Ling He shuang-suo dang Department of Infectious Diseases The Second Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710004Shaanxi ProvinceChina

Achievement of a‘clinical cure’in chronic hepatitis B(CHB)implies sustained virological suppression and immunological control over the infection,which is the ideal treatment goal according to domestic and international CHB management *** practice has shown encouraging results for specific patient cohorts using tailored treatment *** regimens incorporate either nucleos(t)ide analogs,immunomodulatory agents such as pegylated interferonα,or a strategic combination of both,sequentially or concurrently *** these advancements in the clinical handling of hepatitis B,achieving a clinical cure remains elusive for a considerable subset of patients due to the number of challenges that preclude the realization of optimal treatment *** include,but are not limited to,the emergence of antiviral resistance,incomplete immune recovery,and the persistence of covalently closed circular ***,the variance in response to interferon therapy and the lack of definitive biomarkers for treatment cessation also contribute to the complexity of achieving a clinical *** article briefly overviews the current research progress and existing issues in pursuing a clinical cure for hepatitis B.

关键词： Chronic hepatitis B Clinical cure Polyethylene glycol interferon Treatment strategies Research progress

Protective effects of emodin and astragalus polysaccharides on chronic hepatic injury in rats

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Chinese Medical Journal 2008年第11期121卷 1010-1014页

作者： dang shuang-suo ZHANG Xin JIA Xiao-li CHENG Yan-an SONG Ping LIU En-qi HE Qian LI Zong-fang Department of Infectious Diseases the Second Hospital of Xi'an Jiaotong UniversityXi'an Shaanxi 710004 China Experimental Animal Center Medical College of Xi'an JiaotongUniversity Xi'an Shaanxi 710061 China Clinical Laboratory the Second Hospital of Xi'an Jiaotong UniversityXi'an Shaanxi 710004 China Department of Surgery the Second Hospital of Xi'an Jiaotong UniversityXi'an Shaanxi 710004 China

Background Chinese medicine plays an important role in hepatoprotective treatment. This study was conducted to investigate the protective effects of emodin and astragalus polysaccharides （APS） in a rat model of chronic hepatic injury. Methods Chronic hepatic injury was induced by hypodermic injection of an olive oil solution containing 40% carbon tetrachlodde （CCI4） twice a week, in addition to a diet of 79.5% maizena, 20% fat, 0.5% cholesterol, and 10% alcohol in the drinking water ad libitum for 12 weeks. Meanwhile, the rats were exposed to different concentrations of emodin （40 mg·kg^-1·d^-1）, APS （200 mg·kg^-1·d^-1）, combination drug （emodin 40 mg·kg^-1·d^-1 combined with APS 200 mg·kg^-1·d^-1） and colchicine （0.1 mg·kg^-1·d^-1） in parallel by oral gavage （once a day for 12 weeks）. At the end of 12 weeks, blood serum and liver tissue were taken. Serum was collected to determine the levels of total bilirubin （TBIL）, alanine transaminase （ALT）, aspartate transaminose （AST）, and albumin （ALB）. Liver and spleen indexes were assayed, followed by the measurements of the liver associated enzyme superoxide dismutase （SOD） and malondialdehyde （MDA）. Histopathological changes were studied using optical microscopy. Results Splenohepatomegalia was alleviated and serum levels of TBIL and ALT were reduced in the groups treated with emodin and APS when compared to the control group. In addition, the ALB level in the APS and combination groups was higher. Similarly, the SOD activity of liver homogenates was significantly higher in the groups treated with emodin and APS, while administration of the herbal derivatives prevented the elevation in MDA levels. Histological analysis showed that the APS and combination groups significantly ameliorated the hepatic injury. Conclusions Co-administration of emodin and APS demonstrated a synergistic action in reducing ALT and restoring ALB in the serum from a rat model of chronic hepatic injury. Emodin and APS may ameliorate the CCI4-

关键词： emodin astragalus polysaccharides carbon tetrachloride hepatic injury

Prohibitin 1 inhibits cell proliferation and induces apoptosis via the p53-mediated mitochondrial pathway in vitro

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World Journal of Gastrointestinal Oncology 2024年第2期16卷 398-413页

作者： Juan-Juan Shi Yi-Kai Wang Mu-Qi Wang Jiang Deng Ning Gao Mei Li Ya-Ping Li Xin Zhang Xiao-Li Jia Xiong-Tao Liu shuang-suo dang Wen-Jun Wang Department of Infectious Diseases The Second Affiliated Hospital of Xi’an Jiaotong UniversityXi'an 710004Shaanxi ProvinceChina Department of Operating Room The Second Affiliated Hospital of Xi’an Jiaotong UniversityXi'an 710004Shaanxi ProvinceChina

BACKGROUND Prohibitin 1(PHB1)has been identified as an antiproliferative protein that is highly conserved and ubiquitously expressed,and it participates in a variety of essential cellular functions,including apoptosis,cell cycle regulation,prolifera-tion,and *** evidence indicates that PHB1 may play an important role in the progression of hepatocellular carcinoma(HCC).However,the role of PHB1 in HCC is *** To investigate the effects of PHB1 on the proliferation and apoptosis of human HCC cells and the relevant mechanisms in *** HCC patients and healthy individuals were enrolled in this study according to the inclusion and exclusion criteria;then,PHB1 levels in the sera and liver tissues of these participates were determined using ELISA,RT-PCR,and *** HepG2 and SMMC-7721 cells were transfected with the pEGFP-PHB1 plasmid and PHB1-specific shRNA(shRNA-PHB1)for 24-72 *** prolif-eration was analysed with an MTT *** cycle progression and apoptosis were analysed using flow cytometry(FACS).The mRNA and protein expression levels of the cell cycle-related molecules p21,Cyclin A2,Cyclin E1,and CDK2 and the cell apoptosis-related molecules cytochrome C(Cyt C),p53,Bcl-2,Bax,caspase 3,and caspase 9 were measured by real-time PCR and Western blot,*** Decreased levels of PHB1 were found in the sera and liver tissues of HCC patients compared to those of healthy individuals,and decreased PHB1 was positively correlated with low differentiation,TNM stage III-IV,and alpha-fetoprotein≥400μg/*** of PHB1 significantly inhibited human HCC cell proliferation in a time-dependent *** revealed that the overexpression of PHB1 arrested HCC cells in the G0/G1 phase of the cell cycle and induced *** proportion of cells in the G0/G1 phase was significantly increased and the proportion of cells in the S phase was decreased in HepG2 cells that were transfected with pEGFP-PHB1 compar

关键词： Prohibitin 1 Hepatocellular carcinoma cells Apoptosis Cell cycle Mitochondrial pathway

CD_(34)^+细胞Fas抗原表达与疾病相关性的研究进展

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医学综述 2009年第20期15卷 3041-3045页

作者：边静党双锁海南省农垦总局医院放射科海口570311 西安交通大学医学院第二附属医院感染科西安710004

Fas抗原(又称为CD95或Apo-1)是一种肿瘤坏死因子受体,它可与配体或抗体交联后激发一种能够导致细胞凋亡的信号转导级联反应。在正常造血过程中,CD34+造血干细胞表面并不表达Fas抗原。大量国内外研究发现,当CD3+4细胞表面发生Fas抗原的... 详细信息

Fas抗原(又称为CD95或Apo-1)是一种肿瘤坏死因子受体,它可与配体或抗体交联后激发一种能够导致细胞凋亡的信号转导级联反应。在正常造血过程中,CD34+造血干细胞表面并不表达Fas抗原。大量国内外研究发现,当CD3+4细胞表面发生Fas抗原的异常表达时,则与许多造血和非造血疾病的发生、发展密切相关,本文就CD3+4细胞表面Fas抗原的表达与某些疾病相关性予以综述。

关键词： CD34+细胞 Fas抗原凋亡

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浅谈传染病学多媒体教学素材库的建立

西北医学教育 2006年第3期14卷 338-340页

作者：党双锁郑有礼西安交通大学医学院第二附属医院感染科陕西西安 710004 西安交通大学医学院科研科陕西西安 710061

在传染病教学中使用多媒体非常重要.本文从建立传染病学多媒体素材库对传染病教学的必要性、重要性、可行性等进行了论证,提出传染病学多媒体素材库的建立将有助于保证传染病学教学质量的提高.

关键词：传染病多媒体素材库

热炎宁合剂治疗新型冠状病毒肺炎的多中心临床观察

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中国实验方剂学杂志 2020年第14期26卷 7-12页

作者：杨明博党双锁黄胜李元军郭雅玲西安市第八医院西安710061 西安交通大学第二附属医院西安710004 松滋市人民医院湖北松滋434200 延安市第二人民医院陕西延安716000

目的:前期通过冠状病毒疫毒袭肺证病证结合小鼠模型体内实验验证,热炎宁合剂对人新型冠状病毒肺炎(COVID-19)有显著的治疗作用,本次研究进一步评价热炎宁合剂治疗COVID-19的临床疗效,为临床用药提供依据。方法:选取2020年1月21日至2020... 详细信息

目的:前期通过冠状病毒疫毒袭肺证病证结合小鼠模型体内实验验证,热炎宁合剂对人新型冠状病毒肺炎(COVID-19)有显著的治疗作用,本次研究进一步评价热炎宁合剂治疗COVID-19的临床疗效,为临床用药提供依据。方法:选取2020年1月21日至2020年3月2日在西安市第八医院、西安交通大学第二附属医院、湖北省松滋市人民医院、延安市第二人民医院就诊,符合新型冠状病毒肺炎诊断标准普通型患者54例,其中5例不符合方案规定,未予分析,治疗组26例,在化学药物治疗基础上给予热炎宁合剂,对照组23例,给予化学药物治疗,比较两组患者中医证候(咽干咽痛、咳嗽、发热、乏力、胸闷、流涕、鼻塞、头痛)评分,完全退热时间(d),新型冠状病毒核酸检测转阴率及胸部CT缓解率。结果:与对照组治疗后比较,治疗组除咳嗽、乏力外,其余症状均消失,咽干咽痛、咳嗽、乏力、胸闷、头痛等症状评分,差异有统计学意义(P<0. 05);治疗组中位完全退热时间为3 d,较对照组缩短2 d;胸部CT缓解率,治疗组为88. 46%(23/26),高于对照组的73. 91%(17/23),两组比较差异无统计学意义;病毒核酸检测转阴率,治疗组为96. 15%(25/26),对照组为60. 87%(14/23),治疗组高于对照组(P<0. 01)。结论:热炎宁合剂能改善新型冠状病毒肺炎患者临床症状,促进胸部CT好转,缩短患者发热时间,提高核酸转阴率,为临床治疗提供依据。

关键词：热炎宁合剂新型冠状病毒肺炎(COVID-19) 临床症状

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手足口病基因多态性的研究进展

临床医学研究与实践 2017年第8期2卷 192-195页

作者：李亚萍党双锁西安交通大学第二附属医院感染科陕西西安710004

近年来,宿主对EV71的遗传易感性在手足口病发生、发展中的作用逐渐成为研究热点。基因多态性是决定人体对于病原体感染的易患性、疾病轻重程度及药物治疗反应性差异的重要内在因素。在手足口病发生、发展的过程中,模式识别受体、炎性因... 详细信息

近年来,宿主对EV71的遗传易感性在手足口病发生、发展中的作用逐渐成为研究热点。基因多态性是决定人体对于病原体感染的易患性、疾病轻重程度及药物治疗反应性差异的重要内在因素。在手足口病发生、发展的过程中,模式识别受体、炎性因子、趋化因子及免疫相关因子的基因多态性在很大程度上决定着疾病的转归,而宿主遗传背景因素对手足口病疾病进展程度的作用同样受到高度重视。本文就基因多态性与手足口病的遗传易感性、病情程度和预后的研究进展予以综述。

关键词：肠道病毒71型手足口病遗传因素基因多态性

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西安市莲湖区健康教育机构能力建设现况分析

临床医学研究与实践 2017年第15期2卷 194-196页

作者：惠新凤党双锁西安市莲湖区疾病预防控制中心陕西西安710002 西安交通大学第二附属医院陕西西安710004

目的了解莲湖区健康教育机构能力建设现状,为更好地开展健康教育工作提供参考依据。方法采用全国统一的《健康教育所(中心)业务工作调查表》对莲湖区所有健康教育机构与人员情况进行调查分析。结果莲湖区健康教育机构共有28个,健康教育... 详细信息

目的了解莲湖区健康教育机构能力建设现状,为更好地开展健康教育工作提供参考依据。方法采用全国统一的《健康教育所(中心)业务工作调查表》对莲湖区所有健康教育机构与人员情况进行调查分析。结果莲湖区健康教育机构共有28个,健康教育工作人员所学专业以护理为主,公共卫生专业只有2人,专业人员缺乏,且基本都兼职其他工作。结论莲湖区健康教育机构人力资源缺乏,应引起相关部门重视。

关键词：健康教育能力建设专业人员

西安地区36例危重型手足口病患者临床特征分析

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中国皮肤性病学杂志 2012年第3期26卷 219-221页

作者：邓慧玲李梅党双锁张瑜符佳高宁西安市儿童医院感染科陕西西安710002 西安交通大学医学院第二附属医院感染科陕西西安710004

目的了解近年来危重型手足口病(HFMD)患儿临床特征及变化,为临床诊断与治疗提供依据。方法收集36例危重型HFMD患儿临床资料,包括年龄、性别、症状、体征、实验室检查及临床转归情况。结果 36例患儿中男22例,女14例,男女比例1.57:1,3岁... 详细信息

目的了解近年来危重型手足口病(HFMD)患儿临床特征及变化,为临床诊断与治疗提供依据。方法收集36例危重型HFMD患儿临床资料,包括年龄、性别、症状、体征、实验室检查及临床转归情况。结果 36例患儿中男22例,女14例,男女比例1.57:1,3岁以内患儿33例(91.67%),5～7月份发病23例(63.89%),城乡比例为1:8。表现为皮疹36例(100%)、发热35例(97.22%)、肺部啰音30例(83.33%)、呕吐27例(75.00%)、肢体抖动17例(47.22%)、Babinski征阳性17例(47.22%)、休克13例(36.11%)。34例(94.44%)为肠道病毒71型(EV71)感染,18例合并流感病毒感染,23例血白细胞升高,24例出现高血糖,15例合并腺病毒感染。19例死亡病例中13例出现高血糖,13例血白细胞升高。结论 3岁以内婴幼儿为危重型HFMD病高危人群,5～7月为高峰季节。EV71感染是危重型手足口病的主要病原;外周血白细胞升高、高血糖是预测病情进展及预后的主要危险因素,应引起高度重视。EV71合并流感病毒感染、腺病毒感染可能是导致手足口病病情加重的危险因素。

关键词：危重型手足口病肠道病毒71型(EV71) 临床特点