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Biomedical and Environmental Sciences 2020年第11期33卷 839-848页

作者： WU Feng Liang dang lei ZHOU Hua YU Miao WEI Feng JIANG Liang LIU Zhong Jun LIU Xiao Guang Department of Orthopedic Surgery Peking University Third HospitalBeijing 100191China

Objective We aimed to compare the clinical and radiological outcomes of midline lumbar fusion(MIDLF)versus minimally invasive transforaminal lumbar interbody fusion(MI-TLIF)in patients with degenerative spondylolisthesis and/or stenosis in L4-L5 two years after *** Consecutively treated patients with lumbar pathology who underwent MIDLF(n=16)and a historical control group who underwent MI-TLIF(n=34)were *** symptoms were evaluated using Oswestry Disability Index(ODI),the 36-Item Short-Form Health Survey,and visual analog scale(VAS)scores before surgery and 3,6,12,and 24 months after *** The mean operative time and hematocrit(HCT,Day 1)were significantly shorter and lower in MIDLF cases(174 min vs.229 min,P<0.001;0.34 vs.0.36,P=0.037).The MI-TLIF group showed better improvement than the MIDLF group in ODI and VAS back and leg pain at 3 months *** leg pain was higher in MIDLF than in MI-TLIF cases at 6 *** 24 months follow-up,VAS back pain was higher in MI-TLIF than in MIDLF cases(P=0.018).Conclusion MIDLF is comparable to MI-TLIF at L4-5 in clinical outcomes and fusion rates,and the results verified the meaningful advantage of using MIDLF for the elderly with osteoporosis.

关键词： Minimally invasive techniques Cortical bone trajectory Clinical outcomes Midline lumbar fusion Transforaminal lumbar interbody fusion

Targeted inhibition of osteoclastogenesis reveals the pathogenesis and therapeutics of bone loss under sympathetic neurostress

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International Journal of Oral Science 2022年第4期14卷 479-488页

作者： Bingdong Sui Jin Liu Chenxi Zheng lei dang Ji Chen Yuan Cao Kaichao Zhang Lu Liu Minyan dang Liqiang Zhang Nan Chen Tao He Kun Xuan Fang Jin Ge Zhang Yan Jin Chenghu Hu State Key Laboratory of Military Stomatology and National Clinical Research Center for Oral Diseases and Shaanxi International Joint Research Center for Oral Diseases Center for Tissue EngineeringSchool of StomatologyThe Fourth Military Medical UniversityXi'anChina Law Sau Fai Institute for Advancing Translational Medicine in Bone and Joint Diseases School of Chinese MedicineHong Kong Baptist UniversityHong Kong SARChina Xi'an Key Laboratory of Stem Cell and Regenerative Medicine Institute of Medical ResearchNorthwestern Polytechnical UniversityXianChina Xi'an Institute of Tssue Engineering and Regenerative Medicine XianChina Department of Biochemistry and Molecular Biology School of Basic Medical SciencesXi'an Jiaotong UniversityXi'anChina

Sympathetic cues via the adrenergic signaling critically regulate bone homeostasis and contribute to neurostress-induced bone loss,but the mechanisms and therapeutics remain incompletely ***,we reveal an osteoclastogenesis-centered functionally important osteopenic pathogenesis under sympatho-adrenergic activation with characterized micro RNA response and efficient *** discovered that osteoclastic mi R-21 was tightly regulated by sympatho-adrenergic cues downstream theβ2-adrenergic receptor(β2AR)signaling,critically modulated osteoclastogenesis in vivo by inhibiting programmed cell death 4(Pdcd4),and mediated detrimental effects of both isoproterenol(ISO)and chronic variable stress(CVS)on ***,without affecting osteoblastic bone formation,bone protection against ISO and CVS was sufficiently achieved by a(D-Asp8)-lipid nanoparticle-mediated targeted inhibition of osteoclastic mi R-21 or by clinically relevant drugs to suppress ***,these results unravel a previously underdetermined molecular and functional paradigm that osteoclastogenesis crucially contributes to sympatho-adrenergic regulation of bone and establish multiple targeted therapeutic strategies to counteract osteopenias under stresses.

关键词： osteoclast pathogenesis homeostasis

Structural Basis of Glycan Recognition in Globally Predominant Human P[8]Rotavirus

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Virologica Sinica 2020年第2期35卷 156-170页

作者： Xiaoman Sun lei dang Dandi Li Jianxun Qi Mengxuan Wang Wengang Chai Qing Zhang Hong Wang Ruixia Bai Ming Tan Zhaojun Duan National Health Commission Key Laboratory for Medical Virology and Viral Diseases Beijing 102206China National Institute for Viral Disease Control and Prevention China CDC.Beijing 102206China Inner Mongolia Medical University Huhehaote 010059China Institute of Microbiology Chinese Academy of SciencesBeijing 100101China Glycosciences Laboratory Department of MedicineImperial College LondonLondonUK Division of Infectious Diseases University of Cincinnati College of MedicineCincinnatiOHUSA

Rotavirus(RV)causes acute gastroenteritis in infants and children *** studies showed that glycans such as histo-blood group antigens(HBGAs)function as cell attachment factors affecting RV host susceptibility and prevalence.P[8]is the predominant RV genotype in humans,but the structural basis of how P[8]RVs interact with glycan ligands remains *** this study,we characterized the interactions between P[8]VP8~*s and glycans which showed that VP8~*,the RV glycan binding domain,recognized both mucin core 2 and H type 1 antigens according to the ELISA-based oligosaccharide binding ***,we determined the structural basis of P[8]RV-glycans interaction from the crystal structures of a Rotateq P[8]VP8~*in complex with core 2 and H type 1 glycans at 1.82.3?,respectively,revealing a common binding pocket and similar binding *** and sequence analysis demonstrated that the glycan binding site is conserved among RVs in the P[Ⅱ]genogroup,while genotype-specific amino acid variations determined different glycan binding *** data elucidated the detailed structural basis of the interactions between human P[8]RVs and different host glycan factors,shedding light on RV infection,epidemiology,and development of anti-viral agents.

关键词： Rotavirus(RV)·P Glycan binding specificity VPS*structure Mucin core 2 Lacto-N-fucopentaose 1(LNFPl)

Plasmonic enhancement and polarization dependence of nonlinear upconversion emissions from single gold nanorod@SiO_(2)@CaF2:Yb^(3+),Er^(3+)hybrid core–shell–satellite nanostructures

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Light(Science & Applications) 2016年第1期5卷 224-234页

作者： Jijun He Wei Zheng Filip Ligmajer Chi-Fai Chan Zhiyong Bao Ka-Leung Wong Xueyuan Chen Jianhua Hao Jiyan Dai Siu-Fung Yu dang Yuan lei Department of Applied Physics The Hong Kong Polytechnic UniversityHong KongChina Key Laboratory of Optoelectronic Materials Chemistry and Physics Fujian Institute of Research on the Structure of MatterChinese Academy of SciencesFuzhouFujian 350002China Central European Institute of Technology Brno University of TechnologyBrno 61669Czech Republic Department of Chemistry Hong Kong Baptist UniversityHong KongChina

Lanthanide-doped upconversion nanocrystals(UCNCs)have recently become an attractive nonlinear fluorescence material for use in bioimaging because of their tunable spectral characteristics and exceptional *** materials are often introduced into the vicinity of UCNCs to increase their emission intensity by means of enlarging the absorption cross-section and accelerating the radiative decay ***,plasmonic nanostructures(e.g.,gold nanorods,GNRs)can also influence the polarization state of the UC fluorescence—an effect that is of fundamental importance for fluorescence polarization-based imaging methods yet has not been discussed *** study this effect,we synthesized GNR@SiO_(2)@CaF2:Yb^(3+),Er^(3+)hybrid core–shell–satellite nanostructures with precise control over the thickness of the SiO_(2) *** evaluated the shell thicknessdependent plasmonic enhancement of the emission intensity in ensemble and studied the plasmonic modulation of the emission polarization at the single-particle *** hybrid plasmonic UC nanostructures with an optimal shell thickness exhibit an improved bioimaging performance compared with bare UCNCs,and we observed a polarized nature of the light at both UC emission bands,which stems from the relationship between the excitation polarization and GNR *** used electrodynamic simulations combined with Förster resonance energy transfer theory to fully explain the observed *** results provide extensive insights into how the coherent interaction between the emission dipoles of UCNCs and the plasmonic dipoles of the GNR determines the emission polarization state in various situations and thus open the way to the accurate control of the UC emission anisotropy for a wide range of bioimaging and biosensing applications.

关键词： Förster resonance energy transfer gold nanorods lanthanide-doped upconversion nanocrystals plasmon-enhanced nonlinear fluorescence polarization modulation

叠加态涡旋光束经旋转随机粗糙表面的频移特性

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电子学报 2021年第10期49卷 1969-1974页

作者：吕宏党磊贺蕊西安工业大学光电工程学院陕西西安710021

论文基于涡旋光束传输特性及光散射理论,研究了叠加态涡旋光束经旋转随机粗糙表面的场分布及干涉特性.对拓扑荷值大小相同、符号相反的两束涡旋光进行了叠加生成仿真及实验,利用角谱衍射理论,分析了旋转随机粗糙表面均方根粗糙度对光束... 详细信息

论文基于涡旋光束传输特性及光散射理论,研究了叠加态涡旋光束经旋转随机粗糙表面的场分布及干涉特性.对拓扑荷值大小相同、符号相反的两束涡旋光进行了叠加生成仿真及实验,利用角谱衍射理论,分析了旋转随机粗糙表面均方根粗糙度对光束传输的影响,数值计算了不同拓扑荷值的叠加态涡旋光束经旋转随机粗糙表面后,与参考光进行干涉得到不同转速下归一化强度值随时间变化的曲线,并通过光强-时间函数间接求得频移量,再反演得到旋转目标的转速.结果表明:通过仿真曲线的周期反演频率,当转速Ω分别为2π/3 rad/s,2πrad/s,10π/3 rad/s时,对应的频移Δf分别为2/3Hz,2Hz,10/3Hz.研究结果可以为叠加涡旋光的调控及应用提供理论参考.

关键词：叠加态涡旋光束旋转随机粗糙表面频移场分布干涉

Surgical treatment of 21 patients with spinal metastases of differentiated thyroid cancer

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Chinese Medical Journal 2014年第23期127卷 4092-4096页

作者： Jiang Liang Ouyang Hanqiang Liu Xiaoguang Wei Feng Wu Fengliang dang lei Liu Zhongjun Department of Orthopaedics Peking University Third Hospital Beijing 100191 China Peking University Health Science Center Peking University Beijing 100191 China

Background Differentiated thyroid cancer （DTC） is a common primary cancer for spinal metastases （SM）.The treatments for DTC spinal metastases （SM） have evolved from simple surgery and radiotherapy to a multidisciplinary comprehensive therapeutic strategy of combined spinal surgery,general surgery,radiotherapy,nuclear medicine and *** purpose of this study was to discuss the efficacy and prognosis associated with different surgical treatments of SM patients with *** A total of 21 consecutive patients with SM of DTC that were treated between 1999 and 2013 were *** was routinely performed to achieve the pathological diagnosis before *** patients underwent total spondylectomy intralesionally or piecemeally,and 18 had *** recurrence and survival times were analyzed by the Kaplan-Meier *** Nineteen patients （90％） had an average of 42.7 months （range,7-170 months） *** median visual analogue scale for pain reduced from 5 points to 1 point （P ＜0.01）,and the median Karnofsky performance score increased from 70 to 90 points after surgery （P ＜0.01）.Seventeen patients with neurological deficits attained improvements after surgeries,of at least one level according to the Frankel classification （P ＜0.01）.Eight patients with curettage had *** patients died of DTC,12 patients lived with disease,and three patients were *** significant effects on postoperative recurrence or survival were observed between surgery combined with conservative treatment,total spondylectomy,the number of bone metastases and visceral *** DTC-SM have a relatively favorable prognosis,and curettage and stabilization can effectively relieve the pain and improve the quality of life and neurological status of the *** patients with Tomita scores of ＜3,total spondylectomy may have better clinical *** therapeutic strategies including surgery,radioiodine,external

关键词： spinal metastases thyroid cancer surgery survival

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一种基于知网的中文句子情感倾向判别方法

计算机应用研究 2010年第4期27卷 1370-1372页

作者：党蕾张蕾西北大学信息科学与技术学院西安710127

针对基于知网的中文句子情感倾向判别方法中存在的准确率不高的问题,提出采用否定模式匹配与依存句法分析相结合的方法。研究分析了修饰词极性以及否定共享模式,确定修饰词以及扩展极性的定量和否定共享范围,提出依存语法距离的影响因... 详细信息

针对基于知网的中文句子情感倾向判别方法中存在的准确率不高的问题,提出采用否定模式匹配与依存句法分析相结合的方法。研究分析了修饰词极性以及否定共享模式,确定修饰词以及扩展极性的定量和否定共享范围,提出依存语法距离的影响因素来计算情感倾向,并且在否定模式匹配后改进句子极性算法。实验结果表明该方法取得了良好的效果。

关键词：否定词扩展否定共享依存句法关系句子情感倾向知网

A transient process observation method based on the non-homogeneous Poisson process model

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Chinese Physics C 2021年第4期45卷 394-403页

作者： Kuo Zhao Xiao-Ping Ouyang Hui-Ping Guo Liang Chen lei-dang Zhou Jin-Lu Ruan Han Wang Ning Lv Run-Long Gao Xi'an Research Institute of Hi-Tech Xi'an 710025China Northwest Institute of Nuclear Technology Xi'an 710024China Department of Engineering Physics Tsinghua UniversityBejing 100084China Xi'an Jiaotong University Xi'an 710049China

The current-mode-counting method is a new approach to observing transient processes,especially in transient nuclear fusion,based on the non-homogeneous Poisson process(NHPP)*** this paper,a new measurement process model of the pulsed radiation field produced by transient nuclear fusion is built based on the NHPP.A simulated measurement is performed using the model,and the current signal from the detector is obtained by simulation based on Poisson process *** neutron time spectrum is reconstructed and is in good agreement with the theoretical value,with its maximum error of a characteristic parameter less than 2.3%.Verification experiments were carried out on a CPNG-6 device at the China Institute of Atomic Energy,with a detection system with a nanosecond response *** experimental charge amplitude spectra are in good agreement with those obtained by the traditional counting mode,and the characteristic parameters of the time spectrum are in good agreement with the theoretical *** shows that the current-mode-counting method is effective for the observation of transient nuclear fusion processes.

关键词： non-homogeneous poisson process pulsed radiation field current-mode-counting method

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改性树脂炭的石墨化及应用进展

新型炭材料（中英文） 2023年第1期38卷 96-110页

作者：杨平军李铁虎李昊党阿磊袁磊西北工业大学材料学院陕西西安710072 陕西省石墨烯新型炭材料及应用工程实验室陕西西安710072

树脂炭具有良好的力学、电学以及热物理性能,是广泛应用于航空、航天、能源等领域的结构功能一体化材料。树脂固有的分子结构特性导致树脂炭难石墨化,限制了树脂炭的广泛应用。本文综述了近年来改性树脂炭石墨化及应用的研究进展,系统... 详细信息

树脂炭具有良好的力学、电学以及热物理性能,是广泛应用于航空、航天、能源等领域的结构功能一体化材料。树脂固有的分子结构特性导致树脂炭难石墨化,限制了树脂炭的广泛应用。本文综述了近年来改性树脂炭石墨化及应用的研究进展,系统介绍了催化剂、碳纳米材料、易石墨化共炭化剂三类树脂改性剂,可提高树脂炭的石墨化炭含量并降低其石墨化温度。其中催化剂和碳纳米材料改性剂方面的研究较多,催化剂改性剂在较低温度下(低于1400℃)便能使树脂炭的石墨化度达74%,而碳纳米材料改性剂需要在2000℃以上才能较明显地提高树脂炭的石墨化度。相比前两种改性剂,易石墨化的共炭化改性剂不仅能提高树脂炭的石墨化度,还能提高树脂的残炭率。在应用方面,提高树脂炭的石墨化度能提高炭/炭复合材料的导热和导电性能,也能提高超级电容器材料和二次电池电极材料的导电性能、倍率性能和功率密度。最后探讨了改性树脂炭的石墨化及应用面临的挑战和发展方向。

关键词：改性树脂炭石墨化催化剂碳纳米材料共炭化剂应用

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皮质下动脉硬化性脑病伴发抑郁的治疗分析

中国临床康复 2006年第6期10卷 7-9页

作者：索爱琴党雷河南省人民医院神经内科河南省郑州市450003

目的:观察抗抑郁治疗对皮质下动脉硬化性脑病伴发抑郁症患者抑郁症状、神经功能缺损及日常生活能力的改善情况。方法:选择2002-01/2005-06来自于河南省人民医院神经科门诊和住院的患者110例,随机分为米氮平治疗组(n=38),阿米替林治疗组(... 详细信息

目的:观察抗抑郁治疗对皮质下动脉硬化性脑病伴发抑郁症患者抑郁症状、神经功能缺损及日常生活能力的改善情况。方法:选择2002-01/2005-06来自于河南省人民医院神经科门诊和住院的患者110例,随机分为米氮平治疗组(n=38),阿米替林治疗组(n=36)、对照组(n=36),各组均行常规神经营养药物和促智药物治疗,米氮平治疗组同时口服米氮平30mg/次,1次/晚;阿米替林组同时口服阿米替林25mg/次,分早晚两次口服,最大剂量为100mg/d,总疗程均为12～24周,治理期间不合并其他抗抑郁或精神障碍药。治疗前、治疗后1,2,4、8,12周及6个月分别采用汉密顿抑郁量表评定患者的抑郁症状。于治疗前及治疗后12周、6个月进行神经功能缺损和日常生活能力评定。记录治疗期间米氮平治疗组和阿米替林治疗组不良反应发生情况。并于6个月对各组患者的并发症及预后进行评定。结果:纳入患者110例,由于调查过程中停药、失访、患并发症、死亡等原因,米氮平治疗组、阿米替林治疗组和对照组分别脱落5、6和6例,分别进入结果分析33、30和30例。①汉密顿抑郁量表评分结果:米氮平治疗组在治疗第1,2,4,8,12周及6个月时汉密尔顿抑郁量表得分均明显低于治疗前及对照组(P<0.01～0.05),阿米替林组在治疗后第2,4,8,12周及6个月时汉密尔顿抑郁量表得分低于治疗前及对照组(P<0.01～0.05)。②神经功能缺损及日常生活能力评定。结果:米氮平治疗组及阿米替林治疗组在治疗后第12周、6个月时神经功能缺损评分均明显低于治疗前及对照组(P<0.01～0.05),日常生活能力得分明显高于治疗前及对照组(P<0.01～0.05)。③不良反应发生情况:治疗期间米氮平导致口干、便秘、视力模糊、恶心、呕吐、心电图异常、尿潴留等不良反应发生情况明显少于阿米替林治疗组(P<0.01～0.05)。④各组治疗后并发症及预后比较:对照组肺部感染、尿路感染、脑卒中、心血管事件的发生率高于米氮平治疗组、阿米替林治疗组(P<0.01～0.05),其死亡率也明显增高(P<0.01～0.05)。结论:抗抑郁治疗能有效改善皮质下动脉硬化性脑病伴抑郁的症状,有利于患者神经功能康复,提高生活能力,减少并发症,米氮平治疗副反应少,更安全。

关键词：皮质下动脉硬化性脑病抑郁症米氮平阿米替林康复