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Brain region-specific roles of brain-derived neurotrophic factor in social stress-induced depressive-like behavior

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Neural Regeneration Research 2025年第1期20卷 159-173页

作者： man Han Deyang Zeng Wei Tan Xingxing Chen Shuyuan Bai Qiong Wu Yushan Chen Zhen Wei Yufei Mei Yan Zeng Brain Science and Advanced Technology Institute Wuhan University of Science and TechnologyWuhanHubei ProvinceChina Geriatric Hospital Affiliated to Wuhan University of Science and Technology WuhanHubei ProvinceChina School of Public Health Wuhan University of Science and TechnologyWuhanHubei ProvinceChina

Brain-derived neurotrophic factor is a key factor in stress adaptation and avoidance of a social stress behavioral *** studies have shown that brain-derived neurotrophic factor expression in stressed mice is brain region–specific,particularly involving the corticolimbic system,including the ventral tegmental area,nucleus accumbens,prefrontal cortex,amygdala,and *** how brain-derived neurotrophic factor participates in stress processing in different brain regions will deepen our understanding of social stress *** this review,we discuss the expression and regulation of brain-derived neurotrophic factor in stress-sensitive brain regions closely related to the pathophysiology of *** focused on associated molecular pathways and neural circuits,with special attention to the brain-derived neurotrophic factor–tropomyosin receptor kinase B signaling pathway and the ventral tegmental area–nucleus accumbens dopamine *** determined that stress-induced alterations in brain-derived neurotrophic factor levels are likely related to the nature,severity,and duration of stress,especially in the above-mentioned brain regions of the corticolimbic ***,BDNF might be a biological indicator regulating stress-related processes in various brain regions.

关键词： amygdala chronic mild stress chronic social defeat stress corticolimbic system depression hippocampus medial prefrontal cortex nucleus accumbens social stress models ventral tegmental area

醋酸去氨加压素经家兔眼部给药后的药动学及药效学研究

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药学学报 2020年第1期55卷 91-95页

作者：张慧敏马群代嫚嫚白露雨费清松雷芳罗芮何宁安徽中医药大学药学院安徽合肥230012 安徽省中医药科学院药物制剂研究所安徽合肥230012 安徽省教育厅现代药物制剂工程技术研究中心安徽合肥230012

比较醋酸去氨加压素经家兔眼部给药、静脉注射以及灌胃给药后的药动学及药效学特征,探索多肽类药物通过眼部给药进入全身循环的可行性。15只家兔随机分成3组(眼部给药, 7.0μg·kg-1;静脉注射, 0.7μg·kg-1;灌胃给药, 7.0μg·kg-1),... 详细信息

比较醋酸去氨加压素经家兔眼部给药、静脉注射以及灌胃给药后的药动学及药效学特征,探索多肽类药物通过眼部给药进入全身循环的可行性。15只家兔随机分成3组(眼部给药, 7.0μg·kg-1;静脉注射, 0.7μg·kg-1;灌胃给药, 7.0μg·kg-1),给药后按预定时间点心脏取血,采用酶联免疫法(ELISA)测定醋酸去氨加压素的血药浓度;另21只家兔随机分成3组(眼部给药, 7.0μg·kg-1;静脉注射, 0.7μg·kg-1;灌胃给药, 7.0μg·kg-1)进行药效学研究,在给药前和给药后的预定时间段收集尿液。家兔静脉注射给药后峰浓度(Cmax)为143.0 pg·mL-1,血药浓度-时间曲线下的面积(AUC0-t)为999.9 pg·h·mL-1;眼部给药后达峰时间(tmax)为5 min, Cmax为125.6 pg·mL-1, AUC0-t为873.1 pg·h·mL-1,绝对生物利用度(F)为8.7%;灌胃给药后tmax为10 min, Cmax为104.1 pg·mL-1, AUC0-t为451.8 pg·h·mL-1, F为4.5%。滴眼给药与静脉注射给药(给药剂量为1/10)后药效相当, 12 h尿量依然呈抑制现象,而灌胃给药后的第2个收集时间段尿量已经明显上升,给药后12 h已经没有抑制效果。研究表明,醋酸去氨加压素经眼部给药后相对于灌胃给药吸收更快更好,因此多肽类药物通过眼部给药发挥全身治疗作用是可行的。本实验中动物实验过程已通过安徽中医药大学实验动物伦理委员会批准。

关键词：药动学药效学醋酸去氨加压素眼部给药全身转运

ESP理念下的新建地方应用型本科院校大学英语教学发展

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教育教学论坛 2019年第11期 202-203页

作者：代曼漫潘水凡六盘水师范学院贵州六盘水553004

本文对ESP及其基本教育理念进行简要介绍,并讨论在ESP理念指导下新建地方应用型本科院校大学英语教学改革及教师转型发展。该类院校教师要认清本校英语教学现状,充分领会ESP教学的指导作用,从学生学习动机、课堂环境创设和课程设置几个... 详细信息

本文对ESP及其基本教育理念进行简要介绍,并讨论在ESP理念指导下新建地方应用型本科院校大学英语教学改革及教师转型发展。该类院校教师要认清本校英语教学现状,充分领会ESP教学的指导作用,从学生学习动机、课堂环境创设和课程设置几个方面加强转型发展,以推动大学英语教学改革。

关键词：专门用途英语应用型高校大学英语课程改革

Interleukin-6 in epilepsy and its neuropsychiatric comorbidities: How to bridge the gap

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World Journal of Psychiatry 2025年第1期15卷 1-6页

作者： Xiao-man Chen Shuo Zhang Shi-Qi Gao Michael Xu Department of Neurology Shengjing Hospital of China Medical UniversityShenyang 110004Liaoning ProvinceChina Department of Rehabilitation Affiliated Hospital of Liaoning University of Traditional Chinese MedicineShenyang 110004Liaoning ProvinceChina International Education School China Medical UniversityShenyang 110004Liaoning ProvinceChina

There is growing evidence that interleukin(IL)-6 plays an important role in neurological and psychiatric *** editorial comments on the study published in the recent issue of the World Journal of Psychiatry,which employed Mendelian randomization to identify a causal relationship between IL-6 receptor blockade and decreased epilepsy *** purpose of this editorial is to highlight the dual effects of IL-6 in epilepsy and its related neuropsychiatric ***-6 plays a critical role in the facilitation of epileptogenesis and maintenance of epileptic seizures and is implicated in neuroinflammatory proce-sses associated with ***,IL-6 significantly influences mood regulation and cognitive dysfunction in patients with epilepsy,highlighting its involvement in neuropsychiatric *** summary,IL-6 is not only a pivotal factor in the pathogenesis of epilepsy but also significantly contributes to the emergence of epilepsy-related neuropsychiatric *** resear-ch should prioritize elucidating the specific mechanisms by which IL-6 operates across different subtypes,stages and neuropsychiatric comorbidities of epilepsy,with the aim of developing more precise and effective ***,the potential of IL-6 as a biomarker for the early diagnosis and prognosis of epile-psy warrants further investigation.

关键词： Epilepsy Interleukin-6 Neuropsychiatric comorbidities Depression Tocilizu-mab Neuroinflammation Interleukin-6 receptor blockade

广东省部分地区鸡源凝固酶阴性葡萄球菌的耐药基因检测及耐药性分析

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中国人兽共患病学报 2023年第7期39卷 657-664页

作者：劳颖琳贾玉生程进冉刘佳陈雍仪梁啟宇代曼曼华南农业大学兽医学院广州510642

目的了解广东省部分地区鸡源凝固酶阴性葡萄球菌(Coagulase-negative Staphylococci, CNS)的耐药情况。方法对广东省部分地区养鸡场324份鸡肛拭子进行CNS的分离鉴定,并对所分离的菌株进行12种抗生素的最小抑菌浓度(Minimum inhibitory... 详细信息

目的了解广东省部分地区鸡源凝固酶阴性葡萄球菌(Coagulase-negative Staphylococci, CNS)的耐药情况。方法对广东省部分地区养鸡场324份鸡肛拭子进行CNS的分离鉴定,并对所分离的菌株进行12种抗生素的最小抑菌浓度(Minimum inhibitory concentration, MIC)检测以及11种耐药基因检测。结果共分离出58株CNS,占检出葡萄球菌的92.1%。其中,检出率最高的CNS为松鼠葡萄球菌(24.1%)。MIC结果显示CNS分离株对青霉素、环丙沙星和苯唑西林的耐药水平较高,分别为79.3%、74.1%和67.2%。此外,CNS分离株的多重耐药率高达70.7%,耐药谱种类多至20种。CNS的耐药基因检出率最高的为gryA(60.3%),gryA主要介导喹诺酮类药物如环丙沙星的耐药表型。耐药基因的基因组型复杂(28种),有53.4%的分离株携带两种以上的耐药基因。结论本研究揭示了广东部分地区鸡源CNS对喹诺酮类、β-内酰胺类抗生素有较强的耐药性,并且喹诺酮类的耐药基因携带率较高,该地区鸡源CNS耐药情况复杂多样。本研究成果对指导本地区鸡场科学合理使用抗菌药物具有重要意义。

关键词：凝固酶阴性葡萄球菌药物敏感性耐药基因多重耐药

差速离心对J亚群禽白血病病毒分离株SCAU11-H生物学活性影响

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中国兽医杂志 2014年第12期50卷 26-28,31,I0001页

作者：代曼曼冯敏李育豪刘迪黄小容曹伟胜廖明华南农业大学兽医学院广东广州510642

为探讨差速离心对J亚群禽白血病分离株SCAU 11-H生物学活性的影响,本研究通过实时荧光定量RT-PCR、IFA和ELISA等方法验证差速离心后浓缩病毒的生物学活性.结果显示,在透射电镜下病毒粒子直径为60～140 nm,由外部的囊膜和内部的电子致密... 详细信息

为探讨差速离心对J亚群禽白血病分离株SCAU 11-H生物学活性的影响,本研究通过实时荧光定量RT-PCR、IFA和ELISA等方法验证差速离心后浓缩病毒的生物学活性.结果显示,在透射电镜下病毒粒子直径为60～140 nm,由外部的囊膜和内部的电子致密的核心构成,多近似球形,也有一些类似长杆形、鼓锤形的形态;浓缩前后病毒的滴度（TCID50/mL）由原来的1.58×105/Ml上升到8.89×1011/Ml.浓缩病毒（105TCID50）感染细胞后,病毒复制量在1d,3d,5d逐步增长,ALV-J抗原gp85和p27检测均为阳性.以上结果表明,差速离心极大提高了病毒滴度,且并不影响病毒生物学活性,浓缩后的病毒可用于后续试验研究.

关键词： J亚群禽白血病病毒差速离心生物学活性

Recombinant *** LLO/OVA Induces Murine BMDCs Maturation via TLR4 and NOD1 Receptor and Promotes Specific Cytotoxic T Cell Immunity

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Biomedical and Environmental Sciences 2010年第5期23卷 350-356页

作者： man XU MING-SHEN dai Department of Pathology Molecular Medicine and Cancer Research Centre Chongqing Medical University Chongqing 400016 China Centre for Molecular Oncology Institute of Cancer Queen Mary 's School of Medicine and Dentistry London EC1M 6BQ UK

Objective To explore the immune stimulation effect of recombinant *** LLO/OVA on mice bone marrow-derived dendritic cells （BMDCs） and T lymphocytes in *** After BMDCs stimulated by *** LLO/OVA,their Toll-like receptor （TLR） and nucleotide-binding oligomerization domain （NOD） receptor signalling pathway were examined by superarray hybridization;and the priming effect of the vaccine activated BMDCs on CD4＋T and CD8＋T was determined by [3H]thymidine uptake and ELISA,the tumor cytotoxic effect of activated CD8＋T cells was determined by cytotoxic *** After BMDCs were activated by *** LLO/OVA via TLR4,NOD1 receptor and NF-κB signalling pathway,the expression of their surface molecules including MHC class Ⅰ,MHC class Ⅱ,CD40,CD80 and CD86 significantly up-regulated;the secretion of IL-12 and IFN-？ increased *** mature BMDCs stimulated the allergic CD4＋T and CD8＋T cells proliferation and their IL-2 and IFN-γ secretion,and the activated CD8＋T cells effectively killed B16-OVA melanoma cells and RMA-S/OVA lymphoma cells in *** *** LLO/OVA is effective in inducing BMDCs maturation via activating TLR4 and NOD1 receptor signalling pathway and promoting specific anti-tumor T cell immunity in vitro.

关键词： Bone marrow-derived dendritic cells BMDCs Recombinant Escherichia coli Toll-like receptor (TLR) Nucleotide-binding oligomerization domain (NOD) CD8+T cells

Asymptotic false discovery control of the Benjamini-Hochberg procedure for pairwise comparisons

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Science China Mathematics 2025年第1期 223-252页

作者： Weidong Liu Dennis Leung Qi-man Shao School of Mathematical Sciences Shanghai Jiao Tong University School of Mathematics and Statistics University of Melbourne Department of Statistics and Data Science SICMSouthern University of Science and Technology

In a one-way analysis-of-variance(ANOVA) model,the number of pairwise comparisons can become large even with a moderate number of *** by this,we consider a regime with a growing number of groups and prove that,when testing pairwise comparisons,the Benjamini-Hochberg(BH) procedure can asymptotically control false discoveries,despite the fact that the involved t-statistics do not exhibit the wellknown positive dependence structure required for exact false discovery rate(FDR) *** Tukey's perspective that the difference between the means of any two groups cannot be exactly zero,our main result provides control over the directional false discovery rate and directional false discovery proportion.A key technical contribution of our work is demonstrating that the dependence among the t-statistics is sufficiently weak to establish the convergence result typically required for asymptotic FDR *** analysis does not rely on conventional assumptions such as normality,variance homogeneity,or a balanced design,thereby offering a theoretical foundation for applications in more general settings.

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温度和水分对寒温带典型森林类型土壤有机碳矿化的影响

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东北林业大学学报 2025年第2期53卷 127-136页

作者：李雪朱宾宾满秀玲东北林业大学哈尔滨150040 内蒙古呼伦贝尔市林业和草原事业发展中心

通过室内模拟试验,分析寒温带典型森林土壤有机碳矿化随温度和水分的变化特征,揭示土壤有机碳矿化影响机制,以期深入探讨气候变暖背景下,温度和水分对寒温带典型森林类型土壤碳循环的影响。采集白桦林和兴安落叶松林0 详细信息

通过室内模拟试验,分析寒温带典型森林土壤有机碳矿化随温度和水分的变化特征,揭示土壤有机碳矿化影响机制,以期深入探讨气候变暖背景下,温度和水分对寒温带典型森林类型土壤碳循环的影响。采集白桦林和兴安落叶松林0

关键词：寒温带白桦林兴安落叶松林土壤有机碳矿化温度敏感性