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Frontiers of Materials Science 2024年第1期18卷 113-121页

作者： Tianyong Mao jing dai Meiqing Xin Deliang Zeng Zhipeng Xie Jiangxi Province Key Laboratory of Power Batteries and Materials Jiangxi University of Science and TechnologyGanzhou 341000China

Zinc-based flow battery is an energy storage technology with good application prospects because of its advantages of abundant raw materials,low cost,and environmental *** chemical stability of zinc electrodes exposed to electrolyte is a very important issue for zinc-based *** paper reports on details of chemical stability of the zinc metal exposed to a series of solutions,as well as the relationship between the morphological evolution of zinc electrodes and their properties in an alkaline *** corrosion of zinc electrodes by the electrolyte will change their surface ***,we observed that chemical corrosion is not the main contributor to the evolution of zinc electrode surface morphology,but the main contributor is the Zn/Zn^(2+)electrode *** morphological evolution of zinc electrodes was controlled by using ionic liquids,1-ethyl-3-methylimidazolium acetate(EMIA),and 1-propylsulfonic-3-methylimidazolium tosylate(PSMIT),and the electrode performance was recorded during the morphological evolution *** was observed that the reversible change of zinc electrode morphology was accompanied by better electrode performance.

关键词： alkaline medium morphological evolution zinc-based flow battery new energy

Exploration of cyclooxygenase-2 inhibitory peptides from walnut dreg proteins based on in silico and in vitro analysis

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Food Science and Human Wellness 2024年第3期13卷 1636-1644页

作者： Zishan Hong jing Xie Liang Tao jing-jing dai Tingting Li Li Zhang Yuying Bai Xia Hu Jinlian Chen Jun Sheng Yang Tian College of Food Science and Technology Yunnan Agricultural UniversityKunming 650201China Yunnan Provincial Key Laboratory of Precision Nutrition and Personalized Food Manufacturing Yunnan Agricultural UniversityKunming 650201China Engineering Research Center of Development and Utilization of Food and Drug Homologous Resources Ministry of EducationYunnan Agricultural UniversityKunming 650201China School of Tea and Coffee Pu’er UniversityPu’er 665000China Yunnan Provincial Engineering Research Center for Edible and Medicinal Homologous Functional Food Yunnan Agricultural UniversityKunming 650201China Key Laboratory of Pu-er Tea Science Ministry of EducationYunnan Agricultural UniversityKunming 650201China

Walnut dreg protein hydrolysates(WDPHs)exhibit a variety of biological activities,however,the cyclooxygenase-2(COX-2)inhibitory peptide of WDPHs remain *** aim of this study was to rapidly screen for such peptides in WDPHs through a combination of in silico and in vitro *** total,1262 peptide sequences were observed by nano liquid chromatography/tandem mass spectrometry(nano LC-MS/MS)and 4 novel COX-2 inhibitory peptides(AGFP,FPGA,LFPD,and VGFP)were *** kinetic data indicated that AGFP,FPGA,and LFPD displayed mixed-type COX-2 inhibition,whereas VGFP was a non-competitive *** is mainly because the peptides form hydrogen bonds and hydrophobic interactions with residues in the COX-2 active *** results demonstrate that computer analysis combined with in vitro evaluation allows for rapid screening of COX-2 inhibitory peptides in walnut protein dregs.

关键词： Walnut dreg proteins Cyclooxygenase-2 inhibitory peptide Identification Virtual screening Molecular docking

Defects in phospholipase C zeta cause polyspermy and low fertilization after conventional IVF:not just ICSI failure

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Asian Journal of Andrology 2024年第2期26卷 175-182页

作者： Jian-Fang Che Hui-Xia Wu Si-Cong Zeng Yue-Ren Wu jing dai De-Hua Cheng Fei Gong Guang-Xiu Lu Ge Lin Can dai School of Medicine Hunan Normal UniversityChangsha 410013China Reproductive and Genetic Hospital of CITIC-Xiangya Changsha 410008China Clinical Research Center for Reproduction and Genetics in Hunan Province Changsha 410078China National Engineering and Research Center of Human Stem Cell Changsha 410205China

Phospholipase C zeta(PLC)is a key sperm-borne oocyte-activating factor that triggers Ca^(2+)oscillations and the subsequent block to polyspermy following gamete *** in PLCZ1,the gene encoding PLCζ,cause male infertility and intracytoplasmic sperm injection(ICSI)fertilization failure;and PLCζ expression and localization patterns are significantly correlated with ICSI fertilization rate(FR).However,in conventional in vitro fertilization(cIVF),whether and how sperm PLCζ affects fertilization remain ***,we identified one previously reported and two novel PLCZ1 mutations associated with polyspermy in vitro that are characterized by excessive sperm-zona binding and a delay in pronuclei(PN)*** staining and oocyte activation testing revealed that virtually all spermatozoa from patients lacked functional PLCζ and were thus unable to evoke Ca^(2+) *** with an artificial oocyte activation treatment successfully rescued the polyspermic phenotype and resulted in a live ***,we analyzed PLCζ in an additional 58 males after cIVF treatment in the Reproductive and Genetic Hospital of CiTiC-Xiangya(Changsha,China)between February 2019 and January *** found that the proportion of spermatozoa that expressed PLCζ was positively correlated with both 2PN rate and total *** optimal cutoff value below which males were likely to experience low FR(total FR≤30%)after clVF was 56.7%for the proportion of spermatozoa expressing *** study expands the mutation and the phenotypic spectrum of PLCZ1 and further suggests that PLCζ constitutes a promising biomarker for identifying low FRs cases in cIVF due to sperm-related oocyte activation deficiency and that sperm PLCζ analysis may benefit the widermale population and not onlymen with IcsI failure.

关键词： conventional IVF gene variants PLCζ polyspermy

Downstream Competition and Upstream Innovation:Theory and Evidence from China

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China Finance and Economic Review 2024年第1期13卷 67-87页

作者： jing dai Guanchun Liu Ziqi Ye Haiou Mao Yongwei Ye School of Finance Hubei University of Economics Lingnan College Sun Yatsen University School of Business Administration Zhongnan University of Economics and Law College of Economics and Management Huazhong Agricultural University School of Public Economics and Management Shanghai University of Finance and Economics

Competition is the catalyst of corporate innovation,which is the foundation of a country's core *** the view of vertical industrial chain,this paper examines how downstream competition affects upstream firms'innovation *** innovation helps reduce the production cost of each product,increasing demand of intermediate products caused by downstream competition enhances the marginal revenue of upstream firms'innovation,thus leading to an innovation incentive *** identify causality,we utilize China's WTO accession,a quasinatural experiment,to calculate downstream competition combined with import tariff reduction and input-output table,and then run a difference-in-difference *** the data of Annual Survey of Industrial Firms and State Intellectual Property Office,our results find that downstream competition has a significantly positive impact on upstream firms'innovation,and this effect is more pronounced in firms with less industry competition,greater initial innovation capacity and weaker financial ***,the number of firms,the degree of industry competition and the scale of intermediate products in the downstream sector increase,confirming the market size *** sum,our findings document that downstream competition can motivate upstream firms to innovate through vertical industrial chain,providing some useful insights for China to build a fair market competition environment and promote innovation-driven growth regime.

关键词： downstream competition upstream firms'innovation vertical industrial chain market size effect

A multi-objective optimization based on machine learning for dimension precision of wax pattern in turbine blade manufacturing

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Advances in Manufacturing 2024年第3期12卷 428-446页

作者： jing dai Song-Zhe Xu Chao-Yue Chen Tao Hu San-San Shuai Wei-Dong Xuan Jiang Wang Zhong-Ming Ren State Key Laboratory of Advanced Special Steels School of Materials Science and EngineeringShanghai UniversityShanghai200444People’s Republic of China

Wax pattern fabrication in the investment casting of hollow turbine blades directly determines the dimension accuracy of subsequent casting,and therefore significantly affects the quality of final *** this work,we develop a machine learning-based multi-objective optimization framework for improving dimension accuracy of wax pattern by optimizing its process *** consider two optimization objectives on the dimension of wax pattern,i.e.,the surface warpage and core *** active learning of Bayesian optimization is employed in data sampling to determine process parameters,and a validated numerical model of injection molding is used to compute objective results of dimension under varied process *** collected dataset is then leveraged to train different machine learning models,and it turns out that the Gaussian process regression model performs best in prediction accuracy,which is then used as the surrogate model in the optimization framework.A genetic algorithm is employed to produce a non-dominated Pareto front using the surrogate model in searching,followed by an entropy weight method to select the most optimal solution from the Pareto *** optimized set of process parameters is then compared to empirical parameters obtained from previous trial-and-error experiments,and it turns out that the maximum and average warpage results of the optimized solution decrease 26.0%and 20.2%,and the maximum and average errors of wall thickness compared to standard part decrease from 0.22 mm and 0.0517 mm using empirical parameters to 0.10 mm and 0.0356 mm using optimized parameters,*** framework is demonstrated capable of addressing the challenge of dimension control arising in the wax pattern production,and it can be reliably deployed in varied types of turbine blades to significantly reduce the manufacturing cost of turbine blades.

关键词： Hollow turbine blade Wax pattern fabrication Dimension control Multi-objective optimization Machine learning Numerical simulation

Ginger oil-loaded transdermal adhesive patch treats post-traumatic stress disorder

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Journal of Traditional Chinese Medical Sciences 2024年第3期11卷 316-329页

作者： Xingshuang Song Yizhi Zhang Ziyan Tang jing dai Yanping Wu Guiyu Huang Hong Niu Yaxin Wang Xu Jin Lina Du School of Pharmacy Shandong University of Traditional Chinese MedicineJinan 250355China Department of Pharmaceutical Sciences Beijing Institute of Radiation MedicineBeijing 100850China Information Department General Hospital of Western War ZoneChengdu 610083China Pharmaceutical College Henan UniversityKaifeng 475004China Beijing Tiantan Hospital Capital Medical UniversityBeijing 100070China Cancer Hospital Chinese Academy of Medical SciencesBeijing 100021China

Objective To find a viable alternative to reduce the number of doses required for the patients with post-traumatic stress disorder(PTSD),and to improve efficacy and patient *** In this study,we used ginger oil,a phytochemical with potential therapeutic properties,to prepare ginger oil ***-performance liquid chromatography(HPLC)was used to quantify the main active component of ginger oil,*** absorption experiments were conducted to optimize the various pressure-sensitive adhesives and permeation enhancers,including their type and ***,the ginger oil patches were optimized and subjected to content determination and property evaluations.A PTSD mouse model was established using the foot-shock *** therapeutic effect of ginger oil patches on PTSD was assessed through pathological sections,behavioral tests,and the evaluation of biomarkers such as tumor necrosis factor-α(TNF-α),interleukin-6(IL-6),brain-derived neurotrophic factor(BDNF),and melatonin(MT).Results The results demonstrated that ginger oil patches exerted therapeutic effects against PTSD by inhibiting inflammatory responses and modulating MT and BDNF *** experiments revealed that ginger oil patches maintained a stable blood drug concentration for at least one day,addressing the rapid metabolism drawback of 6-gingerol and enhancing its therapeutic *** Ginger oil can be prepared as a transdermal drug patch that meets these requirements,and the bioavailability of the prepared patch is better than that of oral *** can improve PTSD with good patient compliance and ease of ***,it is a promising therapeutic formulation for the treatment of PTSD.

关键词： Post-traumatic stress disorder 6-Gingerol Pressure sensitive adhesive patch Transdermal delivery

光声光谱技术应用于痕量气体浓度测量的研究进展

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光谱学与光谱分析 2024年第1期44卷 1-14页

作者：郑洪全戴景民哈尔滨工业大学仪器科学与工程学院黑龙江哈尔滨150001

光声光谱技术作为实现痕量气体浓度高效率、高精度测量的重要气体传感技术,因其响应速度快、灵敏度高、选择性好等优点被广泛应用到大气环境检测、电力系统故障诊断、医疗健康诊断等领域当中。首先介绍了光声光谱技术痕量气体浓度测量... 详细信息

光声光谱技术作为实现痕量气体浓度高效率、高精度测量的重要气体传感技术,因其响应速度快、灵敏度高、选择性好等优点被广泛应用到大气环境检测、电力系统故障诊断、医疗健康诊断等领域当中。首先介绍了光声光谱技术痕量气体浓度测量的基本原理,对应用光声效应实现痕量气体浓度测量的机理进行了简要的描述,同时,介绍了基于光声光谱技术的典型痕量气体浓度测量装置的结构。其次,从光声信号强度的理论分析出发,引出国内外学者在光声光谱痕量气体浓度测量领域的研究热点,为了实现基于光声光谱技术的痕量气体浓度测量装置更强的抗干扰能力、更紧凑的结构、更低的检测下限、更高的检测灵敏度,国内外学者的研究重点可以总结为以下三点:(1)辐射光源的选取和设计,以实现更佳辐射光源的输出波长、更宽的调谐范围、更高的辐射光源输出功率。(2)更优秀的光声池设计,以实现更高效的声能量积聚、更紧凑的结构和更强的抗干扰能力。(3)声敏探测器的设计,以实现更高的声音灵敏度、更高的信噪比。详细介绍了基于光声光谱痕量气体浓度测量装置的三个核心元件:辐射光源,主要介绍了相干光源和非相干光源的应用研究进展;光声池,主要介绍了光声池的设计原则以及非共振式和共振式光声池的应用研究进展;微音器,主要介绍了电容式微音器、压电式微音器的应用研究进展,并对近期研究热点石英增强光声光谱技术进行简要的介绍。在介绍目前辐射光源、光声池、微音器应用研究进展的同时,分析了各元件的优势和需要解决的问题。最后,总结了光声光谱技术应用于痕量气体浓度测量领域装置存在的信噪比不高、结构复杂、检测灵敏度和检测下限易受混合气体之间的交叉干扰等问题,并且对未来测量装置中的三个核心元件:辐射光源、光声池、微音器的发展趋势进行了展望。

关键词：光声光谱痕量气体检测辐射光源光声池微音器

考虑电力-交通耦合网动态协调的EV集群灵活性挖掘与优化调度

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电力系统自动化 2024年第7期48卷 127-137页

作者：刘志坚戴景杨灵睿昆明理工大学电力工程学院云南省昆明市650500

电动汽车(EV)作为兼具交通与能量双重属性的跨域主体,发挥其时空灵活性将助力电力-交通耦合网的协调运行。为此,文中考虑电力-交通耦合网综合效益,提出了EV集群调控策略。首先,基于弧阻抗函数构建了动态交通网络加载模型。其次,考虑EV... 详细信息

电动汽车(EV)作为兼具交通与能量双重属性的跨域主体,发挥其时空灵活性将助力电力-交通耦合网的协调运行。为此,文中考虑电力-交通耦合网综合效益,提出了EV集群调控策略。首先,基于弧阻抗函数构建了动态交通网络加载模型。其次,考虑EV用户的各特征参数存在的差异性与耦合性,构建了单体EV灵活运行域模型,并采用基于zonotope线性近似的闵可夫斯基和算法对其聚合,得到EV集群的时变灵活运行域。在此基础上,提出了动态交通流最优分配下EV集群灵活性调控的双层模型,迭代求解得到上下两层耦合变量构成的瞬时单位流量出行成本,从而引导EV的出行与充放电行为。最后,通过与最短路径引导策略进行比较,验证了所提EV集群调控策略的有效性。

关键词：电动汽车最优理论电力-交通耦合网动态交通流分配灵活运行域

Treatment of severe radiation proctitis with high dosage of vitamin C in combination with cyclooxygenase-2 inhibitor

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Radiation Medicine and Protection 2024年第2期5卷 113-117页

作者： Han Wu Miaomiao Liu Huangang Jiang Hui Xu Jin Peng jing dai Fuxiang Zhou Department of Radiation and Medical Oncology Zhongnan HospitalWuhan UniversityWuhan 430007China Hubei Key Laboratory of Tumor Biological Behaviors Zhongnan HospitalWuhan UniversityWuhan 430007China Hubei Clinical Cancer Study Center Zhongnan Hospital of Wuhan UniversityWuhan 430007China

Objective:To explore the new treatment strategies for radiation proctitis,which is the most common complication of pelvic tumor ***:Four cases of patients with severe radiation proctitis were treated with high-dosage vitamin C(VC,12–24 g/d,iv)combined with cyclooxygenase-2(cyclooxygenase-2,COX-2)***:For these four cases,the diarrhea,hematochezia,tenesmus,pain,and other symptoms were significantly *** edema of the rectal wall is also significantly improved in the imaging ***:The high-dosage VC combined with the treatment of severe radiation proctitis is safe and effective.

关键词： Radiation proctitis Vitamin C Cyclooxygenase-2 inhibitor Radiotherapy

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抗体片段在铂纳米粒子表面的构象重构

生物化学与生物物理进展 2024年第3期51卷 647-657页

作者：盛玲洁徐佳戴静静王海芳曹傲能上海大学环境与化学工程学院纳米化学与生物学研究所上海200444

目的最近在金纳米粒子(AuNPs)表面重构抗体片段的天然构象和功能的研究表明分子构象工程的可行性。本质上,分子构象工程就是要像蛋白质折叠一样,通过精确控制柔性非功能分子的构象使其产生新功能。本文在铂纳米粒子(PtNPs)表面重构抗体... 详细信息

目的最近在金纳米粒子(AuNPs)表面重构抗体片段的天然构象和功能的研究表明分子构象工程的可行性。本质上,分子构象工程就是要像蛋白质折叠一样,通过精确控制柔性非功能分子的构象使其产生新功能。本文在铂纳米粒子(PtNPs)表面重构抗体互补决定簇区(CDR)片段的天然构象和功能,旨在探索分子构象工程的普适性及揭示蛋白质结构-功能机制。方法本文将抗溶菌酶抗体(cAB-lys3)中的CDR3片段(在单独存在时没有稳定构象和功能)通过两个Pt-S键偶联到PtNPs表面。CDR片段的天然构象和功能的恢复通过它对溶菌酶活性的抑制来表征。结果通过多肽密度优化和表面聚乙二醇修饰,制得基于PtNPs的抗溶菌酶人工抗体(简称铂抗体)。溶菌酶活性测试结果表明,铂抗体可以特异性结合溶菌酶并显著抑制其活性。结论本文第一次在PtNPs表面重构了蛋白质片段的天然构象并恢复了其功能,证明分子构象工程可作为一种通用方法制备基于纳米粒子的人工蛋白质。

关键词：抗体溶菌酶构象工程铂纳米粒子多肽