检索结果-南通市图书馆

A multiscale study of the penetrationenhancing mechanism of menthol

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Traditional Chinese Medical Sciences 2019年第4期6卷 347-354页

作者： Liping Chen Lina Ma Shufang Yang Xiaowen Wu xingxing dai Shifeng Wang Xinyuan Shi School of Chinese Materia Medica Beijing University of Chinese MedicineBeijing 102488China Key Laboratory for Production Process Control and Quality Evaluation of Traditional Chinese Medicine Beijing Municipal Science&Technology CommissionBeijing 100029China Department of Molecular Cellular and Developmental BiologyUniversity of ColoradoBoulderCO 80309USA

Objective:Transdermal drug delivery systems represent a critical focus in the pharmaceutics field;however,their use is limited by the fact that many drugs usually pass through the skin with low *** is a common penetration enhancer because of its high penetration-enhancing efficiency and *** research aimed to reveal the penetrationenhancing mechanisms of menthol via a multiscale ***:First,the interaction of menthol with the stratum corneum was studied using vertical Franz diffusion cells obtained from the abdominal skin of rats as a ***,the skin samples were observed via transmission electron ***,the interaction of different concentrations of menthol with a mixed lipid model of the stratum corneum was investigated via molecular dynamics simulation using the GROMOS 54A7 force field on a microcosmic ***:At concentrations of 3.5%or lower,menthol changed the original structure of the stratum corneum to varying degrees,which increased its fluidity and facilitated the permeation and storage of *** increased the fluidity of the stratum corneum mainly via two ***,menthol had strong hydrogen-bonding capability,and it could compete for the lipidelipid hydrogen bonding sites,thereby weakening the stability of the hydrogenbonding network connecting the skin *** addition,menthol had strong affinity for cholesterol,probably due to their similar molecular structures,suggesting that the incorporation of menthol would increase the fluidity of the lipid membrane similarly to ***:The penetration-enhancing mechanism of menthol was explained using in vitro and molecular dynamics simulation *** findings may advance the basic research of transdermal drug delivery systems and facilitate the discoveries of novel penetration enhancers.

关键词： Menthol Molecular dynamics simulations Permeability

Molecular dynamics simulation studies of transmembrane transport of chemical components in Chinese herbs and the function of platycodin D in a biological membrane

在线全文

学校读者我要写书评

暂无评论

Journal of Traditional Chinese Medical Sciences 2017年第2期4卷 174-183页

作者： Shufang Yang Haiou Ding Ran Wang xingxing dai Xinyuan Shi Yanjiang Qiao School of Chinese Materia Medica Beijing University of Chinese MedicineBeijing 102488China School of Traditional Chinese Medicine Capital Medical UniversityBeijing 100069China

Objective:To study the transmembrane transport of chemical components of Chinese herbs and to explore the function of platycodin D (PD) on ***:Interaction between PD and the dipalmitoylphosphatidylcholine (DPPC) bilayer was reproduced by molecular dynamics simulation with the Martini force field.A model validation and methodological study were first performed,and were based on simulation investigations of transmembrane transport for three herbal compounds with distinct hydrophilic ***:PD increased the mobility of the DPPC bilayer since its aglycone strongly interacted with the hydrophobic layer,which broke the structure of the gate layer,and weakened the ordered performance of hydrophobic ***:The Martini force field was successfully applied to the study of the interaction between herbal compounds and a biological *** combining the dynamics equilibrium morphology,the distribution of drugs inside and outside the biomembrane,and the interaction sites of drugs on the DPPC bilayer,factors influencing transmembrane transport of drugs were elucidated and the function of platycodin D in a biological membrane was reproduced.

关键词： Platycodin D Biomembrane fluidity Molecular dynamics simulations Dipalmitoyl-phosphatidylcholine bilayer Transmembrane transport

Study on the interaction between volatile oil components and skin lipids based on molecular docking techniques

在线全文

学校读者我要写书评

暂无评论

Digital Chinese Medicine 2024年第2期7卷 148-159页

作者： REN Weishuo WULAN Tuya dai xingxing ZHANG Yingying JIA Mingyue FENG Minfang SHI Xinyuan School of Chinese Materia Medica Beijing University of Chinese MedicineBeijing 102488China Key Laboratory for Production Process Control and Quality Evaluation of Traditional Chinese Medicine Beijing Municipal Science&Technology CommissionBeijing 102488China School of Life Sciences Beijing University of Chinese MedicineBeijing 100029China

Objective To analyze the interactions between different structural types of volatile oil compo-nents(VOCs)and skin lipid molecules;and investigate the mechanism of volatile oil in Chi-nese materia medica(VOCMM)as penetration *** In this study;210 different structural types of VOCs were selected from the VOCMM penetration enhancer database;and the molecular docking experiments were conducted with three main lipid molecules of skin:ceramide 2(CER2);cholesterol(CHL);and free fatty acid(FFA).Each VOC was docked individually with each lipid *** analysis was used to explore the relationship between the binding energy of VOCs and their molecular *** specific pathogen-free(SPF)Sprague Dawley(SD)rats were randomly divided in-to Control;Nootkatone;and 3-Butylidenephthalide groups for in vitro percutaneous experi-ments;with three rats in each *** donor pool solutions were 3%gastrodin;3%gas-trodin+3%nootkatone;and 3%gastrodin+3%3-butylidenephthalide;*** pen-etration enhancing effects of VOCs with higher binding energy were evaluated by comparing the 12-hour cumulative percutaneous absorption of gastrodin(Q12;µg/cm²).Results(i)Most of the VOCs were non-hydrogen bonded to the hydrophobic parts of CHL and FFA;and hydrogen bonded to the head group of *** them;sesquiterpene ox-ides showed the most pronounced binding affinity to *** VOCs with 2-4 rings(in-cluding carbon rings;benzene rings;and heterocycles)demonstrated stronger binding affini-ty for three skin lipid molecules compared with the VOCs without intramolecular rings(P<0.01).(ii)According to the cluster analysis;most of the VOCs that bond well to CER2 had 2-3 intramolecular *** non-oxygenated VOCs were bonded to CER2 in a hydrophobic *** oxygenated VOCs were mostly bonded to CER2 by hydrogen bonding.(iii)The results of Franz diffusion cell experiment showed that the Q12 of Control group was 260.60±25.09µg/cm2;and the transdermal absorption o

关键词： Chinese materia medica Volatile oil Stratum corneum lipids Transdermal penetration-enhancing effects Molecular docking Ceramide 2(CER2) Penetration enhancers

汪建民应用推拿手法联合针刺治疗神经根型颈椎病临床经验

在线全文

学校读者我要写书评

暂无评论

中国民间疗法 2020年第15期28卷 19-20页

作者：戴星星南京中医药大学江苏南京210023

神经根型颈椎病指颈椎和椎间盘退行性改变及其继发性病理改变所致的以神经根受压引起相应神经分布区疼痛为主要临床表现的总称。该文总结汪建民在临床中应用推拿手法联合针刺治疗神经根型颈椎病的经验。

关键词：神经根型颈椎病推拿手法针刺汪建民

Approach from the laboratory to the field: New strategies in the control of mosquito-borne infectious diseases

在线全文

学校读者我要写书评

暂无评论

Science China(Life Sciences) 2025年第1期68卷 303-305页

作者： Ziqian Xu Lianpan dai Jun Liu National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases(NITFID) National Institute for Viral Disease Control and PreventionChineseCenter for Disease Control and PreventionBeijing 102206China CAS Key Laboratory of Pathogen Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China

Vector-borne viruses,transmitted among humans and animal hosts through bites of vectors such as mosquitoes and ticks,pose a great and ongoing threat to public health and biosafety(Yang et al.,2022).Among them,dengue virus-induced epidemics,have dramatically increased worldwide in recent *** report released by the World Health Organization(WHO)at the end of 2023 showed that dengue epidemic globally surged in 2023,with the number of reported cases nearing a historical *** the first four months of 2024,more than 6 million people worldwide were infected by dengue virus,with more than 2,000 *** countries around the world especially the American countries issued warnings,reporting three times the number of dengue cases compared with the same period last *** global climate change,population growth,and urbanization,flaviviral diseases transmitted by Aedes mosquitoes remain a major global biosecurity challenge.

关键词： diseases globally

Research status and prospects of the fractal analysis of metal material surfaces and interfaces

在线全文

学校读者我要写书评

暂无评论

International Journal of Minerals,Metallurgy and Materials 2025年第1期32卷 20-38页

作者： Qinjin dai Xuefeng Liu Xin Ma Shaojie Tian Qinghe Cui Beijing Advanced Innovation Center for Materials Genome Engineering University of Science and Technology BeijingBeijing 100083China Beijing Laboratory of Metallic Materials and Processing for Modern Transportation University of Science and Technology BeijingBeijing 100083China Laboratory for Advanced Materials Processing of Ministry of Education University of Science and Technology BeijingBeijing 100083China School of Mechanical and Electrical Engineering Xinjiang Institute of EngineeringUrumqi 830023China

As a mathematical analysis method,fractal analysis can be used to quantitatively describe irregular shapes with self-similar or self-affine *** analysis has been used to characterize the shapes of metal materials at various scales and *** methods make it difficult to quantitatively describe the relationship between the regular characteristics and properties of metal material surfaces and ***,fractal analysis can be used to quantitatively describe the shape characteristics of metal materials and to establish the quantitative relationships between the shape characteristics and various properties of metal *** the perspective of two-dimensional planes and three-dimensional curved surfaces,this paper reviews the current research status of the fractal analysis of metal precipitate interfaces,metal grain boundary interfaces,metal-deposited film surfaces,metal fracture surfaces,metal machined surfaces,and metal wear *** relationship between the fractal dimensions and properties of metal material surfaces and interfaces is *** from three perspectives of fractal analysis,namely,research scope,image acquisition methods,and calculation methods,this paper identifies the direction of research on fractal analysis of metal material surfaces and interfaces that need to be *** is believed that revealing the deep influence mechanism between the fractal dimensions and properties of metal material surfaces and interfaces will be the key research direction of the fractal analysis of metal materials in the future.

关键词： metal material surfaces and interfaces fractal analysis fractal dimension homogeneity

Emerging trends in the selective production of value-added aromatics

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2025年第1期68卷 15-20页

作者： Yuchao Wu Houliang dai Weisheng Yang Yaxing Li Lichen Liu Petrochemical Research Institute Company Limited China National Petroleum CorporationBeijing 102206China Engineering Research Center of Advanced Rare Earth Materials Department of ChemistryTsinghua UniversityBeijing 100084China

1 Introduction Aromatics(mainly benzene,toluene,and xylenes,BTX)are essential intermediates in the chemical *** are employed in the synthesis of a broad spectrum of chemicals and materials,e.g.,various polymers,plastics,resins,solvents,dyes,pharmaceuticals^([1]).The manufacturing pathway of BTX mainly includes petroleum reforming of naphtha,coal-to-aromatics,methanol-to-aromatics^([2]).

关键词： reforming methanol resins

在线全文

学校读者我要写书评

暂无评论

人参皂苷Ro胶束化影响因素的介观模拟研究

世界科学技术-中医药现代化 2012年第4期14卷 1767-1772页

作者：戴幸星王宇光史新元乔延江首都医科大学中医药学院北京100069 北京中医药大学中药学院北京100102

为研究中药制剂过程中不同因素对人参皂苷Ro胶束化的影响,指导中药难溶性成分增溶,本文采用介观动力学方法(MesoDyn),考察Ro的临界胶束浓度(CMC)及聚集形态随温度、难溶性药物柴胡皂苷a(SSa)的浓度及体系盐强度的变化。结果表明,常温条... 详细信息

为研究中药制剂过程中不同因素对人参皂苷Ro胶束化的影响,指导中药难溶性成分增溶,本文采用介观动力学方法(MesoDyn),考察Ro的临界胶束浓度(CMC)及聚集形态随温度、难溶性药物柴胡皂苷a(SSa)的浓度及体系盐强度的变化。结果表明,常温条件下Ro的CMC约为1.29%(V/V);随着温度升高,CMC升高,胶束形成时间延长,不利于Ro胶束形成;难溶性药物SSa可在水溶液中先聚集成核,促进Ro的聚集,从而使其CMC随SSa浓度的增加而显著降低;体系盐强度对Ro的CMC无显著影响。

关键词：介观模拟人参皂苷Ro增溶临界胶束浓度

Predictability Study of Weather and Climate Events Related to Artificial Intelligence Models

在线全文

学校读者我要写书评

暂无评论

Advances in Atmospheric Sciences 2025年第1期42卷 1-8页

作者： Mu MU Bo QIN Guokun dai Department of Atmospheric and Oceanic Sciences&Institute of Atmospheric Sciences Fudan UniversityShanghai 200438China Shanghai Key Laboratory of Ocean-land-atmosphere Boundary Dynamics and Climate Change Fudan UniversityShanghai 200438China Shanghai Frontiers Science Center of Atmosphere-Ocean Interaction Fudan UniversityShanghai 200438China CMA-FDU Joint Laboratory of Marine Meteorology Shanghai 200438China Key Laboratory of Polar Atmosphere-ocean-ice System for Weather and Climate Ministry of EducationShanghai 200438China

Conducting predictability studies is essential for tracing the source of forecast errors,which not only leads to the improvement of observation and forecasting systems,but also enhances the understanding of weather and climate *** the past few decades,dynamical numerical models have been the primary tools for predictability studies,achieving significant ***,with the advances in artificial intelligence(AI)techniques and accumulations of vast meteorological data,modeling weather and climate events using modern data-driven approaches is becoming trendy,where FourCastNet,Pangu-Weather,and GraphCast are successful *** this perspective article,we suggest AI models should not be limited to forecasting but be expanded to predictability studies,leveraging AI's advantages of high efficiency and self-contained optimization *** this end,we first remark that AI models should possess high simulation capability with fine spatiotemporal resolution for two kinds of predictability *** models with high simulation capabilities comparable to numerical models can be considered to provide solutions to partial differential equations in a data-driven ***,we highlight several specific predictability issues with well-determined nonlinear optimization formulizations,which can be well-studied using AI models,holding significant scientific *** addition,we advocate for the incorporation of AI models into the synergistic cycle of the cognition–observation–model *** predictability studies have the potential to transform“big data”to“big and better data”and shift the focus from“AI for forecasts”to“AI for science”,ultimately advancing the development of the atmospheric and oceanic sciences.

关键词： predictability artificial intelligence models simulation and forecasting nonlinear optimization cognition–observation–model paradigm