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Space Life Science of China in 2015

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空间科学学报 2016年第5期36卷 788-804页

作者： MA Hong Lü Xuefei dai rongji LI Yujuan ZHANG Yongqian LI Xiaoqiong WANG Rui QING Hong LI Qiang SUI Li ZHUANG Fengyuan DENG Yulin School of Life Science Beijing Institute of Technology Department of Space Radiobiology Key Laboratory of Heavy Ion Radiation Biology and MedicineInstitute of Modern PhysicsChinese Academy of Sciences Beijing Tandem Accelerator Nuclear Physical National Laboratory Nuclear Physics DepartmentChina Institute of Atomic Energy

With the human space exploration activities,space life science is an emerging interdisciplinary and it covers a wide range of *** on our country's manned space station and recoverable satellite science experimental platform,the development of space life science research is very important to acquire new knowledge or new innovation in technology,to give further services to the human space exploration activities,to improve the national economic and social *** on present situation,both theoretical and applied researches were continuously performed ***,we review and summarize the researches on space life sciences which were contributed by Chinese scientists.

关键词：空间生命科学中国科学家探索活动载人空间站交叉学科实验平台技术学习科学研究

Surface ultrastructure of the olfactory rosette of loach fish,Triplophysa dalaica(Kessler,1876)(Cypriniformes:Balitoridae)

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Surface ultrastructure of the olfactory rosette of loach fis...

中国海洋湖沼学会鱼类学分会、中国动物学会鱼类学分会2012年学术研讨会

作者： Baradi Waryani Zhao Ya-hui dai rongji Zhang Chunguang School of Biological Sciences Beijing Institute of Technology Institute of Zoology Chinese Academy of Sciences Department of Fresh water Biology and Fisheries University of SindhJamshoro Pakistan

The olfactory organ in adult loach Triplophysa dalaica collected from the Dali-Nor Lake,Inner Mongolia,China,was examined by scanning electron microscopy(SEM).The oval shaped olfactory is located on the dorsal side of... 详细信息

关键词： SEM study olfactory epithelium Triplophysa dalaica

Effect of graft ratio to temperature response of Dilute Thermoresponsive Polymer Brush Surfaces

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Effect of graft ratio to temperature response of Dilute Ther...

第二十届全国色谱学术报告会及仪器展览会

作者： Yanli Liang Zongjian Liu rongji dai Weiwei Meng Yulin Deng The school of life science Beijing institute of technology

4 kinds of PNIPAAm grafted silica with variable grafting ratio under the same grafting density were prepared via *** grafting density of ATRP-initiator was regulated through the feed ratio of acetic chloride to 2-bromoisobutyryl *** chemical group of the stationary phase was assayed by a Fourier transform infrared spectroscopy（FT-IR）method and the content of element C、H、N was measured by elemental *** grafting ratio was measured by Thermogravimetric analysis（TGA）.The rentention behavior of 4 kinds of steroids under different temperature was ***,lnk’of 10 kinds of compounds with different hydrophobicity was studied under 30°C and 35°*** results indicated that grafting ratio under the same grafting density had a significant influence on the separation *** the increase of grafting ratio,thermosensitivity was enhanced,peak width was increased,and elution time *** it is critical that best grafting rate of temperature sensitive chromatographic materials to separation.

关键词： temperature response materials separation chromatography retention behavior

Preparation of Thermally Switchable Chromatographic Materials and Investigation on Their Applications in Separation and Enrichment

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Preparation of Thermally Switchable Chromatographic Material...

第二十届全国色谱学术报告会及仪器展览会

作者： rongji dai Yanli Liang Zongjian Liu Weiwei Meng Yulin Deng The school of life science Beijing institute of technology

＜正＞A new thermosensitive chromatographic materials,poly（N-isopropylacrylam-ide-co-2-（diethylamino）ethylmethacrylate-co-N-tert-butylacrylam ide）[poly（NIPAAm-co--DEAEMA-co-t BAAm）]grafted silicafeaturing thermally switchable property was prepared via SI-ATRP and then employedfor the enrichment and separation of biomolecules such as adenosine phosphatesand proteins via a temperature-controlled captureand release *** achieve the desired thermosensitivity,the grafting

关键词： temperature-responsive polymer N-isopropylacrylamide(NIPAAm) N-isopropylacrylamide-co-2-(diethylamino)ethylmethacrylate-co-N-tert-butylacrylamide(DEAEMA) 4-vinylphenylboronic acid(VPBA) switchable chromatography

The thermosensitivity and separation efficiency of steroids on silica bead grafted by varied ratio under same length of poly(N-isopropylacrylamide)

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The thermosensitivity and separation efficiency of steroids ...

中国化学会第29届学术年会

作者： Yanli Liang Linlin Dong Fang Lv Weiwei Meng rongji dai Yulin Deng School of Life Science beijing institute of technology

Poly(N-isopropylacrylamide)(PNIPAAm)-modified silica bead with varied grafting density and same length was prepared via atom transfer radical polymerization(ATRP). The grafting ratio of PNIPAAm was characterized by thermogravimetric analysis(TGA), and length of them was determined by gel permeation chromatography(GPC). Our results showed that all of these stationary phases exhibit a lower critical solution temperature(LCST), it is between 30oC to 40 oC. The elution behavior of five steroids was investigated by using water as mobile phase. The results showed that PIPAAm grafting density has a crucial influence on separation efficiency of thermosensitive chromatographic stationary phase. On less PNPAAm chains on silica surface, short retention time, narrower peak width was observed compared with more PNIPAAm. But if the grafting density was too more, the column efficiently would be get worse. So the proper grafting ratio of the PNIPAAm on the suface of the silica is crucial.

关键词： Poly(N-isopropylacrylamide) grafting ratio thermosensitivity column efficiency

龙血竭抗癌成分的虚拟筛选及体外抗癌活性检测验证

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北京理工大学学报 2023年第4期43卷 429-438页

作者：刘芳戴荣继吕芳邓玉林北京理工大学生命学院北京100081

应用计算机辅助虚拟筛选技术研究龙血竭抗癌活性成分.以HER2为靶蛋白受体,对龙血竭149种已知化合物进行了虚拟筛选,对其中具有潜在活性的成分进行了体外HER2影响测定以及SK-Br-3抗癌活性检测验证.结果表明,HER2靶蛋白分子对接模型具有... 详细信息

应用计算机辅助虚拟筛选技术研究龙血竭抗癌活性成分.以HER2为靶蛋白受体,对龙血竭149种已知化合物进行了虚拟筛选,对其中具有潜在活性的成分进行了体外HER2影响测定以及SK-Br-3抗癌活性检测验证.结果表明,HER2靶蛋白分子对接模型具有较强的活性分子富集能力,与HER2受体有效对接、具有抗癌潜力的活性分子主要为二氢查耳酮、黄烷、甾体以及芪类成分,与HER2胞外域和胞内域结合的4种成分及能与HER2胞内域结合的3种成分均能显著的抑制体外HER2活性,其中反式3-甲氧基-4′,5-二羟基二苯乙烯、反式3,4′,5-三羟基二苯乙烯能够抑制SK-Br-3癌细胞增殖、改变细胞周期,引发SK-Br-3极显著凋亡,具有良好的体外抗癌活性,可为龙血竭抗癌药物的研发提供基础数据.

关键词：龙血竭抗癌成分虚拟筛选体外抗癌活性

Meta-analysis of dragon's blood resin extract as radio-protective agent

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Journal of Coastal Life Medicine 2017年第9期5卷 409-416页

作者： Subaika Mahmood Toseef Fatima Hina Zulfaqar Romana Saher Muhammad Rafiq Abdul Rehman rongji dai Muhammad Ashfaq Murtaza Hasan Department of Biochemistry&Biotechnology(Baghdad-ul-Jadeed Campus) the Islamia University of BahawalpurBahawalpur63100Pakistan School of life Sciences Beijing Institute of TechnologyBeijing100081People’s Republic of China

In health sciences, much efforts had been made in past years to explore the radio-protective agents from natural resources due to rapid exposure of radiations to environment such as space traveling, radiotherapy and largely growing telecommunication industry. It becomes crucial to find natural sources for radio-protection. In correspondence, dragon's blood (DB) is a traditional Chinese medicinal plant that possesses great medicinal values due to the presence of several phenolic compounds. For a long time, DB has been used in treatment of blood stasis, inflammation, oxidative stress, immune suppression and tumors, but recently it has been extensively used as radio-protective agent. There is no comprehensive review on radio-protective characterization of DB resin extract in literature. In our review, an attempt has been made to highlight unique and inherent radio-protection in liver, brain, kidney, lung, spleen and cerebrum. This review will help people in exploring the radioactive protectants from natural resources.

关键词： Dragon's blood Bioreduction Radioprotection Oxidative stress Immune suppression

用于富集磷酸化合物的温度敏感亲和色谱材料的制备及其应用

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色谱 2019年第4期37卷 376-382页

作者：戴国鑫王迪王彦曹之涵戴荣继北京理工大学生命学院北京100081

基于可逆加成断裂链转移聚合(RAFT)法,通过快速引入官能团的方式合成了固定化金属离子温度敏感亲和色谱材料二氧化硅@聚(N-异丙基丙烯酰胺-co-氨甲基膦酸)-钛离子(Ⅳ)(silica@p(NIPAAm-co-AMPA)-Ti^(4+)),并应用于HPLC中。采用红外光谱... 详细信息

基于可逆加成断裂链转移聚合(RAFT)法,通过快速引入官能团的方式合成了固定化金属离子温度敏感亲和色谱材料二氧化硅@聚(N-异丙基丙烯酰胺-co-氨甲基膦酸)-钛离子(Ⅳ)(silica@p(NIPAAm-co-AMPA)-Ti^(4+)),并应用于HPLC中。采用红外光谱、X-射线光电子能谱、热失重和差示量热法对制备的材料进行表征,证明该材料被成功合成并具有较好的温度敏感性能。将该材料用于三磷酸腺苷(ATP)标准品的富集与分离,实现了仅通过改变固定相温度的方式来达到富集与分离小分子磷酸化合物的目的,为富集分离磷酸化肽段奠定了基础。同时该材料还能以在线补充钛离子的方式延长使用寿命。

关键词：可逆加成断裂链转移聚合富集与分离温度敏感色谱材料

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生物样品处理技术研究进展与策略

航天医学与医学工程 2015年第4期28卷 303-308页

作者：石宇戴荣继邓玉林北京理工大学生命学院北京100081

生物样品主要包括生物组织、体液、血液、细胞等,具有成分复杂、活性成分含量高、保存时间短及干扰物质多等特点。在进行生物科学研究时,往往需要对各种生物样品进行处理,以获得目标分析物。常用的样品处理方法有萃取法,膜分离法和色谱... 详细信息

生物样品主要包括生物组织、体液、血液、细胞等,具有成分复杂、活性成分含量高、保存时间短及干扰物质多等特点。在进行生物科学研究时,往往需要对各种生物样品进行处理,以获得目标分析物。常用的样品处理方法有萃取法,膜分离法和色谱法等。随着科技手段的进步,这些传统的方法被不断地改进与创新,在操作过程的简易化、分离提取的高效性和应用的广泛性上获得了极大的提高。本文针对生物样品处理技术在近些年来的研究报道进行了综述,包括技术的特点、方法及其在生物学上的应用。最后预测了其在空间生物学上的应用前景。

关键词：生物样品萃取超滤生物医学微重力