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合并抑郁对妊娠期糖尿病分娩结局的影响

国际精神病学杂志 2024年第2期51卷 557-559页

作者：寇国桢代文华驻马店市中医院驻马店463000

目的探讨合并抑郁对妊娠期糖尿病(gestational diabetes mellitus,GDM)分娩结局的影响。方法选择驻马店市中医院2020年2月~2023年4月82例GDM孕产妇为观察对象,采用汉密尔顿抑郁量表进行产前抑郁评估,根据是否抑郁设为观察组以及对照组... 详细信息

目的探讨合并抑郁对妊娠期糖尿病(gestational diabetes mellitus,GDM)分娩结局的影响。方法选择驻马店市中医院2020年2月~2023年4月82例GDM孕产妇为观察对象,采用汉密尔顿抑郁量表进行产前抑郁评估,根据是否抑郁设为观察组以及对照组。比较两组孕产妇围产期不良事件以及新生儿不良分娩结局。结果82例GDM孕产妇合并抑郁28例;观察组胎膜早破、剖宫产率显著高于对照组(P0.05);观察组早产、巨大儿、窒息发生率显著高于对照组(P0.05)。结论GDM孕产妇抑郁检查率较高,合并抑郁会增加剖宫产率以及孕产妇围产期不良事件以及新生儿不良分娩结局发生率。

关键词：抑郁妊娠期糖尿病分娩结局

基于多尺度卷积神经网络的多源数据融合岩性分类方法

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激光与光电子学进展 2024年第14期61卷 363-372页

作者：戴嵩孙喜明张精明朱永山王斌宋冬梅中国石油大学(华东)海洋与空间信息学院山东青岛266580 中国石油集团东方地球物理勘探有限责任公司河北涿州072750

在岩性分类任务中,利用单一数据源获取的特征信息有限,因此多源数据融合成为提高岩性分类准确性的重要手段。航空遥感影像和数字高程模型作为典型的遥感数据源,可以提供互补的光谱和高程信息。为了提升岩性分类的精度,提出一种融合通道... 详细信息

在岩性分类任务中,利用单一数据源获取的特征信息有限,因此多源数据融合成为提高岩性分类准确性的重要手段。航空遥感影像和数字高程模型作为典型的遥感数据源,可以提供互补的光谱和高程信息。为了提升岩性分类的精度,提出一种融合通道空间注意力机制与多尺度卷积神经网络的多源遥感数据岩性分类方法。该方法通过设计多尺度空洞卷积模块,增强卷积神经网络对航空遥感影像和数字高程模型深层特征的学习能力,从而更好地捕捉特征的空间关系,并有效消除异构数据在原始数据空间上的结构差异。此外,通过设计局部和全局的多尺度通道空间注意力模块,以自适应方式为多源数据的光谱通道和空间区域赋予不同的权重,从而利用特征的显著性实现更有针对性的网络训练,进一步提升模型的分类性能。最后,以四川某盆地为研究区域进行有效性验证。实验结果表明,所提方法在总体分类精度、平均分类精度等评价指标上明显优于4种典型的机器学习方法,证实了所提多源数据融合方法能够充分利用不同数据源的互补优势,从而有效提高地质岩性的判别精度。

关键词：航空遥感影像数字高程模型岩性分类特征融合卷积神经网络

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低碳钢淬火强化工艺在链传动行业的应用

热处理技术与装备 2024年第3期45卷 37-41页

作者：代玉杰毕高杰青岛征和工业股份有限公司山东青岛266705

低碳钢淬火后可得到低碳马氏体组织,具有高强度和良好的塑韧性匹配以及低的冷脆转变温度,同时还有缺口敏感性和过载敏感度较低、断裂韧性高、耐磨性强等优点。为了获得低碳马氏体,必须注意低碳钢材料的选择、淬火加热温度、保温时间、... 详细信息

低碳钢淬火后可得到低碳马氏体组织,具有高强度和良好的塑韧性匹配以及低的冷脆转变温度,同时还有缺口敏感性和过载敏感度较低、断裂韧性高、耐磨性强等优点。为了获得低碳马氏体,必须注意低碳钢材料的选择、淬火加热温度、保温时间、冷却介质和回火等工艺参数,并且结合具体实例确定了低碳马氏体在链传动零件中实际应用的可行性。

关键词：低碳钢低碳马氏体机械性能淬火链传动

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Serum sex hormone and growth arrest-specific protein 6 levels in male patients with coronary heart disease

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Asian Journal of Andrology 2016年第4期18卷 644-649页

作者： Rui Zhao Yan Li Wen dai Department of Clinical Laboratory Renmin Hospital of Wuhan University Wuhan 430060 Hubei Province China.

Epidemiological studies have shown a high prevalence of low serum testosterone levels in men with cardiovascular disease. Moreover, the tyrosine kinase receptor Axl, the ligand of which is growth arrest-specific protein 6 （GAS6）, is expressed in the vasculature, and serum GAS6 levels are associated with endothelial dysfunction and cardiovascular events. Testosterone regulates GAS6 gene transcription directly, which inhibits calcification of vascular smooth muscle cells and provides a mechanistic insight into the cardioprotective action of androgens. This study was designed to determine the correlation between serum GAS6 and testosterone levels in male patients with coronary heart disease （CHD）. We recruited 225 patients with CHD and 102 apparently healthy controls, Serum concentrations of GAS6 and soluble Axl were quantified by an enzyme-linked immunosorbent assay. Levels of high-sensitivity C-reactive protein, testosterone, estradiol, and other routine biochemical markers were also measured. Testosterone decreased from 432.69 ± 14.40 to 300.76± 6.23 ng d1-1 （P 〈 0.001） and GAS6 decreased from 16.20± 0.31 to 12.51 ± 0.19 ng ml-1 （P 〈 0.001） in patients with CHD, compared with control subjects. Multiple linear regression analysis showed that serum testosterone and GAS6 levels were positively associated in male patients with CHD. Alterations in GAS6 levels may influence the development of CHD. Downregulation of GAS6/Axl signaling in the presence of low sex hormone levels during disease progression is a potential mechanism by which GAS6 affects CHD. This study provides novel results regarding the influence of sex hormones on serum GAS6 levels in patients with CHD.

关键词： coronary heart disease growth arrest-specific protein 6 soluble Axl testosterone

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樟树港辣椒高口感品质嫩果尖椒产业的发展

中国蔬菜 2024年第7期 1-5页

作者：邹学校杨莎戴雄泽朱凡徐昊远方湖南农业大学园艺学院湖南长沙410128 园艺作物种质创新与分子育种教育部国际合作研究联合实验室湖南长沙410128 园艺作物种质创新与新品种选育教育部工程研究中心湖南长沙410128 蔬菜生物学湖南省重点实验室湖南长沙410128 农业农村部园艺作物(蔬菜、茶叶等)基因资源评价与利用重点实验室(试运行) 湖南长沙410128 岳麓山实验室湖南长沙410128

樟树港辣椒已有200多年的栽培历史。本文重点介绍了樟树港辣椒嫩果尖椒的来源,高口感品质形成的机理,产业发展历史和存在问题。针对嫩果尖椒产业存在的问题,育成能满足不同市场需求的高品质嫩果尖椒新品种,研发高口感品质嫩果尖椒高产... 详细信息

樟树港辣椒已有200多年的栽培历史。本文重点介绍了樟树港辣椒嫩果尖椒的来源,高口感品质形成的机理,产业发展历史和存在问题。针对嫩果尖椒产业存在的问题,育成能满足不同市场需求的高品质嫩果尖椒新品种,研发高口感品质嫩果尖椒高产栽培的技术,并迅速在全国推广。高口感品质嫩果尖椒迅速畅销全国,实现了周年均衡供应。樟树港辣椒由地方品牌提升为全国知名高端品牌,实现樟树港辣椒高口感品质嫩果尖椒向“樟树港辣椒”品牌高口感品质嫩果尖椒的飞跃。

关键词：樟树港辣椒高口感品质嫩果尖椒产业育种与栽培

Industrial Agglomeration Externalities, City Size, and Regional Economic Development： Empirical Research Based on Dynamic Panel Data of 283 Cities and GMM Method

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Chinese Geographical Science 2017年第3期27卷 456-470页

作者： ZHU Huayou dai Zejuan JIANG Ziran College of Economic and Management Zhejiang Normal University Jinhua 321004 China

Local governments have long been ardently pursuing the industrial specialization effect(MAR externalities) and industrial diversification effect(Jacobs externalities). Such a pursuit has resulted in severe distortion of resource allocation and negative effect on sustainability of local economic development. Regarding the effect from both MAR and Jacobs externalities on local economic development existing literature records notable disputes. Therefore, for local economic development, one important issue is which externality(MAR or Jacobs) can better bring the effect into play. By studying a panel data of 283 Chinese cities from 2003 to 2012 and applying dynamic plane data GMM method, this paper conducted a regression analysis of the relationship among industrial agglomeration externalities, city size, and regional economic development. The result indicates that with regard to the whole nation, MAR externalities are conducive to regional economy development whereas Jacobs externalities will, to an extent, restrain regional economic development. As regards eastern, middle, and western regions, MAR externalities are conducive only to the economic development of the eastern region; their effects on middle and western regions are insignificant. Moreover, the interaction item between MAR externalities and city size has a significant negative synergistic effect on national economic development and a certain acceleration effect on eastern region as well as a strong negative synergistic effect on the middle region and an insignificant effect on the western region. The interaction item between Jacobs externalities and city size has a positive synergistic effect on only the middle region and has an insignificant synergistic effect on both eastern and western regions. Capital stock and labor input have significant accelerating effects on GDP growth per capita of Chinese cities, whereas material capital and labor input remain primary driving forces for Chinese local economic deve

关键词： MAR externalities Jacobs externalities city size regional economic development

Air pollution, food production and food security: A review from the perspective of food system

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Journal of Integrative Agriculture 2017年第12期16卷 2945-2962页

作者： Feifei Sun dai Yun Xiaohua Yu Department of Agricultural Economics and Rural Development University of Goettingen Lingnan College Sun Yat-sen University

Air pollution negatively impacts food security. This paper reviews the current literature on the relationship between air pollution and food security from the perspective of food system. It highlights that agricultural emissions which substantially contribute to air pollution could happen at every stage along the food supply chain. Meanwhile, air pollution can not only affect plant growth and animal health but also shift market equilibrium of both agro-inputs and outputs in the food supply chain and thereby affect food security indirectly. Furthermore, this study evaluates the effects of agricultural policy and energy policy on food security and air pollution, respectively, and provides an overview of potential policy instruments to reduce air pollution while ensuring food security. Finally, we identify the remaining research and policy issues for further studies, mainly focusing on the study of household＇s bounded rational behaviors and the issue of rural aging population.

关键词： Air pollution food production and food security: A review from the perspective of food system

Asymmetric Dearomatization of Electron-Deficient Heteroarenes by a Phosphine-Catalyzed[3+2]Annulation with Vinylcyclopropanes

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CCS Chemistry 2023年第9期5卷 2023-2032页

作者： Xuan dai Fuhao Zhang Lei dai Yixin Lu Department of Chemistry National University of SingaporeSingapore 117543 School of Chemical Engineering Nanjing University of Science and TechnologyNanjing 210094

Asymmetric dearomatization reactions of various electron-deficient heteroarenes,including benzofurans,benzothiophenes,and indoles,have been *** a phosphine-catalyzed[3+2]annulation with vinylcyclopropanes,readily available heteroarene feedstocks undergo smooth dearomatization reactions,delivering a diverse array of valuable chiral cyclopentabenzodihydrofuran and cyclopentaindoline scaffolds in a highly diastero-and enantioselective ***,the employment of cyclopropanes in phosphine-mediated annulation for the dearomatization of electron-deficient arenes is unknown.

关键词： dearomatization enantioselectivity phosphine catalysis electron-deficient heteroarenes vinylcyclopropanes

柴胡疏肝颗粒调控Keap1-Nrf2/HO-1信号通路改善四氯化碳诱导的小鼠急性肝损伤

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中国药学杂志 2024年第8期59卷 703-712页

作者：黄海锋庞晓妍戴卫波黄曼婷曾聪彦广州中医药大学附属中山中医院广东中山528400 广东江门中医药职业学院广东江门529000

目的探讨柴胡疏肝颗粒对小鼠急性肝损伤的保护作用及可能机制。方法将柴胡疏肝颗粒按低、中、高(生药量:11.4、22.8、45.6 g·kg^(-1))3个剂量连续给药7 d,末次给药2 h后,除正常对照组外,用体积分数0.2%四氯化碳(tetrachloromethane,CC... 详细信息

目的探讨柴胡疏肝颗粒对小鼠急性肝损伤的保护作用及可能机制。方法将柴胡疏肝颗粒按低、中、高(生药量:11.4、22.8、45.6 g·kg^(-1))3个剂量连续给药7 d,末次给药2 h后,除正常对照组外,用体积分数0.2%四氯化碳(tetrachloromethane,CCl4)溶液造模,12 h后,收集小鼠的血清和肝组织,制作肝组织病理切片。测定血清中丙氨酸氨基转移酶(alanine aminotransferase,ALT)、天门冬氨酸氨基转移酶(aspartate aminotransferase,AST)和肝组织中超氧化物歧化酶(superoxide dismutase,SOD)、丙二醛(malondialdehyde,MDA)、白细胞介素6(interleukin 6,IL-6)、肿瘤坏死因子α(tumor necrosis factorα,TNF-α),以及活性氧自由基(reactive oxygen species,ROS)含量;转录组学获得肝脏组织差异表达mRNA并富集与差异表达基因显著相关的通路;代谢组学研究肝组织中内源性代谢物变化并进行通路富集分析;免疫组织化学法及Western blot法检测肝组织中c-Jun氨基末端激酶(c-Jun N-terminal kinase,JNK)、p38丝裂原活化蛋白激酶(p38 mitogen-activated protein kinase,p38 MARK)、Kelch样ECH关联蛋白1(kelch-like ECH-associated protein 1,Keap1)、核因子E2相关因子2(nuclear factor erythroid 2-related factor 2,Nrf2)、血红素加氧酶-1(heme oxygenase-1,HO-1)表达及定位情况。结果与模型组比较,柴胡疏肝颗粒能显著降低小鼠血清ALT、AST和肝组织MDA、IL-6、TNF-α及ROS水平(P<0.05或P<0.01),显著升高肝组织中SOD水平(P<0.01),明显减轻肝细胞坏死及炎性浸润程度;上调Nqo1基因,上调醌氧化还原酶1[NAD(P)H:quinone oxidoreductase 1,NQO1]表达;下调Ccl2基因,下调单核细胞趋化蛋白-1(monocyte chemotactic protein 1,MCP-1)表达,且代谢物中有机酸类显著下调,糖类显著上调。肝组织中JNK、p38 MARK、Keap1表达均显著下调(P<0.05或P<0.01),Nrf2、HO-1表达显著上调(P<0.01)。结论柴胡疏肝颗粒可能通过激活Keap1-Nrf2/HO-1信号通路,对CCl4诱导的小鼠急性肝损伤具有保护作用。

关键词：柴胡疏肝颗粒急性肝损伤氧化应激 Kelch样ECH关联蛋白-核因子E1/血红素加氧酶-1信号通路