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Energy-efficient Approach to minimizing the Energy Consumption in An Extended Job-shop Scheduling Problem

Chinese Journal of Mechanical Engineering 2015年第5期28卷 1048-1055页

作者： TANG Dunbing dai min College of Mechanical and Electrical Engineering Nanjing University of Aeronautics & Astronautics Jiangsu Key Laboratory of Precision and Micro-manufacturing Technology Nanjing University of Aeronautics & Astronautics

The traditional production planning and scheduling problems consider performance indicators like time, cost and quality as optimization objectives in manufacturing processes. However, environmentally-friendly factors like energy consumption of production have not been completely taken into consideration. Against this background, this paper addresses an approach to modify a given schedule generated by a production plarming and scheduling system in a job shop floor, where machine tools can work at different cutting speeds. It can adjust the cutting speeds of the operations while keeping the original assignment and processing sequence of operations of each job fixed in order to obtain energy savings. First, the proposed approach, based on a mixed integer programming mathematical model, changes the total idle time of the given schedule to minimize energy consumption in the job shop floor while accepting the optimal solution of the scheduling objective, makespan. Then, a genetic-simulated annealing algorithm is used to explore the optimal solution due to the fact that the problem is strongly NP-hard. Finally, the effectiveness of the approach is performed small- and large-size instances, respectively. The experimental results show that the approach can save 5%-10% of the average energy consumption while accepting the optimal solution of the makespan in small-size instances. In addition, the average maximum energy saving ratio can reach to 13%. And it can save approximately 1%-4% of the average energy consumption and approximately 2.4% of the average maximum energy while accepting the near-optimal solution of the makespan in large-size instances. The proposed research provides an interesting point to explore an energy-aware schedule optimization for a traditional production planning and scheduling problem.

关键词： energy consumption makespan production planning and scheduling job-shop floor different cutting speeds

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Modular Total Synthesis of (-)-Palmyrolide A and (+)-(5S,7S)-Palmyrolide A via Ring-Closing Metathesis and Alkene Isomerization

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Chinese Journal of Chemistry 2021年第1期39卷 69-74页

作者： Yecai Lai Wei-min dai Laboratory of Advanced Catalysis and Synthesis Department of Chemistry and Hong Kong Branch of the Southern Marine Science and Engineering Guangdong Laboratory(Guangzhou)The Hong Kong University of Science and TechnologyClear Water BayKowloonHong Kong SARChina Baiyunshan Pharmaceutical General Factory Guang-zhou Baiyunshan Pharmaceutical Holdings Co.Ltd.Guangzhou 510515China

A pentamodule assembly approach has been established for total synthesis of the naturally occurring(-)-palmyrolide A and(+)-5,7-epi-palmyrolide *** using the racemic tert-butyl carbinol-containing alkyl iodide,the two diastereoisomeric macrolides could be obtained from the same sequence of reactions,demonstrating the flexibility of the multimodule assembly strategy for diverted total synthesis.

关键词： Alkene B-Alky Suzuki-Miyaura cross-coupling Modular total synthesis Cross coupling Ring-closing metathesis

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Modified Therapeutic Antibodies: Improving Efficacy

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Engineering 2021年第11期7卷 1529-1540页

作者： Ji-min dai Xue-Qin Zhang Jing-Yao dai Xiang-min Yang Zhi-Nan Chen Department of Cell Biology National Translational Science Center for Molecular MedicineState Key Laboratory of Cancer BiologyThe Fourth Military Medical UniversityXi’an 710032China Department of Hepatobiliary Surgery Chinese PLA General HospitalBeijing 100853China Department of Hepatobiliary Surgery Air Force Medical CenterBeijing 100142China

The prosperity of the biotherapeutics market reflects the feasibility and effectiveness of therapeutic antibodies for the treatment of cancers,inflammatory disorders,and refractory *** drawbacks emerge in clinical trials and practice,such as impeded binding,reduced effector functions,and frequent adverse reactions,modifications of therapeutic antibodies are unprecedently burgeoning in research and development(R&D).These modifications include:①modified glycosylation;②fragment of crystallizable domain(Fc)amino acid alterations;③cross-isotype or cross-subclass exchanges;④antibody–drug conjugates(ADCs);⑤single chain of variable region fragment(scFv)for chimeric antigen receptor T(CAR-T)cells;and⑥bispecific antibodies(bsAbs)in order to promote binding affinity,half-life in circulation,effectiveness toward target cells and,ultimately,to achieve overall improved *** many achievements have been made around the world in the past decades,China has been playing an active role in this realm,with its great demand for biotherapeutics with R&D *** review recapitulates the international progress that has been achieved with modified therapeutic antibodies,and then focuses on that of China in an independent section.

关键词： Therapeutic antibody Modification Efficacy Antigen Antibody-drug conjugate Bispecific antibody

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Anti-infectious efficacy of essential oil from Caoguo(Fructus Tsaoko)

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Journal of Traditional Chinese Medicine 2016年第6期36卷 799-804页

作者： dai min Peng Cheng Sun Fenghui School of Laboratory Medicine Chengdu Medical College State Key Laboratory of Systematic Research and Exploitation of Traditional Chinese College of Pharmaceuticals Chengdu University of Traditional Chinese Medicine

OBJECTIVE: To evaluate the anti-infectious efficacy of essential oil extracted from Caoguo(Fructus Tsaoko).METHODS: minimum inhibitory concentrations(MICs) against clinical isolates of three extracts andthe essential oil from Caoguo(Fructus Tsaoko) were determined by the agar dilution method. The anti-infectious efficacy of the essential oil was evaluated using a mouse peritonitis model which was infected with Staphylococcus aureus or Escherichia coli. The chemical components of the essential oil were ***: The results showed that the essential oil exhibited strong antibacterial activity in vitro, with MICs ranging from 22.49 to 1438.91 μg/m L. The results of in vivo anti-infectious efficacy showed that the Caoguo(Fructus Tsaoko) essential oil can protect the mice from Staphylococcus aureus or Escherichia coli infection. The compositions of the essential oil and relative component percentages were examined. A total of 32 compounds, were identified. The major compounds of essential oil were 1,8-cineole(25.92%) and geraniol(13.69%).CONCLUSION: Our findings suggest that Caoguo(Fructus Tsaoko) essential oil has broad-spectrum antibacterial properties. It warrants further investigation as an antibacterial agent targeting some bacterium with multi-drug resistance.

关键词： Amomum tsaoko Oils,volatile Anti-bacterial agents Chemistry

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A Concise Total Synthesis of Amphidinin B

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Chinese Journal of Chemistry 2013年第1期31卷 105-110页

作者： Dongdong Wu Jinlong Wu Wei-min dai Laboratory of Asymmetric Catalysis and Synthesis Department of Chemistry Zhejiang University Hangzhou Zhejiang 310027 China Laboratory of Advaneed Catalysis and Synthesis Department of Chemistry The Hong Kong University of Science and Technology Clear Water Bay Kowloon Hong Kong SAR China

A concise total synthesis of amphidinin B, a cytotoxic linear dicarboxylic acid associated with amphidinolide T marine macrolides, has been accomplished from the 19-membered cycloalkene intermediates designed for diverted total synthesis of amphidinolide T1 and T3-T5. The lH and 13C NMR spectra of the synthesized amphidinin B in C6D6 and CDC13 were compared with those for the natural and synthetic forms reported in the literature, showing solvent-dependence of the ^1H and ^13C NMR signals of amphidinin B in C6D6 and CDC13.

关键词： amphidinin B cycloalkene dihydroxylation oxidative cleavage total synthesis

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Flow field effect of delayed neutron precursors in liquid-fueled molten salt reactors

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Nuclear Science and Techniques 2022年第8期33卷 16-32页

作者： Xian-Di Zuo Mao-Song Cheng Yu-Qing dai Kai-Cheng Yu Zhi-min dai Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China University of Chinese Academy of Sciences Beijing 100049China

In molten salt reactors(MSRs),the liquid fuel salt circulates through the primary loop and a part of the delayed neutron precursors(DNPs)decays outside the reactor *** model and analyze the flow field effect of DNPs in channel-type liquid-fueled MSRs,a three-dimensional space-time dynamics code,named ThorCORE3D,that couples neutronics,core thermalhydraulics,and a molten salt loop system was developed and validated with the Molten Salt Reactor Experiment(MSRE)*** effects of external loop recirculation time,fuel flow rate,and core flow field distribution on the delayed neutron fraction loss of MSRE at steadystate were modeled and simulated using the ThorCORE3D ***,the flow field effect of the DNPs on the system responses of the MSRE in the reactivity insertion transient under different initial conditions was analyzed systematically for the channel-type liquid-fueled *** results indicate that the flow field condition has a significant effect on the steady-state delayed neutron fractions and will further affect the transient power and temperature responses of the reactor *** analysis results for the effect of the DNP flow field can provide important references for the design optimization and safety analysis of liquid-fueled MSRs.

关键词： Molten salt reactor Delayed neutron precursor Nodal expansion method Coupled neutronics and thermal-hydraulics

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Feasibility of an innovative long-life molten chloride-cooled reactor

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Nuclear Science and Techniques 2020年第4期31卷 1-15页

作者： ming Lin Mao-Song Cheng Zhi-min dai Shanghai Institute of Applied Physics Chinese Academy of SciencesJiading CampusShanghai 201800China University of Chinese Academy of Sciences Beijing 100049China

Molten salt-cooled reactor is one of the six GenIV reactors with promising characteristics including safety,reliability,proliferation resistance,physical protection,economics,and *** this paper,a small innovative molten chloride-cooled fast reactor(MCCFR)with 30-year core and a target 120-MWt thermal power was *** its feasible study,neutronics,thermal-hydraulics,and radiation damage analysis were *** key design properties including kinetics parameters,reactivity swing,reactivity feedback coefficients,maximum accumulated displacement per atom(DPA)of reactor pressure vessel(RPV)and fuel cladding,and maximum coolant,cladding,and fuel temperatures were *** results showed the MCCFR could operate without refueling for 30 years with overall negative reactivity feedback coefficients up the end of its *** its 30-year life,the excess reactivity was well managed by constantly pulling out the control *** maximum accumulated DPA on RPV and fuel cladding were 8.92 dpa and 197.03 dpa,respectively,which are both below the design ***,the maximum coolant,cladding and fuel center temperatures were all below the design limits during its entire *** to these results,the MCCFR core design with long life is feasible.

关键词： Molten salt-cooled reactor Neutronics Radiation damage Thermal-hydraulics

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Colorectal Cancer Screening in China:Status,Challenges,and Prospects——China,2022

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China CDC weekly 2022年第15期4卷 322-328页

作者： Hongda Chen Bin Lu min dai Medical Research Center Peking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

Colorectal cancer(CRC)ranks third among the most commonly diagnosed cancers in *** proof that screening can decrease CRC incidence and mortality,there are still gaps remaining between CRC screening objectives and reality in *** this review,we provided an overview of the status of CRC screening in ***,we summarized the current CRC screening programs and strategies in ***,we reviewed the authoritative CRC screening and early detection guidelines in China to orient future evidence-based guideline ***,we identified current challenges and further provided some suggestions to improve the implementation of CRC screening *** maximize the effectiveness of CRC screening,further research on risk prediction models including polygenic risk scores and prior screening outcomes,novel biomarkers and artificial intelligence,and personalized screening strategies are *** cohort study and microsimulation techniques are recommended for long-term evaluations of the effectiveness of CRC screening strategies.

关键词： summarized spite screening

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Energy-Efficient Process Planning Using Improved Genetic Algorithm

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Transactions of Nanjing University of Aeronautics and Astronautics 2016年第5期33卷 602-609页

作者： dai min Tang Dunbing Huang Zhiqing Yang Jun College of Mechanical and Electrical Engineering Nanjing University of Aeronautics and Astronautics

Nowadays,energy consumption which closely contacts with environmental impacts of manufacturing processes has been highly commented as a new productivity ***,little attention has paid to the development of process planning methods that take energy consumption into *** energy-efficient process planning model that incorporates manufacturing time and energy consumption is *** solving the problem,an improved genetic algorithm method is employed to explore the optimal ***,a case study for process planning is *** experimental result generates interesting effort,and therefore allows improving the energy efficiency of manufacturing processes in process planning.

关键词： energy consumption process planning improved genetic algorithm energy efficiency

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Study on the optimal incident proton energy of ^(7)Li(p,n)^(7)Be neutron source for boron neutron capture therapy

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Nuclear Science and Techniques 2024年第3期35卷 170-180页

作者： Yi-Nan Zhu Zuo-Kang Lin Hai-Yan Yu Ye dai Zhi-min dai Xiao-Han Yu Shanghai Institute of Applied Physics Chinese Academy of SciencesShanghai 201800China University of Chinese Academy of Science Beijing 100049China

Boron neutron capture therapy(BNCT)is recognized as a precise binary targeted radiotherapy technique that effectively eliminates tumors through the^(10)B(n,α)^(7)Li nuclear *** various neutron sources,accelerator-based sources have emerged as particularly promising for BNCT ***^(7)Li(p,n)^(7)Be reaction is highly regarded as a potential neutron source for BNCT,owing to its low threshold energy for the reaction,significant neutron yield,appropriate average neutron energy,and additional *** study utilized Monte Carlo simulations to model the physical interactions within a lithium target subjected to proton bombardment,including neutron moderation by an MgF_(2)moderator and subsequent BNCT dose analysis using a Snyder head *** study focused on calculating the yields of epithermal neutrons for various incident proton energies,finding an optimal energy at 2.7 ***,the Snyder head phantom was employed in dose simulations to validate the effectiveness of this specific incident energy when utilizing a^(7)Li(p,n)^(7)Be neutron source for BNCT purposes.

关键词： Boron neutron capture therapy ^(7)Li(p,n)7Be neutron source Incident proton energy Monte Carlo simulation

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