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Research trends in exercise therapy for the treatment of pain in postmenopausal osteoporosis over the past decade:A bibliometric analysis

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World Journal of Orthopedics 2024年第10期15卷 950-964页

作者： Zhao-Qiu dai Xiao-Yan Gong Rong Zhang Mei-Qin jin Wei Lu Wen Wen jie Chen Fang-jie Lu Yi-Fan Yang Lei Wang Xiao-jin He Changshu Hospital Affiliated with Nanjing University of Chinese Medicine Changshu 215500Jiangsu ProvinceChina Affiliated Hospital of Nanjing University of Chinese Medicine Jiangsu Province Hospital of Chinese MedicineNanjing 210029Jiangsu ProvinceChina Nanjing University of Chinese Medicine Nanjing 210023Jiangsu ProvinceChina

BACKGROUND Postmenopausal osteoporosis(PMOP)is the most common form of primary osteoporosis among women,and the associated pain often drives patients to seek clinical *** studies have highlighted the unique clinical benefits of exercise therapy(ET)in alleviating PMOP-related ***,bibliometric analyses examining collaboration,development trends,and research frontiers in the field of ET for PMOP pain remain *** To explore the research trends in ET for pain treatment in PMOP patients over the past *** All scholarly works were meticulously sourced from the Science Citation Index-Expanded within the prominent Web of Science Core *** the capabilities of CiteSpace 6.2.R5,we conducted a thorough analysis of publications,authors,frequently cited scholars,contributing nations,institutions,journals of significant citation,comprehensive references,and pivotal ***,our examination explored keyword cooccurrences,detailed timelines,and periods of heightened citation *** comprehensive search,from 2014 through 2023,was completed within a single day,on October 11,*** In total,2914 articles were ultimately included in the *** was a rapid increase in annual publication output in 2015,followed by stable growth in subsequent ***,Michael L,is the most prolific author,whereas Ware JE has the most *** United States’global influence is significant,surpassing all other *** University of California System and Harvard University are the most influential academic institutions.J Bone Joint Surg Am is the most influential journal in this field.“Spinal cord injury”is the keyword that has garnered the most attention from *** developmental pattern in this field is characterized by interdisciplinary fusion,with different disciplines converging to drive *** The academic development of the field of ET for pain in PMOP has matured and stabili

关键词： Exercise therapy Pain Postmenopausal osteoporosis CiteSpace Bibliometric analysis Web of Science

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抗丁香酚单克隆抗体的研制及胶体金试纸条检测方法的建立

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核农学报 2025年第2期39卷 339-350页

作者：董晓涵翟璐黄雅丽杨加成陈青舟廖杰金仁耀浙江工商大学海洋食品研究院浙江杭州310012 杭州博岳生物技术有限公司浙江杭州310018 杭州医学院公共卫生学院浙江杭州310013 杭州南开日新生物技术有限公司浙江杭州310000 浙江华才检测技术有限公司浙江绍兴311800

为制备高特异性和高灵敏度的抗丁香酚(Eugenol)单克隆抗体,建立检测丁香酚的胶体金免疫层析法,本研究采用亲核取代法合成丁香酚半抗原(Eugenol-COOH)并进行质谱(HRMS)鉴定;采用碳二亚胺法制备丁香酚免疫抗原(Eugenol-BSA)和包被抗原(Eug... 详细信息

为制备高特异性和高灵敏度的抗丁香酚(Eugenol)单克隆抗体,建立检测丁香酚的胶体金免疫层析法,本研究采用亲核取代法合成丁香酚半抗原(Eugenol-COOH)并进行质谱(HRMS)鉴定;采用碳二亚胺法制备丁香酚免疫抗原(Eugenol-BSA)和包被抗原(Eugenol-OVA),进行十二烷基硫酸钠-聚丙烯酰胺凝胶电泳(SDS-PAGE)和紫外扫描鉴定;利用免疫抗原Eugenol-BSA免疫小鼠,经细胞融合、筛选和克隆,最终得到1株能稳定分泌抗丁香酚单克隆抗体的杂交瘤细胞株(3D9),并准备腹水,利用间接竞争ELISA(icELISA)方法测定腹水效价;对获得的单克隆抗体进行鉴定,经条件优化建立胶体金免疫层析试纸条检测方法,对试纸条的灵敏度和稳定性进行评价。结果表明,Eugenol-BSA偶联比约为16∶1,Eugenol-OVA偶联比约为10∶1,完全抗原偶联成功;3D9细胞株的抗体类型及亚类均为免疫球蛋白G(IgG1),轻链为κ链;单克隆抗体效价达1×10^(-6);丁香酚浓度与抑制率之间的线性回归方程为y=9.671lnx+10.539(R^(2)=0.998),半数抑制浓度(IC_(50))为59.2 ng·mL^(-1),表明制备的抗丁香酚单克隆抗体具有较高的检测灵敏度。所制备的胶体金免疫试纸条优化参数为:胶体金标记最适pH值9、0.2 mol·L^(-1)K2CO3添加量12μL、抗体最佳标记量7μg·mL^(-1)、胶体金试纸条的T线消失浓度1.8μg·mL^(-1),该参数下的裸眼检出限0.3μg·mL^(-1)。本研究可为丁香酚的现场检测提供有效方法。

关键词：丁香酚单克隆抗体人工抗原胶体金试纸条

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Effect of M-EMS on the solidification structure of a steel billet

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International Journal of Minerals,Metallurgy and Materials 2011年第2期18卷 159-164页

作者： Hua-jie Wu Ning Wei Yan-ping Bao Guo-xin Wang Chao-ping Xiao jin-jin Liu Engineering Research Institute University of Science and Technology Beijing Beijing 100083 China School of Metallurgical and Ecological Engineering University of Science and Technology Beijing Beijing100083 China

Effects of mold electromagnetic stirring （M-EMS） on the solidification structure of 45# steel billet were investigated by examination of interdendritic corrosion. The results show that the primary and secondary dendrite arm spacings increase from the edge of the billet to the center and decrease obviously with increasing electromagnetic torque, which will be beneficial to refine the solidification structure and enlarge the equiaxed crystal zone. The ratio of equiaxed crystal increases by 15.9% with the electromagnetic torque increasing from 230 to 400 cN·cm. The increase of stirring intensity can improve the cooling rate and the impact of M-EMS on it reduces from the edge of the billet to the central area, where the cooling rates are similar at different torques. The closer to the central area, the less the influence of M-EMS on the cooling rate is. The ratio of the primary to secondary dendrite arm spacing is approximately 2.0, namely, λ1≈2λ2, and is constant irrespective of the stirring intensity and position of the billet. Original position analysis （OPA） results indicate that the center segregation of the billet is greatly improved, and the more uniform and compact solidification structure will be obtained with the increase of stirring intensity.

关键词： continuous casting electromagnetic stirring dendrite arm spacing cooling rate solidification

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A kind of modified bovine serum albumin with great potential for applying in gene delivery

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Chinese Chemical Letters 2013年第7期24卷 659-662页

作者： Ning Zhang Chong-Xi Wang jin-Hao Liu jin-Feng Xing An-jie Dong Department of Polymer Science and Engineering School of Chemical Engineering and Technology Tianjin University

Bovine serum albumin （BSA） was modified through a facile synthesis method to increase its isoelectric point （pl） from 4.8 to 6.0. When pH is higher than 6.0, the protein shows a negative surface charge, on the contrary, the protein is positively charged. In this study, the charge-reversal modified BSA （crBgA） was utilized to assemble with the binary complexes of pDNA/poly（vinylpyrrolidone）-graft-poly（2- dimethylaminoethyl methacrylate）（pDNA/PVP-g-PDMAEMA） to shield the excess positive charges of complexes at physiological pH （pH 7.4）. When the complex coated with crBSA located in the environment at endosomal pH （pH 5.0）, the charge-reversal of crBSA led to the deviation of crBSA from polyplex by electrostatic repulsion, which would benefit the transfection of the target gene. The crBSA shows great potential for improving the transfection efficiency of ~DNA/PVP-^-PDMAEMA.

关键词： Bovine serum albumin Gene delivery Charge reversal Polyplexes

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Development of a monitoring system for grain loss of paddy rice based on a decision tree algorithm

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International Journal of Agricultural and Biological Engineering 2021年第1期14卷 224-229页

作者： Yi Lian jin Chen Zhuohuai Guan jie Song College of Mechanical Engineering Jiangsu UniversityZhenjiang 212013JiangsuChina Synergistic Innovation Center of Jiangsu Modern Agricultural Equipment and Technology Zhenjiang 212013JiangsuChina

China has the world’s largest planting area of paddy rice,but large quantities of paddy rice fall to the ground and are lost during harvesting with a combine *** grain loss is an effective way to increase production and *** this study,a monitoring system was developed to monitor the grain loss of the paddy rice and this approach was tested on the test bench for verifying the *** development of the monitoring system for grain loss included two stages:the first stage was to collect impact signals using a piezoelectric film,extract the four features of Root Mean Square,Peak number,Frequency and Amplitude(fundamental component),and identify the kernel impact signals using the J48(C4.5)Decision Tree *** the second stage,the precision of the monitoring system was tested for the paddy rice at three different moisture contents(10.4%,19.6%,and 30.4%)and five different grain/impurity ratios(1/0.5,1/1,1/1.5,1/2,and 1/2.5).According to the results,the highest monitoring accuracy was 99.3%(moisture content 30.8%and grain/impurity ratio 1/2.5),the average accuracy of the monitoring tests was 92.6%,and monitoring of grain/impurity ratios between 1/1 and 1/1.5(>95.4%)had higher accuracy than monitoring the other grain/impurity *** accuracy decreased as impurities *** lowest accuracy for grain loss monitoring was obtained when the grain/impurity ratio was 1/2.5,with monitoring accuracies of 88.2%,75.7%and 78.8%at moisture contents of 10.4%,19.6%and 30.4%.

关键词： monitoring system combine harvester paddy rice grain loss sensor data mining decision tree development

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Measurement of the distance from grain divider to harvesting boundary based on dynamic regions of interest

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International Journal of Agricultural and Biological Engineering 2021年第4期14卷 226-232页

作者： jin Chen jie Song Zhuohuai Guan Yi Lian College of Mechanical Engineering Jiangsu UniversityZhenjiang 212013JiangsuChina Synergistic Innovation Center of Jiangsu Modern Agricultural Equipment and Technology Zhenjiang 212013JiangsuChina

Combine harvesters need to work along the crop boundary line during *** deviation(the distance between the grain divider and the harvesting boundary line)is important navigation *** the measurement accuracy and real-time performance of lateral deviation is an effective way to improve navigation *** at the problems of poor real-time performance and low measurement accuracy of existing lateral deviation measurement methods,a method of dynamic selection of the region of interest in the process of image processing was proposed and verified by field *** calculation of lateral deviation includes the following stages:analyzing the average gray value of each column in the field image;drawing dynamic region of interest using maximum average gray value;extracting the rice boundary line by using the probabilistic Hough transform algorithm;predicting the location of the boundary line by using the Kalman filter algorithm;measuring the lateral deviation by using the inverse perspective transform *** analysis of images under different rice fields showed that the method can effectively identify crop boundary *** to the test results of calling cameras in different installation positions,the highest extraction success rate of the boundary line was 96.9%,the average success rate was 94.8%,and the speed of real-time measurement of lateral deviation was 0.065 s/*** the driving speed was 0.4 m/s,the detection error of linear tracking detection was less than 4.3 *** the increase of speed,the error gradually *** algorithm has a good real-time performance and high accuracy during low-speed driving.

关键词： distance harvesting boundary dynamic region of interest combine harvester measurement

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Trends of the precipitation acidity over China during 1992–2006

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Chinese Science Bulletin 2010年第17期55卷 1800-1807页

作者： TANG jie XU XiaoBin BA jin WANG ShuFeng Key Laboratory for Atmospheric Chemistry Centre for Atmosphere Watch and Services Chinese Academy of Meteorological Sciences China Meteorological Administration Beijing 100081 China

The trends of the precipitation acidity from 1992 to 2006 were studied, based on the long-term acid rain observations at 74 sites in China. The results show that there was no remarkable change or extension of acid rain area (i.e., with annual mean of precipitation pH<5.6) during the 15 years. The largest and continuous acid rain area exists in the south of the Yangtze River, while the acid rain areas north of the Yangtze River remain separate. The severe acid rain area (i.e., with annual mean of precipitation pH<4.5) exists mainly in the south of the Yangtze River. The overall precipitation acidity for the 74 stations showed different trends before 1999 and after 2000. In the period 1992–1999, the precipitation acidity at most of the sites remained steady or showed a decreasing trend. After 2000, however, an increasing trend of the precipitation acidity was observed at many sites in North China, Central China, East China, and South China. As a result, the pattern of acid rain area changed during 1992–2006. The precipitation over North China, Central China, and South China became more acidified in the 15 years, with more pronounced trends in North China and the north of Central China. A slight decrease in the precipitation acidity was found in Southwest China, an area characterized as severest acid rain area for about two decades after the early 1980s. Consequently, the center of severe acid rain area in the south of the Yangtze River moved eastwards. The non-hydrogen conductivity (NHC), which is defined as the difference between the measured precipitation conductivity and the H+ conductivity calculated from measured pH, was estimated and treated as a proxy of soluble ions in precipitation. The result shows that the overall trend of the NHC before 1999 was pronounced and positive, while the trend after 2000 was inconspicuous or slightly negative. During 2000–2006, the change rate of pH was positively correlated to that of the NHC at 21 sites, implying that the increa

关键词： China acid rain precipitation acidity trend

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Peptide-Based Electrochemical Biosensors and Their Applications in Disease Detection

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Journal of Analysis and Testing 2022年第2期6卷 193-203页

作者： jin-Ge Zhao jie Cao Wei-Zhi Wang Key Laboratory of Medical Molecule Science and Pharmaceutics Engineering Ministry of Industry and Information TechnologyKey Laboratory of Cluster Science of Ministry of EducationBeijing Key Laboratory of Photoelectronic/Electro-Photonic Conversion MaterialsSchool of Chemistry and Chemical EngineeringBeijing Institute of TechnologyBeijing 100081China

Biosensors based on small molecule peptides have developed rapidly in the detection of disease markers with the characteristics of high sensitivity, rapid analysis speed and easy miniaturization. The properties of the sensor, such as the sensitivity and detection range, are closely related to the material and structure of the electrodes. The electrodes mainly used in peptidebased biosensors are gold electrodes, glassy carbon electrodes(GCE), indium tin oxide(ITO) conductive glass electrodes and screen-printed electrodes. In addition, to improve the biomolecule loading rate, antifouling performance, electrical conductivity of the biosensor, a variety of nanomaterials and organic molecules are used to construct the biosensor for disease detection. This review summarizes the properties of several commonly used electrodes for peptide-based electrochemical biosensors, and introduces some modified materials of the electrode and their effects on sensor performance. In the future,the peptide-based biosensors will be widely used in clinical detection and other related fields.

关键词： Peptide Biosensor Electrode Nanomaterials

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Rail Expansion Devices Monitored by FBG Sensors on an Urban Railway Viaduct

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Photonic Sensors 2014年第2期4卷 173-179页

作者： Weilai LI jin PANG Xiaoshan LU jie LIU National Engineering Lab of Fiber Optic Sensing Technology Wuhan University of Technology 122 Luoshi RoadWuhan 430070 China Key Lab of Fiber Optic Sensing Technology and Information Processing Wuhan University of Technology 122 LuoshiRoad Wuhan 430070 China

The fiber Bragg grating （FBG） sensing technology was used to monitor the situation of a crevice of the continuous beam joint and rails near rail expansion devices on a viaduct of the urban railway. The monitoring items consisted of the rail temperature, rail displacement, viaduct beam displacement, and strain of sliding rail in the rail expansion device section. The strain sensor was a prefabricate FBG strain gauge, the displacement sensor with different scales used an FBG stress ring, and the FBG of the temperature sensor was pre-drawn and fixed in a metal tube. Compensation sensors were used to balance environmental temperature changes. All FBGs were suspended adhered, therefore the chirped phenomenon of the FBG reflection peak was avoided, and the measurement accuracy was improved. The monitoring results matched to the manual test and theoretical estimation.

关键词： Fiber Bragg grating urban rail viaduct rail expansion device monitor

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A novel ocean bathymetry technology based on an unmanned surface vehicle

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Acta Oceanologica Sinica 2018年第9期37卷 99-106页

作者： jin Jiucai ZHANG jie SHAO Feng LYU Zhichao WANG Dong The First Institute of Oceanography State Oceanic Administration College of Information and Control Engineering China University of Petroleum College of Underwater Acoustic Engineering Harbin Engineering University College of Electronics and Information Engineering Harbin Institute of Technology

In ocean bathymetry, the instantaneous depth measured by survey ships or by unmanned surface vehicles（USVs）cannot be directly taken as the chart depth because of the effect of waves and the tide. A novel ocean bathymetry technology is proposed based on the USV, the aim is to evaluate the potential of the USV using a real-time kinematic（RTK） and a single beam echo sounder for ocean bathymetry. First, using the RTK height of the USV with centimeter-level precision, the height of the sea level is obtained by excluding wave information using a low pass filter. Second, the datum distance between the reference ellipsoid and the chart depth is obtained by a novel method using tide tables and the height of the sea level from the USV. Previous work has usually achieved this using long-term tidal observation from traditional investigations. Finally, the chart depth is calculated using the transformation between the instantaneous depth of the USV measurement and the datum of the chart *** were performed around the Wuzhizhou Island in Hainan Province using the unmanned surface bathymetry vehicle to validate the proposed technology. The successful results indicate the potential of the bathymetry technology based on the USV.

关键词： unmanned surface vehicle bathymetry attitude correction tidal observation

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