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Hydrophobic cell penetrating peptides conjugate with proapoptotic domain peptide for cancer therapy

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Hydrophobic cell penetrating peptides conjugate with proapop...

Near-field wideband beam training for ELAA with uniform circular array

2014年中国药学大会暨中国药师周

作者： Xiucong Yang Wei Gao Wen bing dai bing He Hua Zhang Xueqing Wang Qiang Zhang State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking University

Intracellular drug delivery can improve efficacy and reduce the side effect of a variety of therapeutically active molecules,which can be facilitated by cell‐penetrating peptides（CPPs）,such as RKKRRQRRR（TAT）.TAT is the first discovered CPP derived from HIV‐1 protein,which has been widely *** of CPPs have a positively charged residue that is essential for their breaching biological membranes while highly cationic residues can also damage cell membrane and exihibit ***,a number of hydrophobic CPPs that contain only apolar residues were discovered and thought to be with lower toxicity than cationic *** have been widely used to deliver bioactive peptides including sequences that accelerate or inhibit *** example is the proapoptotic domain peptide PAD（klaklak）2 that was recently shown to induce mitochondrial swelling and apoptosis in the models of *** peptide alone is non‐toxic to cells at relatively high concentrations（＞300n M）but exhibited high‐toxic when conjugated to *** this study we investigated whether the hydrophobic peptide Cyclosporine A（Cs A）has the capacity to deliver a proapoptotic domain peptide into cells,thus testing its potential as a vehicle for delivering therapeutics into the *** A was aminated by ethanediamine and then coupled with PAD through EDC/NHS reaction to get Cs A‐*** vitro cytotoxicity assays show that Cs A‐PAD conjugate is toxic to six different cell lines in the low micromolar range,which is comparable to a TAT‐PAD conjugate,while PAD shows to be non‐*** confocal microscopy analysis shows the cell uptake of TAT‐PAD and Cs A‐PAD is much higher than *** results of apoptotic assay are also consistent to the cell uptake after treated with PAD,TAT‐PAD and Cs A‐PAD for 2 *** results show that Cs A,as well as TAT,can deliver large biological cargoes into cell cytosol and induce the biological effects of the *** lactate dehydrogenase（LDH）release experiment s

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来源： cnki会议评论

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Science China(Information Sciences) 2024年第6期67卷 370-383页

作者： Yuhao CHEN Linglong dai Department of Electronic Engineering Tsinghua UniversityBeijing National Research Center for Information Science and Technology (BNRist)

Extremely large-scale antenna array(ELAA) at millimeter wave(mmWave) and Terahertz(THz)band has been considered a key technology for combating high attenuation in high-frequency bands in future6G communications. Uniform circular arrays(UCAs) have attracted much attention because of their ability to provide flat beamforming gain at all angles. To realize efficient beamforming, beam training is widely used to acquire channel state information. However, with a large antenna number, the beam training overhead in ELAA systems becomes overwhelming. Moreover, with a large bandwidth, the beam defocus effect severely degrades beam training accuracy. To address these issues, this paper proposes a frequency-dependent focusing(FDF)-based beam training scheme to realize effective beam training in near-field wideband ELAA systems with UCA. Specifically, we first analyze the FDF property of UCA, where signals at different subcarriers can simultaneously focus on different distances. Then, by exploiting the FDF property to search different distances using different subcarriers simultaneously, we design a hierarchical codebook and propose an FDFbased beam training scheme. To reveal the effectiveness of the proposed scheme, we compare its necessary beam training overhead with that of existing schemes. Finally, the simulation results demonstrate that the proposed scheme can achieve accurate beam training in near-field wideband UCA systems with a low beam training overhead.

关键词： extremely large-scale antenna array (ELAA) uniform circular array (UCA) near-field wideband beam training

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基于文献的知识发现新近研究综述

数据分析与知识发现 2021年第4期5卷 1-12页

作者：代冰胡正银中国科学院成都文献情报中心成都610041 中国科学院大学经济与管理学院图书情报与档案管理系北京100190

【目的】对基于文献的知识发现(Literature-Based Discovery,LBD)近十年的文献进行综述,了解该主题的最新研究进展、发展趋势与面临的挑战。【文献范围】在Web of Science、CNKI和百度学术中使用"literature based discovery"、"literat... 详细信息

【目的】对基于文献的知识发现(Literature-Based Discovery,LBD)近十年的文献进行综述,了解该主题的最新研究进展、发展趋势与面临的挑战。【文献范围】在Web of Science、CNKI和百度学术中使用"literature based discovery"、"literature AND knowledge discovery"、"文献知识发现"、"文献AND知识挖掘"进行检索,限定文献发表时间为2010年-2020年,共筛选出72篇代表性文献进行述评。【方法】从研究对象、方法技术、结果评估与典型应用4个方面对文献进行归纳梳理,并总结LBD的发展趋势与面临的挑战。【结果】LBD发展呈现出研究对象复杂化、分析方法智能化、发现结果丰富化与应用服务实践化的趋势;LBD在多源异构数据融合、知识发现可解释性、结果有效性评估、多领域专家协同方面面临重大挑战。【局限】主要基于文献对LBD新近进展进行综述,对LBD工具系统及产业界应用覆盖不够。【结论】作为情报学、信息学、数据科学的交叉研究领域,LBD对挖掘跨学科领域隐性知识与提供高质量学科化知识服务具有重要意义,但真正实现支持潜在的科学新发现还存在诸多挑战。

关键词：文献挖掘知识发现知识图谱文本挖掘情报研究

Seismic performance evaluation of water supply pipes installed in a full-scale RC frame structure based on a shaking table test

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Earthquake Engineering and Engineering Vibration 2024年第1期23卷 163-178页

作者： Wu Houli Guo Endong Wang Jingyi dai Xin dai Chenxi Key Laboratory of Earthquake Engineering and Engineering Vibration Institute of Engineering MechanicsChina Earthquake AdministrationHarbin 150080China Key Laboratory of Earthquake Disaster Mitigation Ministry of Emergency ManagementHarbin 150080China

As an important part of nonstructural components,the seismic response of indoor water supply pipes deserves much *** paper presents shaking table test research on water supply pipes installed in a full-scale reinforced concrete(RC)frame *** material pipes and different methods for penetrating the reinforced concrete floors are combined to evaluate the difference in seismic *** response spectra and pipe acceleration amplification factors based on test data are discussed and compared with code provisions.A seismic fragility study of displacement demand is conducted based on numerical *** acceleration response and displacement response of different combinations are *** results show that the combination of different pipe materials and different passing-through methods can cause obvious differences in the seismic response of indoor riser pipes.

关键词： water supply pipe different materials shaking table test amplification factor seismic fragility

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C3肾小球病诊治进展

第二军医大学学报 2014年第12期35卷 1373-1377页

作者：孙云嘉戴兵第二军医大学学员旅上海200433 第二军医大学长征医院肾内科上海200003

C3肾小球病是新提出的肾脏疾病分类,是指一些罕见的肾炎,包括致密物沉积病(DDD)、C3肾小球肾炎(C3GN)和CFHR5肾病等。C3肾小球病具有相同的病因,即补体旁路途径的异常调节,有时伴基因缺陷或自身抗体异常。C3肾小球病目前尚无持续有效的... 详细信息

C3肾小球病是新提出的肾脏疾病分类,是指一些罕见的肾炎,包括致密物沉积病(DDD)、C3肾小球肾炎(C3GN)和CFHR5肾病等。C3肾小球病具有相同的病因,即补体旁路途径的异常调节,有时伴基因缺陷或自身抗体异常。C3肾小球病目前尚无持续有效的治疗方法,但临床正在针对特定的补体成分进行研究治疗,治疗的时机和持续时间仍有待探索。本文就C3肾小球病的组织学和临床特征、补体检查手段及治疗方法作一综述。

关键词： C3肾小球病 C3肾小球肾炎致密物沉积病补体C3

ρ-meson longitudinal leading-twist distribution amplitude revisited and the D→ρsemileptonic decay

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Chinese Physics C 2024年第6期48卷 82-91页

作者：钟涛代亚红付海冰 Department of Physics Guizhou Minzu UniversityGuiyang 550025China

Motivated by our previous study[***.D 104(1),016021(2021)]on the pionic leading-twist distribution amplitude(DA),we revisit theρ-me son leading-twist longitudinal DAφ_(2;ρ)^(‖)(x,μ)in this study.A model proposed by Chang based on the DYyson-Schwinger equations is adopted to describe the behavior ofφ_(2;ρ)^(‖)(x,μ).However,theξ-moments ofφ_(2;ρ)^(‖)(x,μ)are calculated with the QCD sum rules in the framework of the background field *** sum rule formulas for these moments are *** accurate values for the first five nonzeroξ-moments at the typical scaleμ=(1.0,1.4,2.0,3.0)GeV are given,e.g.,atμ=1 GeV,(ξ^(2))>_(2;ρ)^(‖)=0.220(6),(ξ^(4))>_(2;ρ)^(‖)=0.103(4),(ξ^(6))>_(2;ρ)^(‖)=0.066(5),(ξ^(8))>_(2;ρ)^(‖)=0.046(4),and(ξ^(10))>_(2;ρ)^(‖)=0.035(3).By fitting these values with the least squares method,the DSE model forφ_(2;ρ)(x,μ)is *** taking the left-handed current light-cone sum rule approach,we obtain the transition form factor in the large recoil region,i.e.,A_(1)(0)=0.498_(-0.012)^(+0.014),A_(2)(0)=0.460_(-0.047)^(+0.055),and V(0)=0.800_(-0.014)^(+0.015),and the ratio r_(2)=0.923_(-0.119)^(+0.133),rV=1.607_(-0.071)^(+0.071).After extrapolating with a rapidly converging series based on z(t)-expansion,we present the|V_(cd)|-independent decay width for the semileptonic decays D→ρ^(l+)v_(l).Finally,the branching fractions are B(D^(0)→ρ^(-)e+v_(e))=1.825_(-0.162)^(+0.170)±0.004,B(D^(+)→ρ^(0)e+v_(e))=2.299_(-0.204)^(+0.214)±0.011,B(D^(0)→ρ^(-)μ^(+)v_(μ))=1.816_(-0.160)^(+0.168)±0.004,and B(D^(+)→ρ^(0)μ+v_(μ))=2.288_(-0.201)^(+0.212)±0.011.

关键词： QCD sum rule charmed meson semileptonic decay Rho meson light-cone distribution amplitude

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层状地基中刚性承台群桩竖向力学分析

同济大学学报（自然科学版） 2007年第4期35卷 446-450页

作者：李早黄茂松戴兵同济大学地下建筑与工程系上海200092

基于Winkler地基模型,建立分层土中单桩的荷载传递矩阵,并考虑被动桩与桩周土的相互作用,建立被动桩的位移控制方程,得到两根桩的相互影响系数α.提出了刚性承台下受荷群桩的位移内力计算的解析方法,并和有限元计算的结果进行了比较,得... 详细信息

基于Winkler地基模型,建立分层土中单桩的荷载传递矩阵,并考虑被动桩与桩周土的相互作用,建立被动桩的位移控制方程,得到两根桩的相互影响系数α.提出了刚性承台下受荷群桩的位移内力计算的解析方法,并和有限元计算的结果进行了比较,得到了较好的一致性.

关键词：群桩桩-桩相互作用荷载传递矩阵成层土

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岩体可爆性分级的未确知均值分级方法及应用

中南大学学报（自然科学版） 2015年第6期46卷 2157-2161页

作者：戴兵赵国彦董陇军中南大学资源与安全工程学院湖南长沙410083

将未确知测度理论应用到岩石可爆性分级问题中,提出未确知均值分级方法,建立岩石可爆性分级的未确知均值分级模型;选用岩石容重、岩石抗拉强度、岩石完整性系数作为分级模型的判定指标;以14种岩石的实测判定指标建立分类判别指标的未确... 详细信息

将未确知测度理论应用到岩石可爆性分级问题中,提出未确知均值分级方法,建立岩石可爆性分级的未确知均值分级模型;选用岩石容重、岩石抗拉强度、岩石完整性系数作为分级模型的判定指标;以14种岩石的实测判定指标建立分类判别指标的未确知测度函数,并求得各分级样本指标的平均值和单指标测度矩阵;根据信息熵理论确定各指标的权重,利用置信度识别准则对岩石进行判定分级。利用该模型对矿区岩石进行分类预测,并与实测结果进行比较。研究结果表明:利用岩石可爆性分级的未确知均值分级模型所得预测结果与实测结果相吻合,准确率达100%为岩石可爆性分级提供了一条新的途径。

关键词：岩石可爆性分级未确知均值分级方法

A Strategy for Loading Oblique Photogrammetry Models and Multilayer Basemap Data

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Journal of Computer and Communications 2019年第7期7卷 1-8页

作者： Weiye Zhang Zhiqing Tang Guangyang Zhu bing dai Zhuorong Song Jun Li College of Electronic Science National University of Defense Technology Changsha China The 2nd Surveying and Mapping Institute of Hunan Province Changsha China

With the development of drone technology and oblique photogrammetry technology, the acquisition of oblique photogrammetry models and basemap becomes more and more convenient and quickly. The increase in the number of basemap leads to excessively redundant basemap tiles requests in 3D GIS when loading oblique photogrammetry models, which slows down the system. Aiming at improving the speed of running system, this paper proposes a dynamic strategy for loading basemap tiles. Different from existing 3D GIS which loading oblique photogrammetry models and basemap tiles inde-pendently, this strategy dynamically loads basemap tiles depending on different height of view and the range of loaded oblique photogrammetry models. We achieve dynamic loading of basemap tiles by predetermining whether the basemap tiles will be covered by the oblique photogrammetry models. The experimental results show that this strategy can greatly reduce the num-ber of redundant requests from the client to the server while ensuring the user’s visual requirements for the oblique photogrammetric model.

关键词： Dynamic Loading of Basemap Tiles Oblique Photogrammetry Model Data Visualization 3D Tile Cesium