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FOXO1 reshapes neutrophils to aggravate acute brain damage and promote late depression after traumatic brain injury

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Military Medical Research 2024年第4期11卷 521-542页

作者： Mi Zhou Yang-Wu-Yue Liu Yu-Hang He Jing-Yu Zhang Hao Guo Hao Wang Jia-Kui Ren Yi-Xun Su Teng Yang Jia-Bo Li Wen-Hui He Peng-Jiao Ma Man-Tian Mi shuang-shuang dai Department of Biochemistry and Molecular Biology School of Basic MedicineArmy Medical UniversityChongqing 400038China Research Center for Nutrition and Food Safety Chongqing Key Laboratory of Nutrition and HealthInstitute of Military Preventive MedicineArmy Medical UniversityChongqing 400038China Department of Neurosurgery Daping HospitalArmy Medical UniversityChongqing 400042China Department of Trauma and Emergency Southwest HospitalArmy Medical UniversityChongqing 400038China Department of Histology and Embryology Chongqing Key Laboratory of NeurobiologyBrain and Intelligence Research Key Suyixun Laboratory of Chongqing Education CommissionArmy Medical UniversityChongqing 400038China Research Center Seventh Affiliated Hospital of Sun Yat-Sen UniversityShenzhen 518107GuangdongChina

Background:Neutrophils are traditionally viewed as first responders but have a short onset of action in response to traumatic brain injury(TBI).However,the heterogeneity,multifunctionality,and time-dependent modulation of brain damage and outcome mediated by neutrophils after TBI remain poorly ***:Using the combined single-cell transcriptomics,metabolomics,and proteomics analysis from TBI patients and the TBI mouse model,we investigate a novel neutrophil phenotype and its associated effects on TBI outcome by neurological deficit scoring and behavioral *** also characterized the underlying mechanisms both invitro and invivo through molecular simulations,signaling detections,gene expression regulation assessments[including dual-luciferase reporter and chromatin immunoprecipitation(ChIP)assays],primary cultures or co-cultures of neutrophils and oligodendrocytes,intracellular iron,and lipid hydroperoxide concentration measurements,as well as forkhead box protein O1(FOXO1)conditional knockout ***:We identified that high expression of the FOXO1 protein was induced in neutrophils after TBI both in TBI patients and the TBI mouse *** of these FOXO1high neutrophils in the brain was detected not only in the acute phase but also in the chronic phase post-TBI,aggravating acute brain inflammatory damage and promoting late TBI-induced *** the acute stage,FOXO1 upregulated cytoplasmic Versican(VCAN)to interact with the apoptosis regulator B-cell lymphoma-2(BCL-2)-associated X protein(BAX),suppressing the mitochondrial translocation of BAX,which mediated the antiapoptotic effect companied with enhancing interleukin-6(IL-6)production of FOXO1high *** the chronic stage,the“FOXO1-transferrin receptor(TFRC)”mechanism contributes to FOXO1high neutrophil ferroptosis,disturbing the iron homeostasis of oligodendrocytes and inducing a reduction in myelin basic protein,which contributes to the progression of late depression afte

关键词： Traumatic brain injury(TBI) Neutrophil Forkhead box protein O1(FOXO1) Acute stage Chronic stage

新文科背景下大学生创新创业教育中存在的问题及对策研究

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创新创业理论研究与实践 2024年第12期7卷 91-93,104页

作者：沈龙戴爽吉林工商学院吉林长春130507

新文科背景下大学生创新创业教育存在对创新创业认识不足,“专创融合”难度大,教师队伍整体水平有待加强,教材滞后且无案例库支撑,比赛参与度低等问题。该文针对大学生创新创业教育中存在的问题提出了革新教学内容,提高新文科大学生对... 详细信息

新文科背景下大学生创新创业教育存在对创新创业认识不足,“专创融合”难度大,教师队伍整体水平有待加强,教材滞后且无案例库支撑,比赛参与度低等问题。该文针对大学生创新创业教育中存在的问题提出了革新教学内容,提高新文科大学生对创新创业能力的认识;修改人才培养方案,开展“专创融合”教育;鼓励教师参加培训实践,提升教师团队综合素质;编写教材,建立创新创业案例库;以新文科项目参赛,提高参赛获奖率等整改措施,以解决上述问题,促进创新创业教育的发展。

关键词：新文科创新创业教育 “专创融合” 创新创业能力学科竞赛案例库

大蒜多糖提取、结构测定、化学修饰及生物活性研究进展

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食品工业科技 2024年第1期45卷 9-17页

作者：代爽李琳琳尹卫王乐王煜伟梁健青海大学省部共建三江源生态与高原农牧业国家重点实验室青海西宁810016 青海大学农牧学院青海西宁810016

作为大蒜的主要活性成分之一,大蒜多糖具有增强免疫力、抗菌、抗病毒、抗氧化、保肝、降血脂、降血糖等多种生物活性,应用前景广阔。大蒜多糖的提取方法以热水法、酶法和超声辅助法最为常见,大蒜多糖是由果糖、葡萄糖、半乳糖、甘露糖... 详细信息

作为大蒜的主要活性成分之一,大蒜多糖具有增强免疫力、抗菌、抗病毒、抗氧化、保肝、降血脂、降血糖等多种生物活性,应用前景广阔。大蒜多糖的提取方法以热水法、酶法和超声辅助法最为常见,大蒜多糖是由果糖、葡萄糖、半乳糖、甘露糖、半乳糖醛酸等组成的杂多糖,乙酰化、硒化和磷酸化等化学修饰可以增加大蒜多糖抗氧化等生物活性。本文从大蒜多糖的提取、结构测定、化学修饰及生物活性的角度出发,系统总结了大蒜多糖的研究现状,未来应关注多糖结构与生物活性的构效关系,深入探讨大蒜多糖的功效机理,以期为大蒜多糖作为功能性产品的开发利用提供理论参考。

关键词：大蒜多糖提取结构测定化学修饰生物活性

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一回路条件下甲醇水溶液的辐射分解研究进展

辐射研究与辐射工艺学报 2024年第3期42卷 1-10页

作者：王怡汤嘉杨雨杨旸鲁芸芸代爽曹骐中国核动力研究设计院反应堆运行与应用研究所成都610200

采取有效的水化学技术可以抑制压水堆一回路冷却剂辐射分解并减缓材料腐蚀。相关研究与运行经验表明,甲醇有望作为压水堆冷却剂水质转型的候选添加物,但目前缺乏一回路条件下甲醇辐解行为及机制的深刻认识,难以支撑基于甲醇的水化学控... 详细信息

采取有效的水化学技术可以抑制压水堆一回路冷却剂辐射分解并减缓材料腐蚀。相关研究与运行经验表明,甲醇有望作为压水堆冷却剂水质转型的候选添加物,但目前缺乏一回路条件下甲醇辐解行为及机制的深刻认识,难以支撑基于甲醇的水化学控制目标。本文首先介绍了甲醇辐解研究的必要性,总结了国内外甲醇及其水溶液辐解研究的进展情况,详细论述了常温下甲醇辐解产物产额与自由基反应,以及一回路条件下甲醇水溶液的辐解及其对材料腐蚀的影响,并对后期开展甲醇水溶液辐解相关研究提出建议。

关键词：甲醇水溶液辐解腐蚀一回路条件

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消费主义视域下大学生精神生活的消解与重塑

潍坊工程职业学院学报 2024年第1期37卷 43-50页

作者：戴双月宫晓虹安徽工业大学马克思主义学院安徽马鞍山243002

大学生的精神生活是物质生活的升华,是大学生精神生活状态和精神生活方式的体现。当代大学生精神生活既具有精神生活的普遍性,又具有大学生的独特性,主要聚焦于理想信仰、文化娱乐、人际交往等层次。消费主义是消费手段与消费目的不一... 详细信息

大学生的精神生活是物质生活的升华,是大学生精神生活状态和精神生活方式的体现。当代大学生精神生活既具有精神生活的普遍性,又具有大学生的独特性,主要聚焦于理想信仰、文化娱乐、人际交往等层次。消费主义是消费手段与消费目的不一致的反映,是消费异化的一种现象,潜移默化中消解了大学生理想信念、价值追求和人际交往,要扬弃虚假消费、符号消费和攀比消费等不理智的消费行为,引导大学生增强理想信念的精神力量、树立科学理性的价值追求和形成健康合理的精神交往,推动大学生精神生活向有序、高质量方向发展。

关键词：消费主义大学生精神生活路径

Mid-Cretaceous Hothouse Climate and the Expansion of Early Angiosperms

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Acta Geologica Sinica(English Edition) 2018年第5期92卷 2004-2025页

作者： ZHANG Mingzhen dai shuang DU Baoxia JI Liming HU Shusheng Key Laboratory of Petroleum Resources Gansu Province/ Key Laboratory of Petroleum Resources Research Northwest Institute of Eco-Environment and Resources Chinese Academy of Sciences Key Laboratory of Mineral Resources in Western China (Gansu Province) and School of Earth Science Lanzhou University Division of Paleobotany Peabody Museum of Natural History Yale University

The remarkable transition of early angiosperms from a small to a dominant group characterized the terrestrial ecosystem of the Cretaceous. This transition was instigated and promoted by environmental changes. Mid-Cretaceous is characterized by major geological events that affected the global environment. δ^18O, palaeothermometer TEX86, and other climatic indices from marine sediments suggest rapid temperature increase during mid-Cretaceous despite occasional short cooling events. Simultaneously, terrestrial deposits in East Asia changed from coal-bearing to shale, then to red beds and evaporites. Plant assemblages and other paleoclimate indicators point to rapid aridification for midCretaceous terrestrial environments. In addition, the wildfires were frequently spread all over the earth by the numerous charcoal evidence during the Mid-Cretaceous. Thus, we speculate that the seasonally dry and hot conditions of mid-Cretaceous created a fiery hothouse world. Early angiosperms increased in abundance and diversity and evolved from a few aquatic species to terrestrial herbaceous and then to the diversified flora of today. Angiosperms showed rapid physiological evolution in vein density and leaf area that improved photosynthesis and water absorption. These ecophysiological changes made early angiosperms well adapted to the hot and dry environment in mid-Cretaceous. Moreover, these physiological changes facilitated the fire–angiosperm cycles in mid-Cretaceous that likely further stimulated the early angiosperm evolution.

关键词： Mid-Cretaceous hothouse wildfire early angiosperm diversification

Timing,Displacement and Growth Pattern of the Altyn Tagh Fault:A Review

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Acta Geologica Sinica(English Edition) 2017年第2期91卷 669-687页

作者： dai shuang dai Wei ZHAO Zhenbin LUO Junhua QIANG Lei MA Xin ZHANG Xianwen XU Jianjun Key Laboratory of Western China's Environmental Systems(Ministry of Education) College of Earth and Environmental SciencesLanzhou UniversityLanzhou 730000China Gansu Bureau of Seismology Lanzhou 730000China

The Altyn Tagh Fault（ATF） is the longest, lithospheric scale and strike-slip fault in East Asia. In the last three decades, multidisciplinary studies focusing on the timing, displacement of strikeslip and growth mechanics of the ATF have made great progresses. Most studies revealed that the ATF is a sinistral strike-slip and thrust fault, which underwent multiple episodes of activation. The fault is oriented NEE with a length of 1600 km, but the direction, timing of activity and magnitude of its extension eastward are still unclear. The AFT was predominately active during the Mesozoic and Cenozoic, in relation to the Mesozoic collision of the Cimmerian continent（Qiangtang and Lhasa block） and Cenozoic collision of India with Asia. The AFT strike-slipped with a left-lateral displacement of ca. 400 km during the Cenozoic and the displacement were bigger in the western segment and stronger in the early stage of fault activation. The slip-rates in the Quaternary were bigger in the middle segment than in the western and eastern segment. We roughly estimated the Mesozoic displacement as ca. 150-300 km. The latest paleomagnetic data showed that the clockwise vertical-axis rotation did not take place in the huge basins（the Tarim and Qaidam） at both side of ATF during the Cenozoic, but the rotation happened in the small basins along the ATF. This rotation may play an important role on accommodating the tectonic deformation and displacement of the ATF. Even if we have achieved consensus for many issues related to the ATF, some issues still need to be study deeply; such as：（a） the temporal and spatial coupling relationship between the collision of Cimmerian continent with Asia and the history of AFT in the Mesozoic and（b） the tectonic deformation history which records by the sediments of the basins within and at both side of AFT and was constrained by a high-resolution and accurate chronology such as magnetostratigraphy and paleomagnetic data.

关键词： timing displacement of strike-slip growth paleomagnetism Altyn Tagh fault Proto-Tethys

Magnetostratigraphy of the Zanda basin in southwest Tibet Plateau and its tectonic implications

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Chinese Science Bulletin 2008年第9期53卷 1393-1400页

作者： WANG ShiFeng ZHANG WeiLin FANG XiaoMin dai shuang Oliver KEMPF Institute of Tibetan Plateau Research Chinese Academy Sciences Beijing 100085 China Key Laboratory of Western China's Environmental Systems Ministry of Education of China & College of Resources and Environ- ment Lanzhou University Lanzhou730000 China Institut fer Umweltgeologie Technische University Braunschweig Braunschweig 38106 Germany

The Zanda basin is one of the very important basins at the north slope of the Himalaya Range. Thus the study of the basin strata will provide critical information about the tectonic evolution of the Himalayan Orogenic Belt. 268 oriented block samples were collected in the 750-m-thick sections of the Zanda ba- sin. The characteristic remanent magnetization (ChRM) was isolated that decays linearly to the origin between 500oC and 690oC for most studied samples. An age range of 9.5―2.6 Ma was estimated from the correlation between our observed polarity column and the Geomagnetic Polarity Time Scale (GPTS). The age of the Zanda basin does not support the models that the South Tibetan Detach system (STDS) is one of the basin controlling faults. Given the sedimentological features in the basin and the tectonic features at the north edge of the basin, the Zanda basin was a half graben that was possibly controlled by the Karakorum fault on the northeast.

关键词：盆地磁性地层学断层西藏南部

A spatialized digital database for all bird species in China

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Science China(Life Sciences) 2019年第5期62卷 661-667页

作者： shuang dai Duole Feng Karen Kie Yan Chan Peng Gong Bing Xu Department of Earth System Science Tsinghua University Department of Geography University of Utah State Key Laboratory of Remote Sensing Science College of Global Change and Earth System Science Beijing Normal University

The lack of refined spatial detail on bird distribution in China has hindered further research due to the large geographic unit(provincial level) in existing national bird distribution data. Based on multi-source bird distribution data, we built a more spatially detailed distribution database for every bird species(1,371 species) in China, covering 2,908 counties. The sources on bird distribution are grouped into six categories: Handbooks, Literature; Fauna, Avifauna; Paper; Citizen Science data by ornithologists or birders; GPS tracing; and Website data. The database contains the following records: taxonomy, distribution data, suspicious species information, and data sources. Our database recorded 835 species(61%) appearing outside the distribution range previously known. The use of provincial boundaries as the smallest geographical unit has created misleading distribution results due to geographic aggregation for most species. The new database was built based on increased observational frequency and individuals observed in previously undetected areas particularly in Western China and towards higher altitudes and latitudes. They coincided with the discovery of the range expansion of some waterfowls into Xinjiang. The dataset provides a new base for Chinese and international ornithology studies, especially for those requiring more detailed distribution information for many taxa and large-scale regional research.

关键词： birds biodiversity China database distribution