检索结果-南通市图书馆

Aggregation-induced emission luminogens reveal cell cycle-dependent telomerase activity in cancer cells

在线全文

学校读者我要写书评

暂无评论

National Science Review 2021年第6期8卷 70-79页

作者： Xia Wu jun Wu jun dai Biao Chen Zhe Chen Shixuan Wang Feng Wu Xiaoding Lou Fan Xia Engineering Research Center of Nano-Geomaterials of Ministry of Education Faculty of Materials Science and ChemistryChina University of Geosciences Department of Obstetrics and Gynecology Tongji HospitalTongji Medical CollegeHuazhong University of Science and Technology

Telomerase acts as an important biomarker for tumor identification, and synthesizes telomeric repeats at the end of chromosome telomeres during the replicative phase of the cell cycle; thus, the expression level of telomerase changes as the cell cycle progresses. TERT m RNA expression and telomerase activity were significantly increased in over 80% of human cancers from tissue specimens. Although many efforts have been made in detecting the activity of TERT m RNA and active telomerase, the heterogeneous behavior of the cell cycle was overlooked, which might affect the accuracy of the detection results. Herein, the AIEgen-based biosensing systems of Py TPA-DNA and Silole-R were developed to detect the cellular level of TERT m RNA and telomerase in different cell cycles. As a result, the fluorescence signal of cancer cells gradually increased from G0/G1, G1/S to S phase. In contrast, both cancer cells arrested at G2/M phase and normal cells exhibited negligible fluorescence intensities. Compared to normal tissues, malignant tumor samples demonstrated a significant turn-on fluorescence signal. Furthermore, the transcriptomics profiling revealed that tumor biomarkers changed as the cell cycle progressed and biomarkers of CA9, TK1 and EGFR were more abundantly expressed at early S stage. In this vein, our study presented advanced biosensing tools for more accurate analysis of the cell-cycle-dependent activity of TERT m RNA and active telomerase in clinical tissue samples.

关键词： cell cycle TERT mRNA telomerase activity AIEgens biomarkers

Characterization and performance of graphene-PbSe thin film heterojunction

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Rare Metals 2021年第1期40卷 219-224页

作者： Bo He Yi-Xuan Ren Tian-jun dai Shuang Hou Xing-Zhao Liu School of Electronics Science and Engineering University of Electronic Science and Technology of ChinaChengdu 611731China State Key Laboratory of Electronic Thin Films and Integrated Devices Chengdu 611731China

An infrared detector with high responsivity based on graphene-PbSe thin film heterojunction was ***-quality PbSe thin film and graphene were prepared by molecular beam epitaxy and chemical vapor deposition,*** physical characteristics of PbSe thin film and graphene were performed using X-ray diffraction(XRD),X-ray photoelectron spectroscopy(XPS)and Raman *** photo transistor using PbSe thin film as a sensitizer and graphene as a channel to transport excitons exhibits peak responsivity and detectivity up to~420 A·W^(-1) and 5.9×10^(11) Jones(radiation intensity:0.75 mW·cm^(-2))at room temperature in the near-infrared(NIR)region,*** high optical response is attributed to the photo-excited holes transferring from PbSe film to graphene under ***,it is revealed that the responsivity of graphene-PbSe photo transistor is gate-tunable which is important in photodetectors.

关键词： PbSe Graphene Heterojunction Infrared photodetectors

Nasobiliary drainage after endoscopic papillary balloon dilatation may prevent postoperative pancreatitis

在线全文

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2015年第8期21卷 2443-2449页

作者： Xiao-Dan Xu Jian-jun dai Jian-Qing Qian Wei-jun Wang Department of Gastroenterology Changshu Affiliated Hospital of Suzhou University

AIM:To evaluate the necessity of endoscopic nasobiliary drainage(ENBD)catheter placement after clearance of common bile duct(CBD)***:Patients enrolled in this study were randomly divided into two groups,according to whether or not they received ENBD after the removal of CBD *** 1(ENBD group)was then subdividedinto three groups:G1a patients received an endoscopic papillary balloon dilatation(EPBD),G1b patients received an endoscopic sphincterotomy(EST),and G1c patients received *** 2(non-ENBD group)patients were also subdivided into three groups(G2a,G2b,and G2c),similar to Group *** maximum CBD diameter,the time for C-reactive protein(CRP)to normalize,levels of serum amylase,total serum bilirubin(TB)and alanine aminotransferase(ALT),and postoperative hospitalization duration(PHD)were ***:A total of 218 patients(139 males,79females),with an average age of 60.1±10.8 years,were enrolled in this *** hundred and thirteen patients who received ENBD were included in Group 1,and 105patients who did not receive ENBD were included in Group *** baseline clinical characteristics were similar in both *** were no significant differences in post-endoscopic retrograde cholangiopancreatography(ERCP)-related complications when Groups 1 and 2 were ***-seven patients underwent EPBD,and41 received an ENBD tube(G1a)and 36 did not(G2a).Seventy-three patients underwent EST,and 34 patients received an ENBD tube(G1b)and 39 did not(G2b).The remaining 68 patients underwent neither EPBD nor EST;of these patients,38 received an ENBD tube(G1c)and 30 did not(G2c).For each of the three pairs of subgroups(G1a vs G2a,G1b vs G2b,G1c vs G2c),there were no significant differences detected in the PHD or the time to normalization of CRP,TB and *** the EPBD group,the incidence of post-ERCP pancreatitis,hyperamylasemia and overall patient complications was significantly higher for G2a(post-ERCP pancreatitis:6/36vs 0/41,P=0.0217;hyp

关键词： Endoscopic papillary balloon dilatation Endoscopic

3-PRS serial-parallel machine tool error calibration and parameter identification

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

重庆邮电大学学报（自然科学版） 2009年第2期21卷 284-291页

作者： ZHAO jun-wei dai jun HUANG jun-jie School of Mechanical and Power Engineering Henan Polytechnic University Jiaozuo 454003P. R. China

3-PRS serial-parallel machine tool consists of a 3-degree-of-freedom (DOF) implementation platform and a 2-DOF X-Y platform. The error modeling and parameter identification methods were deduced based on 3-PRS serial-parallel machine tool. 3-PRS serial-parallel machine tool was researched, and the mechanism of error analysis, modeling, identification of error parameters and measurement equipment for the use of agency error of measurement were conducted. In order to achieve the geometric parameters calibration and error compensation of the serial-parallel machine tool, the nominal structural parameters of the controller was adjusted by identifying the structure of the machine tool. With the establishment of a vector space size chain, we can do the error analysis, error modeling, error measurement and error compensation can be done.

关键词：串并联机床参数辨识误差标定串行 3自由度误差建模代理平台结构参数

Three-dimensional structure of an observed cyclonic mesoscale eddy in the Northwest Pacific and its assimilation experiment

在线全文

学校读者我要写书评

暂无评论

Acta Oceanologica Sinica 2021年第5期40卷 1-19页

作者： jun dai Huizan Wang Weimin Zhang Pinqiang Wang Tengling Luo College of Meteorology and Oceanography National University of Defense TechnologyChangsha 410073China

Mesoscale eddies play an important role in modulating the ocean *** previous studies on the threedimensional structure of mesoscale eddies were mainly based on composite analysis,and there are few targeted observations for individual eddies.A cyclonic eddy surveyed during an oceanographic cruise in the Northwest Pacific Ocean is investigated in this *** three-dimensional structure of this cyclonic eddy is revealed by observations and simulated by the four-dimensional variational data assimilation(4 DVAR)system combined with the Regional Ocean Modeling *** observation and assimilation results together present the characteristics of the cyclonic *** cold eddy has an obvious dual-core structure of temperature *** core is at 50–150 m and another is at 300–550 m,which both have the average temperature anomaly of approximately-3.5℃.The salinity anomaly core is between 250 m and 500 m,which is *** horizontal velocity structure is axis-asymmetric and it is enhanced on the eastern side of the cold *** the assimilation experiment,sea level anomaly,sea surface temperature,and in situ measurements are assimilated into the system,and the results of assimilation are close to the *** on the high-resolution assimilation output results,the study also diagnoses the vertical velocity in the mesoscale eddy,which reaches the maximum of approximately 10 m/*** larger vertical velocity is found to be distributed in the range of 0.5 to 1 time of the normalized radius of the *** validation of the simulation result shows that the 4 DVAR method is effective to reconstruct the three-dimensional structure of mesoscale eddy and the research is an application to study the mesoscale eddy in the Northwest Pacific by combining observation and assimilation methods.

关键词： mesoscale eddy three-dimensional structure 4DVAR assimilation vertical velocity

Risk identification and safety assessment of human-computer interaction in integrated avionics based on STAMP

在线全文

学校读者我要写书评

暂无评论

Journal of Systems Engineering and Electronics 2024年第3期35卷 689-706页

作者： ZHAO Changxiao LI Hao ZHANG Wei dai jun DONG Lei School of Safety Science and Engineering Civil Aviation University of ChinaTianjin 300300China Shenzhen Dajiang Innovation Technology Co. Ltd.Shenzhen 518057China Key Laboratory of Civil Aircraft Airworthiness Technology Civil Aviation Administration of ChinaTianjin 300300China

To solve the problem of risk identification and quantitative assessment for human-computer interaction(HCI)in complex avionics systems,an HCI safety analysis framework based on system-theoretical process analysis(STPA)and cognitive reliability and error analysis method(CREAM)is *** can identify unsafe control actions and find the causal path during the interaction of avionics systems and pilot with the help of formal verification tools *** common performance conditions(CPC)of avionics systems in the aviation environment is established and a quantitative analysis of human failure is carried *** the head-up display(HUD)system interaction process as an example,a case analysis is carried out,the layered safety control structure and formal model of the HUD interaction process are *** the interactive behavior“Pilots approaching with HUD”,four unsafe control actions and35 causal scenarios are identified and the impact of common performance conditions at different levels on the pilot decision model are *** results show that HUD's HCI level gradually improves as the scores of CPC increase,and the quality of crew member cooperation and time sufficiency of the task is the key to its *** case analysis,it is shown that STPACREAM can quantitatively assess the hazards in HCI and identify the key factors that impact safety.

关键词： avionics human-computer interaction(HCI) safety assessment system-theoretic accident model and process human reliability analysis

Base position planning of mobile manipulators for assembly tasks in construction environments

在线全文

学校读者我要写书评

暂无评论

Advances in Manufacturing 2023年第1期11卷 93-110页

作者： dai-jun Xie Ling-Dong Zeng Zhen Xu Shuai Guo Guo-Hua Cui Tao Song Shanghai Key Laboratory of Intelligent Manufacturing and Robotics School of Mechatronic Engineering and AutomationShanghai UniversityShanghai200444People’s Republic of China National Demonstration Center for Experimental Engineering Training Education Shanghai UniversityShanghai200444People’s Republic of China School of Mechanical and Automotive Engineering Shanghai University of Engineering ScienceShanghai201620People’s Republic of China Shanghai Collaborative Innovation Center of Intelligent Manufacturing Robot Technology for Large Components Shanghai201620People’s Republic of China

With good mobility and flexibility,mobile manipulators have shown broad applications in construction *** position(BP)planning,which refers to the robot autonomously determining its working station in the environment,is an important technique for mobile manipulators when performing the construction assembly task,especially in a large-scale construction ***,the BP planning process is tedious and time-consuming for a human worker to carry ***,to improve the efficiency of construction assembly tasks,a novel BP planning method is proposed in this paper,which can lead to appropriate BPs and minimize the number of BPs at the same ***,the feasible BP regions are generated based on the grid division and the variable workspace of the mobile ***,the positioning uncertainties of the mobile manipulator are considered in calculating the preferred BP areas using ***,a set coverage optimization model is established to obtain the minimum number of BPs using an optimization algorithm according to the greedy *** simulated experiment based on a 9-degree of free(DoF)mobile manipulator has been *** results illustrated that the time for BP planning was significantly reduced and the number of BPs was reduced by 63.41%compared to existing manual planning,which demonstrated the effectiveness of the proposed method.

关键词： Base position(BP)planning Mobile manipulators Variable workspace Positioning uncertainties Construction environments

New index to predict esophageal variceal bleeding in cirrhotic patients

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Gastroenterology 2014年第22期20卷 6989-6994页

作者： Xiao-Dan Xu Jian-jun dai Jian-Qing Qian Xun Pin Wei-jun Wang Department of Gastroenterology Changshu Affiliated Hospital of Suzhou University

AIM: To develop a safe, simple, noninvasive and affordable system to predict esophageal variceal bleeding (EVB) in decompensated cirrhosis patients.

关键词： Portal hypertension Ultrasound-Doppler Esophageal variceal bleeding Decompensated cirrhosis Endoscopy

Probing Intermittent Motion of Polymer Chains in Weakly Attractive Nanocomposites

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Polymer Science 2020年第6期38卷 620-628页

作者： Li-jun dai Cui-Liu Fu You-Liang Zhu Zhan-Wei Li Zhao-Yan Sun State Key Laboratory of Polymer Physics and Chemistry Changchun Institute of Applied ChemistryChinese Academy of SciencesChangchun 130022China University of Chinese Academy of Sciences Beijing 100049China

In this study,we investigate the motion of polymer segments in polymer/nanoparticle composites by varying nanoparticle(NP)volume *** studying the probability distribution of segment displacement,segment trajectory,and the square displacement of segment,we find the intermittent motion of segments,accompanied with the coexistence of slow and fast segments in polymer nanocomposites(PNCs).The displacement distribution of segments exhibits an exponential tail,rather than a Gaussian *** intermittent dynamics of chain segments is comprised of a long-range jump motion and a short-range localized motion,which is mediated by the weakly attractive interaction between NP and chain segment and the strong confinement induced by ***,the intermittent motion of chain segments can be described by the adsorption-desorption transition at low particle loading and confinement effect at high particle *** findings may provide important information for understanding the anomalous motion of polymer chains in the presence of NPs.

关键词： Nanocomposites Intermittent dynamics The probability distribution of displacement Confinement Adsorption-desorption mechanism