检索结果-南通市图书馆

Application of Cone-beam Computed Tomography in Interventional Therapies for Liver Malignancy:A Consensus Statement by the Chinese College of Interventionalists

在线全文

学校读者我要写书评

暂无评论

Journal of Clinical and Translational Hepatology 2024年第10期12卷 886-891页

作者： Bin-Yan zhong zhong-Zhi Jia Wen Zhang Chang Liu Shi-hong Ying Zhi-Ping Yan Cai-Fang Ni Clinical Guidelines Committee of Chinese College of Interventionalists Department of Interventional Radiology The First Affiliated Hospital of Soochow UniversitySuzhouJiangsuChina Department of Interventional and Vascular Surgery The Affiliated Changzhou Second People’s Hospital of Nanjing Medical UniversityChangzhouJiangsuChina Department of Interventional Radiology Zhongshan HospitalFudan University Shanghai Institution of Medical ImagingFudan UniversityShanghaiChina Division of Liver Department of General SurgeryWest China HospitalSichuan UniversityChengduSichuanChina Department of Minimal Invasive Surgery Shangjin Nanfu HospitalChengduSichuanChina Department of Radiology First Affiliated HospitalZhejiang University School of MedicineHangzhouZhejiangChina 不详

Despite its crucial role in interventional therapies for liver malignancy,cone-beam computed tomography(CBCT)has not yet been fully integrated into clinical practice due to several complicating factors,including nonstandardized operations and limited recognition of CBCT among interventional *** response,the Chinese College of Interventionalists has released a consensus statement aimed at standardizing and promoting the application of CBCT in the interventional therapies for liver *** statement summarizes CBCT scanning techniques,and operational standards,and highlights its potential applications in clinical practice.

关键词： Cone-beam computed tomography Interventional radiology Liver malignancy Consensus statement Chemoembolization Ablation

Exploring the role of interleukin-6 receptor blockade in epilepsy and associated neuropsychiatric conditions through a mendelian randomization study

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Psychiatry 2024年第8期14卷 1244-1253页

作者： Yan-Mei Yu Gui-hong Jin Chong zhong Hao Qian Lei Wang Feng Zhan Department of Pediatrics The First People's Hospital of ChuzhouChuzhou 239001Anhui ProvinceChina Department of Wenzhou Institute University of Chinese Academy of SciencesWenzhou 325000Zhejiang ProvinceChina

BACKGROUND The interplay between inflammation,immune dysregulation,and the onset of neurological disorders,including epilepsy,has become increasingly ***(IL)-6,a pro-inflammatory cytokine,is suspected to not only mediate traditional inflammatory pathways but also contribute to neuroinflammatory responses that could underpin neuropsychiatric symptoms and broader psychiatric disorders in epilepsy *** role of IL-6 receptor(IL6R)blockade presents an intriguing target for therapeutic intervention due to its potential to attenuate these *** conditions due to *** Mendelian randomization(MR)analysis employing single nucleotide poly-morphisms(SNPs)in the vicinity of the IL6R gene(total individuals=408225)was used to evaluate the putative causal relationship between IL6R blockade and epilepsy(total cases/controls=12891/312803),focal epilepsy(cases/controls=7526/399290),and generalized epilepsy(cases/controls=1413/399287).SNP weights were determined by their effect on C-reactive protein(CRP)levels and integrated using inverse variance-weighted meta-analysis as surrogates for IL6R *** address potential outlier and pleiotropic influences,sensitivity analyses were conducted employing a variety of MR methods under different modeling *** The genetic simulation targeting IL6R blockade revealed a modest but significant reduction in overall epilepsy risk[inverse variance weighting:Odds ratio(OR):0.827;95%confidence interval(CI):0.685-1.000;P=0.05].Subtype analysis showed variability,with no significant effect observed in generalized,focal,or specific childhood and juvenile epilepsy *** the primary inflammatory marker CRP,the findings also suggested potential non-inflammatory pathways mediated by IL-6 signaling contributing to the neurobiological landscape of epilepsy,hinting at possible links to neuroinflammation,psychiatric symptoms,and associated mental *** The i

关键词： Epilepsy Interleukin-6 receptor blockade Mendelian randomization Neuroinflammation Psychiatric disorders

CoFe_(2)O_(4) decorated graphene/C_(18)-functionalized mesoporous silica nanocomposites prepared for magnetic enrichment and electrochemical detection of promethazine in beef

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2024年第3期35卷 208-213页

作者： Xingdong Yang Shi-Ming Ying Sen Zhang Jinxia dai Wei Gao Tian-Qi Wang Jun-Qin Qiao hong-Zhen Lian Li Mao State Key Laboratory of Analytical Chemistry for Life Science School of Chemistry&Chemical Engineering and Centre of Materials AnalysisNanjing UniversityNanjing 210023China Ministry of Education(MOE)Key Laboratory of Modern Toxicology School of Public HealthNanjing Medical UniversityNanjing 211166China

Promethazine(PHZ)is used as a sedative in veterinary medicine,and its residue can threaten the health of *** electrochemical detection of PHZ is suitable method for application in the ***,the traditional electroanalysis is difficult to perform directly in meat samples due to matrix *** work integrates magnetic solid-phase extraction and differential pulse voltammetry for highly sensitive and selective determination of PHZ in beef and beef liver for the first ***_(2)O_(4)/graphene coated with C_(18)-functionalized mesoporous silica(MG@mSiO_(2)-C_(18))is synthesized as dispersed magnetic adsorbent to extract *** glassy carbon electrode modified with nitrogen-doped hollow carbon microspheres(HCM)attracts the MG@mSiO_(2)-C_(18)with PHZ,and directly detects the PHZ without elution ***@mSiO_(2)-C_(18)can separate PHZ to avoid the interference of impurities on following detection,and also concentrate PHZ on magnetic ***,the electrode modification with HCM can amplify the electrochemical signal of ***,the integrated PHZ determination method exhibits a wide linear range from 0.08μmol/L to 300μmol/L with a low limit of detection of 9.8 nmol/*** beef sample analysis presents excellent recovery,demonstrating that this protocol is promising for the rapid and onsite detection of PHZ in real meat samples。

关键词： Promethazine(PHZ) Drug residue Magnetic solid phase extraction Electrochemical detection Beef

Flavonoid extracts from chrysanthemum with appropriate anthocyanins turn blue when exposed to iron ions

在线全文

学校读者我要写书评

暂无评论

Horticultural Plant Journal 2024年第3期10卷 837-852页

作者： Yanfei Li Jiaying Wang Chenfei Lu zhongman Wang Chengyan Deng Kang Gao Jingjing Li Zhijun Fang Hao Liu Yan hong Silan dai Beijing Key Laboratory of Ornamental Plants Germplasm Innovation&Molecular Breeding National Engineering Research Center for FloricultureBeijingLaboratory of Urban and Rural Ecological EnvironmentKey Laboratory for Genetics and Breeding of Forest Trees and Ornamental Plants of Ministry of EducationSchool of Landscape ArchitectureBeijing Forestry UniversityBeijing 100083China Beijing Greenland Maintenance and Management Service Center Beijing 102211China Beijing North Asia Landscape Co. Beijing 102211China

Although some species that accumulate only cyanidin(Cy)in nature can produce blue flowers through iron ions,there has been no evidence of blue chrysanthemums being generated in this *** study revealed that flavonoid extracts from the ray florets of the chrysanthemum cultivar‘Wandai Fengguang’turned blue when exposed to Fe^(3+).Samples that could turn blue were labeled as CB(Cy-determined blue flowers),while samples that did not turn blue were labeled as CN(Cy-determined non-blue flowers).After a series of experiments,a stable screening system was established using flavonoid extracts containing NaAc buffer at pH 5.5 and a total anthocyanin concentration(TAC)of 30 μmol·L^(-1),and the addition of Fe^(3+)from 0 to 0.25 μmol·L^(-1)allowed for the selection of five CB samples from 39 chrysanthemum *** five CB samples exhibited flower color phenotypes that belonged to Cluster-I with redness(a*)values ranging from 29.03 to 45.99,yellowness(b*)values from-11.31 to 3.77,and brightness(L*)values from 29.07 to ***,the ratio of TAC to total luteolin concentration(TLC)was found to be a critical factor for distinguishing between CB and CN *** realize the desired blue hue in the flavonoid extracts with the participation of Fe^(3+),a TAC to TLC ratio of 2.25 and above is ***,the protoplasts and ray florets of CB samples that turned blue with the involvement of Fe^(2+)showed great potential for cultivating blue chrysanthemums through ferric-anthocyanin ***,this study reveals that blue flowers can be cultivated through the increase in the iron ion concentration,combined with the accumulation of Cy.

关键词： Chrysanthemum×morifolium Cyanidin Copigment Ferric-anthocyanin chelate Blue flower

Basic Survey Scheduling for the Wide Field Survey Telescope(WFST)

在线全文

学校读者我要写书评

暂无评论

Research in Astronomy and Astrophysics 2024年第1期24卷 59-69页

作者： Yan-Peng Chen Ji-An Jiang Wen-Tao Luo Xian-zhong Zheng Min Fang Chao Yang Yuan-Yu hong Zong-Fei Lü Purple Mountain Observatory Chinese Academy of SciencesNanjing 210023China School of Astronomy and Space Science University of Science and Technology of ChinaHefei 230026China Department of Astronomy University of Science and Technology of ChinaHefei 230026China National Astronomical Observatory of Japan National Institutes of Natural Sciences2-21-1 OsawaMitakaTokyo 181-8588Japan Institute of Deep Space Sciences Deep Space Exploration LaboratoryHefei 230026China

Aiming at improving the survey efficiency of the Wide Field Survey Telescope, we have developed a basic scheduling strategy that takes into account the telescope characteristics, observing conditions, and weather conditions at the Lenghu site. The sky area is divided into rectangular regions, referred to as “tiles,” with a size of2°. 577 × 2°. 634 slightly smaller than the focal area of the mosaic CCDs. These tiles are continuously filled in annulars parallel to the equator. The brightness of the sky background, which varies with the moon phase and distance from the moon, plays a significant role in determining the accessible survey fields. Approximately 50connected tiles are grouped into one block for observation. To optimize the survey schedule, we perform simulations by taking into account the length of exposures, data readout, telescope slewing, and all relevant observing conditions. We utilize the Greedy Algorithm for scheduling optimization. Additionally, we propose a dedicated dithering pattern to cover the gaps between CCDs and the four corners of the mosaic CCD array, which are located outside of the 3° field of view. This dithering pattern helps to achieve relatively uniform exposure maps for the final survey outputs.

关键词： telescopes surveys Moon

Pursue the nature of science: Advocate for a better research environment

在线全文

学校读者我要写书评

暂无评论

The Innovation 2024年第5期5卷 3-4页

作者： Ji dai Shenzhen Technological Research Center for Primate Translational Medicine Shenzhen-Hong Kong Institute of Brain ScienceShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China CAS Key Laboratory of Brain Connectome and Manipulation the Brain Cognition and Brain Disease InstituteShenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China Guangdong Provincial Key Laboratory of Brain Connectome and Behavior Shenzhen Institute of Advanced TechnologyChinese Academy of SciencesShenzhen 518055China University of Chinese Academy of Sciences Beijing 100049China

WHAT IS REAL SCIENCE?Science is often viewed through the lens of its tangible outcomes—publications,grants,academic titles,and *** markers of success in the academic world are undoubtedly important and serve as measures of productivity and ***,focusing solely on these external rewards risks oversimplifying the true essence of science and overlooking its fundamental purpose—the pursuit of knowledge through a process of discovery.1 At its core,science is a systematic and methodical approach to understanding the natural world,unraveling its mysteries,and uncovering the underlying principles that govern the *** is a process of inquiry and exploration that is driven by curiosity,creativity,and a relentless quest for truth(Figure 1).Science is not merely a means to an end but a journey of discovery that transcends individual accomplishments and external *** example is the study of gravitational waves,which are ripples in the fabric of spacetime and are predicted by Einstein’s theory of general *** 2015,the Laser Interferometer Gravitational-Wave Observatory(LIGO)detected gravitational waves for the first *** a major scientific breakthrough was the result of a collaboration between physicists and engineers from multiple institutions around the world,and it was also the result of pure curiosity.

关键词： doubt breakthrough Figure

Self-adaptive gas flow and phase change behaviors during hydrate exploitation by alternate injection of N_(2) and CO_(2)

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Petroleum Science 2024年第3期21卷 2120-2129页

作者： Bo-Jian Cao Yi-Fei Sun hong-Nan Chen Jin-Rong zhong Ming-Long Wang Ming Wang Chang-Yu Sun Guang-Jin Chen State Key Laboratory of Heavy Oil Processing China University of PetroleumBeijing102249China School of Chemistry and Chemical Engineering Changsha University of Science&TechnologyChangsha410114HunanChina

Since hydrate resources play a part of the stratigraphic framework structure in sediments,establishing a safe and economic method for hydrates exploitation remains the primary challenge to this *** the proposed methods,the spontaneous displacement of CH_(4) from hydrate cages by CO_(2) seems to be a perfect mechanism to address gas production and CO_(2) storage,especially in today's strong demand for carbon reduction and replacing clean *** extensive lab researches,in the past decade,injecting a mixture of CO_(2) and small molecule gas has become a key means to enhance displacement efficiency and has great potential for ***,there is a lack of in-depth research on gas flow in the reservoir,while the injected gas always passes through low-saturated hydrate areas with high permeability and then occurs gas channel in a short term,finally resulting in the decreases in gas production efficiency and produced gas ***,we explored a new injection-production mode of alternate injection of N2 and CO_(2) in order to fully coordinate the advantages of N_(2) in enhanced hydrate decomposition and CO_(2) in solid storage and heat *** alternate"taking"and"storing"processes perfectly repair the problem of the gas channel,achieving self-regulation effect of CH_(4) recovery and CO_(2) *** 3-D experimental results show that compared to the mixed gas injection,CH_(4) recovery is increased by>50%and CO_(2) storage is increased by>70%.Additionally,this alternate injection mode presented a better performance in CH_(4) concentration of produced gas and showed outstanding N_(2) utilization ***,we analyzed its self-adaptive gas flow mechanism and proposed an application model of"one injection and multiple production".We look forward to this study accelerating the application of CO_(2)-CH_(4) replacement technology.

关键词： Hydrate Replacement CH_(4)recovery CO_(2)storage Reservoir remediation

Single-celled metasurface for labeled vortex beam generator

在线全文

学校读者我要写书评

暂无评论

Journal of Materiomics 2024年第4期10卷 811-818页

作者： Congling Liang Qi dai Tian Huang hong-Chao Liu Zhiqiang Guan Rao Fu Jin Tao Zile Li Shaohua Yu Guoxing Zheng Electronic Information School and School of MicroelectronicsWuhan UniversityWuhan430072China Wuhan Institute of Quantum Technology Wuhan430206China Peng Cheng Laboratory Shenzhen518055China Suzhou Institute of Wuhan University Suzhou215123China Institute of Applied Physics and Materials Engineering University of MacaoAvenida da UniversidadeTaipaMacao SARMacao999078China State Key Laboratory of Optical Communication Technologies and Networks China Information Communication Technologies Group Corporation(CICT)Wuhan430074China

Vortex light is a unique beam characterized by a spiral phase as it propagates. A fundamental parameter of vortex light is the topological charge, which determines the amount of angular momentum and plays a crucial role in tailoring its behavior. However, conventional measurement methods for determining the topological charge, such as those based on interference and phase modulation, tend to be intricate and complex. In this regard, a labeled vortex beam generator is proposed, composed of a metasurface with a single-celled configuration. When the metasurface is illuminated by light of the designed wavelength, the outgoing light exhibits a vortex structure. Furthermore, the topological charge numbers can be directly observed with distinct labeled patterns when the metasurface is placed in an orthogonal-polarized optical path. With advantages such as ultra-compactness, high robustness, and exceptional precision, the proposed metasurface exhibits significant potential for applications in optical communication, light manipulation, optical sensing, etc.

关键词： Metasurface Vortex beam generator Topological charge

Lindqvist-type Polyoxometalates Act as Anti-breast Cancer Drugs via Mitophagy-induced Apoptosis

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Current Medical Science 2024年第4期44卷 809-819页

作者： Chen-guang YAO Zi-jia ZHAO Ting TAN Jiang-ning YAN zhong-wei CHEN Jun-tao XIONG Han-luo LI Yan-hong WEI Kang-hong HU Sino-German Biomedical Center Hubei Provincial Key Laboratory of Industrial MicrobiologyCooperative Innovation Center of Industrial Fermentation(Ministry of Education&Hubei Province)Key Laboratory of Fermentation Engineering(Ministry of Education)National“111”Center for Cellular Regulation and Molecular PharmaceuticsHubei University of TechnologyWuhan430068China Center for Evaluation of Hubei Medical Products Administration Wuhan430068China

Objective Lindqvist-type polyoxometalates(POMs)exhibit potential antitumor *** study aimed to examine the effects of Lindqvist-type POMs against breast cancer and the underlying *** Using different cancer cell lines,the present study evaluated the antitumor activities of POM analogues that were modified at the body skeleton based on molybdenum-vanadium-centered negative oxygen ion polycondensations with different side *** colony formation assay,autophagy detection,mitochondrial observation,qRT-PCR,Western blotting,and animal model were used to evaluate the antitumor activities of POMs against breast cancer cells and the related *** MO-4,a Lindqvist-type POM linking a proline at its side strain,was selected for subsequent experiments due to its low half maximal inhibitory concentration in the inhibition of proliferation of breast cancer *** was found that MO-4 induced the apoptosis of multiple types of breast cancer ***,MO-4 activated intracellular mitophagy by elevating mitochondrial reactive oxygen species(ROS)levels and resulting in *** vivo,breast tumor growth and distant metastasis were significantly reduced following MO-4 *** Collectively,the results of the present study demonstrated that the novel Lindqvist-type POM MO-4 may exhibit potential in the treatment of breast cancer.

关键词： antitumor breast cancer polyoxometalate mitochondria mitophagy