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Pericytes protect rats and mice from sepsis-induced injuries by maintaining vascular reactivity and barrier function:implication of miRNAs and microvesicles

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Military Medical Research 2024年第1期11卷 1-18页

作者： Zi-Sen Zhang Yi-Yan Liu Shuang-Shuang He dai-Qin Bao hong-Chen Wang Jie Zhang Xiao-Yong Peng Jia-Tao Zang Yu Zhu Yue Wu Qing-Hui Li Tao Li Liang-Ming Liu State Key Laboratory of Trauma Burns and Combined InjuryDepartment of Shock and TransfusionResearch Institute of SurgeryDaping HospitalArmy Medical UniversityChongqing 400042China

Background Vascular hyporeactivity and leakage are key pathophysiologic features that produce multi-organ damage upon *** hypothesized that pericytes,a group of pluripotent cells that maintain vascular integrity and tension,are protective against sepsis via regulating vascular reactivity and *** We conducted a series of in vivo experiments using wild-type(WT),platelet-derived growth factor receptor-β(PDGFR-β)-Cre+mT/mG transgenic mice and Tie2-Cre+Cx43^(flox/flox)mice to examine the relative contribution of pericytes in sepsis,either induced by cecal ligation and puncture(CLP)or lipopolysaccharide(LPS)*** a separate set of experiments with Sprague-Dawley(SD)rats,pericytes were depleted using CP-673451,a selective PDGFR-βinhibitor,at a dosage of 40 mg/(kg·d)for 7 consecutive *** pericytes,vascular endothelial cells(VECs)and vascular smooth muscle cells(VSMCs)were used for mechanistic *** effects of pericytes and pericyte-derived microvesicles(PCMVs)and candidate miRNAs on vascular reactivity and barrier function were also *** CLP and LPS induced severe injury/loss of pericytes,vascular hyporeactivity and leakage(P<0.05).Transplantation with exogenous pericytes protected vascular reactivity and barrier function via microvessel colonization(P<0.05).Cx43 knockout in either pericytes or VECs reduced pericyte colonization in microvessels(P<0.05).Additionally,PCMVs transferred miR-145 and miR-132 to VSMCs and VECs,respectively,exerting a protective effect on vascular reactivity and barrier function after sepsis(P<0.05).miR-145 primarily improved the contractile response of VSMCs by activating the sphingosine kinase 2(Sphk2)/sphingosine-1-phosphate receptor(S1PR)1/phosphorylation of myosin light chain 20 pathway,whereas miR-132 effectively improved the barrier function of VECs by activating the Sphk2/S1PR2/zonula occludens-1 and vascular endothelial-cadherin *** Pericytes are protective a

关键词： Pericyte Vascular reactivity Vascular permeability Cx43 Microvesicle

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Alterations in Serum Lipids and Lipoproteins Induced by Neoadjuvant Chemotherapy in Patients with Osteosarcoma around the Knee Joint:A Retrospective Analysis

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Current Medical Science 2024年第4期44卷 741-747页

作者： Su-guo WANG Yong-gang WANG Guo-wei QIAN Li-na TANG Xin ZHOU Dong-dong CHENG Chen-liang ZHOU Qing-cheng YANG Zan SHEN Gao-zhong HUANG hong-tao LI Department of General Medicine Shenzhen Third People's HospitalShenzhen 518112China Department of VIP Clinic Shanghai Jiao Tong University Afiliated Sixth People's HospitalShanghai 200233China Department of Oncology Shanghai Jiao Tong University Affiliated Sixth People's HospitalShanghai 200233China Cancer Research Institute of Jilin University the First Hospital of Jilin UniversityChangchun 130021China Department of Orthopedics Shanghai Jiao Tong University Afiliated Sixth People's HospitalShanghai 200233China

Objective To investigate the serum lipid profiles of patients with localized osteosarcoma around the knee joint before and after neoadjuvant *** After retrospectively screening the data of 742 patients between January 2007 and July 2020,50 patients aged 13 to 39 years with Enneking stage II disease were included in the *** lipid levels,including total cholesterol(TC),triglycerides(TG),high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C),lipoprotein-α[Lp(a)],and apolipoprotein A1,B,and E(ApoA1,ApoB,and ApoE),and clinicopathological characteristics were collected before and after neoadjuvant *** The mean levels of TC,TG,and ApoB were significantly increased following neoadjuvant chemotherapy(16%,38%,and 20%,respectively,*** values;P<0.01).The mean levels of LDL-C and ApoE were also 19%and 16%higher,respectively(P<0.05).No correlation was found between the pretreatment lipid profile and the histologic response to *** increase in Lp(a)was strongly correlated with the Ki-67 index(R=0.31,P=0.023).Moreover,a trend toward longer disease-free survival(DFS)was observed in patients with decreased TG and increased LDL-C following chemotherapy,although this difference was not statistically significant(P=0.23 and P=0.24,respectively).Conclusion Significant elevations in serum lipids were observed after neoadjuvant chemotherapy in patients with localized *** was no prognostic significance of pretreatment serum lipid levels on histologic response to neoadjuvant *** scale of increase in serum Lp(a)might have a potential prognostic role in *** with increased LDL-C or reduced TG after chemotherapy seem to exhibit a trend toward favorable DFS.

关键词： osteosarcoma neoadjuvant chemotherapy serum lipids

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Human-induced pluripotent stem cell-derived neural stem cell exosomes improve blood-brain barrier function after intracerebral hemorrhage by activating astrocytes via PI3K/AKT/MCP-1 axis

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Neural Regeneration Research 2025年第2期20卷 518-532页

作者： Conglin Wang Fangyuan Cheng Zhaoli Han Bo Yan Pan Liao Zhenyu Yin Xintong Ge dai Li Rongrong zhong Qiang Liu Fanglian Chen Ping Lei Department of Geriatrics Tianjin Medical University General HospitalTianjinChina School of Medicine Nankai UniversityTianjinChina Tianjin Neurological Institute TianjinChina

Cerebral edema caused by blood-brain barrier injury after intracerebral hemorrhage is an important factor leading to poor ***-induced pluripotent stem cell-derived neural stem cell exosomes(hiPSC-NSC-Exos)have shown potential for brain injury repair in central nervous system *** this study,we explored the impact of hiPSC-NSC-Exos on blood-brain barrier preservation and the underlying *** results indicated that intranasal delivery of hiPSC-NSC-Exos mitigated neurological deficits,enhanced blood-brain barrier integrity,and reduced leukocyte infiltration in a mouse model of intracerebral ***,hiPSC-NSC-Exos decreased immune cell infiltration,activated astrocytes,and decreased the secretion of inflammatory cytokines like monocyte chemoattractant protein-1,macrophage inflammatory protein-1α,and tumor necrosis factor-αpost-intracerebral hemorrhage,thereby improving the inflammatory *** sequencing indicated that hiPSC-NSC-Exo activated the PI3K/AKT signaling pathway in astrocytes and decreased monocyte chemoattractant protein-1 secretion,thereby improving blood-brain barrier *** with the PI3K/AKT inhibitor LY294002 or the monocyte chemoattractant protein-1 neutralizing agent C1142 abolished these *** summary,our findings suggest that hiPSC-NSC-Exos maintains blood-brain barrier integrity,in part by downregulating monocyte chemoattractant protein-1 secretion through activation of the PI3K/AKT signaling pathway in astrocytes.

关键词： AKT astrocyte blood-brain barrier cerebral edema exosomes human-induced pluripotent stem cells intracerebral hemorrhage neural stem cells neuroinflammation PI3K

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考虑状态受限和一致性的微电网二次控制

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控制理论与应用 2024年第1期41卷 183-188页

作者：吴忠强程洪强燕山大学工业计算机控制工程河北省重点实验室河北秦皇岛066004

为解决交流微电网下垂控制产生的偏差问题,本文采用二次控制对分布式电源输出电压和频率进行调节.将微电网看成分布式多智能体系统,智能体间通过稀疏网络进行通信,运用多智能体一致性协议,本文提出一种基于障碍Lyapunov函数和自适应模... 详细信息

为解决交流微电网下垂控制产生的偏差问题,本文采用二次控制对分布式电源输出电压和频率进行调节.将微电网看成分布式多智能体系统,智能体间通过稀疏网络进行通信,运用多智能体一致性协议,本文提出一种基于障碍Lyapunov函数和自适应模糊系统的二次电压和频率控制器.采用障碍Lyapunov函数设计控制器,不但能保持系统的稳定性,还可使输出的电压和频率限制在预设的范围内.采用自适应模糊系统可对系统中的一些参变量的变化进行估计,提高了控制器的鲁棒性.本文给出了严格的稳定性证明.通过对负载变化,以及拓扑结构改变等的仿真测试,验证了所提方案的有效性.

关键词：微电网多智能体系统自适应模糊系统障碍Lyapunov函数 Backstepping

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Method for the multi-view estimation of fish mass using a two-stage neural network with edge-sensitive module

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International Journal of Agricultural and Biological Engineering 2024年第3期17卷 222-229页

作者： Zeyu Jiao Yingjie Cai Qi Zhang Zhenyu zhong Guangdong Key Laboratory of Modern Control Technology Institute of Intelligent ManufacturingGuangdong Academy of SciencesGuangzhou 510070China Department of Electronic Engineering The Chinese University of Hong KongHong Kong 999077China College of Economics and Management Northwest A&F UniversityYangling 712100ShaanxiChina

The estimation of fish mass is one of the most basic and important tasks in *** the mass of fish at different growth stages is of great significance for feeding,monitoring the health status of fish,and making breeding plans to increase *** existing estimation methods for fish mass often stay in the 2D plane,and it is difficult to obtain the 3D information on fish,which will lead to the *** solve this problem,a multi-view method was proposed to obtain the 3D information of fish and predict the mass of fish through a two-stage neural network with an edge-sensitive *** the first stage,the side-and downward-view images of the fish and some 3D information,such as side area,top area,length,deflection angle,and pitch angle,were captured to estimate the size of the fish through two vertically placed *** the area of the fish at different views was estimated accurately through the pre-trained image segmentation neural network with an edgesensitive *** the second stage,a fully connected neural network was constructed to regress the fish mass based on the 3D information obtained in the previous *** experimental results indicate that the proposed method can accurately estimate the fish mass and outperform the existing estimation methods.

关键词： fish mass multi-view estimation two-stage neural network edge-sensitive module image segmentation

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华西雨屏区苦竹林土壤呼吸对模拟氮沉降的响应

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植物生态学报 2009年第4期33卷 728-738页

作者：涂利华胡庭兴黄立华李仁洪戴洪忠雒守华向元彬四川农业大学林学院四川省林业生态工程省级重点实验室四川雅安625014

2007年11月至2008年11月,对华西雨屏区苦竹(Pleioblastus amarus)人工林进行了模拟氮沉降试验,氮沉降水平分别为对照(CK,0gN·m–2·a–1)、低氮(5gN·m–2·a–1)、中氮(15gN·m–2·a–1)和高氮(30gN·m–2·a–1)。每月下旬,采用红外... 详细信息

2007年11月至2008年11月,对华西雨屏区苦竹(Pleioblastus amarus)人工林进行了模拟氮沉降试验,氮沉降水平分别为对照(CK,0gN·m–2·a–1)、低氮(5gN·m–2·a–1)、中氮(15gN·m–2·a–1)和高氮(30gN·m–2·a–1)。每月下旬,采用红外CO2分析法测定土壤呼吸速率,并定量地对各处理施氮(NH4NO3)。结果表明:2008年试验地氮沉降量为8.241g·m–2,超出该地区氮沉降临界负荷。在生长季节,苦竹林根呼吸占总土壤呼吸的60%左右。模拟氮沉降促进了苦竹林土壤呼吸速率,使苦竹林土壤每年向大气释放的CO2增加了9.4%～28.6%。在大时间尺度上(如1a),土壤呼吸主要受温度的影响。2008年6～10月,土壤呼吸速率24h平均值均表现为:对照<低氮<中氮<高氮。氮沉降处理1a后,土壤微生物呼吸速率和土壤微生物生物量碳、氮增加,并且均与氮沉降量具有相同趋势。各处理土壤呼吸速率与10cm土壤温度、月平均气温呈极显著指数正相关关系,利用温度单因素模型可以解释土壤呼吸速率的大部分。模拟氮沉降使得土壤呼吸Q10值增大,表明氮沉降可能增强了土壤呼吸的温度敏感性。在氮沉降持续增加和全球气候变暖的背景下,氮沉降和温度的共同作用可能使得苦竹林向大气中排放的CO2增加。

关键词：氮沉降土壤呼吸根呼吸微生物呼吸温度敏感性苦竹林华西雨屏区

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Production and test of sPHENIX W/SciFiber electromagnetic calorimeter blocks in China

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Nuclear Science and Techniques 2024年第8期35卷 167-176页

作者： Xiao‑Zhou Yu Xi‑Yang Wang Wei‑Hu Ma Shi‑hong Fu Peng‑Fei Sun Jin‑Xing Song Wan‑Bing He Yang Shen Long Ma Jin‑Hui Chen Huan‑zhong Huang Si‑Guang Wang Jing Zhou Xiao‑Mei Li Institute of Modern Physics Fudan UniversityShanghai 200433China Key Laboratory of Nuclear Physics and Ion‑Beam Application(MOE) Fudan UniversityShanghai 200433China Science and Technology on Nuclear Data Laboratory China Institute of Atomic EnergyBeijing 102413China Department of Physics and Astronomy University of CaliforniaLos AngelesCA 90095USA State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China

The sPHENIX experiment is a new generation of large acceptance detectors at the relativistic heavy ion collider at Brookhaven National Laboratory,with scientific goals focusing on probing the strongly interacting Quark–Gluon plasma with hard probes of jets,open heavy flavor particles,andγ*** EMCal detector,which covers the pseudo-rapidity region of|η|≤1.1,is an essential subsystem of *** this study,we focused on producing and testing EMCal blocks covering a pseudo-rapidity of|η|∈[0.8,1.1].These,in conjunction with the central pseudo-rapidity EMCal blocks,significantly enhance the sPHENIX physics capability of the jet andγparticle *** this paper,the detector module production and testing of sPHENIX W-powder/scintillating fiber(W/ScFi)electromagnetic calorimeter blocks are *** selection of the tungsten powder,mold fabrication,QA procedures,and cosmic ray test results are discussed.

关键词： sPHENIX Tungsten/scintillating fiber electromagnetic calorimeter Cosmic ray test

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Predictability of the 7·20 extreme rainstorm in Zhengzhou in stochastic kinetic-energy backscatter ensembles

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Science China Earth Sciences 2024年第7期67卷 2226-2241页

作者： Min YANG Peilong YU Lifeng ZHANG Xiaobing PAN Quanjia zhong Yunying LI College of Meteorology and Oceanography National University of Defense TechnologyChangsha 410073China Key Laboratory of High Impact Weather(Special) China Meteorological AdministrationChangsha 410073China Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters/Key Laboratory of Meteorological Disaster Ministry of Education/Joint International Research Laboratory of Climate and Environment ChangeNanjing University of Information Science and TechnologyNanjing 210044China Department of Ocean Science Hong Kong University of Science and TechnologyHong Kong 999077China

The scale-dependent predictability of the devastating 7·20 extreme rainstorm in Zhengzhou,China in 2021 was investigated via ensemble experiments,which were perturbed on different scales using the stochastic kinetic-energy backscatter(SKEB)scheme in the WRF model,with the innermost domain having a 3-km grid *** daily rainfall(RAIN24h)and the cloudburst during 1600-1700 LST(RAIN1h)were *** demonstrated that with larger perturbation scales,the ensemble spread for the rainfall maximum widens and rainfall forecasts become closer to the *** ensembles with mesoscale or convective-scale perturbations,RAIN1h loses predictability at scales smaller than 20 km and RAIN24h is predictable for all *** in ensembles with synoptic-scale perturbations,the largest scale of predictability loss extends to 60 km for both RAIN1h and ***,the average positional error in forecasting the heaviest rainfall for RAIN24h(RAIN1h)was 400 km(50-60)*** southerly low-level jet near Zhengzhou was assumed to be directly responsible for the forecast uncertainty of *** rapid intensification in low-level cyclonic vorticity,mid-level divergence,and upward motion concomitant with the jet dynamically facilitated the *** analysis of the divergent,rotational and vertical kinetic spectra and the corresponding error spectra showed that the error kinetic energy at smaller scales grows faster than that at larger scales and saturates more quickly in all ***-scale perturbations not only boost larger-scale error growth but are also conducive to error growth at all scales through a downscale cascade,which indicates that improving the accuracy of larger-scale flow forecast may discernibly contributes to the forecast of cloudburst intensity and position.

关键词： Stochastic kinetic-energy backscatter(SKEB) Extreme rainfall Ensemble forecast Predictability

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Human-like adrenal features in Chinese tree shrews revealed by multi-omics analysis of adrenal cell populations and steroid synthesis

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Zoological Research 2024年第3期45卷 617-632页

作者： Jing-Hang Jiang Yi-Fu Wang Jie Zheng Yi-Ming Lei zhong-Yuan Chen Yi Guo Ya-Jie Guo Bing-Qian Guo Yu-Fang Lv hong-hong Wang Juan-Juan Xie Yi-Xuan Liu Ting-Wei Jin Bi-Qi Li Xiao-Shu Zhu Yong-Hua Jiang Zeng-Nan Mo Center for Genomic and Personalized Medicine Guangxi Collaborative Innovation Center for Genomic and Personalized MedicineGuangxi Key Laboratory for Genomic and Personalized MedicineGuangxi Medical UniversityNanningGuangxi 530021China Department of Urology First Affiliated Hospital of Guangxi Medical UniversityNanningGuangxi 530021China Reproductive Medicine Center Jingmen People’s HospitalJingChu University of Technology Affiliated Central HospitalJingmenHubei 448000China School of Computer Science and Engineering Yulin Normal UniversityYulinGuangxi 537000China Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Co-constructed by the Province and Ministry Guangxi Medical UniversityNanningGuangxi 530021China Department of Pathology Second Affiliated Hospital of Guangxi Medical UniversityNanningGuangxi 530007China Department of Obstetrics and Gynecology Second Affiliated Hospital of Guangxi Medical UniversityNanningGuangxi 530007China

The Chinese tree shrew(Tupaia belangeri chinensis)has emerged as a promising model for investigating adrenal steroid synthesis,but it is unclear whether the same cells produce steroid hormones and whether their production is regulated in the same way as in ***,we comprehensively mapped the cell types and pathways of steroid metabolism in the adrenal gland of Chinese tree shrews using single-cell RNA sequencing,spatial transcriptome analysis,mass spectrometry,and *** compared the transcriptomes of various adrenal cell types across tree shrews,humans,macaques,and *** showed that tree shrew adrenal glands expressed many of the same key enzymes for steroid synthesis as humans,including CYP11B2,CYP11B1,CYB5A,and *** analysis confirmed the production of aldosterone,cortisol,and dehydroepiandrosterone but not dehydroepiandrosterone sulfate in the tree shrew adrenal ***,genes in adrenal cell types in tree shrews were correlated with genetic risk factors for polycystic ovary syndrome,primary aldosteronism,hypertension,and related disorders in humans based on genome-wide association ***,this study suggests that the adrenal glands of Chinese tree shrews may consist of closely related cell populations with functional similarity to those of the human adrenal *** comprehensive results(publicly available at http://***:16245/scAGMap/)should facilitate the advancement of this animal model for the investigation of adrenal gland disorders.

关键词： Tree shrew Adrenal gland Dehydroepiandrosterone Genome-wide association studies Disease model

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Design and prototyping of the readout electronics for the transition radiation detector in the high energy cosmic radiation detection facility

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Nuclear Science and Techniques 2024年第4期35卷 189-199页

作者： Jie-Yu Zhu Yang-Zhou Su Hai-Bo Yang Fen-Hua Lu Yan Yang Xi-Wen Liu Ping Wei Shu-Cai Wan Hao-Qing Xie Xian-Qin Li Cong dai Hui-Jun Hu hong-Bang Liu Shu-Wen Tang Cheng-Xin Zhao Institute of Modern Physics Chinese Academy of SciencesLanzhou 730000China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China Guangxi Key Laboratory for Relativistic Astrophysics School of Physical Science and TechnologyGuangxi UniversityNanning 530004China

The high energy cosmic-radiation detection(HERD)facility is planned to launch in 2027 and scheduled to be installed on the China Space *** serves as a dark matter particle detector,a cosmic ray instrument,and an observatory for high-energy gamma rays.A transition radiation detector placed on one of its lateral sides serves dual purpose,(ⅰ)calibrating HERD's electromagnetic calorimeter in the TeV energy range,and(ⅱ)serving as an independent detector for high-energy gamma *** this paper,the prototype readout electronics design of the transition radiation detector is demonstrated,which aims to accurately measure the charge of the anodes using the SAMPA application specific integrated circuit *** electronic performance of the prototype system is evaluated in terms of noise,linearity,and *** the presented design,each electronic channel can achieve a dynamic range of 0–100 fC,the RMS noise level not exceeding 0.15 fC,and the integral nonlinearity was<0.2%.To further verify the readout electronic performance,a joint test with the detector was carried out,and the results show that the prototype system can satisfy the requirements of the detector's scientific goals.

关键词： HERD Dark matter particle detection TRD Readout electronics SAMPA Data acquisition Performance test

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