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Microbial phenolic metabolites are associated with better frontal lobe cognition

Food science and Human Wellness 2024年

作者： Inés domínguez-lópez Isabella Parilli-Moser Anna Vallverdú-Queralt Anna Tresserra-Rimbau Cinta Valls-Pedret Zenaida Vázquez-Ruiz Olga Casta?er Ramon Estruch Emili Ros Rosa M.lamuela-Raventós lipid Clinic， Endocrinology and Nutrition service， Institut d'Investigacions Biomèdiques August Pi i sunyer， Hospital Clínic 08036 Barcelona， Spain Unit of Cardiovascular Risk and Nutrition， Institut Hospital del Mar de Investigaciones Médicas (IMIM) department of Preventive Medicine and Public Health， University of Navarra departament de Nutrició， Ciències de l'Alimentació i Gastronomía， Facultat de Farmacia， Universitat de Barcelon (UB)， Av.de Joan XXII department of Endocrinology， Hospital Clinic IDIBAPS， Barcelona， Spain department of Internal Medicine， Hospital Clinic， Institut d'Investigació Biomèdica August Pi i sunyer (IdIBAPs)， University of Barcelona CIBER Fisiopatología de la Obesidad y Nutrición (CIBEROBN)， Instituto de salud Carlos III Institut de Nutrició i seguretat Alimentària (INsA)， Universitat de Barcelona (UB)

With increasing life expectancy， neurodegenerative diseases have become one of the leading causes of ill-health in the elderly. Preventive strategies include following healthy diets， such as the Mediterranean diet， which is particularly rich in polyphenols， bioactive compounds with neuroprotective properties. The aim of this study was to assess the association of microbial phenolic metabolites (MPM) with cognition. This cross-sectional analysis was performed with 200 participants of the PREdIMEd trial (Barcelona-Clinic recruitment center). A novel method based on liquid chromatography coupled to mass spectrometry was used to identify urinary MPM (protocatechuic acid， enterodiol glucuronide， enterolactone glucuronide， urolithin B glucuronide， and vanillic acid glucuronide)， and cognitive function was evaluated with neuropsychological tests. Multivariable-adjusted ordinary least squares regression was used to assess the associations between cognitive function and MPM， and a score was calculated as the weighted sum of MPM. A higher MPM score was associated with better frontal lobe function. Among individual metabolites， vanillic acid glucuronide was correlated with frontal cognitive performance. Participants with higher concentrations of vanillic acid glucuronide and urolithin B glucuronide obtained better scores in the Color Trail Test part 2. A higher score for urinary multi-MPM was associated with better frontal cognitive performance in an older Mediterranean population.

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基于氯化胆碱的低共熔体系在Au上电沉积无枝晶Zn

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Transactions of Nonferrous Metals society of China 2024年第7期34卷 2367-2380页

作者： Vesna s.CVETKOVIĆ Nebojša d.NIKOlIĆ Tanja s.BARUdŽIJA silvana B.dIMITRIJEVIĆ Jovan N.JOVIĆEVIĆ department of Electrochemistry Institute of ChemistryTechnology and MetallurgyUniversity of BelgradeNjegoševa 1211000 BelgradeSerbia Institute for Nuclear sciences Vinča University of BelgradeP.O.Box 52211001 BelgradeSerbia Mining and Metallurgy Institute Zeleni bulevar 3519210 BorSerbia

以氯化胆碱和乙二醇混合液为低共熔溶剂,不使用其他添加剂,电化学沉积无枝晶Zn/Au合金。在不同的Zn(Ⅱ)浓度下,采用恒电位电沉积法在相对较低的Zn电沉积过电位下进行电沉积。通过循环伏安法(CV)和计时安培法(CA)揭示Zn电沉积的电化学机... 详细信息

以氯化胆碱和乙二醇混合液为低共熔溶剂,不使用其他添加剂,电化学沉积无枝晶Zn/Au合金。在不同的Zn(Ⅱ)浓度下,采用恒电位电沉积法在相对较低的Zn电沉积过电位下进行电沉积。通过循环伏安法(CV)和计时安培法(CA)揭示Zn电沉积的电化学机理。采用扫描电子显微镜和X射线衍射分析(XRd)对沉积层的形貌和结构进行表征,并用能谱仪对沉积层进行元素分析。CV结果表明,Zn的电沉积始于Zn欠电位沉积区,并一直持续到Zn过电位沉积(OPd)区。随着Zn(Ⅱ)浓度的增加,Zn/Zn(Ⅱ)电偶的沉积电位向更高的正值偏移。CA分析表明,在Zn的OPd区开始三维渐进形核,随后形成三维生长。形貌分析表明,电沉积始于致密Zn岛的形成,随后形成无枝晶Zn/Au合金。XRd分析表明,其物相为金属Zn、立方AuZn3和Au Zn金属间化合物。

关键词：锌电沉积低共熔溶剂锌金合金形貌结构

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Anti-amyloid antibodies in Alzheimer’s disease: what did clinical trials teach us?

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Neural Regeneration Research 2025年第4期20卷 1092-1093页

作者： danko Jeremic lydia Jiménez-díaz Juan d.Navarro-lópez NeuroPhysiology&Behavior lab University of Castilla-La ManchaBiomedical Research Center(CRIB)School of Medicine of Ciudad RealCiudad RealSpain

Although many causes of Alzheimer’s disease(Ad)may exist,both the original amyloid cascade and tau hypotheses posit that abnormal misfolding and accumulation of amyloid-β(Aβ)and tau protein is the central event causing the ***,that conclusion could be only partly true,and there is conflicting evidence about the role of both proteins in Ad,being able to precede and influence one *** researchers argue that these proteins are mere executors rather than primary causes of ***,there have been continuing refinements of both hypotheses,with alternative explanations proposed.Aβand tau proteins may be independently involved in specific neurotoxic pathways;yet there may be other crucial processes going on in early ***,accumulating evidence suggests that Aβand tau act synergistically,rather than additively in disease onset(Jeremic et al.,2021,2023a).

关键词： amyloid Alzheimer additive

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A review of selected parasitic plants in Nigeria:converting harms to benefits

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Natural Therapy Advances 2024年第3期7卷 14-28页

作者： Funmilayo I.d.Afolayan Ridwan A.salaam Ebenezer s.Oladokun samson d.Adesoye department of Zoology University of IbadanIbadan 200132Nigeria

Parasitic plants are challenging to agricultural crops and forestry development,which are sources of major revenues in several countries,including ***,parasitic plants are important to human society as they have an abundance of bioactive compounds with pharmacological ***,it becomes expedient to know the benefits of these plants and potential means of *** review discusses four selected parasitic plants in Nigeria,namely Viscum album,striga hermonthica,Tapinanthus bangwensis and Cuscuta *** information about their pharmacological relevance and biocontrol was obtained from credible databases,including the National library of Medicine,sCOPUs,and Google *** review showed that all four plants have been extensively studied for their antioxidant and antitumor ***,antimicrobial and anti-inflammatory activities are common pharmacological values among parasitic *** are largely due to the presence of abundant beneficial classes of ***,there is an increasing number of biocontrol studies on the use of microorganisms,such as Phaeobotryosphaeria visci,sphaeropsis visci,Pandoraea pulminicol,Colletotrichum gloeosporioides,and Fusarium oxysporum in controlling and managing these seemingly disastrous *** is hoped that this review will spur further studies into the conservation and proper management of parasitic plants using strategically developed biocontrol.

关键词： parasitic plants pharmacological values biocontrol plant management and control ethnopharmacology

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determining the Checkpoint of Transition from Thin to Thick Periodontal Phenotypes in the Maxillary and Mandibular Anterior Regions of south Indian Population

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Journal of Forensic science and Medicine 2024年第1期10卷 55-61页

作者： Mohan Kumar Pasupuleti Rasagna Chowdary G Gautami sPenmetsa Vivek Bypalli Ramesh s.V.Konathala sruthima N.V.s.Gottumukkala department of Periodontics and Implantology Vishnu Dental CollegeBhimavaramAndhra PradeshIndia2Vishnu Dental CollegeBhimavaramAndhra PradeshIndia

Aim:The aim of this study was to compare and investigate the tissue thickness at the maxillary and mandibular central incisors utilizing the probe visibility method and traditional way of measuring gingival thickness(GT)by endodontic ***:In 200 selected patients,the GT was measured at both the maxillary and mandibular anterior using an endodontic file after local infiltration at the mid-distance from the gingival margin to the mucogingival *** checkpoint of transition from thin to thick periodontal phenotype was determined by probe visibility method in the following age groups:Group A:21-30 years;Group B:31-40 years;Group C:41-50 years;and Group d:51-60 ***:GT varied from 0.3 to 1.9 *** translucency was observed up to the thickness of 0.7 *** 0.8 mm of GT,there was no probe ***:According to the present research,the gingiva appears transparent up to a thickness of around 0.7 *** checkpoint of transition between thin and thick periodontal phenotypes at both the maxillary and mandibular anterior was associated with a GT of 0.8 mm.

关键词： Gingiva periodontal phenotype probe visibility

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Advancements in Catalysts for Electrochemical Nitrate Reduction: A sustainable Approach for Mitigating Nitrate Pollution: A Review

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Modern Research in Catalysis 2024年第1期13卷 1-28页

作者： Gerald d. s. Quoie Jr. Jean Pierre Bavumiragira Varney Kromah state Key laboratory of Pollution Control and Resources Reuse College of Environmental Science and Engineering Tongji University Shanghai China Key laboratory of Yangtze River Water Environment Ministry of Education Tongji University Shanghai China department of Mining Engineering College of Engineering University of Liberia Monrovia Liberia

Nitrate pollution is of great importance in both the environmental and health contexts, necessitating the development of efficient mitigation strategies. This review provides a comprehensive analysis of the many catalysts employed in the electrochemical reduction of nitrate to ammonia, and presents a viable environmentally friendly approach to address the issue of nitrate pollution. Hence, the electrochemical transformation of nitrate to ammonia serves the dual purpose of addressing nitrate pollution in water bodies, and is a useful agricultural resource. This review examines a range of catalyst materials such as noble and non-noble metals, metal oxides, carbon-based materials, nitrogen-doped carbon species, metal complexes, and semiconductor photocatalysts. It evaluates catalytic efficiency, selectivity, stability, and overall process optimization. The performance of catalysts is influenced by various factors, including reaction conditions, catalyst structure, loading techniques, and electrode interfaces. Comparative analysis was performed to evaluate the catalytic activity, selectivity, Faradaic efficiency, current density, stability, and durability of the catalysts. This assessment offers significant perspectives on the structural, compositional, and electrochemical characteristics that affect the efficacy of these catalysts, thus informing future investigations and advancements in this domain. In addition to mitigating nitrate pollution, the electrochemical reduction of nitrate to ammonia is in line with sustainable agricultural methods, resource conservation, and the utilization of renewable energy resources. This study explores the factors that affect the catalytic efficiency, provides new opportunities to address nitrate pollution, and promotes the development of sustainable environmental solutions.

关键词： Nitrate Pollution Electrochemical Reduction Ammonia sustainable Farming Catalysts

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Taxonomic study of Five Parasitic Polypores of the Hymenochaetaceae Family of TIN Vegetation in Western Burkina Faso

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American Journal of Plant sciences 2024年第6期15卷 441-454页

作者： Kusiélé somda Andjièrèyir Nankoné samson Nana R. sylvie Bakiono Benovana sédégo K. Jean Edouard dabiré Kounbo sanon Elise department of Plant Biology and Physiology Joseph Ki-Zerbo University Ouagadougou Burkina Faso life and Earth sciences laboratory Science and Technology Training and Research Unit Norbert Zongo University Koudougou Burkina Faso Tenkodogo University Center Ouagadougou Burkina Faso

The aim of this work is to inventory and study the lignicolous parasitic macrofungi of the Tin plant formation. The mycological outings from July to september 2018 and 2019, collected forty-four (44) basidiomes through a random sampling device over an area of 40,000 m2 including 1000 m long by 40 m2 wide. The standard methods and techniques used in mycology for taxonomic studies were used to describe and classify the carpophores collected in three families: Hymenochaetaceae, Ganodermataceae and Polyporaceae, into eight genera: Onnia (4.55%), Amauroderma (4.55%), Ganoderma (20.45%), Phellinus (52.27%), Inonotus (4.55%), Phellinopsis (6.82%), Grammothele (2.27%) and Trametes (4.55%). The genera Phellinus and Ganoderma were the most abundant. Finally, eight species were identified: Inonotus cf. ochroporus, Inonotus cf. pachyphloeus, Phellinus cf. cryptarum, Phellinus cf. hartigii, Phellinus cf. hippophaecola;Phellinus cf. robustus, Phellinus cf. igniarius, et Amauroderma cf. fasciculatum. seven fungal species belong to the family Hymenochaetaceae and only the species Amauroderma cf. fasciculatum is a Ganodermataceae. However, all these fungal species are shown to be parasites of trunks and/or branches of the following woody: Parkia biglobosa (50%), Anogeissus leiocarpus (25%), Annona senegalensis (12.5%) and Mangifera indica (12.5%). Authors attest that the presence of phytoparasitic polypores in a plant formation is an indicator of aging hence the urgency to put in place the appropriate measures to safeguard and restore Tin’s plant formation.

关键词： Identification Macrofungi lignicolous Parasites Vegetation Tin Burkina Faso

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decoding bovine coronavirus immune targets:an epitope informatics approach

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Animal diseases 2024年第2期4卷 138-153页

作者： swati Rani Mehnaj Khatoon Jagadish Hiremath Kuralayanapalya Puttahonnappa suresh Jayashree Anandakumar Nagendra Nath Barman sheethal Manjunath Yamini sri s sharanagouda s.Patil spatial Epidemiology lab ICAR-National Institute of Veterinary Epidemiology and Disease InformaticsYelahankaBengaluruKarnataka 560064India College of Veterinary science Assam Agricultural UniversityGuwahatiAssam 785013India Yuvaraja’s College Mysuru University of MysuruMysuruKarnataka 570005India

Bovine coronavirus(BCoV)poses a significant threat to the global cattle industry,causing both respiratory and gastrointestinal infections in cattle *** necessitates the development of efficacious *** several inactivated and live BCoV vaccines exist,they are predominantly limited to *** immunization of adult cattle is imperative for BCoV infection control,as it curtails viral transmission to calves and ameliorates the impact of enteric and respiratory ailments across all age groups within the *** study presents an in silico methodology for devising a multiepitope vaccine targeting *** spike glycoprotein(s)and nucleocapsid(N)proteins,which are integral elements of the BCoV structure,play pivotal roles in the viral infection cycle and immune *** constructed a remarkably effective multiepitope vaccine candidate specifically designed to combat the BCoV *** immunoinformatics technology,B-cell and T-cell epitopes were predicted and linked together using linkers and adjuvants to efficiently trigger both cellular and humoral immune responses in *** in silico construct was characterized,and assessment of its physicochemical properties revealed the formation of a stable vaccine *** 3d modeling of the vaccine construct,molecular docking revealed a stable interaction with the bovine receptor ***,the viability of the vaccine’s high expression and simple purification was demonstrated by codon optimization and in silico cloning expression into the pET28a(+)*** applying immunoinformatics approaches,researchers aim to better understand the immune response to bovine coronavirus,discover potential targets for intervention,and facilitate the development of diagnostic tools and vaccines to mitigate the impact of this virus on cattle health and the livestock *** anticipate that the design will be useful as a preventive treatment for BCoV sickness in cattle,opening the door for furthe

关键词： Immunoinformatics Bovine coronavirus Multiepitope vaccine Molecular docking In silico cloning

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Facile synthesis of accordion-like porous carbon from waste PET bottles-based MIl-53(Al) and its application for high-performance Zn-ion capacitor

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Green Energy & Environment 2024年第7期9卷 1138-1150页

作者： Jiaxin li shuai Zhang Yumeng Hua Yichao lin Xin Wen Ewa Mijowska Tao Tang Xuecheng Chen Rodney s.Ruoff Faculty of Chemical Technology and Engineering West Pomeranian University of Technology Key state Key laboratory of Polymer Physics and Chemistry Changchun Institute of Applied Chemistry Chinese Academy of Sciences school of safety Engineering China University of Mining and Technology Institute of Advanced Electrical Materials Qingdao University of Science and Technology Institute for Basic science Center for Multiple dimensional Carbon Materials department of Chemistry Ulsan National Institute of Science and Technology (UNIST) department of Materials science and Engineering Ulsan National Institute of Science and Technology (UNIST) school of Energy and Chemical Engineering Ulsan National Institute of Science and Technology (UNIST)

It is of great scientific and economic value to recycle waste poly（ethylene terephthalate）(PET) into high-value PET-based metal organic frameworks（MOFs） and further convert it into porous carbon for green energy storage applications. In the present study, a facile and costeffective hydrothermal process was developed to direct recycle waste PET bottles into MIl-53（Al） with a 100% conversation, then the MOFderived porous carbon was assembled into electrodes for high-performance supercapacitors. The results indicated that the as-synthesized carbon exhibited high ssA of 1712 m2g-1and unique accordion-like structure with hierarchical porosity. Benefit to these advantageous characters, the assembled three-electrode supercapacitor displayed high specific capacitances of 391 F g-1at the current density of 0.5 A g-1and good rate capability of 73.6% capacitance retention at 20 A g-1in 6 mol l-1KOH electrolyte. Furthermore, the assembled zinc ion capacitor still revealed outstanding capacitance of 335 F g-1at 0.1 A g-1, excellent cycling stability of 92.2% capacitance retention after 10 000 cycles and ultra-high energy density of 150.3 Wh kg-1at power density of 90 W kg-1in 3 mol l-1ZnsO4electrolyte. It is believed that the current work provides a facile and effective strategy to recycle PET waste into high-valuable MOF, and further expands the applications of MOF-derived carbons for high-performance energy storage devices, so it is conducive to both pollution alleviation and sustainable economic development.

关键词： PET Recycling Porous carbon supercapacitor Energy storage

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Magnesium-reinforced Electrospun synthetic-polymer Nanofibers designed for Promoting Tissue Growth

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Journal of Bionic Engineering 2024年第3期21卷 1412-1426页

作者： Muheeb Rafiq Anjum Hamid Rather Rumysa saleem Khan Taha Umair Wani Haseeb A.Khan Abdullah s.Alhomida Faheem A.sheikh Nanostructured and Biomimetic lab Department of NanotechnologyUniversity of Kashmir HazratbalSrinagarJammu and Kashmir190006India Non-Clinical Evaluation Center Biomedical Research InstituteJeonbuk National University HospitalJeonjuJeollabuk-do54907South Korea College of Pharmacy and Research Institute of Pharmaceutical sciences Gyeongsang National UniversityJinju52828South Korea Research Chair for Biomedical Applications of Nanomaterials Department of BiochemistryCollege of ScienceKing Saud UniversityRiyadh11451Saudi Arabia

The creation of 3d nanofibers offering desirable functions for bone regeneration is developed due to the latest improvisations to the electrospinning *** polymers are among the best choices for medical usage due to their lower costs,high tensile properties,and ease of spinnability compared to natural *** this communication,we report a series of interventions to polymers modified with Mg-based fillers for ideal tissue engineering *** literature survey indicated that these filler materials(e.g.,nano-sized particles)enhanced biocompatibility,antibacterial activity,tensile strength,and anti-corrosive *** review discusses electrospinning parameters,properties,and applications of the poly(ε-caprolactone),poly(lactic acid),poly(3-hydroxybutyric acid-co-3-hydroxy valeric acid),polyurethane,and poly(vinyl pyrrolidone)nanofibers when modified with Mg-based *** report encourages researchers to use synthetic polymers with Mg as fillers and validate them for tissue engineering applications.

关键词： Bone regeneration Magnesium Nanofibers Tissue engineering

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