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Experimental and numerical characterization of 3d‑printed scaffolds under monotonic compression with the aid of micro‑CT volume reconstruction

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Bio-design and Manufacturing 2021年第2期4卷 222-242页

作者： R.Baptista M.F.C.Pereira A.Maurício d.rechena V.Infante M.Guedes CdP2T Departamento de Engenharia MecanicaEscola Superior de Tecnologia de SetúbalInstituto Politécnico de Setúbal2910‑761 SetúbalPortugal CERENA DECivilInstituto Superior TécnicoUniversidade de LisboaAv.Rovisco Pais11049‑001 LisbonPortugal IdMEC Instituto Superior TécnicoUniversidade de LisboaAv.Rovisco Pais11049‑001 LisbonPortugal IPFN Instituto Superior TécnicoUniversidade de Lisboa1049‑001 LisbonPortugal CeFEMA Instituto Superior TécnicoUniversidade de LisboaAv.Rovisco Pais11049‑001 LisbonPortugal

Even when damaged by injury or disease bone tissue has the remarkable ability to *** this process is limited by large size bone defects,tissue engineering is responsible for restoring,maintaining or improving tissue *** are support structures,designed to be implanted in the damaged site,supporting mechanical loads and protecting the regenerating bone *** this paper,3d-printed PLA scaffolds with three different porosity values and two different geometries were experimentally and numerically ***-CT analysis showed that fused filament fabrication can be used to produce scaffolds with the desired porosity and 100%of interconnected *** monotonical compression,scaffolds apparent compressive modulus increased from 89 to 918 MPa,while yield stress increased from 2.9 to 27.5 MPa as porosity decreased from 70 to 30%.Open porosity decreased up to 8%on aligned scaffolds and 14%on staggered scaffolds,after compression,while scaffold’s surface-to-volume ratio highest reduction(7.48 to 4.55 mm−1)was obtained with aligned low porosity ***-CT volume reconstruction allowed for scaffold simplified numerical models to be built and *** agreement was found when predicting scaffold’s apparent compressive ***,it can be concluded that 3d printing is a viable scaffold manufacturing technique for trabecular bone replacement.

关键词： Scaffold Pore design Mechanical behavior Micro-CT analysis Finite element method

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