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Anti-amyloid antibodies in Alzheimer’s disease: what did clinical trials teach us?

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Neural Regeneration Research 2025年第4期20卷 1092-1093页

作者： danko Jeremic Lydia Jiménez-díaz Juan d.Navarro-López NeuroPhysiology&Behavior Lab University of Castilla-La ManchaBiomedical Research Center(CRIB)School of Medicine of Ciudad RealCiudad RealSpain

Although many causes of Alzheimer’s disease(Ad)may exist,both the original amyloid cascade and tau hypotheses posit that abnormal misfolding and accumulation of amyloid-β(Aβ)and tau protein is the central event causing the ***,that conclusion could be only partly true,and there is conflicting evidence about the role of both proteins in Ad,being able to precede and influence one *** researchers argue that these proteins are mere executors rather than primary causes of ***,there have been continuing refinements of both hypotheses,with alternative explanations proposed.Aβand tau proteins may be independently involved in specific neurotoxic pathways;yet there may be other crucial processes going on in early ***,accumulating evidence suggests that Aβand tau act synergistically,rather than additively in disease onset(Jeremic et al.,2021,2023a).

关键词： amyloid Alzheimer additive

Remaking a connection:molecular players involved in post-injury synapse formation

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Neural Regeneration Research 2025年第6期20卷 1719-1720页

作者： diogo Tomé Ramiro d.Almeida iBiMEd-Institute of Biomedicine Department of Medical SciencesUniversity of AveiroAveiroPortugal CNC-Center for Neuroscience and Cell Biology University of CoimbraCoimbraPortugal

Functional recovery from central nervous system(CNS)trauma depends not only on axon regeneration or compensatory sprouting of uninjured fibers but also on the ability of newly grown axons to establish functional synapses with appropriate *** several studies have successfully promoted long-distance axonal regeneration in distinct CNS injury models,none of them have resulted in a viable therapeutic approach for patient recovery.A possible reason may be the lack of new synaptogenesis for reestablishing the circuitry lost after ***,we discuss how our understanding of the mechanisms that instruct synapse formation in the injured nervous system may contribute to the design of new strategies to promote functional restoration in traumatic CNS disorders.

关键词： viable injury instru

Modeling the drain current and its equation parameters for lightly doped symmetrical double-gate MOSFETs

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Journal of Semiconductors 2015年第4期36卷 44-50页

作者： mini Bhartia Arun Kumar Chatterjee Electronics and Communication department Thapar Institute of Engineering and Technology

A 2d model for the potential distribution in silicon film is derived for a symmetrical double gate MOS- FET in weak inversion. This 2d potential distribution model is used to analytically derive an expression for the subthreshold slope and threshold voltage. A drain current model for lightly doped symmetrical dG MOSFETs is then presented by considering weak and strong inversion regions including short channel effects, series source to drain resistance and channel length modulation parameters. These derived models are compared with the simulation results of the SILVACO （Atlas） tool for different channel lengths and silicon film thicknesses. Lastly, the effect of the fixed oxide charge on the drain current model has been studied through simulation. It is observed that the obtained analytical models of syrnmetrical double gate MOSFETs are in good agreement with the simulated results for a channel length to silicon film thickness ratio greater than or equal to 2.

关键词： double gate MOSFET 2d potential distribution model drain current model

Treating amyotrophic lateral sclerosis with allogeneic Schwann cell-derived exosomal vesicles: a case report

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Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal J.Goldschmidt-Clermont Aisha Khan George Jimsheleishvili Patricia Graham Adriana Brooks Risset Silvera Alexander J.P.Goldschmidt damien d.Pearse W.dalton dietrich Allan d.Levi James d.Guest Miller School of Medicine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA The Miami Project to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and function of motor neurons,axonal networks,and the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and potential trophic activities of Schwann cell-derived exosomal vesicles have been *** case report describes the treatment of a patient with advanced amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles,marking,to our knowledge,the first instance of such *** 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral *** initial diagnosis,the patient underwent a combination of generic riluzole,sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and *** patient volunteered to participate in an FdA-approved single-patient expanded access treatment and received weekly intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles to potentially restore impaired Schwann cell and motor neuron *** confirmed that cultured Schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)and that exposure of the patient’s Schwann cells to allogeneic Schwann cell-derived exosomal vesicles,cultured expanded from a cadaver donor improved their growth capacity in *** a period of observation lasting 10 weeks,during which amyotrophic lateral sclerosis Functional Rating Scale-Revised and pulmonary function were regularly monitored,the patient received weekly consecutive infusions of 1.54×1012(×2),and then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-derived exosomal vesicles diluted in 40 mL of dulbecco’s phosphate-buffered *** of the infusions were associated with adverse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell

Biochemical dissection of STAT3 signaling in amyotrophic lateral sclerosis

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Neural Regeneration Research 2025年第11期20卷 3229-3230页

作者： Savina Apolloni Nadia d’Ambrosi department of Biology University of Rome Tor VergataRomeItaly

Amyotrophic lateral sclerosis(ALS)is a progressive neurodegenerative disease characterized by the loss of upper and lower motor neurons,clinically marked by muscle atrophy and *** the clinical course is highly variable,the average time from the onset of symptoms to the need for respiratory support or death is 3-5 *** is the most prevalent motor neuron disease in adults,occurring at a rate of 2 per 100,000 individuals and affecting 5.4 per 100,000 individuals overall.

关键词： STAT3 dissection sclerosis

Assessing resource vulnerability quadrants under changing precipitation trends in Uttarakhand,Central Himalayan region

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Journal of Mountain Science 2021年第10期18卷 2722-2741页

作者： Ayushi VLJHANI Vinay Shankar Prasad SINHA mini GOVINdAN department of Natural Resources TERI School of Advanced Studies10 Institutional AreaVasant Kunj New Delhi 110070India The Energy and Resources Institute India Habitat CentreNew Delhi 110003India

The Central Himalayan region is vulnerable to the adverse effects of climate change and characterized by regional climatic *** livelihood of the mountain communities across the Himalaya is at risk owing to the consequences of variable precipitation *** exists limited empirical research on precipitation variability due to inadequate hydro-meteorological stations at highaltitude *** study uses a novel methodology which integrates precipitation variability with resource sensitivity over the three verticals of Central Himalaya:Himadri,Himachal and Shivaliks and across four major river basins:Yamuna,Upper Ganga,Ghaghar and *** magnitude of the significant precipitation trends was estimated through time series analysis at a 95%confidence *** assess the sensitivity of natural resources(forest,water and land)and human resources,fourteen mountain-specific indicators were identified which captured resource index using data standardization and principal component ***’s slope and Resource index were plotted in a 2d Cartesian coordinate to draw precipitation-resource quadrants with their effective coverage area:High Precipitation and Scarce Resources(35.92%);Low Precipitation and Abundant Resources(30.10%);Low Precipitation and Scarce Resources(22.33%)and High Precipitation and Abundant Resources(11.65%).This helped in developing quadrant-specific adaptation strategies under regional variability of *** methodology and the research findings will certainly assist water experts,resource managers and policy makers to strengthen adaptive capacity and improve the resilience of vulnerable communities across Himalaya.

关键词： Climate Change Trend analysis Resource-quadrant Vulnerability Adaptation Central Himalaya

An Imbalanced dataset and Class Overlapping Classification Model for Big data

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Computer Systems Science & Engineering 2023年第2期44卷 1009-1024页

作者： mini Prince P.M.Joe Prathap department of Information Technology St.Peter’s College of Engineering and TechnologyChennai600054TamilnaduIndia department of Information Technology R.M.D Engineering CollegeChennai601206TamilnaduIndia

Most modern technologies,such as social media,smart cities,and the internet of things(IoT),rely on big *** big data is used in the real-world applications,two data challenges such as class overlap and class imbalance *** dealing with large datasets,most traditional classiﬁers are stuck in the local optimum *** a result,it’s necessary to look into new methods for dealing with large data *** solutions have been proposed for overcoming this *** rapid growth of the available data threatens to limit the usefulness of many traditional *** such as oversampling and undersampling have shown great promises in addressing the issues of class *** all of these techniques,Synthetic Minority Oversampling TechniquE(SMOTE)has produced the best results by generating synthetic samples for the minority class in creating a balanced *** issue is that their practical applicability is restricted to problems involving tens of thousands or lower instances of *** this paper,we have proposed a parallel mode method using SMOTE and MapReduce strategy,this distributes the operation of the algorithm among a group of computational nodes for addressing the aforementioned *** proposed solution has been divided into three ***ﬁrst stage involves the process of splitting the data into different blocks using a mapping function,followed by a pre-processing step for each mapping block that employs a hybrid SMOTE algo-rithm for solving the class imbalanced *** each map block,a decision tree model would be ***,the decision tree blocks would be com-bined for creating a classiﬁcation *** have used numerous datasets with up to 4 million instances in our experiments for testing the proposed scheme’s *** a result,the Hybrid SMOTE appears to have good scalability within the framework proposed,and it also cuts down the processing time.

关键词： Imbalanced dataset class overlapping SMOTE MapReduce parallel programming oversampling

A Novel Approach to design distribution Preserving Framework for Big data

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Intelligent Automation & Soft Computing 2023年第3期35卷 2789-2803页

In several fields like financial dealing,industry,business,medicine,et cetera,Big data(Bd)has been utilized extensively,which is nothing but a collection of a huge amount of ***,it is highly complicated along with time-consuming to process a massive amount of ***,to design the distribution Preserving Framework for Bd,a novel methodology has been proposed utilizing Manhattan distance(Md)-centered Partition Around Medoid(Md–PAM)along with Conjugate Gradient Artificial Neural Network(CG-ANN),which undergoes various steps to reduce the complications of ***,the data are processed in the pre-processing phase by mitigating the data repetition utilizing the map-reduce function;subsequently,the missing data are handled by substituting or by ignoring the missed *** that,the data are transmuted into a normalized ***,to enhance the classification performance,the data’s dimensionalities are minimized by employing Gaussian Kernel(GK)-Fisher discriminant Analysis(GK-FdA).Afterwards,the processed data is submitted to the partitioning phase after transmuting it into a structured *** the partition phase,by utilizing the Md-PAM,the data are partitioned along with grouped into a ***,by employing CG-ANN,the data are classified in the classification phase so that the needed data can be effortlessly retrieved by the *** analogize the outcomes of the CG-ANN with the prevailing methodologies,the NSL-Kdd openly accessible datasets are *** experiential outcomes displayed that an efficient result along with a reduced computation cost was shown by the proposed *** proposed work outperforms well in terms of accuracy,sensitivity and specificity than the existing systems.

关键词： Big data artiﬁcial neural network ﬁsher discriminant analysis distribution preserving framework manhattan distance

decellularized extracellular matrix particle-based biomaterials for cartilage repair applications

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Journal of Materials Science & Technology 2023年第29期160卷 194-203页

作者： Peng Guo Nan Jiang Carina mini Gregor Miklosic Songsong Zhu Andrea J.Vernengo Matteo d’Este Sibylle Grad Mauro Alini Zhen Li AO Research Institute davos Davos 7270Switzerland department of Spine Surgery The Sixth Affiliated HospitalSun Yat-sen UniversityGuangzhou 510655China State Key Laboratory of Oral diseases and National Clinical Research Center for Oral disease and West China Hospital of Stomatology Sichuan UniversityChengdu 610041China Institute for Biomechanics ETH ZürichZürich 8093Switzerland

Cartilage decellularized ExtraCellular Matrix(dECM)materials have shown promising cartilage regenera-tion capacity due to their chondrogenic ***,the limited retention of ECM components and the reduced integrity of functional ECM molecules during traditional decellularization processes im-pair the biomimicry of these *** current study aims to fabricate biomimetic materials con-taining decellularized cartilage particles that have an intact molecular structure and native composition as biomaterial inks and hydrogels for cartilage *** this,we established a novel two-fraction de-cellularization strategy for the preparation of reconstituted dECM(rdECM)particles by mixing the two-fraction components,as well as a one-fraction decellularization strategy for the preparation of biomimetic dECM(bdECM)*** acid-tyramine(THA)hydrogels containing rdECM or bdECM particles were produced and characterized via rheological test,swelling and stability evaluation,and compression *** results showed that our novel decellularization strategies preserved intact proteoglycans and collagen at a higher retention rate with adequate dNA removal compared to traditional methods of *** addition of rdECM or bdECM particles significantly increased the shear moduli of the THA bioinks while preserving their shear-thinning *** particle-embedded THA hydrogels also achieved long-term stability with a swelling ratio of 70%and high retention of glycosaminoglycans and collagen after long-term incubation,while rdECM particle-embedded THA hydrogels showed unsat-isfactory stability as self-standing *** to pure THA hydrogels,the addition of bdECM particles significantly enhanced the compression *** summary,our decellularization methods are successful in the retention of functional and intact cartilage components with high *** rdECM and bdECM particles can be supplemented in THA bioinks for biomimet

关键词： Cartilage tissue engineering decellularized extracellular matrix Proteoglycan integrity Biomimetic hydrogels Biomaterial Bioink