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Highly toxic Aβ begets more Aβ

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Neural Regeneration Research 2024年第9期19卷 1871-1872页

作者： Merc M.Kemeh Noel d.Lazo Gustaf H.Carlson School of Chemistry and Biochemistry Clark UniversityWorcesterMAUSA

Alzheimer’s disease(Ad)is the most common form of dementia-the 7th leading cause of death *** the tissue level,Ad is characterized by the presence of extracellular amyloid plaques that are comprised primarily of the amyloid-βpeptide(Aβ),and by intraneuronal neurofibrillary tangles composed of *** genetics of early-onset Ad and longitudinal brain-imaging studies of late-onset Ad indicate that extracellular Aβdeposition,in general,precedes neurofibrillary tangle formation in neurons(Hampel et al.,2021;Young-Pearse et al.,2023).

关键词： Aβ tau Alzheimer death

The multi-impurity system in CdSe nanoplatelets:electronic structure and thermodynamic properties

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Communications in Theoretical Physics 2024年第3期76卷 165-173页

作者： d A Baghdasaryan V A Harutynyan E M Kazaryan H A Sarkisyan Russian-Armenian University H Emin 1230051YerevanArmenia Institute of Applied Problems of Physics 25 Nersisyan St0014YerevanArmenia

This paper theoretically studies the impurity states and the effects of impurity concentration and configuration on the optical,electrical,and statistical properties of CdSe nanoplatelets(NPLs).An image charge-based model of electron-impurity interaction is *** charge-carrier energy spectra and corresponding wave functions depending on the impurity number and configuration are *** electron binding energies are calculated for different NPL *** is shown that the image charge-based interaction potential that arises due to the dielectric constants mismatch is much stronger than the interaction potential that does not take such a mismatch into ***,it is demonstrated that the binding energies are increasing with the number of *** calculate the canonical partition function using the energy levels of the electron,which in turn is used to obtain the mean energy,heat capacity,and entropy of the non-interacting electron *** thermodynamic properties of the non-interacting electron gas that depend on the geometric parameters of the NPL,impurity number,configuration,and temperature are studied.

关键词： nanoplateletes thermodynamic properties impurity states

Application of flame-formed carbon nanoparticle films for ethanol sensing Author links open overlay panel

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Particuology 2024年第8期91卷 202-210页

作者： Pegah darvehi Luca Basta Mario Commodo Patrizia Minutolo Andrea d'Anna Istituto di Scienze e Tecnologie per l’Energia e la MobilitàSostenibili Consiglio Nazionale delle RicercheP.le Tecchio 8080125NapoliItaly dipartimento di Ingegneria Chimica dei Materiali e della Produzione IndustrialeUniversitàdegli Studi di Napoli Federico IIP.le Tecchio 8080125NapoliItaly

Carbon nanoparticles(CNPs)have received considerable attention due to their exceptional qualities and *** unique physical and chemical characteristics make them extremely intriguing as materials for numerous high-potential applications,such as electronics and gas *** study focused on producing carbon-based nanomaterial devices by deposition of flame-formed carbon nanoparticles on a suitable substrate and investigating their gas-sensing *** were produced in a fuel-rich laminar premixed ethylene/air flame and the collected CNP film was morphologically and electrically *** electrical conductivity of the film was investigated as a function of ethanol concentration and amount of deposited ***,CNP films exhibited high sensitivity to ambient ethanol gas concentrations,and rapid recovery times at room temperature,and showed a sensitivity increasing with the amount of deposited material and the surface *** findings demonstrate the high potential of combustion-generated CNPs as building materials for low-cost and portable ethanol sensors.

关键词： Flame synthesis Carbon nanoparticles Soot Nanostructured thin film Optical and electrical characterization Atomic force microscopy Sensors

Near resonance vibration isolation on a levered-dual response(LEdAR)Coulomb-damped system by differential preloads/offsets in linear springs

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Applied Mathematics and Mechanics(English Edition) 2024年第6期45卷 1033-1050页

作者： T.I.TOLUWALOJU C.K.THEIN d.HALIM department of Mechanical Materials and Manufacturing EngineeringUniversity of Nottingham Ningbo ChinaNingbo 315100Zhejiang ProvinceChina Nottingham Ningbo China Beacons of Excellence Research and Innovation Institute University of Nottingham Ningbo ChinaNingbo 315048Zhejiang ProvinceChina

The levered-dual response(LEdAR)Coulomb-damped system attains near resonant vibration isolation by differential preloads/offsets in linear *** takes the advantages of both the preloads/offsets in linear springs and the guiderail friction for realizing different levels of vibration *** isolation capacities are investigated on the strategies with both the horizontal and vertical guiderails,with the horizontal rail only,and without *** compressive preloads generally result in the consumption of most of the initial excitation energy so as to overcome the potential *** isolation onsets at the frequency ratio of 1∓0.095 on the left-hand side(LHS)and the right-hand side(RHS)of the lever are relative to the load plate *** observed near resonant isolation thus makes the LEdAR system a candidate for the isolation of the mechanical systems about resonance while opening a path for simultaneous harvesterisolation functions and passive functions at extreme frequencies.

关键词： lever ratio Coulomb damping preload tension/compression isolation band/depth offset potential

BMPRⅡ^(+)neural precursor cells isolated and characterized from organotypic neurospheres:an in vitro model of human fetal spinal cord development

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Neural Regeneration Research 2024年第2期19卷 447-457页

作者： Michael W.Weible II Michael d.Lovelace Hamish d.Mundell Tsz Wai Rosita Pang Tailoi Chan-Ling Bosch Institute Discipline of Anatomy and Histology(F13)University of SydneySydneyNSWAustralia School of Environment and Science Griffith UniversityNathanQLDAustralia discipline of Medicine Nepean Clinical SchoolFaculty of Medicine and HealthUniversity of SydneyKingswoodNSWAustralia New South Wales Brain Tissue Resource Centre School of Medical SciencesFaculty of Medicine and HealthUniversity of SydneyCharles Perkins Centre(D17)SydneyNSWAustralia

Roof plate secretion of bone morphogenetic proteins(BMPs)directs the cellular fate of sensory neurons during spinal cord development,including the formation of the ascending sensory columns,though their biology is not well ***-ⅡBMP receptor(BMPRⅡ),the cognate receptor,is expressed by neural precursor cells during embryogenesis;however,an in vitro method of enriching BMPRⅡ^(+)human neural precursor cells(hNPCs)from the fetal spinal cord is *** was undertaken on intact second-trimester human fetal spinal cord using antibodies to BMPRⅡand leukemia inhibitory factor(LIF).Regions of highest BMPRⅡ^(+)immunofluorescence localized to sensory *** and meningeal-associated BMPRⅡ^(+)vascular cells were identified in both intact fetal spinal cord and cortex by co-positivity with vascular lineage markers,Cd34/*** immunostaining identified a population of somas concentrated in dorsal and ventral horn interneurons,mirroring the expression of LIF receptor/Cd118.A combination of LIF supplementation and high-density culture maintained culture growth beyond 10 passages,while synergistically increasing the proportion of neurospheres with a stratified,*** neurospheres were characterized by BMPRⅡ^(+)/MAP2ab^(+/–)/βⅢ-tubulin^(+)/nestin^(–)/vimentin^(–)/GFAP^(–)/NeuN^(–)surface hNPCs surrounding a heterogeneous core ofβⅢ-tubulin^(+)/nestin^(+)/vimentin^(+)/GFAP^(+)/MAP2ab^(–)/NeuN^(–)multipotent *** cultures from tripotential neurospheres contained neuronal(βⅢ-tubulin^(+)),astrocytic(GFAP+),and oligodendrocytic(O4+)lineage ***-activated cell sorting-sorted BMPRⅡ^(+)hNPCs were MAP2ab^(+/–)/βⅢ-tubulin^(+)/GFAP^(–)/O4^(–)in *** is the first isolation of BMPRⅡ^(+)hNPCs identified and characterized in human fetal spinal *** data show that LIF combines synergistically with high-density reaggregate cultures to support the organotypic reorganization of neurospheres,characterize

关键词： BMPRⅡ bone morphogenetic protein histotypic human spinal cord development leukemia inhibitory factor neurosphere organotypic reaggregate sensory columns

development and testing of a high-power S-band klystron at BINP SB RAS

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Nuclear Science and Techniques 2024年第7期35卷 58-67页

作者： A.Levichev A.Barnyakov S.Samoylov d.Nikiforov V.Ivanov M.Arsentyeva d.Chekmenev O.Pavlov I.Pivovarov Budker Institute of Nuclear Physics Lavrentyeva Av.11NovosibirskRussia630090 Novosibirsk State University Pirogova Str.2NovosibirskRussia630090

This paper details the development and testing of the first working prototype of the S-band high-power klystron,accomplished at the Budker Institute of Nuclear Physics,Siberian Branch,Russian Academy of Sciences(BINP SB RAS).Upon testing,the klystron demonstrated the following parameters:an operating frequency of 2856 MHz and a peak power output of 50 *** paper presents the klystron's design,its constituent units,and pertinent processing procedures,along with discussions on the measurement of its parameters.

关键词： Klystron Linear accelerator Electron beam

Feasibility of achieving net-zero energy performance in high-rise buildings using solar energy

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Energy and Built Environment

Energy and Built Environment 2024年第6期5卷 946-956页

作者： Mehrdad Shirinbakhsh L.d.danny Harvey University of Toronto 100St.George StreetTorontoONM5S 3G3Canada

As part of a broad strategy to reach net-zero greenhouse gas emissions and limit global warming,many countries are requiring all new buildings to have net-zero energy *** requires that on-site energy use not exceed on-site generation of renewable energy(taken here to be solar energy),or equivalently,that the building Energy Use Intensity(EUI,kWh/m^(2)a)not exceed the supply of on-site solar energy(electricity and heat)per m^(2)of floor area per *** this basis,we find that achieving net-zero energy performance in an archetype 40-story square building in 16 different cities of North America requires EUI of 17–24 kWh/m^(2)a using PV panels,and 19–28 kWh/m^(2)a using PVT *** building orientation to a non-square floor shape can improve maximum permitted EUI by up to 50%in PV and 60%in PVT ***,the best-performing residential and commercial buildings have EUIs of 50–75 kWh/m^(2)*** if building heights are limited to 5–10 floors does the available solar energy,and thus the permitted EUI,reach 50–75 kWh/m^(2)***,we recommend that policymakers not require high-rise buildings to be net-zero energy,unless they are prepared to limit building heights to 5–10 floors.

关键词： High-rise net-zero energy buildings Building geometry Building height Solar NZEB

Green building research in South Africa:A scoping review and future roadmaps

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Energy and Built Environment 2024年第2期5卷 316-335页

作者： Favour d.Agbajor Modupe Cecilia Mewomo department of Construction Management and Quantity Surveying Durban University of TechnologySteve Biko CampusDurban4001South Africa

The construction industry is recognised to pose serious environmental threats due to its anthropogenic *** confront this challenge,green building has been famed as an auspicious strategy to alleviate energy-related carbon emissions alongside climate change ***,it has birthed diverse empirical studies and holistic reviews by the research ***,these previous studies have been carried out from a global and continental viewpoint regardless of the green building development specifically in emerging *** present study seeks to fill the sparse research upshots on the synthesis of green building research at the country level with core focus on South *** this light,the current study provides a scoping overview of the intellectual exploration on green building research in the South African *** study’s findings highlight the varying growth regarding the subject matter,the drivers,drawbacks,and socio-economic issues confronting in developing green building projects in the *** optimize the advancement of green building in the region,this study recommends the implementation of financing schemes,utilization of advanced digital technologies,and promotion of green and sustainable building curricula across the institutions as well as post-occupancy-related studies within the green building spectrum towards a safe and salutogenic built-environment in the country.

关键词： Green building Sustainable construction Energy efficiency Review South Africa

Predictor-corrector FdM analysis of MHd darcy-Forchheimer flow of a micropolar fluid with viscous dissipation and heterogeneoushomogeneous

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Propulsion and Power Research 2024年第2期13卷 257-272页

作者： d.Thenmozhi M.Eswara Rao department of Mathematics Saveetha School of EngineeringSIMATSChennaiTamilnaduIndia

This research delves into an intricate exploration ofﬂuid dynamics within heat transfer systems,with a speciﬁc focus on enhancing our understanding and improving system efﬁ*** a sophisticated mathematical model,the study incorporates micropolarﬂuid dynamics,micro rotational effects,laminarﬂow characterized by the darcy-Forchheimer model,inertia effects,and chemical reactions within a heat transfer system featuring boundary layer *** mathematical framework consists of partial differential equations(PdEs),and the study utilizes advanced numerical techniques,including the(PC4-FdM)Predictor-Corrector Finite difference Method and the shooting method,to solve these govern-ing *** inclusion of quantized mesh points and analysis of convergence using 4th orderﬁnite difference methods enhances the precision of the obtained *** param-eters are scrutinized to draw meaningful *** heterogeneous parameter reveals an increasing trend inﬂuid concentration,while the homogeneous parameter indicates a collision effect leading to a decrease inﬂuid *** Eckert number,associated with viscous dissipation,exhibits a correlation with decreasedﬂuid temperature and increasedﬂuid *** rotation parameters suggest a parallel increase inﬂuid velocity and a marginal decrease inﬂuid ***,the darcy-Forchheimer parameter,reﬂective of inertial effects,showcases an increase inﬂuid temperature and decrease in velocity in the convection *** the industrial implications,the study underscores the signiﬁcance of convection heat transfer systems in the context of ***ﬁndings offer valuable insights for optimizing heating and cooling processes in diverse industrial applications,ranging from power plants to waste heat recovery units and pharmaceutical industries.ª2024 The *** services by Elsevier *** behalf of KeAi Communications ***.

关键词： Predictor-corrector Micropolarﬂuid Magnetohydrodynamics(MHd) Viscous dissipation Homogeneous-heterogeneous