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Pharmacological methods for ovarian function and fertility preservation in women with cancer:A literature review

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Oncology Research 2024年第8期32卷 1309-1322页

作者： ANA S.CVETANOVIC mATTEO LAmBERTINI KEVIN PUNIE GORANA G.mATOVINA BRKO NIKOLA d.ZIVKOVIC mAJA J.popovic mARIJANA m.mILOVIC KOVACEVIC LAZAR S.popovic department for Oncology Medical Faculty NisUniversity of NisNis18000Serbia Clinic of Oncology University Clinical Centre NisNis18000Serbia department of Internal medicine and medical Sciences(dimI) School of MedicineUniversity of GenovaGenova16100Italy department of medical Oncology U.O.C Clinica di Oncologia MedicaIRCCS Ospedale Policlinico San MartinoGenova16100Italy department of General medical Oncology and multidisciplinary Breast Centre Leuven Cancer InstituteUniversity Hospitals LeuvenLeuven3001Belgium department of medical Oncology Oncology Institute of VojvodinaSremska Kamenica21208Serbia department for Pathology Medical Faculty NisUniversity of NisNis18000Serbia Center for Pathology University Clinical Centre NisNis18000Serbia Faculty of medicine University of Novi SadNovi Sad21000Serbia department of medical Oncology Institute of Oncology and Radiology SerbiaBelgrade11000Serbia

Oncofertility is an extremely signiﬁcant topic that is increasingly being discussed owing to increased evidence indicating that fertility preservation does not affect the treatment outcomes of patients with cancer but signiﬁcantly contributes to preserving life *** effect of chemotherapy can range from minimal effects to complete ovarian *** data are available on the effects of monoclonal antibodies and targeted therapies on the ovaries and *** ovarian suppression by administering a gonadotropin-releasing hormone agonist(GnRHa)during chemotherapy decreases the gonadotoxic effect of chemotherapy,thereby diminishing the chance of developing premature ovarian insufﬁciency(POI).At present,the concomitant administration of GnRH analogs during chemotherapy is the only accepted pharmacological method for preserving ovarian ***,most randomized studies on the effectiveness of luteinizing hormone-releasing hormone agonists during chemotherapy in preventing POI have been conducted in women with breast cancer,with a considerably small number of studies on patients with hematological ***,most randomized controlled trials on breast cancer have revealed a decrease in treatment-induced POI risk,regardless of the hormone receptor *** addition,studies on hematological malignancies have yielded negative results;nevertheless,theﬁndings must be interpreted with caution owing to numerous *** guidelines from the American Society of Clinical Oncology and ESmO Clinical Practice Guidelines recommend sperm,oocyte,and embryo cryopreservation as a standard practice and only offering GnRHa to patients when proven fertility preservation methods are not *** this manuscript,we present a comprehensive literature overview on the application of ovarian suppression with GnRHa during chemotherapy in patients with cancer by addressing preclinical and clinical data,as well as future perspectives in thisﬁeld

关键词： Gonadotropin-releasing hormone agonists(GnRHa) Fertility preservation Premature ovarian insufficiency(POI) Premenopausal patients

Effect of special types of bread with select herbal components on postprandial glucose levels in diabetic patients

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World Journal of diabetes 2024年第4期15卷 664-674页

作者： drasko m Gostiljac Srdjan S popovic Vesna dimitrijevic-Sreckovic Sasa m Ilic Jelena A Jevtovic dragan m Nikolic Ivan A Soldatovic Clinic for Endocrinology Diabetes and Metabolic DiseasesUniversity Clinical Centre of SerbiaBelgrade 11000Serbia Faculty of medicine University of BelgradeBelgrade 11000Serbia Clinic for Gastroenterology and Hepatology University Clinical Centre of SerbiaBelgrade 11000Serbia Clinic for Endocrinology Diabetes and Metabolic Diseases-Laboratory for Human Pancreatic Islets CultureUniversity Clinical Centre of SerbiaBelgrade 11000Serbia

BACKGROUNd Nutrition recommendations in patients with type 2 diabetes mellitus(T2dm)are to consume rye or integral bread instead of white bread.A positive effect on glucoregulation has been achieved by enriching food with various biologically active substances of herbal origin,so we formulated an herbal mixture that can be used as a supplement for a special type of bread(STB)to achieve better effects on postprandial glucose and insulin levels in patients with *** To compare organoleptic characteristics and effects of two types of bread on postprandial glucose and insulin levels in T2dm *** This trial included 97 patients with T2dm.A parallel group of 16 healthy subjects was also *** participants were given 50 g of rye bread and the same amount of a STB with an herbal mixture on 2 consecutive *** blood glucose and insulin levels were compared at the 30^(th),60^(th),90^(th) and 120th min.A questionnaire was used for subjective estimation of the organoleptic and satiety features of the two types of *** Compared to patients who consumed rye bread,significantly lower postprandial blood glucose and insulin concentrations were found in T2dm patients who consumed *** relevant differences were found among the healthy *** estimated organoleptic and satiety characteristics are better for STB than for rye *** STB have better effects than rye bread on postprandial glucoregulation in T2dm *** estimated organoleptic and satiety characteristics are better for STB than for rye ***,STB can be recommended for nutrition in T2dm patients.

关键词： Special types of bread Postprandial glucoregulation Insulin Nutrition Type 2 diabetes mellitus

Numerical calculation of Z-scan measurements for nonlinear media with large phase shift

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Optoelectronics Letters 2024年第3期20卷 177-182页

作者： m.d.Zidan A.Allahham department of Physics Atomic Energy Commission of SyriaP.O.Box 6091DamascusSyria

We have reported the characteristics of a Z-scan for the poly(azaneylylidene-acylene)(dAZA) polymer, as nonlinear medium with a large nonlinear phase shift using continuous-wave(CW) laser beam. It has been verified that the Fresnel diffraction model is applicable for analyses of Z-scan measurements with dAZA polymer at high laser power. It was found that Z-scan curves with peak-to-valley features appear as the applied light intensity increases in the case of a large nonlinear phase shift. The Z-scan experiments were carried out using a CW laser to verify the theoretical calculations in the case of a large nonlinear phase shift model. Our results show good agreements between the experimental data and the proposed theoretical models.

关键词： nonlinear phase media

Highly toxic Aβ begets more Aβ

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Neural Regeneration Research 2024年第9期19卷 1871-1872页

作者： merc m.Kemeh Noel d.Lazo Gustaf H.Carlson School of Chemistry and Biochemistry Clark UniversityWorcesterMAUSA

Alzheimer’s disease(Ad)is the most common form of dementia-the 7th leading cause of death *** the tissue level,Ad is characterized by the presence of extracellular amyloid plaques that are comprised primarily of the amyloid-βpeptide(Aβ),and by intraneuronal neurofibrillary tangles composed of *** genetics of early-onset Ad and longitudinal brain-imaging studies of late-onset Ad indicate that extracellular Aβdeposition,in general,precedes neurofibrillary tangle formation in neurons(Hampel et al.,2021;Young-Pearse et al.,2023).

关键词： Aβ tau Alzheimer death

The multi-impurity system in CdSe nanoplatelets:electronic structure and thermodynamic properties

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Communications in Theoretical Physics 2024年第3期76卷 165-173页

作者： d A Baghdasaryan V A Harutynyan E m Kazaryan H A Sarkisyan Russian-Armenian University H Emin 1230051YerevanArmenia Institute of Applied Problems of Physics 25 Nersisyan St0014YerevanArmenia

This paper theoretically studies the impurity states and the effects of impurity concentration and configuration on the optical,electrical,and statistical properties of CdSe nanoplatelets(NPLs).An image charge-based model of electron-impurity interaction is *** charge-carrier energy spectra and corresponding wave functions depending on the impurity number and configuration are *** electron binding energies are calculated for different NPL *** is shown that the image charge-based interaction potential that arises due to the dielectric constants mismatch is much stronger than the interaction potential that does not take such a mismatch into ***,it is demonstrated that the binding energies are increasing with the number of *** calculate the canonical partition function using the energy levels of the electron,which in turn is used to obtain the mean energy,heat capacity,and entropy of the non-interacting electron *** thermodynamic properties of the non-interacting electron gas that depend on the geometric parameters of the NPL,impurity number,configuration,and temperature are studied.

关键词： nanoplateletes thermodynamic properties impurity states

Enhancement of coercivity,permeability,and dielectric properties of Co_(0.2)Zn_(0.3)Ni_(0.5)Eu_(x)Fe_(2-x)O_(4) ferrites for memory and high frequency devices

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Journal of Rare Earths 2024年第6期42卷 1128-1135,I0005页

作者： I.Sardar m.d.Hossain m.S.Sikder m.N.I.Khan m.R.Rahman Physics discipline Khulna UniversityKhulna9208Bangladesh department of Physics Khulna University of Engineering&TechnologyKhulna9203Bangladesh department ofComputer Science and Engineering Northern University of Business&Technology KhulnaKhulna9100Bangladesh material Science division Atomic Energy CentreDhaka1000Bangladesh

Spinel cubic ferrites have huge applications in me mory and high frequency *** the improvement of these modern devices,the magnetic coercivity,permeability,and dielectric properties of a ferrite are the important *** article focuses on improving the magnetic coercivity,magnetic permeability,and dielectric properties of Co_(0.2)Zn_(0.3)Ni_(0.5)Eu_(x)Fe_(2-x)O_(4) ferrites,where x=0.00,0.06,and *** X-ray diffraction(XRd),Fourier transform infrared spectroscopy(FTIR),field emission scanning electron microscopy(FESEm),energy dispersive X-ray(EdX),vibrating sample magnetometer(VSm),and an impedance analyzer were used to characterize the structural,magnetic,and dielectric properties of the *** XRd patterns indicate the formation of spinel cubic structure of the samples with a secondary peak(EuFeO_(3))for Eu doped *** densities and porosities of the samples follow an inverse trend,where the doped samples’lattice parameters are increased with the increment of rare earth Eu *** FTIR analysis also proves the spinel cubic phase of the *** average grain size of the ferrites is obtained via FESEm images,and it is increased from 121 to 198 *** analysis confirms that doping of the Eu content also changes other hysteresis loop properties of Co_(0.2)Zn_(0.3)Ni_(0.5)Eu_(x)Fe_(2-x)O_(4) ***,the coercivity of the Eu doped samples is greater than that of the mother alloy(x=0.00).The EdX study shows that there is no impurity contamination in the *** permeability and dielectric measurements show an improved quality factor of the Eu-doped samples with low magnetic and dielectric *** dependent resistivity and impedance analysis also show the improved *** the observed properties of the samples,all the investigated ferrites might be strong candidates for potential applications in memory devices,magnetic sensors,and high frequency applications.

关键词： Ferrites Raree arths Coercivity Permeability EdX Resistivity

Radioisotope production using lasers:From basic science to applications

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matter and Radiation at Extremes 2024年第3期9卷 31-44页

作者： m.R.d.Rodrigues A.Bonasera m.Scisciò J.A.Pérez-Hernández m.Ehret F.Filippi P.L.Andreoli m.Huault H.Larreur d.Singappuli d.molloy d.Raffestin m.Alonzo G.G.Rapisarda d.Lattuada G.L.Guardo C.Verona Fe.Consoli G.Petringa A.mcNamee m.La Cognata S.Palmerini T.Carriere m.Cipriani G.di Giorgio G.Cristofari R.de Angelis G.A.P.Cirrone d.margarone L.Giuffrida d.Batani P.Nicolai K.Batani R.Lera L.Volpe d.Giulietti S.Agarwal m.Krupka S.Singh Fa.Consoli Cyclotron Institute Texas A&M UniversityCollege StationTexas 77840USA Laboratori Nazionali del Sud Istituto Nazionale di Fisica Nucleare(LNS-INFN)CataniaItaly ENEA Fusion and Technologies for Nuclear Safety and Security Department-CFrascatiItaly Centro de Láseres Pulsados(clpu) VillamayorSpain Universidad de Salamanca SalamancaSpain Centre Lasers Intenses et Applications(CELIA) Universitéde BordeauxCNRSCEATalenceFrance HB11 Energy Holdings Pty FreshwaterNew South WalesAustralia School of mathematics and Physics Queen’s University BelfastBelfastUnited Kingdom dipartimento di Fisica e Astronomia“E.majorana ”Università di CataniaCataniaItaly Facoltàdi Ingegneria e Architettura Universitàdegli Studi di Enna“Kore”EnnaItaly dipartimento di Ingegneria Industriale Universitàdi Roma“Tor Vergata”RomaItaly dipartimento di Fisica e Geologia Universitàdegli Studi di PerugiaPerugiaItaly Istituto Nazionale di Fisica Nucleare Sezione di PerugiaPerugiaItaly ELI Beamlines Facility the Extreme Light Infrastructure ERICDolni BrezanyCzech Republic ETSIA Universidad Politécnica de MadridMadridSpain dipartimento Fisica “E.Fermi”Universitàdi Pisa and INFNPisaItaly FZU–Institute of Physics of Czech Academy of Sciences PragueCzech Republic Institute of Plasma Physics of Czech Academy of Sciences PragueCzech Republic

The discovery of chirped pulse amplification has led to great improvements in laser technology,enabling energetic laser beams to be compressed to pulse durations of tens of femtoseconds and focused to a few *** with energies of tens of meV can be accelerated using,for instance,target normal sheath acceleration and focused on secondary *** such conditions,nuclear reactions can occur,with the production of radioisotopes suitable for medical *** use of high-repetition lasers to produce such isotopes is competitive with conventional methods mostly based on *** this paper,we study the production of^(67)Cu,^(63)Zn,^(18)F,and^(11)C,which are currently used in positron emission tomography and other *** the same time,we study the reactions^(10)B(p,α)^(7)Be and^(70)Zn(p,4n)^(67)Ga to put further constraints on the proton distributions at different angles,as well as the reaction^(11)B(p,α)^(8)Be relevant for energy *** experiment was performed at the 1 PW laser facility at VegaⅢin Salamanca,*** distributions of radioisotopes in the forward(with respect to the laser direction)and backward directions were measured using a high purity germanium *** results are in reasonable agreement with numerical estimates obtained following the approach of Kimura and Bonasera[*** ***.,Sect.A 637,164–170(2011)].

关键词： purity estimates backward

Charting the course to solid-state dual-ion batteries

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Carbon Energy 2024年第3期6卷 132-177页

作者： Habtom d.Asfaw Antonia Kotronia Nuria Garcia-Araez Kristina Edström daniel Brandell department of Chemistry Ångström LaboratoryUppsala UniversityUppsalaSweden department of Chemistry University of SouthamptonSouthamptonUK

An electrolyte destined for use in a dual-ion battery(dIB)must be stable at the inherently high potential required for anion intercalation in the graphite electrode,while also protecting the Al current collector from anodic dissolution.A higher salt concentration is needed in the electrolyte,in comparison to typical battery electrolytes,to maximize energy density,while ensuring acceptable ionic conductivity and operational *** recent years,studies have demonstrated that highly concentrated organic electrolytes,ionic liquids,gel polymer electrolytes(GPEs),ionogels,and water-in-salt electrolytes can potentially be used in *** can help reduce the use of solvents and thus lead to a substantial change in the Coulombic efficiency,energy density,and long-term cycle life of ***,GPEs are suited to manufacture compact dIB designs without separators by virtue of their mechanical strength and electrical *** this review,we highlight the latest advances in the application of different electrolytes in dIBs,with particular emphasis on GPEs.

关键词： anion intercalation concentrated electrolytes dual-ion battery graphite ionic liquids polymer electrolyte

Converting TREx-RGB green-channel data to 557.7 nm auroral intensity:methodology and initial results

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Earth and Planetary Physics 2024年第1期8卷 258-274页

作者： Jun Liang d.m.Gillies E.Spanswick E.F.donovan University of Calgary CalgaryT2N 1N4Canada

The recently deployed Transition Region Explorer(TREx)-RGB(red-green-blue)all-sky imager(ASI)is designed to capture“true color”images of the aurora and *** the 557.7 nm green line is usually the brightest emission line in visible auroras,the green channel of a TREx-RGB camera is usually dominated by the 557.7 nm *** this rationale,the TREx mission does not include a specific 557.7 nm imager and is designed to use the RGB green-channel data as a proxy for the 557.7 nm *** this study,we present an initial effort to establish the conversion ratio or formula linking the RGB green-channel data to the absolute intensity of 557.7 nm auroras,which is crucial for quantitative uses of the RGB *** illustrate two approaches:(1)through a comparison with the collocated measurement of green-line auroras from the TREx spectrograph,and(2)through a comparison with the modeled green-line intensity according to realistic electron precipitation flux measurements from low-Earth-orbit satellites,with the aid of an auroral transport *** demonstrate the procedures and provide initial results for the TREx-RGB ASIs at the Rabbit Lake and Lucky Lake *** RGB response is found to be *** conversion ratios or formulas between RGB green-channel data and the green-line auroral intensity are given and can be applied immediately by TREx-RGB data *** methodology established in this study will also be applicable to the upcoming SmILE ASI mission,which will adopt a similar RGB camera system in its deployment.

关键词： TREx RGB green-line aurora auroral transport model