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Loss of A-type lamin expression compromises nuclear envelope integrity in breast cancer

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Chinese Journal of Cancer 2011年第6期30卷 415-425页

作者： Callinice d. Capo-chichi kathy Q. Cai Jennifer Smedberg Parvin Ganjei-Azar Andrew k. Godwin Xiang-Xi Xu Sylvester Comprehensive Cancer Center University of Kansas Medical Center Kansas City KS 66160 USA. department of Medicine University of Kansas Medical Center Kansas City KS 66160 USA. Ovarian Cancer Program Fox Chase Cancer Center Philadelphia PA 19111 USA department of Pathology University of Kansas Medical Center Kansas City KS 66160 USA. department of Pathology and Laboratory Medicine University of Kansas Medical Center Kansas City KS 66160 USA. department of Obstetrics and Gynecology University of Miami School of Medicine Miami FL 33136 USA

Through advances in technology,the genetic basis of cancer has been investigated at the genomic level,and many fundamental questions have begun to be *** several key unresolved questions in cancer biology,the molecular basis for the link between nuclear deformation and malignancy has not been *** hallmark of human cancer is aneuploidy;however,the causes and consequences of aneuploidy are unanswered and are hotly contested *** found that nuclear lamina proteins lamin A/C are absent in a significant fraction(38%) of human breast cancer *** in lamin A/C-positive breast cancer,lamin A/C expression is heterogeneous or aberrant(such as non-nuclear distribution) in the population of tumor cells,as determined by immunohistology and immunofluorescence *** most breast cancer cell lines,a significant fraction of the lamin A/C-negative population was *** determine the consequences of the loss of lamin A/C,we suppressed their expression by shRNA in noncancerous primary breast epithelial ***-regulation of lamin A/C in breast epithelial cells led to morphological deformation,resembling that of cancer cells,as observed by immunofluorescence *** lamin A/C-suppressed breast epithelial cells developed aneuploidy as determined by both flow cytometry and fluorescence in situ *** conclude that the loss of nuclear envelope structural proteins lamin A/C in breast cancer underlies the two hallmarks of cancer aberrations in nuclear morphology and aneuploidy.

关键词：核纤层蛋白乳腺癌蛋白表达损失核被膜乳腺上皮细胞非整倍体整性

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儿童和青少年肥胖的预防和管理指南

儿童和青少年肥胖的预防和管理指南

抗OX-40和抗IL-4抗体体外促进Th1细胞的初步探讨

作者： Fitch A fox C Bauerly k Gross A Heim C Judge-dietz J kaufman T krych E kumar S Landin d Larson J Leslie d Martens N Monaghan-Beery N Newell T O’Connor P Spaniol A Thomas A Webb B 张娜美国ICSI(临床工作促进协会)

指南推荐条目及证据质量(质量等级"高"意味着进一步研究非常不可能改变此指南中对效应估计值的确信程度;"中"意味着进一步研究有可能对此指南中对效应估计值的确信程度造成重要影响,且可能改变该估计值;"低"意味着进一步研究很有可能对...

指南推荐条目及证据质量(质量等级"高"意味着进一步研究非常不可能改变此指南中对效应估计值的确信程度;"中"意味着进一步研究有可能对此指南中对效应估计值的确信程度造成重要影响,且可能改变该估计值;"低"意味着进一步研究很有可能对此指南中对效应估计值的确信程度造成重要影响,且很可能改变该

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上海免疫学杂志 2001年第3期21卷 148-150,169页

作者：储以微 Bernard A fox 复旦大学医学院免疫学教研室上海200032 Portland Medical Center Oregon Health Science University

将灭活的自身黑色素瘤细胞MEL 72与BCG混合免疫MEL 72黑色素瘤病人 ,10d后手术方法获取局部引流淋巴结 ,制成淋巴细胞悬液 ,以抗Cd3抗体体外培养 ,ELISA方法检测细胞上清中肿瘤特异性Th1、Th2细胞因子的表达。进一步用抗OX 40抗体与Cd4... 详细信息

将灭活的自身黑色素瘤细胞MEL 72与BCG混合免疫MEL 72黑色素瘤病人 ,10d后手术方法获取局部引流淋巴结 ,制成淋巴细胞悬液 ,以抗Cd3抗体体外培养 ,ELISA方法检测细胞上清中肿瘤特异性Th1、Th2细胞因子的表达。进一步用抗OX 40抗体与Cd4+ T淋巴细胞表面OX 40作用或用抗IL 4抗体阻断IL 4的分泌 ,观察肿瘤特异性免疫反应能否向Th1方向转换。结果表明 :用灭活的自体肿瘤细胞免疫机体能诱导出该肿瘤细胞特异性的Th1和Th2。应用抗OX 40抗体与抗IL 4抗体作用后 ,Th1细胞因子分泌水平增加 (TNF β和IFN γ ) ,结果提示 ,应用抗OX 40和抗IL 4抗体可诱导肿瘤特异性Th1反应。

关键词： OX-40 IL-4 Th1细胞肿瘤细胞抗肿瘤作用肿瘤免疫

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应用MRI测量口腔-盲肠通过时间

国际医学放射学杂志 2015年第4期 399-400页

作者： E.Savarino V.Savarino M.fox G.d.Leo M.Furnari E.Marabotto 刘春明 division of Gastroenterology Department of SurgicalOncological and Gastroenterological Sciences

摘要目的前瞻性地评估乳果糖氢呼气试验(LHBT)和MRI测量健康个体口腔-盲肠通过时间(OCTT)的一致性。方法所有志愿者均行空腹及摄入乳果糖(10 g/125 m L)后的

关键词：乳果糖 MRI测量呼气试验扫描序列呼气相末端回肠权序列分割法四分位间距团注

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现代世界伦理学新趋向

冠状动脉介入治疗后有无肝素方案对临床预后的影响

1990年

作者： J.P.·德马科(J.P. demarco) R.M.·福克斯(R.M. fox)

来源：南通市图书馆图书汇雅图书（南通市图书馆... 评论

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中国急救医学 2004年第2期24卷 92-94页

作者：高传玉黄克钧沈玉祥 Patracia fox Rob Whitboun 马业新高恩民李俊秀朱中玉李牧尉牛振民陈岩河南省人民医院心内科 450003 Cardiology of StVincent Hospital Melbourne 华中科技大学同济医学院同济医院心内科

目的　探讨冠状动脉支架置入术后是否应用肝素对临床预后的影响。方法　回顾性分析了 1998- 10～ 2 0 0 1- 10所有冠状动脉支架术病人在鞘管拔出后用或不用静脉肝素方案对住院期间、30d缺血事件和出血并发症的影响。结果　肝素组住院期... 详细信息

目的　探讨冠状动脉支架置入术后是否应用肝素对临床预后的影响。方法　回顾性分析了 1998- 10～ 2 0 0 1- 10所有冠状动脉支架术病人在鞘管拔出后用或不用静脉肝素方案对住院期间、30d缺血事件和出血并发症的影响。结果　肝素组住院期间缺血并发症低于无肝素组 ,缺血并发症减少 5 8% (3.70 %vs 9.10 % ,P d靶血管再梗死率降低 75 % (0 .34%vs 1.4 0 % ,P 0 .2 5 ) ;进一步分析发现 ,隔夜肝素组和 3d肝素组缺血和出血并发症也无明显区别 (2 .0 0 %vs3.90 % ,P>0 .1和 5 .90 %vs7.2 0 % ,P>0 .5 )。结论　冠状动脉支架术后常规应用肝素能减少住院期间和 30dQMI、NQMI、靶血管再PTCA的发生率和亚急性血栓形成。延长静脉应用肝素不能进一步改善病人的缺血并发症 ,但也不增加出血可能性。

关键词：冠状动脉支架静脉肝素应用缺血并发症出血并发症临床预后

A tissue-engineered rostral migratory stream for directed neuronal replacement

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Neural Regeneration Research 2018年第8期13卷 1327-1331页

作者： John C.O'donnell kritika S.katiyar kate V.Panzer d.kacy Cullen Center for Brain Injury & Repair Department of Neurosurgery Perelman School of Medicine University of Pennsylvania Center for Neurotrauma Neurodegeneration & Restoration Corporal Michael Crescenz Veterans Affairs Medical Center School of Biomedical Engineering Drexel University department of Bioengineering School of Engineering and Applied Science University of Pennsylvania

New neurons are integrated into the circuitry of the olfactory bulb throughout the lifespan in the mamma- lian brain--including in humans. These new neurons are born in the subventricular zone and subsequently mature as they are guided over long distances via the rostral migratory stream through mechanisms we are only just beginning to understand. Regeneration after brain injury is very limited, and although some neuroblasts from the rostral migratory stream will leave the path and migrate toward cortical lesion sites, this neuronal replacement is generally not sustained and therefore does not provide enough new neurons to alleviate functional deficits. Using newly discovered microtissue engineering techniques, we have built the first self-contained, implantable constructs that mimic the architecture and function of the rostral migratory stream. This engineered microtissue emulates the dense cord-like bundles of astrocytic somata and processes that are the hallmark anatomical feature of the glial tube. As such, our living microtissue-en- gineered rostral migratory stream can serve as an in vitro test bed for unlocking the secrets of neuroblast migration and maturation, and may potentially serve as a living transplantable construct derived from a patient＇s own cells that can redirect their own neuroblasts into lesion sites for sustained neuronal replace- ment following brain injury or neurodegenerative disease. In this paper, we summarize the development of fabrication methods for this microtissue-engineered rostral migratory stream and provide proof-of-princi- ple evidence that it promotes and directs migration of immature neurons.

关键词： rostral migratory stream glial tube astrocyte neuroblast brain injury neural repair neural regeneration tissue engineering

美国威斯康星州的Lower fox River和Lower Green Bay水域的污染沉积物对鱼类影响的研究

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水生生物学报 1997年第3期21卷 248-253页

作者：张甫英 JohnsonR.d 中国科学水生生物研究所武汉430072 EPA.ERL-dU.S.A

LowerfoxRiver和LowerGreenBy水域的沉积物造成了该地区的轻度污染。经测定和分析，沉积物中含有较高的PCBs和较低含量的PCdFs及PCdds，在鱼样品中呈现有PCBs和农药。组织病理学检查，鱼体内寄生虫感染发生率较高，部分肝组织坏死，出... 详细信息

LowerfoxRiver和LowerGreenBy水域的沉积物造成了该地区的轻度污染。经测定和分析，沉积物中含有较高的PCBs和较低含量的PCdFs及PCdds，在鱼样品中呈现有PCBs和农药。组织病理学检查，鱼体内寄生虫感染发生率较高，部分肝组织坏死，出现肉芽瘤状物，胰腺纤维化，但没有发现鱼体上有肿瘤。

关键词：鱼纲环境污染沉积物组织病理学

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儿童复杂的胰腺血管畸形

世界核心医学期刊文摘（儿科学分册） 2006年第8期2卷 46-47页

作者： Vogel A. M. Alesbury J. M fox V. L Fishman S.J 朱新菊(译) 不详 -J. PEdIATR. SURG. 2006 41/3 (473-478)

Background:Vascular anomalies are vascular tumors and congenital malformation s that rarely involve the *** and management of these lesions is ***:An institutional review board-approved retrospective databas e and record review from 1994 through 2004 at a quaternary referral center for v ascular anomalies was ***:Of 5051 patients with a vascular anoma ly,6 had a lesion involving the *** patients were younger than 3 year *** were three tumors(two infantile hemangiomas and one kaposiform hemangi oendothelioma)and three malformations(two lymphatic and one venous).The refer ring diagnoses were correct for 4 *** anomalies were diagnosed with a combination of cross-sectional imaging and *** patients received medical therapy including two malformation patients who were initially treated w ith antiangiogenic *** patients with lymphatic malformations underwent op erative *** infantile hemangioma was treated with percutaneous bil iary drainage for obstructive ***:Complex pancreatic vascular anomalies are *** tumors are generally amenable to treatment with ant iangiogenic *** resection is reserved for refractory cases or *** vascular malformations are treated exclusively by su *** and management of these lesions is complex and may benefit fro m coordinated interdisciplinary care.

关键词：先天性血管畸形胰腺复杂内科药物治疗卡波西样血管内皮瘤毛细血管瘤淋巴管畸形血管异常儿童相干断层扫描