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Biochemical dissection of STAT3 signaling in amyotrophic lateral sclerosis

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Neural Regeneration Research 2025年第11期20卷 3229-3230页

作者： Savina Apolloni Nadia d’Ambrosi department of Biology University of Rome Tor VergataRomeItaly

Amyotrophic lateral sclerosis(ALS)is a progressive neurodegenerative disease characterized by the loss of upper and lower motor neurons,clinically marked by muscle atrophy and *** the clinical course is highly variable,the average time from the onset of symptoms to the need for respiratory support or death is 3-5 *** is the most prevalent motor neuron disease in adults,occurring at a rate of 2 per 100,000 individuals and affecting 5.4 per 100,000 individuals overall.

关键词： STAT3 dissection sclerosis

Anti-amyloid antibodies in Alzheimer’s disease: what did clinical trials teach us?

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Neural Regeneration Research 2025年第4期20卷 1092-1093页

作者： danko Jeremic Lydia Jiménez-díaz Juan d.Navarro-López NeuroPhysiology&Behavior Lab University of Castilla-La ManchaBiomedical Research Center(CRIB)School of Medicine of Ciudad RealCiudad RealSpain

Although many causes of Alzheimer’s disease(Ad)may exist,both the original amyloid cascade and tau hypotheses posit that abnormal misfolding and accumulation of amyloid-β(Aβ)and tau protein is the central event causing the ***,that conclusion could be only partly true,and there is conflicting evidence about the role of both proteins in Ad,being able to precede and influence one *** researchers argue that these proteins are mere executors rather than primary causes of ***,there have been continuing refinements of both hypotheses,with alternative explanations proposed.Aβand tau proteins may be independently involved in specific neurotoxic pathways;yet there may be other crucial processes going on in early ***,accumulating evidence suggests that Aβand tau act synergistically,rather than additively in disease onset(Jeremic et al.,2021,2023a).

关键词： amyloid Alzheimer additive

Generalized Multiobjective Symmetric duality under Second-Order(F, α, ρ, d)-Convexity

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Acta Mathematicae Applicatae Sinica 2015年第2期31卷 529-542页

作者： S.k.Gupta d.dangar department of Mathematics Indian Institute of Technology Roorkee department of Mathematics and Humanities IT Nirma University

In this paper, we first formulate a second-order multiobjective symmetric primal-dual pair over arbitrary cones by introducing two different functions f ： R^n × R^m → Rk and g ： R^n × R^m → R^l in each k-objectives as well as l-constraints. Further, appropriate duality relations are established under second-order（F, α, ρ, d）-convexity assumptions. A nontrivial example which is second-order（F, α, ρ, d）-convex but not secondorder convex/F-convex is also illustrated. Moreover, a second-order minimax mixed integer dual programs is formulated and a duality theorem is established using second-order（F, α, ρ, d）-convexity assumptions. A self duality theorem is also obtained by assuming the functions involved to be skew-symmetric.

关键词： multiobjective symmetric duality second-order(F α ρ d)-convex duality theorems minimax self duality

Remaking a connection:molecular players involved in post-injury synapse formation

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Neural Regeneration Research 2025年第6期20卷 1719-1720页

作者： diogo Tomé Ramiro d.Almeida iBiMEd-Institute of Biomedicine Department of Medical SciencesUniversity of AveiroAveiroPortugal CNC-Center for Neuroscience and Cell Biology University of CoimbraCoimbraPortugal

Functional recovery from central nervous system(CNS)trauma depends not only on axon regeneration or compensatory sprouting of uninjured fibers but also on the ability of newly grown axons to establish functional synapses with appropriate *** several studies have successfully promoted long-distance axonal regeneration in distinct CNS injury models,none of them have resulted in a viable therapeutic approach for patient recovery.A possible reason may be the lack of new synaptogenesis for reestablishing the circuitry lost after ***,we discuss how our understanding of the mechanisms that instruct synapse formation in the injured nervous system may contribute to the design of new strategies to promote functional restoration in traumatic CNS disorders.

关键词： viable injury instru

Hsp90 inhibition induces destabilization of actin cytoskeleton in tumor cells:functional significance of Hsp90 interaction with F-actin

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Asian Pacific Journal of Tropical Medicine 2010年第9期3卷 715-722页

作者： Vishal chaturvedi Amere Subbarao Sreedhar Centre for Cellular and Molecular Biology Uppal RoadHyderabad 500 007India

Objective:To examine the role of heat shock protein 90(Hsp90) in the maintenance of actin cytoskeleton in human neuroblastoma tumor ***:Co-precipitation experiments were performed to examine Hsp90 interaction with ***90 and actin interactions were evaluated by protein refolding and acto-myosin motility assays.17-(AUylamino)-17- demethoxygeldanamycin(17AAG) induced actin-cytoskeleton re-organization was examined by laser scanning confocal ***:It was shown that inhibition of Hsp90 by 17AAC accelerates detergent induced cell lysis of neuroblastoma tumor cells through destabilization of actin *** in vitro co-precipitation experiments showed that functional but not mutant Hsp90 binds with *** biochemical modifications,phopshorylation and oligomerization enhanced Hsp90 binding with F-actin.F-actin binding to Hsp90 interfered with Hsp90 chaperone activity in protein refolding assays,and Hsp90 binding to F-actin interfered with actin motility on myosin coated flow *** the combination treatment,17AAG irreversibly augmented the effect of cytochalasin d,an inhibitor of actin ***:It can be concluded that Hsp90 binds to F-actin in tumor cells and maintains the cellular integrity. The results display a novel element of Hsp90 inhibition in destabilizing the actin cytoskeleton of tumor cells,therefore suggest that 17AAG combination with cytoskeletal disruptor may be effective in combating cancer.

关键词： Hsp90 F-actin Cytoskeleton 17AAG Tumor cells Combination treatment

Effects of P301L-TAU on post-translational modifications of microtubules in human iPSC-derived cortical neurons and TAU transgenic mice

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Neural Regeneration Research 2025年第8期20卷 2348-2360页

作者： Mohamed Aghyad Al kabbani Christoph köhler Hans Zempel Institute of Human Genetics Faculty of Medicine and University Hospital CologneUniversity of CologneCologneGermany Center for Molecular Medicine Cologne(CMMC) University of CologneCologneGermany Center Anatomy Department ⅡMedical FacultyUniversity of CologneCologneGermany

TAU is a microtubule-associated protein that promotes microtubule assembly and stability in the *** is missorted and aggregated in an array of diseases known as *** are essential for neuronal function and regulated via a complex set of post-translational modifications,changes of which affect microtubule stability and dynamics,microtubule interaction with other proteins and cellular structures,and mediate recruitment of microtubule-severing *** impairment of microtubule dynamics causes neuronal dysfunction,we hypothesize cognitive impairment in human disease to be impacted by impairment of microtubule *** therefore aimed to study the effects of a disease-causing mutation of TAU(P301L)on the levels and localization of microtubule post-translational modifications indicative of microtubule stability and dynamics,to assess whether P301L-TAU causes stability-changing modifications to *** investigate TAU localization,phosphorylation,and effects on tubulin post-translational modifications,we expressed wild-type or P301L-TAU in human MAPT-kO induced pluripotent stem cell-derived neurons(i Neurons)and studied TAU in neurons in the hippocampus of mice transgenic for human P301L-TAU(p R5 mice).Human neurons expressing the longest TAU isoform(2N4R)with the P301L mutation showed increased TAU phosphorylation at the AT8,but not the p-Ser-262 epitope,and increased polyglutamylation and acetylation of microtubules compared with endogenous TAU-expressing neurons.P301L-TAU showed pronounced somatodendritic presence,but also successful axonal enrichment and a similar axodendritic distribution comparable to exogenously expressed 2N4R-wildtype-TAU.P301L-TAU-expressing hippocampal neurons in transgenic mice showed prominent missorting and tauopathy-typical AT8-phosphorylation of TAU and increased polyglutamylation,but reduced acetylation,of microtubules compared with non-transgenic *** sum,P301L-TAU results in changes in micr

关键词： human induced pluripotent stem cell microtubules P301L pR5 mice TAU tauopathy tubulin code

Impact of invasive Ageratina adenophora on relative performance of woody vegetation in different forest ecosystems of kumaun Himalaya,India

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Journal of Mountain Science 2023年第9期20卷 2557-2579页

作者： Bhawna NEGI kavita kHATRI Surendra S.BARGALI kiran BARGALI Archana FARTYAL R.k.chaturvedi department of Botany D.S.B CampusKumaun UniversityNainital-263002UttarakhandIndia Center for Integrative Conservation Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesMenglun 666303China

Invasive plant Ageratina adenophora(Sprengel)***&*** has invaded majority of the temperate forests in kumaun,Central *** on *** invaded forest types,their structural attributes,population demography and regeneration status are still at rudimentary *** this,the present study was conducted to assess the impacts of *** on vegetational attributes and regeneration status of three forest types,viz.,Oak(Quercus oblongata ***),Pine(Pinus roxburghii Sarg.)and Cypress(Cupressus torulosa ***).We selected three sites for each forest type and each site was further purposively stratified into paired sampling plots of 1 ha each i.e.,*** invaded and uninvaded *** results showed large densities of cut stumps or felled trees throughout invaded sites,but with fewer fire signs in comparison to uninvaded *** uninvaded sites,total density and basal area calculated for woody species were relatively higher than those in invaded sites,although results were insignificant(p>0.05).With the exception for Cypress forests,vegetation indices showed low woody species richness and diversity in invaded Oak and Pine ***,regeneration of ***,*** and *** tree species did not differ significantly(p>0.05)between invaded and uninvaded *** insignificant differences clearly imply that ***'s presence has not entirely changed the perennial plant communities in terms of composition,structure and natural ***,tree species with poor or no regeneration status requires special attention and needs management strategies involving control of invasive species in forest ecosystems.

关键词： Ageratina adenophora Seedling density Forests Population structure Regeneration

Parameters Estimation of an Electric Fan Using ANN

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Journal of Intelligent Learning Systems and Applications 2010年第1期2卷 43-48页

作者： Himanshu Vijay d. k. chaturvedi 不详

Electric Fans are very commonly used in the industries, domestic applications and in tunnels for cooling and ventila-tion purposes. Fan parameters estimation is an important task as far as the reliable operation of a fan system is con-cerned. Basically, a fan is mainly consisting of a single phase induction motor and therefore fan system parameters are essentially the electrical parameters e.g. resistances, reactances and some load parameters (fan blades).These parame-ters often change under varying operating conditions and the knowledge of these parameters is necessary to have opti-mum and efficient operation of the system. Therefore, fan system parameters are required to be estimated. Further, fan system parameters estimation is required to ensure the smooth system operation and to avoid any malfunctioning of the system during abnormal working conditions. In this paper, Artificial Neural Networks (ANN) approach has been used for parameter estimation of a fan system. The simulated and experimental results are compared.

关键词： Artificial Neural Networks Fan System Mathematical Modeling Parameters Estimation

The sexually dimorphic expression of glutamate transporters and their implication in pain after spinal cord injury

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Neural Regeneration Research 2025年第11期20卷 3317-3329页

作者： Jennifer M.Colón-Mercado Aranza I.Torrado-Tapias Iris k.Salgado Jose M.Santiago Samuel E.Ocasio Rivera dina P.Bracho-Rincon Luis H.Pagan Rivera Jorge d.Miranda department of Physiology University of Puerto RicoMedical Sciences CampusSan JuanPRUSA National Institutes of Health National Human Genome Research InstituteBethesdaMDUSA Universidad Central del Caribe School of MedicineBayamónPRUSA University of Puerto Rico Carolina CampusCarolinaPRUSA Institute of Neurobiology San JuanPRUSA

In addition to the loss of motor function,~60% of patients develop pain after spinal cord *** cellular-molecular mechanisms are not well understood,but the data suggests that plasticity within the rostral,epicenter,and caudal penumbra of the injury site initiates a cellularmolecular interplay that acts as a rewiring mechanism leading to central neuropathic *** can lead to the formation of new connections triggering abnormal sensory *** excitatory glutamate transporters are responsible for the reuptake of extracellular glutamate which makes them a critical target to prevent neuronal hyperexcitability and *** previous studies showed a sexually dimorphic therapeutic window for spinal cord injury after treatment with the selective estrogen receptor modulator *** this study,we investigated the anti-allodynic effects of tamoxifen in male and female rats with spinal cord *** hypothesized that tamoxifen exerts anti-allodynic effects by increasing the expression of glutamate transporters,leading to reduced hyperexcitability of the secondary neuron or by decreasing aberrant *** and female rats received a moderate contusion to the thoracic spinal cord followed by subcutaneous slow-release treatment of tamoxifen or matrix pellets as a control(placebo).We used von Frey monofilaments and the“up-down method”to evaluate mechanical *** treatment decreased allodynia only in female rats with spinal cord injury revealing a sexdependent *** expression profile of glutamatergic transporters(excitatory amino acid transporter 1/glutamate aspartate transporter and excitatory amino acid transporter 2/glutamate transporter-1)revealed a sexual dimorphism in the rostral,epicenter,and caudal areas of the spinal cord with a pattern of expression primarily on *** rodents showed a significantly higher level of excitatory amino acid transporter-1 expression while male rodents showed increased

关键词： allodynia central neuropathic pain EAAT-1/GLAST EAAT-2/GLT-1 glutamate transporters selective estrogen receptor modulator sexual dimorphism spinal cord injury trauma