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Pneumonia relevant to lung transplantation and pathogen distribution

Chinese Medical journal 2013年第17期126卷 3209-3214页

作者： HE Xuan dAI Hua-ping CHEN Qi-rui MIAO jin-bai SUN Bing BAO Na HU Bin LI Hui WU An-shi BAN Cheng-jun GE Su-juan WANG Chen hou Sheng-cai department of Respiratory and Critical Care Medicine Beijing Chao-Yang Hospital Capital Medical University Beijing 100020 China department of Thoracic SurgeryBeijing Chao-Yang Hospital Capital Medical University Beijing 100020 China department of ImageBeijing Chao-Yang Hospital Capital Medical University Beijing 100020 China department of Anesthesia Beijing Chao-Yang Hospital Capital Medical University Beijing 100020 China Beijing Key Laboratory of Respiratory and Pulmonary Circulation Beijing Institute of Respiratory Medicine Beij ing 100020 China Beijing Hospital Beijing 100730 China

Background Pneumonia is the most common cause of morbidity and mortality in lung transplant （LT） recipients. The aim of the present study was to evaluate the incidence, etiology, risk factors and prognosis of pneumonia in LT recipients. Methods The LT cohort consisted of 28 recipients receiving LT in Beijing Chao-Yang Hospital from August 2005 to April 2011. data collected included demographic data, underlying disorders, time and type of transplant, follow-up information, date of last follow-up, and patient status. A retrospective analysis was made of observational data that were prospectively collected. Results Twenty-two patients of 28 LT recipients had 47 episodes of pneumonia throughout the study period. Thirty- eight episodes of pneumonia in 19 recipients occurred post-LT with a median follow-up of 257.5 days （1-2104 days）, the incidence of pneumonia was 192.4 episodes per 100 LT/year and its median time of onset was 100.5 days （0-946 days） post-transplantation. Bacteria, virus and fungi accounted for 62%, 16% and 15% of the microbial pathogens, respectively. The most frequent were Pseudomonas aeruginosa （20%）, cytomegalovirus （CMV）（15%）, and Aspergillus fumigatus （10%）. A total of 29% （11/38） of pneumonias occurred in the first month post-LT, and then the incidence decreased gradually. The incidence of CMV pneumonia was 25% （7/28） with a median time of 97 days （10-971 days）. More than one bacterial infection and CMV infection were independent risk factors for aspergillus infection. The incidence of pulmonary tuberculosis （TB） was 18% （5/28）, and the history of TB was a risk factor for TB relapse. There were 58% （7/12） of recipients who died of infection, and 71% （5/7） of these died in the first year after LT. Conclusions Pneumonia is still a major cause of morbidity and mortality in LT recipients. The most frequent microorganisms were Pseudornonas aeruginosa, CMV, and Aspergillus fumigates. The incidence of CMV pneumonia decreases with a delayed median time o

关键词： lung transplantation pneumonia infection pathogen

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基于零模行波波速量化的高压输电线路双端故障定位方法

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电力自动化设备 2022年第12期42卷 165-170页

作者：王炜王全金尹力孙海霞王华侯添钰梁睿国网江苏电力有限公司连云港供电分公司江苏连云港222004 中国矿业大学电气与动力工程学院江苏徐州221116

结合行波零模分量传播的依频特性和衰减特性,提出基于零模行波波速量化的高压输电线路双端故障定位方法。利用最小二乘法拟合零模行波波速与故障零模行波到达首末端的传输时间差之间的关系。基于故障发生后实际测量行波信号的传输时间差... 详细信息

结合行波零模分量传播的依频特性和衰减特性,提出基于零模行波波速量化的高压输电线路双端故障定位方法。利用最小二乘法拟合零模行波波速与故障零模行波到达首末端的传输时间差之间的关系。基于故障发生后实际测量行波信号的传输时间差,获取对应首末端的零模行波实际波速代入改进的双端行波测距方程实现故障定位。在PSCAd/EMTdC中搭建500 kV高压输电线路依频特性模型对所提方法进行仿真验证,结果表明该方法基本不受故障位置和故障电阻的影响,具有较高的故障定位精度。

关键词：高压输电线路波速量化双端故障定位传输时间差零模行波

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Shexiang Tongxin dropping Pill(麝香通心滴丸)Reduces Coronary Microembolization in Rats via Regulation of Mitochondrial Permeability Transition Pore Opening and AKT-GSK3βPhosphorylation

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Chinese journal of Integrative Medicine 2021年第7期27卷 527-533页

作者： dING Yu ZHU hou-yong ZHANG Li-zong GAO Bei-bei Zhou Liang HUANG jin-yu Central Laboratory Hangzhou First People's HospitalZhejiang University School of MedicineHangzhou310006China department of Cardiology Hangzhou Chinese Medical HospitalHangzhou310007China Experimental Animal Research Center Zhejiang Chinese Medical UniversityHangzhou310053China department of Cardiology Hangzhou First People's HospitalZhejiang University School of MedicineHangzhou310006China

Objective To investigate the protective effects of Shexiang Tongxin dropping Pill(麝香通心滴丸,STdP)following sodium laurate-induced coronary microembolization(CME)in *** Forty rats were divided into 4 groups:the control(sham)group,CME group,low-dose STdP pretreatment group(20 mg·kg^(−1)·d^(−1)),and high-dose STdP pretreatment group(40 mg·kg^(−1)·d^(−1)).The rats were intragastric administrated with STdP 2 weeks before ***,the histopathological alterations were observed using optical microscopy and transmission electron *** biomarkers were analyzed by enzyme-linked immunosorbent *** functions including the mitochondrial permeability transition pore(mPTP)mtdNA copy number were determined and proteins of AKT/GSK3βwere analyzed by Western *** The rats in the CME group showed a significant increase in the fibrinogen-like protein 2 expression level and mitochondrial dysfunction and a decrease in the expression level of antioxidant biomarkers(superoxide dismutase and catalase,Pd high-dose STdP pretreatment groups showed a significant decrease in coronary microthrombi(PdP restored the antioxidant-related protein activities and mitochondrial function,inhibited mPTP opening,decreased AKT-Ser473 phosphorylation,and increased GSK3β-Ser9 phosphorylation(PdP may be useful for treatment of CME,possibly via regulation of mPTP opening and AKT/GSK3βphosphorylation.

关键词： Shexiang Tongxin dropping Pill Chinese medicine coronary microembolization mitochondrial permeability transition pore AKT GSK3β

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Screening Apolar extracts from South Australian marine sponges for Cytotoxicity properties against three human breast cancer cell lines

Screening Apolar extracts from South Australian marine spong...

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2014年中国药学大会暨中国药师周

作者： Shuang Peng Wei Zhang Barbara Sanderson hou-Wen Lin department of Medical Biotechnology School of MedicineFlinders University Key Laboratory for Marine drugs Shanghai Jiaotong University School of Medicine

Marine sponges[Porifera]are the single best novel marine natural products,accountly for30%of all marine natural products discovered by *** oceans in South Australia have largely untapped resource of marine sponge with an estimated number over 800 species,which accounts for approximately over 58%species in *** aim of this study is to screen these untapped marine sponges in South Australian water for their anti-breast cancer ***-five marine sponge species were collected and subjected to crude apolar *** extracts were tested against three breast cancer cell lines（T47d,MCF7 and MdA-MB-231）using Crystal Violet assay.60%of crude apolar extracts showed cytotoxicity activity to these three breast cancer cell *** apolar extracts from five sponges（Tedania sp,Chondropsis ***,Chondropsis sp1,and Chondropsis sp2）have significant（p＜0.05）Cytotoxicity result compared with untreated *** IC50 values range between 12.43 to 25.89μg/ml（24h treatment）,2.03 to 12.92μg/ml（48h treatment）and 1.02 to 3.55μg/ml（72h treatment）.These apolar extracts showed significant（p＜0.05）difference on cancer cell lines compared to a normal breast cell lines 184B5（IC50:12.11 to 23.36μg/ml）at 48h *** cytometry was used to assess the induction of apoptosis and potential cell cycle *** extracts induced apoptosis at 10μg/ml in MCF7 and MdA-MB-231 cell lines,and arrest cell cycle in G1 and S phase compare with untreated cells.

关键词： Sponge Anticancer Cytotoxicity Apoptosis Cell cycle

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Ag,Fe,Ce对ZnTi-LdO可见光催化性能的影响及作用机理

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环境科学学报 2022年第6期42卷 101-110页

作者：李一菲侯诗敏卫柴汇吉莉张越太原科技大学环境科学与工程学院太原030024 山西大学化学化工学院精细化学品教育部工程研究中心太原030006

为了解金属及其氧化物对锌钛类水滑石衍生氧化物(ZnTi-LdO)可见光催化性能的影响,并获得在可见光下可快速降解染料的LdO光催化剂,制备了Ag、Fe、Ce修饰的复合材料(M-ZnTi-LdO,M=Ag,Ag_(2)O,Fe,Ce).通过XRd、TEM\HRTEM、XPS、BET、UV-Vis... 详细信息

为了解金属及其氧化物对锌钛类水滑石衍生氧化物(ZnTi-LdO)可见光催化性能的影响,并获得在可见光下可快速降解染料的LdO光催化剂,制备了Ag、Fe、Ce修饰的复合材料(M-ZnTi-LdO,M=Ag,Ag_(2)O,Fe,Ce).通过XRd、TEM\HRTEM、XPS、BET、UV-Vis、PL对所合成材料的结构、形貌、表面化学状态、光学性质进行了表征,评价了上述材料在可见光下对亚甲基蓝(MB)的催化降解性能,通过自由基捕获实验确定了催化降解活性物种,提出了相关催化机理.结果表明,Fe、Ce金属氧化物及金属Ag抑制了材料的可见光催化性能,Ag_(2)O则显著提升了ZnTi-LdO的可见光催化性能.Ag_(2)O-ZnTi-LdO在20 min内即可使MB降解率>98%,其表观降解速率常数是ZnTi-LdO的7倍.此外,Ag_(2)O-ZnTi-LdO稳定性良好,循环5次无催化性能下降.•O_(2)^(-)是Ag_(2)O-ZnTi-LdO催化降解MB的主要活性物种.Ag_(2)O与ZnTiO_(3)/TiO_(2)形成p-n异质结是其催化性能显著提高的原因.

关键词：锌钛类水滑石可见光催化亚甲基蓝

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应力波在美国红松立木中传播机理的试验研究

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北京林业大学学报 2010年第2期32卷 145-148页

作者：张厚江王喜平苏娟 Robert j Ross 北京林业大学工学院美国农业部林产品实验室

为了解应力波在立木中的传播机理,本试验用3根新砍伐的美国红松原木来模拟立木,用FAKOPP应力波微秒计测量不同横截面上各个网格节点处的应力波到达时间。结果表明:1)在原木中纵截面上,应力波传播时间等值线在开始阶段为倾斜曲线;随着距... 详细信息

为了解应力波在立木中的传播机理,本试验用3根新砍伐的美国红松原木来模拟立木,用FAKOPP应力波微秒计测量不同横截面上各个网格节点处的应力波到达时间。结果表明:1)在原木中纵截面上,应力波传播时间等值线在开始阶段为倾斜曲线;随着距离的增大,等值线倾斜度逐渐减小,直至最后与原木长度方向近似垂直。2)应力波到达同一个横截面各部位的时间差与传播距离和原木直径有关,传播距离越长,时间差越小;原木直径越小,时间差越小。3)应力波在中纵截面上,原木表层的传播距离与传播时间之间有很好的比例关系。

关键词：应力波传播时间中纵截面等值线

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开关柜局部放电超声-TEV融合检测技术

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高电压技术 2023年第12期49卷 5052-5060页

作者：孙源宋颜峰王昊天侯嘉琛韩旭涛李军浩西安交通大学电工材料电气绝缘国家重点实验室西安710049

开关柜是电力系统的重要组成设备,其在出厂和长期运行中不可避免地会出现绝缘缺陷,导致设备故障。局部放电检测是发现开关柜绝缘缺陷的有效手段,为了提高开关柜局部放电检测的灵敏度,提出了超声–暂态对地电压(transient earth voltage,... 详细信息

开关柜是电力系统的重要组成设备,其在出厂和长期运行中不可避免地会出现绝缘缺陷,导致设备故障。局部放电检测是发现开关柜绝缘缺陷的有效手段,为了提高开关柜局部放电检测的灵敏度,提出了超声–暂态对地电压(transient earth voltage,TEV)融合传感技术并设计了融合传感器,实现了超声信号与TEV信号在时空上的同步测量。对融合传感器的校准试验结果表明,超声的平均灵敏度在20~60 kHz内为63.90 dB;TEV的平均灵敏度在1~40 MHz内为46.98 d B,满足开关柜局部放电检测需求。在10 k V开关柜上进行了基于缺陷模型的局部放电试验,结果表明,该文提出的融合传感技术在准确测量局部放电信号的同时可以准确地实现放电定位,为开关柜局部放电检测提供了新的思路与方案。

关键词：局部放电高压开关柜超声暂态对地电压融合传感器

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Finite-Time Stability and Stabilization of discrete-Time Switching Markov jump Linear System

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journal of Shanghai jiaotong university(Science) 2020年第5期25卷 674-680页

作者：靳云云宋杨刘永壮侯维岩 department of Automation School of Mechatronics Engineering and AutomationShanghai UniversityShanghai 200444China Shanghai Key Laboratory of Power Station Automation Technology Shanghai UniversityShanghai 200444China School of Information Engineering Zhengzhou UniversityZhengzhou 450001China

Switching Markov jump linear system(SMjLS),a special hybrid system,has attracted a lot of studies *** is governed by stochastic and deterministic *** paper focuses on the switching strategy which stabilizes the SMjLS in a finite time interval in order to further expand the existing results and investigate new aspects of such *** sufficient conditions for finite-time stability of discrete-time SMjLS are provided,and the numerical problems in these sufficient conditions are solved by solving linear matrix inequalities(LMIs).Finally,numerical examples are given to show the feasibility and effectiveness of the results.

关键词： switching Markov jump linear system(SMjLS) finite-time stability stochastic switching deterministic switching minimum dwell time

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Soil water content and nitrogen differentially correlate with multidimensional leaf traits of two temperate broadleaf species

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Plant diversity 2023年第6期45卷 694-701页

作者： Ming-Yue jin daniel j.johnson Guang-Ze jin Qing-Xi Guo Zhi-Li Liu Center for Ecological Research Key Laboratory of Sustainable ForestEcosystem Management-Ministry of EducationNortheast Asia Biodiversity Research CenterNortheast Forestry UniversityHarbin 150040HeilongjiangChina School of Forest Resources and Conservation University of FloridaGainesvilleFLUSA

The variation and correlation of leaf economics and vein traits are crucial for predicting plant ecological strategies under different environmental ***,correlations between these two suites of traits and abiotic factors such as soil water and nitrogen content remain *** measured leaf economics and vein traits as well as soil water and nitrogen content for two different shade-tolerant species(Betula platyphylla and Acer mono)in four mixed broadleaved-Korean pine(Pinus koraiensis)forests along a latitudinal gradient in Northeast *** found that leaf economics traits and vein traits were decoupled in shade-intolerant species,Betula platphylla,but significantly coupled in a shadetolerant species,*** found stronger correlations among leaf traits in the shade tolerant species than in the shade intolerant ***,leaf economic traits were positively correlated with the soil water gradient for both species,whereas vein traits were positively correlated with soil water gradient for the shade intolerant species but negatively correlated in the shade tolerant *** economic traits were positively correlated with soil nitrogen gradient in shade intolerant species but not correlated in shade tolerant species,vein traits were negatively correlated with soil nitrogen gradient in shade tolerant species but not correlated in shade intolerant *** study provides evidence for distinct correlations between leaf economics and vein traits and local abiotic factors of species differing in light *** recommend that the ecological significance of shade tolerance be considered for species when evaluating ecosystem functions and predicting plant responses to environmental changes.

关键词： Leaf trait multidimensionality Economics traits Vein traits Soil water content Soil total nitrogen Shade tolerance

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超快速冷却结合不同包装贮藏对冷鲜猪肉品质的影响

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中国食品学报 2023年第10期23卷 238-248页

作者：王素张德权王卫颜统晶李海宾侯成立中国农业科学院农产品加工研究所农业农村部农产品质量安全收贮运管控重点实验室北京100193 成都大学肉类加工四川省重点实验室成都610106 北京顺鑫农业股份有限公司鹏程食品分公司北京101316

为探究超快速冷却(冷却速度14.43℃/h)结合不同包装方式对贮藏猪肉品质的影响,对超快速冷却处理的猪背最长肌分别进行有氧托盘包装、气调包装(50%O_(2)+50%CO_(2))、真空包装和真空收缩包装,分析猪背最长肌在(-1.0±0.5)℃贮藏过程中pH... 详细信息

为探究超快速冷却(冷却速度14.43℃/h)结合不同包装方式对贮藏猪肉品质的影响,对超快速冷却处理的猪背最长肌分别进行有氧托盘包装、气调包装(50%O_(2)+50%CO_(2))、真空包装和真空收缩包装,分析猪背最长肌在(-1.0±0.5)℃贮藏过程中pH、肉色、蒸煮损失、质构特性、菌落总数、挥发性盐基氮和脂肪氧化的变化,以期明确超快速冷却结合4种包装的猪肉在贮藏期间的品质变化规律。结果表明,在贮藏30 d时,超快速冷却结合气调包装猪肉红度值a^(*)(3.62)高于超快速冷却结合有氧托盘包装(3.35)、真空包装(3.20)和真空收缩包装(1.66)的猪肉;超快速冷却结合真空包装和真空收缩包装的猪肉蒸煮损失分别为20.82%和21.83%,显著低于有氧托盘包装和气调包装的猪肉(PdA/kg,显著低于其它3种包装猪肉(Pd。

关键词：超快速冷却包装方式贮藏肉品品质货架期

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