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bone Research 2024年第1期12卷 122-136页

作者： Nan-Yu Zou Ran Liu Mei huang Yu-Rui jiao jie Wei Yangzi jiang Wen-Zhen he Min huang Yi-Li Xu Ling Liu Yu-Chen Sun Mi Yang Qi Guo Yan huang Tian Su Ye Xiao Wei-Shan Wang Chao Zeng Guang-hua Lei Xiang-hang Luo Chang-jun Li department of Endocrinology Endocrinology Research CenterXiangya Hospital of Central South UniversityChangshaHunan 410008China department of Orthopaedics Xiangya Hospital of Central South UniversityChangshaHunan 410008China department of Epidemiology and health Statistics Xiangya School of Public HealthCentral South UniversityChangshaChina hunan Key Laboratory of joint degeneration and Injury ChangshaHunan 410008China Key Laboratory of Aging-related bone and joint diseases Prevention and Treatment Ministry of EducationXiangya HospitalCentral South UniversityChangshaChina School of biomedical Sciences Institute for Tissue Engineering and Regenerative MedicineFaculty of MedicineThe Chinese University of Hong KongHong Kong SARChina department of Orthopaedics The First Affiliated Hospital of Shihezi UniversityShiheziXinjiangChina National Clinical Research Center for Geriatric disorders Xiangya HospitalCentral South UniversityChangshaHunan 410008China

Skeletal stem/progenitor cell(SSPC)senescence is a major cause of decreased bone regenerative potential with aging,but the causes of SSPC senescence remain *** this study,we revealed that macrophages in calluses secrete prosenescent factors,including grancalcin(GCA),during aging,which triggers SSPC senescence and impairs fracture *** injection of human rGCA in young mice induced SSPC senescence and delayed fracture *** deletion of Gca in monocytes/macrophages was sufficient to rejuvenate fracture repair in aged mice and alleviate SSPC ***,GCA binds to the plexin-b2 receptor and activates Arg2-mediated mitochondrial dysfunction,resulting in cellular *** of Plxnb2 in SSPCs impaired fracture *** of GCA-neutralizing antibody enhanced fracture healing in aged ***,our study revealed that senescent macrophages within calluses secrete GCA to trigger SSPC secondary senescence,and GCA neutralization represents a promising therapy for nonunion or delayed union in elderly individuals.

关键词： healing union senescence

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Rapid Antidepressant-Like Potential of Chaihu Shugan San depends on Suppressing Glutamate Neurotransmission and Activating Synaptic Proteins in hippocampus of Female Mice

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Chinese journal of Integrative Medicine 2024年第8期30卷 692-700页

作者： LU Chao GAO Zi-wei XING Shan WANG hui-hui huang Yun-ke ZhOU hang WU Lei department of Chinese Medicine Preparations Affiliated Hospital of Nanjing University of Chinese MedicineJiangsu Province Hospital of Chinese MedicineNanjing210029China College of Chinese Medicine Nanjing University of Chinese MedicineNanjing210046China department of Chinese Medicine Women’s HospitalSchool of MedicineZhejiang UniversityHangzhou310000China

Objective To explore the rapid antidepressant potential and the underlying mechanism of Chaihu Shugan San(CSS)in female *** Liquid chromatography mass spectrometry(LC-MS)/MS was used to determine the content of main components in CSS to determine its *** C57bL/6j mice were randomly divided into 4 groups,including control(saline),vehicle(saline),CSS(4 g/kg)and ketamine(30 mg/kg)*** were subjected to irregular stress stimulation for 4 weeks to establish the chronic mild stress(CMS)model,then received a single administration of *** hours later,the behavioral tests were performed,including open field test,tail suspension test(TST),forced swimming test(FST),novelty suppression feeding test(NSF),and sucrose preference test(SPT).Western blot analysis was used to detect the expression levels of N-methyl-d-aspartate receptor(NMdA)subtypes[N-methyl-d-aspartate receptor 1(NR1),NR2A,NR2b],synaptic proteins[synapsin1 and post synaptic density protein 95(PSd95)],and brain-derived neurotrophic factor(bdNF).Moreover,the rapid antidepressant effect of CSS was tested by pharmacological technologies and optogenetic interventions that activated glutamate receptors,*** Compared with the vehicle group,a single administration of CSS(4 g/kg)reversed all behavioral defects in TST,FST,SPT and NSF caused by CMS(Pdecreased the expressions of NMdA subtypes(NR1,NR2A,NR2b)at 2 h in hippocampus of mice(all Pddition,similar to ketamine,CSS increased levels of synaptic proteins and bdNF(Phermore,the rapid antidepressant effects of CSS were blocked by transient activation of NMdA receptors in the hippocampus(all Pd antidepressant effects of CSS by improving behavioral deficits in female CMS mice depended on rapid suppression of NMdA receptors and activation of synaptic proteins.

关键词： Chaihu Shugan San female rapid antidepressant potential N-methyl-d-aspartate receptor synapticprotein optogenetic Chinesemedicine

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determination of the number ofψ(3686)events taken at bESⅢ

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Chinese Physics C 2024年第9期48卷 8-20页

作者： M.Ablikim M.N.Achasov P.Adlarson O.Afedulidis X.C.Ai R.Aliberti A.Amoroso Q.An Y.bai O.bakina I.balossino Y.ban h.-R.bao V.batozskaya K.begzsuren N.berger M.berlowski M.bertani d.bettoni F.bianchi E.bianco A.bortone I.boyko R.A.briere A.brueggemann h.Cai X.Cai A.Calcaterra G.F.Cao N.Cao S.A.Cetin j.F.Chang G.R.Che G.Chelkov C.Chen C.h.Chen Chao Chen G.Chen h.S.Chen h.Y.Chen M.L.Chen S.j.Chen S.L.Chen S.M.Chen T.Chen X.R.Chen X.T.Chen Y.b.Chen Y.Q.Chen Z.j.Chen Z.Y.Chen S.K.Choi G.Cibinetto F.Cossio j.j.Cui h.L.dai j.P.dai A.dbeyssi R.E.de boer d.dedovich C.Q.deng Z.Y.deng A.denig I.denysenko M.destefanis F.de Mori b.ding X.X.ding Y.ding Y.ding j.dong L.Y.dong M.Y.dong X.dong M.C.du S.X.du Y.Y.duan Z.h.duan P.Egorov Y.h.Fan j.Fang j.Fang S.S.Fang W.X.Fang Y.Fang Y.Q.Fang R.Farinelli L.Fava F.Feldbauer G.Felici C.Q.Feng j.h.Feng Y.T.Feng M.Fritsch C.d.Fu j.L.Fu Y.W.Fu h.Gao X.b.Gao Y.N.Gao Yang Gao S.Garbolino I.Garzia L.Ge P.T.Ge Z.W.Ge C.Geng E.M.Gersabeck A.Gilman K.Goetzen L.Gong W.X.Gong W.Gradl S.Gramigna M.Greco M.h.Gu Y.T.Gu C.Y.Guan Z.L.Guan A.Q.Guo L.b.Guo M.j.Guo R.P.Guo Y.P.Guo A.Guskov j.Gutierrez K.L.han T.T.han F.hanisch X.Q.hao F.A.harris K.K.he K.L.he F.h.heinsius C.h.heinz Y.K.heng C.herold T.holtmann P.C.hong G.Y.hou X.T.hou Y.R.hou Z.L.hou b.Y.hu h.M.hu j.F.hu S.L.hu T.hu Y.hu G.S.huang K.X.huang L.Q.huang X.T.huang Y.P.huang T.hussain F.hölzken N.hüsken N.in der Wiesche j.jackson S.janchiv j.h.jeong Q.ji Q.P.ji W.ji X.b.ji X.L.ji Y.Y.ji X.Q.jia Z.K.jia d.jiang h.b.jiang P.C.jiang S.S.jiang T.j.jiang X.S.jiang Y.jiang j.b.jiao j.K.jiao Z.jiao S.jin Y.jin M.Q.jing X.M.jing T.johansson S.Kabana N.Kalantar-Nayestanaki X.L.Kang X.S.Kang M.Kavatsyuk b.C.Ke V.Khachatryan A.Khoukaz R.Kiuchi O.b.Kolcu b.Kopf M.Kuessner X.Kui N.Kumar A.Kupsc W.Kühn j.j.Lane P.Larin L.Lavezzi T.T.Lei Z.h.Lei M.Lellmann T.Lenz C.Li C.Li C.h.Li Cheng Li d.M.Li F.Li G.Li h.b.Li h.j.Li h.N.Li hui Li j.R.Li j.S.Li Ke Li L.j.Li L.K.Li Lei Li M.h.Li P.R.Li Q.M.Li Q.X.Li R.Li S.X.Li T.Li W.d.Li W.G.Li X.Li X.h.Li X.L.Li X.Z.Li Xi Institute of high Energy Physics Beijing 100049China beihang University Beijing 100191China bochum Ruhr-University D-44780BochumGermany budker Institute of Nuclear Physics Sb RAS(bINP) Novosibirsk 630090Russia Carnegie Mellon University PittsburghPennsylvania 15213USA Central China Normal University Wuhan 430079China Central South University Changsha 410083China China Center of Advanced Science and Technology Beijing 100190China China University of Geosciences Wuhan 430074China Chung-Ang University Seoul06974Republic of Korea COMSATS University Islamabad Lahore CampusDefence RoadOff Raiwind Road54000LahorePakistan Fudan University Shanghai 200433China GSI helmholtzcentre for heavy Ion Research Gmbh D-64291DarmstadtGermany Guangxi Normal University Guilin 541004China Guangxi University Nanning 530004China hangzhou Normal University Hangzhou 310036China hebei University Baoding 071002China helmholtz Institute Mainz Staudinger Weg 18D-55099MainzGermany henan Normal University Xinxiang 453007China henan University Kaifeng 475004China henan University of Science and Technology Luoyang 471003China henan University of Technology Zhengzhou 450001China huangshan College Huangshan 245000China hunan Normal University Changsha 410081China hunan University Changsha 410082China Indian Institute of Technology Madras Chennai 600036India Indiana University BloomingtonIndiana 47405USA INFN Laboratori Nazionali di Frascati (A)INFN Laboratori Nazionali di FrascatiI-00044FrascatiItaly(B)INFN Sezione di PerugiaI-06100PerugiaItaly(C)University of PerugiaI-06100PerugiaItaly INFN Sezione di Ferrara (A)INFN Sezione di FerraraI-44122FerraraItaly(B)University of FerraraI-44122FerraraItaly Inner Mongolia University Hohhot 010021China Institute of Modern Physics Lanzhou 730000China Institute of Physics and Technology Peace Avenue 54BUlaanbaatar 13330Mongolia Instituto de Alta Investigación Universidad de TarapacáCasilla 7DArica 1000000Chile jilin University Changchun 130012China joha

The number ofψ(3686)events collected by the bESⅢdetector during the 2021 run period is determined to be(2259.3±11.1)×10~6 by counting inclusiveψ(3686)hadronic *** uncertainty is systematic and the statistical uncertainty is ***,the numbers ofψ(3686)events collected during the 2009 and 2012run periods are updated to be(107.7±0.6)×10~6 and(345.4±2.6)×10~6,*** numbers are consistent with the previous measurements within one standard *** total number ofψ(3686)events in the three data samples is(2712.4±14.3)×10~6.

关键词： ψ(3686) inclusive process hadronic events bESⅢdetector

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Ground-state mass of ^(22)Al and test of state-of-the-art ab initio calculations

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Chinese Physics C 2024年第3期48卷 72-78页

作者：孙铭泽于越王新鹏王猛李健国张玉虎 K.blaum 陈祖毅陈瑞九邓涵宇付超义葛文文黄文嘉焦红扬李红蕙李宏福罗胤芳廖挺 YuALitvinov 司敏帅鹏史金阳王茜邢元明徐星徐瑚珊许甫荣袁琪 T.Yamaguchi 颜鑫亮杨建成原有进周小红周旭张敏曾奇 CAS Key Laboratory of high Precision Nuclear Spectroscopy Institute of Modern PhysicsChinese Academy of SciencesLanzhou 730000China School of Nuclear Science and Technology University of Chinese Academy of SciencesBeijing 100049China Max-Planck-Institut für Kernphysik Saupfercheckweg 169117 HeidelbergGermany GSI helmholtzzentrum für Schwerionenforschung Planckstraße 164291 DarmstadtGermany Advanced Energy Science and Technology Guangdong Laboratory Huizhou516007China State Key Laboratory of Nuclear Physics and Technology School of PhysicsPeking UniversityBeijing 100871China department of Physics Saitama UniversitySaitama 338-8570Japan School of Nuclear Science and Engineering East China University of TechnologyNanchang 330013China

The ground-state mass excess of the T_(z)=−2 drip-line nucleus ^(22)Al is measured for the first time as 18103(10)keV using the newly-developed bρ-defined isochronous mass spectrometry method at the cooler storage ring in *** new mass excess value allowed us to determine the excitation energies of the two low-lying 1+states in ^(22)Al with significantly reduced uncertainties of 51 *** compared to the analogue states in its mirror nucleus ^(22)F,the mirror energy differences of the two 1^(+)states in the ^(22)Al-^(22)F mirror pair are determined to be−625(51)keV and−330(51)*** excitation energies and mirror energy differences are used to test the state-of-the-art ab initio valence-space in-medium similarity renormalization group calculations with four sets of interactions derived from the chiral effective field *** mechanism leading to the large mirror energy differences is investigated and attributed to the occupation of theπs_(1/2) orbital.

关键词： nuclear mass bρ-defined IMS mirror energy difference ab initio VS-IMSRG calculations chiral interactions

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Fine 3d control of Thz emission in air with dual femtosecond laser pre-pulses at tunnelling ionisation regime

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Light(Advanced Manufacturing) 2024年第3期5卷 62-74页

作者： hsin-hui huang Takeshi Nagashima Kota Kumagai Yoshio hayasaki Saulius juodkazis Vladimir T.Tikhonchuk Koji hatanaka Optical Sciences Centre ARC Training Centre in Surface Engineering for Advanced Materials(SEAM)School of ScienceSwinburne University of TechnologyHawthornVictoria 3122Australia Faculty of Science and Engineering Setsunan University17-8 Ikeda-NakamachiNeyagawaOsaka572-8508Japan Center for Optical Research and Education(CORE) Utsunomiya University7-1-2 YotoUtsunomiya 321-8585Japan WRh Program International Research Frontiers Initiative(IRFI)Tokyo Institute of Technology Nagatsuta-choMidori-kuYokohamaKanagawa 226-8503 Japan Laser Research Center Physics FacultyVilnius UniversitySauletekio Ave.1010223 VilniusLithuania Centre Lasers Intenses et Applications Universite de Bordeaux351Cours de la Liberation33405 Talence cedexFrance Extreme Light Infrastructure ERIC ELI Beamlines FacilityZa Radnicic 83525241 Dolni BřežanyCzech Republic Organization for Research Strategy and development Okayama Univ.1-1-1 Tsushima-nakaKita-kuOkayama 700-8530Japan

Emission of Thz radiation from air breakdown at focused ultra-short fs-laser pulses(800 nm/35 fs)was investigated for the 3d spatio-temporal control where two pre-pulses are used before the *** laser pulse induced air breakdown forms a~120μm-long focal volume generate shockwaves which deliver a denser air into the focal region of the main pulse for enhanced generation of Thz radiation at 0.1-2.5 Thz spectral *** intensity of 162 pre-and main-pulses was at the tunnelling ionisation intensities(1-3)×10 W/cm and corresponded to sub-critical(transparent)plasma formation in *** analysis of Thz radiation revealed that orientation of the air density gradients generated by pre-pulses and their time-position locations defined the ellipticity of the generated Thz electrical *** rotational component of electric current is the origin of Thz radiation.

关键词： Thz radiation Femtosecond laser induced breakdown Air breakdown spatio-temporal control

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PLASMA SPRAYEd Ti ANd hA COATINGS: A COMPARATIVE STUdY bETWEEN APS ANd VPS

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Acta Metallurgica Sinica(English Letters) 2005年第3期18卷 339-344页

作者： X.b.Zheng h.ji j.Q.huang C.X.ding ShanghaiInstituteofCeramics TheChineseAcademyofSciencesShanghai200050China

Titanium (Ti) and hydroxyapatite (hA) coatings have been prepared via air (APS) and vacuum plasma spraying (VPS), and then their composition, structure, bonding strength and bioactivity were examined. The results obtained reveal that in APS process many of Ti were oxidized, but in VPS the oxidization was avoided. VPS T i coating possesses better bonding condition than APS Ti coating. As for hA coat ing, higher crystallinity has been obtained while the coating was deposited by V PS as compared with APS. The simulated body fluid (SbF) tests show that both of APS and VPS hA coatings possess good bioactivity. As compared with APS, VPS is r ecommended as a better method to deposit Ti and hA coatings that can be applied as hard tissue replacement implants.

关键词： vacuum plasma spray Ti hA biocoating

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Recent development of chemically complex metallic glasses: from accelerated compositional design, additive manufacturing to novel applications

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Materials Futures 2022年第1期1卷 9-31页

作者： j Y Zhang Z Q Zhou Z b Zhang M h Park Q Yu Z Li j Ma A d Wang h G huang M Song b S Guo Q Wang Y Yang department of Mechanical Engineering College of EngineeringCity University of Hong KongKowloon TongKowloonHong KongPeople’s Republic of China Shenzhen Key Laboratory of high Performance Nontraditional Manufacturing College of Mechatronics and Control EngineeringShenzhen UniversityShenzhenGuangdong 518060People’s Republic of China School of Materials Science and Engineering Dongguan University of TechnologyDongguanGuangdong 523808People’s Republic of China Institute of Materials China Academy of Engineering PhysicsJiangyouSichuan 621907People’s Republic of China State Key Laboratory of Powder Metallurgy Central South UniversityChangshaHunan 410083People’s Republic of China Institute of Advanced Wear&Corrosion Resistant and Functional Materials Jinan UniversityGuangzhouGuangdong 510632People’s Republic of China Institute of Materials Laboratory for MicrostructuresShanghai UniversityShanghai 200444People’s Republic of China department of Materials Science and Engineering College of EngineeringCity University of Hong KongKowloon TongKowloonHong KongPeople’s Republic of China department of Advanced design and System Engineering College of EngineeringCity University of Hong KongKowloon TongKowloonHong KongPeople’s Republic of China

Metallic glasses(MGs)or amorphous alloys are an important engineering material that has a history of research of about 80–90 *** different fast cooling methods were developed for multi-component MGs between 1960s and 1980s,1990s witnessed a surge of research interest in the development of bulk metallic glasses(bGMs).Since then,one central theme of research in the metallic-glass community has been compositional design that aims to search for MGs with a better glass forming ability,a larger size and/or more interesting properties,which can hence meet the demands from more important *** this review article,we focus on the recent development of chemically complex MGs,such as high entropy MGs,with new tools that were not available or mature yet until recently,such as the state-of-the-art additive manufacturing technologies,high throughput materials design techniques and the methods for big data analyses(*** learning and artificial intelligence).We also discuss the recent use of MGs in a variety of novel and important applications,from personal healthcare,electric energy transfer to nuclear energy that plays a pivotal role in the battle against global warming.

关键词： metallic glasses amorphous alloys alloy design additive manufacturing machine learning high throughput materials design

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Spray granulation of Fe and C nanoparticles and their impedance match for microwave absorption

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journal of Materials Science & Technology 2018年第3期34卷 496-502页

作者： h.huang Y.Gao C.F.Fang A.M.Wu X.L.dong b.S.Kim j.h.byun G.F.Zhang d.Y.Zhou Key Laboratory of Materials Modification by Laser Ionand Electron Beams(Ministry of Education)School of Materials Science and EngineeringDalian University of TechnologyDalian116024China Composites Research division Korea Institute of Materials Science797 Changwon-daeroSeongsan-guChangwonGyeongnam642-831Republic of Korea

The microwave absorbents of Fe and C nanoparticles as magnetic loss and dielectric loss material respectively were composited with the polyvinyl alcohol （PVA） as binder by spray granulation method, The electromagnetic parameters of Fe and C composite particles were analyzed by vector network. The complex permittivity and magnetic permeability of Fe and C composite particles matched well with increasing C nanoparticle content, and then the microwave loss property was improved. A minimum reflection loss （RL） of -42.7 db at 3.68 Ghz for a composite with 4.6 mm in thickness can be obtained when the content ratio of the C nanoparticles, the modified Fe nanoparticles and the PVA is 21：49：30 （Sample 3）.

关键词： dielectric loss Magnetic loss Spray granulation method Impedance match

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Shock compression and spallation damage of high-entropy alloy Al_(0.1)CoCrFeNi

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journal of Materials Science & Technology 2022年第33期128卷 1-9页

作者： N.b.Zhang j.Xu Z.d.Feng Y.F.Sun j.Y.huang X.j.Zhao X.h.Yao S.Chen L.Lu S.N.Luo Key Laboratory of Advanced Technologies of Materials Ministry of EducationSouthwest Jiaotong UniversityChengdu 610031China The Peac Institute of Multiscale Sciences Chengdu 610031China department of Engineering Mechanics South China University of TechnologyGuangzhou 510641China

Shock compression and spallation damage of a face-center cubic phase high-entropy alloy(hEA)Al_(0.1)CoCrFeNi were investigated via plate impact experiments along with free surface velocity *** samples were characterized with transmission electron microscopy and electron backscatter *** hugoniot equation of state and spall strength at different impact strengths were *** exists a power-law relation between spall strength and strain *** spall strength of Al_(0.1)CoCrFeNi hEA is about 50%higher than those of previously studied hEAs and comparable to those widely applied structural stainless steels at the same shock *** glide and stacking faults are the important deformation mechanisms in the Al_(0.1)CoCrFeNi *** are only observed at high shock *** in the Al_(0.1)CoCrFeNi hEA is ductile in *** are nucleated preferentially in grain interiors,and the intragranular voids show a strong dependence on grain boundary misorientation and peak stress.

关键词： Al_(0.1)CoCrFeNi high-entropy alloy hugoniot Spall damage Microstructure

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Establishment of a humanized mouse model using steady-state peripheral blood-derived hematopoietic stem and progenitor cells facilitates screening of cancer-targeted T-cell repertoires

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Cancer Innovation 2024年第3期3卷 1-21页

作者： Yulin Xu Wei Shan Qian Luo Meng Zhang dawei huo Yijin Chen honghu Li Yishan Ye Xiaohong Yu Yi Luo he huang bone Marrow Transplantation Center The First Affiliated HospitalZhejiang University School of MedicineHangzhouChina Liangzhu Laboratory Zhejiang UniversityHangzhouChina Institute of hematology Zhejiang UniversityHangzhouChina Zhejiang Province Engineering Research Center for Stem Cell and Immunity Therapy HangzhouChina School of Medicine Zhejiang UniversityHangzhouChina

background:Cancer-targeted T-cell receptor T(TCR-T)cells hold promise in treating cancers such as hematological malignancies and breast ***,approaches to obtain cancer-reactive TCR-T cells have been ***:here,we developed a novel strategy to screen for cancer-targeted TCR-T cells using a special humanized mouse model with person-specific immune *** steady-state circulating hematopoietic stem and progenitor cells were expanded via three-dimensional culture of steady-state peripheral blood mononuclear cells,and then the expanded cells were applied to establish humanized *** human immune system was evaluated according to the kinetics of dendritic cells,monocytes,T-cell subsets,and *** fully stimulate the immune response and to obtain b-cell precursor NAML-6-and triple-negative breast cancer MdA-Mb-231-targeted TCR-T cells,we used the inactivated cells above to treat humanized mice twice a day every 7 ***,human T cells were processed for TCRβ-chain(TRb)sequencing *** the repertoires had been constructed,features such as the fraction,diversity,and immune signature were ***:The results demonstrated an increase in diversity and clonality of T cells after *** preferential usage and features of TRbV,TRbj,and the V–j combination were also *** stress also induced highly clonal Science and Technology,Grant/Award Number:2021C03010;Zhejiang Provincial Natural Science Foundation of China,Grant/Award Numbers:LTGY24h080003,LY21h080004 *** burden and survival analysis demonstrated that stress induction could significantly inhibit the growth of subsequently transfused live tumor cells and prolong the survival of the humanized ***:We constructed a personalized humanized mouse model to screen cancer-targeted TCR-T *** platform provides an effective source of cancer-targeted TCR-T cells and allows for the design of patient-specific engineered T cells.

关键词： cancer-targeted T-cell receptor T(TCR-T)cells circulating hematopoietic stem and progenitor cells(hSPCs) humanized mouse model steady-state peripheral blood T-cell receptorβ-chain(TRb) three-dimensional culture

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