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Shugan Liangxue decoction(舒肝凉血方)down-Regulates Estrogen ReceptorαExpression in Breast Cancer Cells

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Chinese Journal of Integrative Medicine 2018年第7期24卷 518-524页

作者： zhou Ning HAN Shu-yan CHEN yan-zhi zhou Fei ZHENG Wen-xian LI Ping-ping Key Laboratory of Carcinogenesis and Translational Research(Ministry of Education) Department of Integration of Chinese and Western MedicinePeking University Cancer Hospital InstituteBeijing 100142China department of Oncology Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China

Objective： To observe the effect of Shugan Liangxue decoction（舒肝凉血方, SGLXd） on estrogen receptor α（ERα） in human breast cancer cells. Methods： The effect of SGLXd（0.85–5.10 mg/m L） on the proliferation of breast cancer cells were evaluated by 3-（4,5-dimethyl-2-thiazolyl）-2,5-diphenyl-2-H-tetrazolium bromide（MTT） assay. The nuclear ERα protein levels in MCF-7, T47 d and ZR-75-1 cells which treated by SGLXd for 24 h were examined by western blot and immunofluorescence assay. MCF-7 and MdA-MB-231 cells were treated by 17β-estradiol（E2） with or without SGLXd, for 24 h, and the E2 targeted genes c-myc and bcl-2 protein product was evaluated by western blot. Results： SGLXd showed dose-dependent inhibition on the proliferation of MCF-7, T47 d and ZR-75-1 cells, but did not inhibit the proliferation of MdA-MB-231 cells. Furthermore, the promotive effect on cell growth induced by E2 was also significantly inhibited by SGLXd treatment. With the treatment of 1.70, 3.40, 5.10 mg/m L SGLXd, the nuclear ERα protein level was reduced to 88.1%, 70.4% and 60.9% in MCF-7 cells, and was decreased to 43.0%, 38.4% and 5.9% in ZR-75-1 cells as compared with the control group. In T47 d cells, the nuclear ERα protein was down-regulated to 51.3% and 4.3% by 3.40 and 5.10 mg/m L SGLXd treatment. The down-regulative effect of SGLXd on nuclear ERα was confirmed by immunofluorescence assay. SGLXd decreased the protein product of c-myc and bcl-2. Conclusions： SGLXd may exhibit selective inhibition effect on the proliferation of ER positive breast cancer cells. SGLXd reduced the nuclear ERα expression and the protein product of E2 target gene c-myc and bcl-2.

关键词： breast cancer estrogen receptor Shugan Liangxue decoction estrogen receptor inhibitor

Reward Function design Method for Long Episode Pursuit Tasks Under Polar Coordinate in Multi-Agent Reinforcement Learning

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Journal of Shanghai Jiaotong university(Science) 2024年第4期29卷 646-655页

作者： dONG yubo CUI Tao zhou yufan SONG Xun ZHU yue dONG Peng School of Aeronautics and Astronautics Shanghai Jiao Tong UniversityShanghai200240China Beijing Institute of Electronic System Engineering Beijing100854China

Multi-agent reinforcement learning has recently been applied to solve pursuit ***,it suffers from a large number of time steps per training episode,thus always struggling to converge effectively,resulting in low rewards and an inability for agents to learn *** paper proposes a deep reinforcement learning(dRL)training method that employs an ensemble segmented multi-reward function design approach to address the convergence problem mentioned *** ensemble reward function combines the advantages of two reward functions,which enhances the training effect of agents in long ***,we eliminate the non-monotonic behavior in reward function introduced by the trigonometric functions in the traditional 2d polar coordinates observation *** results demonstrate that this method outperforms the traditional single reward function mechanism in the pursuit scenario by enhancing agents’policy scores of the *** ideas offer a solution to the convergence challenges faced by dRL models in long episode pursuit problems,leading to an improved model training performance.

关键词： multi-agent reinforcement learning deep reinforcement learning(dRL) long episode reward function

Population Evolution of Rydberg Rubidium Atoms by Half-Cycle Pulses

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Chinese Physics Letters 2012年第11期29卷 47-51页

作者： JIA Guang-Rui ZHAO yue-Jin ZHANG Xian-zhou LIU yu-Fang yU Kun School of Optoelectronics Beijing Institute of TechnologyBeijing 100081 College of Physics and Information Engineering Henan Normal UniversityXinxiang 453007

Using the B-spline basis set method combined with model potential,the Stark energy level of rubidium atoms in the vicinity of n=30 is *** using a using time-dependent multilevel approach,we calculate the population redistribution of high Rydberg rubidium atoms under the interaction of external time-dependent half-cycle *** numerical results show that the population of rubidium atoms can be driven to lower or higher n levels with a train of half cycle pulses,the final population distribution of all the l states for the same n is observed after these interactions.

关键词： Rydberg spline cycle

The dynamics of Rubidium Atoms in THz Laser Fields

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Chinese Physics Letters 2013年第7期30卷 56-59页

By using B-spline basis set combined with model potential,energy levels and wave functions of rubidium atoms are *** a time-dependent multi-level approach,we study the dependence of the population of rubidium atoms excited from a low lying state to a target state on the parameters of a single or two broadband terahertz laser *** population redistribution between the states n=23 and n=24 due to the interaction with terahertz pulses is analyzed in *** oscillation in the initial and final states as a function of the time delay between two half cycle pulses is shown,and the oscillation period is the same as the Kepler period of the selected *** calculation results agree well with the experiment and can be explained by the semiclassical picture.

关键词： oscillation delay state

Improved drought tolerance by α-naphthaleneacetic acid-induced ROS accumulation in two soybean cultivars

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Journal of Integrative Agriculture 2016年第8期15卷 1770-1784页

作者： XING Xing-hua FANG Chuan-wen LI Long JIANG Hong-qiang zhou Qin JIANG Hai-dong WANG Shao-hua Key Laboratory of Crop Physiology and Ecology in Southern China Ministry of Agriculture/High-Tech Key Laboratory of Information Agriculture of Jiangsu Province Jiangsu Collaborative Innovation Center for Modern Crop Production Nanjing Agricultural University

funded by the program supported by the National Key Technologies R＆d Program of China during the 11th Five-year Plan period （2009BAdA8B02）;the Fundamental Research Funds for the Central Universities, China （KyZ201... 详细信息

关键词： ROS levels antioxidant system drought NAA soybean

Retrieval of Winter Wheat Canopy Carotenoid Content with Ground-and Airborne-Based Hyperspectral data

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Phyton-International Journal of Experimental Botany 2023年第9期92卷 2633-2648页

作者： Ting Cui Xianfeng zhou yufeng Huang yanting Guo yunrui Lin Leyi Song Jingcheng Zhang College of Artificial Intelligence Hangzhou Dianzi UniversityHangzhou310018China

Accurate assessment of canopy carotenoid content(CC_(x+c)C)in crops is central to monitor physiological conditions in plants and vegetation stress,and consequently supporting agronomic ***,due to the overlap of absorption peaks of carotenoid(C_(x+c))and chlorophyll(C_(a+b)),accurate estimation of carotenoid using reflectance where carotenoid absorb is *** objective of present study was to assess CC_(x+c)C in winter wheat(Triticum aestivum L.)with ground-and aircraft-based hyperspectral measurements in the visible and near-infrared ***-situ hyperspectral reflectance were measured and airborne hyperspectral data were acquired during major growth stages of winter wheat in five consecutive field *** the canopy level,a remarkable linear relationship(R^(2)=0.95,pd between C_(x+c) and Ca+b,and correlation between CC_(x+c)C and wavelengths within 400 to 1000 nm range indicated that CC_(x+c)C could be estimated using reflectance ranging from visible to near-infrared *** of Cx+c assessment based on chlorophyll and carotenoid indices showed that red edge chlorophyll index(CI red edge)performed with the highest accuracy(R^(2)=0.77,RMSE=22.27μg/cm^(2),MAE=4.97μg/cm^(2)).Applying partial least square regression(PLSR)in CC_(x+c)C retrieval emphasized the significance of reflectance within 700 to 750 nm range in CC_(x+c)C *** on CI red edge index,use of airborne hyperspectral imagery achieved satisfactory results in mapping the spatial distribution of CC_(x+c)*** study demonstrates that it is feasible to accurately assess CC_(x+c)C in winter wheat with red edge chlorophyll index provided that C_(x+c) correlated well with C_(a+b) at the canopy *** is therefore a promising method for CC_(x+c)C retrieval at regional scale from aerial hyperspectral imagery.

关键词： Hyperspectra carotenoid spectral index partial least squares regression winter wheat

Postoperative complications after robotic resection of colorectal cancer:An analysis based on 5-year experience at a large-scale center

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World Journal of Gastrointestinal Surgery 2021年第12期13卷 1660-1672页

作者： Zhi-Xiang Huang Zhen zhou Hao-Ran Shi Tai-yuan Li Shan-Ping ye General Surgery The First Affiliated Hospital of Nanchang UniversityNanchang 330006Jiangxi ProvinceChina The First Clinical Medical College Jiangxi Medical College of Nanchang UniversityNanchang 330006Jiangxi ProvinceChina

BACKGROUNd As a common gastrointestinal malignancy,colorectal cancer(CRC)poses a serious health threat *** surgery is one of the future trends in surgical treatment of *** surgery has several technical advantages over laparoscopic surgery,including 3d visualization,elimination of the fulcrum effect,and better ergonomic positioning,which together lead to better surgical outcomes and faster ***,analysis of independent factors of postoperative complications after robotic surgery is still *** To analyze the incidence and risk factors for postoperative complications after robotic surgery in patients with *** In total,1040 patients who had undergone robotic surgical resection for CRC between May 2015 and May 2020 were analyzed *** complications were categorized according to the Clavien-dindo(C-d)classification,and possible risk factors were *** Among 1040 patients who had undergone robotic surgery for CRC,the overall,severe,local,and systemic complication rates were 12.2%,2.4%,8.8%,and 3.5%,*** analysis revealed that multiple organ resection(Pd level III American Society of Anesthesiologists(ASA)score(P=0.006)were independent risk factors for overall *** analysis identified multiple organ resection(Pd comorbidities(P=0.029)as independent risk factors for severe complications(C-d grade III or higher).Regarding local complications,multiple organ resection(P=0.002)and multiple bowel resection(P=0.027)were independent risk *** organ resection(Pd level III ASA score(P=0.007)were independent risk factors for systemic ***,sigmoid colectomy had a lower incidence of overall complications(6.4%;P=0.006)and local complications(4.7%;P=0.028)than other types of colorectal *** Multiple organ resection,level III ASA score,comorbidities,and multiple bowel resection were risk

关键词： Colorectal neoplasms Surgery Robot Complication Postoperative Classification Retrospective studies

development of Soybean EST-SSR Markers and Their Use to Assess Genetic diversity in the Subgenus Soja

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Agricultural Sciences in China 2010年第10期9卷 1423-1429页

作者： LIU yu-lin LI ying-hui zhou Guo-an Uzokwe N CHANG Ru-zhen CHEN Shou-yi QIU Li-juan The National Key Facility for Crop Gene Resources and Genetic Improvement (NFCRI)/Key Laboratory of Germplasm Utilization Ministry of Agricuhure/lnstitute of Crop Sciences Chinese Academy of Agricultural Sciences Beijing 100081 P.R. China Plant Gene Research Centre National Key Laboratory of Plant Genomics/Institute of Genetics and Developmental Biology Chinese Academy of Sciences Beijing 100101 P.R. China

developing expressed sequence tag-derived SSR （EST-SSR） markers is imperative in genetic research. In this paper, we reported 37 EST-SSR markers which were developed from 286 unigenes obtained from soybean cdNA library. Among the 286 markers designed for the 4 accessions of Glycine max and 6 of its wild progenitor （G. soja） within the subgenus Soja, 209 markers amplified dNA fragments, taking 73.1% and 37 markers appeared to be polymorphic, which was 12.9% of the total. The 37 loci detected a total of 142 alleles, while the PIC values varied from 0.194 to 0.794. Both the number of alleles per locus and PIC value were significantly related to the SSR motif. Six EST-SSR loci may be fixed for different alleles between G. max and G. soja since they were particularly polymorphic among the 6 G. soja accessions. A neighbor-joining tree placed the G. max accessions together as a group within the G. soja, though the average genetic distance among G. soja accessions was much higher. These new EST-SSRs markers will be useful for genetic diversity analysis, genetic mapping construction and gene discovery in Soja subgenus.

关键词： EST-SSR diversity Soja subgenus

detection and monitoring of water-filled voids using transient electromagnetic method:a case study in Shanxi,China

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Detection and monitoring of water-filled voids using transie...