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前瞻性和回顾性心电门控冠状动脉64层CT成像:影像质量和病人放射剂量的对照性研究

国际医学放射学杂志 2008年第5期31卷 400-400页

作者： w.P. Shuman K.R. Branch J.M. May L.M. Mitsumori d.w. lockhart T.J.dubinsky 邱建星（译）唐光健（校） department of Radiology University of Washington School of Medicine 1959 NE Pacific St Seattle WA 98195USA. 不详

目的比较一组接受前瞻性心电门控64层CT冠状动脉成像病人及另一组接受回顾性心电门控64层CT冠状动脉病人的成像质量及病人放射剂量。方法本研究依从HIPAA法案并得到了机构审查委员会的批准。由于设计是回顾性研究故不需要知情同意。2位... 详细信息

目的比较一组接受前瞻性心电门控64层CT冠状动脉成像病人及另一组接受回顾性心电门控64层CT冠状动脉病人的成像质量及病人放射剂量。方法本研究依从HIPAA法案并得到了机构审查委员会的批准。由于设计是回顾性研究故不需要知情同意。2位独立阅片者分别对100例病人心脏CT成像（每组各50例）的冠状动脉进行分段影像质量评分和综合评分。计算观察者间偏差。记录对应实际扫描Z轴长度的病人放射剂量，以Z轴长度为12cm的典型心脏计算标准化剂量。结果2组病例的临床特征及CT参数匹配良好。

关键词：回顾性心电门控冠状动脉病放射剂量 CT成像影像质量 64层CT 冠状动脉成像质量评分

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Intensive outpatient comprehensive behavioral intervention for tics: A case series

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world Journal of Clinical Cases 2014年第10期2卷 569-577页

作者： Tabatha H Blount Ann-Louise T lockhart Rocio V Garcia Jeslina J Raj Alan L Peterson department of Psychiatry The University of Texas Health Science Center at San AntonioSan Antonio TX 78229 United States Child and Adolescent Psychology San Antonio Military Medical Center Joint Base San Antonio Ft. Sam Houston TX 78234 United States

Recent randomized clinical trials have established the efficacy of Comprehensive Behavioral Intervention for Tics(CBIT) in treating children and adults with Tourette syndrome and persistent tic disorders. However, the standard CBIT protocol uses a weekly outpatient treatment format(i.e., 8 sessions over 10 wk), which may be inconvenient or impractical for some patients, particularly patients, who are required to travel long distances in order to receive care. In contrast, an intensive outpatient program may increase accessibility to evidence-based behavioral treatments for Tourette syndrome and other persistent tic disorders by eliminating the necessity of repeated travel. This case series evaluated the use of an intensive outpatient program CBIT(IOP CBIT) for the treatment of 2 preadolescent males(ages 10 and 14 years) with Tourette syndrome. The IOP CBIT treatment protocol included several hours of daily treatment over a 4-d period. Both children evi-denced notable reductions in their tics and maintained treatment gains at follow-up. Moreover, both patients and their parents expressed treatment satisfaction with the IOP CBIT format. This case series addresses an important research gap in the behavioral treatment of tic disorders literature. The patients' treatment outcomes indicate that IOP CBIT is a promising treatment that warrants more systematic investigation.

关键词： Tourette syndrome Tics Habit reversal Intensive outpatient Behavior therapy

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以便秘和腹泻为主的肠易激综合征与5-羟色胺信号改变

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世界核心医学期刊文摘（胃肠病学分册） 2006年第6期2卷 32-33页

作者： Atkinson w. lockhart S. whorwell P. J. L.A. Houghton. 李宏宇(译) 郑世成(校) 不详 Neurogastroenterology Unit Academic Division of Medicine and Surgery Wythenshawe Hospital F Block Southmoor Road WythenshaweManchester M23 9LT United Kingdom

Background &Aims: Evidence suggests that postprandial platelet-depleted plasma 5-hydroxytryptamine (5-HT) concentrations may be abnormal in irritable bowel syndrome (IBS). However, interpretation of the data has been hampered by the variable methodology and rather small numbers used in previous studies. Therefore, the aim of this study was to measure concentrations of platelet-depleted plasma 5-HT and its metabolite 5-HIAA under fasting and fed conditions in a large group of patients with diarrhea-predominant (d-) and constipation-predominant (c-) IBS, compared.w.th controls. The ratio of plasma 5-HIAA:5-HT and platelet stores was also assessed. Methods: Twenty-nine c-IBS patients (aged, 19-53 years), 55 d-IBS patients (aged, 19-52 years), and 35 healthy volunteers (aged, 18-46 years) had platelet-depleted plasma 5-HT/5-HIAA concentrations measured using reverse-phase, high-performance liquid chromatography with fluorimetric detection before and after a standard meal. Results: d-IBS patients had raised platelet-depleted plasma 5-HT concentrations under fasting and fed conditions (P wever, the postprandial relative to fasting concentration was similar to controls. In contrast, c-IBS patients failed to show an increase in platelet-depleted plasma 5-HT concentration with meal ingestion compared.w.th controls (P was associated.w.th decreased 5-HIAA (P d d-IBS with normal 5-HIAA concentrations but reduced 5-HIAA:5-HT ratio (P d-IBS patients had increased platelet 5-HT. Conclusions: These results support the concept that d-IBS is characterized by reduced 5-HT reuptake, whereas impaired release may be a feature of c-IBS. These results also provide a rational basis for current pharmacologic approaches involving modulation of different 5-HT receptors in c-and d-IBS.

关键词：肠易激综合征(IBS) 腹泻型IBS 5-羟色胺便秘型信号改变反相高效液相色谱法血小板血浆 IBS患者 5-羟吲哚乙酸

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对28078例钆特醇增强MR成像病人的不良反应率的评估

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国际医学放射学杂志 2011年第3期 285-285页

作者： d.E.Morgan J.S.Spann M.E.lockhart B.winningham d.N.Bolus 孙海涛 department of Radiology University of Alabama at Birmingham

目的测定应用钆特醇作为常规MR成像对比剂在第3期临床使用情况的不良反应率。材料与方法本研究经机构伦理委员会同意,病人签署知情同意书,符合HIPAA

关键词：反应率 MR 钆特醇病人

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