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Frontiers of physics 2012年第4期7卷 418-423页

作者： d.v.b.murthy Gopalan Srinivasan Physics department Oakland UniversityRochesterMI 48309USA

A systematic study has been carried out on the effects of interface bonding on the strain mediated magnetoelectric （ME） coupling in ferromagnetic-ferroelectric bilayers. The technique used involves the static electric field E tuning of the ferromagnetic resonance （FMR） in yttrium iron garnet （YIG） and lead zirconate titanate （PZT） or lead magnesium niobate-lead titanate （PMN-PT）. A broad band detection technique has been developed for studies over 1 40 GHz in three types of bilayers： epoxy bonded, eutectic bonded and YIG films directly grown onto piezoelectric substrate by electrophoretic deposition. The strength A of the converse ME effect （CME） defined as the ratio of the frequency shift 8f in FMR in E, A = 8f/E, varies over the range 0.8 to 4.3 ***/kv, and is the highest for eutectic bonded samples and is the weakest for epoxy bonded bilayers. The results presented here as of importance for dual electric and magnetic field tunable ferrite ferroelectric microwave resonators and filters.

关键词： Keywords ferrite ferroelectric magnetoelectric ferromagnetic resonance

A comprehensive investigation on nonlinear vibration and bending characteristics of bio-inspired helicoidal laminated composite structures

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Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 81-100页

作者： S.SAURAbH R.KIRAN d.SINGH R.vAISH v.S.CHAUHAN School of Mechanical and Materials Engineering Indian Institute of Technology Mandi

bio-inspired helicoidal composite laminates, inspired by the intricate helical structures found in nature, present a promising frontier for enhancing the mechanical properties of structural designs. Hence, this study provides a comprehensive investigation into the nonlinear free vibration and nonlinear bending behavior of bio-inspired composite plates. The inverse hyperbolic shear deformation theory(IHSdT) of plates is employed to characterize the displacement field, with the incorporation of Green-Lagrange nonlinearity. The problem is modeled using the C0finite element method(FEM), and an in-house code is developed in the MATLAb environment to solve it numerically. various helicoidal layup configurations including helicoidal recursive(HR), helicoidal exponential(HE), helicoidal semi-circular(HS), linear helicoidal(LH), and Fibonacci helicoidal(FH)with different layup sequences and quasi-isotropic configurations are studied. The model is validated, and parametric studies are conducted. These studies investigate the effects of layup configurations, side-to-thickness ratio, modulus ratios, boundary conditions, and loading conditions at different load amplitudes on the nonlinear vibration and nonlinear bending behaviors of bio-inspired composite plates. The results show that the laminate sequence exerts a substantial impact on both nonlinear natural frequencies and nonlinear bending behaviors. Moreover, this influence varies across different side-to-thickness ratios and boundary conditions of the bio-inspired composite plate.

关键词： bio-inspired composite plate finite element method (FEM) Green-Lagrange helicoidal inverse hyperbolic shear deformation theory (IHSdT) nonlinear O322

Platform for laser-driven X-ray diagnostics of heavy-ion heated extreme states of matter

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Matter and Radiation at Extremes 2025年第1期10卷 57-71页

作者： P.Hesselbach J.Lütgert v.bagnoud R.belikov O.Humphries b.Lindqvist G.Schaumann A.Sokolov A.Tauschwitz d.varentsov K.Weyrich b.Winkler X.Yu b.Zielbauer d.Kraus d.Riley Zs.Major P.Neumayer Institut für Angewandte Physik Goethe-Universität Frankfurt am MainMax-von-Laue Str.160438 FrankfurtGermany GSI Helmholtzzentrum für Schwerionenforschung GmbH Planckstr.164291 DarmstadtGermany Institut für Physik Universität RostockAlbert-Einstein-Str.2318059 RostockGermany Institut für Angewandte Physik Technische Universität DarmstadtSchlossgartenstr.764289 DarmstadtGermany Helmholtz Institut Jena Fröbelstieg 307743 JenaGermany Institut für Geowissenschaften Goethe-Universität Frankfurt am MainAltenhöferallee 160438 Frankfurt am MainGermany Helmholtz-Zentrum dresden-Rossendorf Bautzner Landstr.40001328 DresdenGermany European XFEL GmbH Holzkoppel 422869 SchenefeldGermany Institut für Kernphysik Technische Universität DarmstadtSchlossgartenstr.964289 DarmstadtGermany Centre for Light-Matter Interaction School of Mathematics and PhysicsQueen’s University BelfastUniversity RoadBelfast BT71NNUnited Kingdom

We report on commissioning experiments at the high-energy,high-temperature(HHT)target area at the GSI Helmholtzzentrum für Schwerionenforschung GmbH,darmstadt,Germany,combining for the first time intense pulses of heavy ions from the SIS18 synchrotron with high-energy laser pulses from the PHELIX laser *** demonstrate the use of X-ray diagnostic techniques based on intense laserdriven X-ray sources,which will allow probing of large samples volumetrically heated by the intense heavy-ion beams.A new target chamber as well as optical diagnostics for ion-beam characterization and fast pyrometric temperature measurements complement the experimental *** platform is designed for experiments at the future Facility for Antiproton and Ion Research in Europe GmbH(FAIR),where unprecedented ion-beam intensities will enable the generation of millimeter-sized samples under high-energy-density conditions.

关键词： heated intense extreme

MicroRNAs as potential diagnostic biomarkers for bipolar disorder

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Neural Regeneration Research 2025年第6期20卷 1681-1695页

作者： bridget Martinez Philip v.Peplow department of Pharmacology University of Nevada-RenoRenoNVUSA department of Medicine University of Nevada-RenoRenoNVUSA department of Anatomy University of OtagoDunedinNew Zealand

Abnormal expression of microRNAs is connected to brain development and disease and could provide novel biomarkers for the diagnosis and prognosis of bipolar disorder. We performed a PubMed search for microRNA biomarkers in bipolar disorder and found 18 original research articles on studies performed with human patients and published from January 2011 to June 2023. These studies included microRNA profiling in bloodand brain-based materials. From the studies that had validated the preliminary findings,potential candidate biomarkers for bipolar disorder in adults could be miR-140-3p,-30d-5p,-330-5p,-378a-5p,-21-3p,-330-3p,-345-5p in whole blood, miR-19b-3p,-1180-3p,-125a-5p, let-7e-5p in blood plasma, and miR-7-5p,-23b-5p,-142-3p,-221-5p,-370-3p in the blood serum. Two of the studies had investigated the changes in microRNA expression of patients with bipolar disorder receiving treatment. One showed a significant increase in plasma miR-134 compared to baseline after 4 weeks of treatment which included typical antipsychotics, atypical antipsychotics, and benzodiazepines. The other study had assessed the effects of prescribed medications which included neurotransmitter receptorsite binders(drug class b) and sedatives, hypnotics, anticonvulsants, and analgesics(drug class C) on microRNA results. The combined effects of the two drug classes increased the significance of the results for miR-219 and-29c with miR-30e-3p and-526b* acquiring significance. MicroRNAs were tested to see if they could serve as biomarkers of bipolar disorder at different clinical states of mania, depression, and euthymia. One study showed that upregulation in whole blood of miR-9-5p,-29a-3p,-106a-5p,-106b-5p,-107,-125a-3p,-125b-5p and of miR-107,-125a-3p occurred in manic and euthymic patients compared to controls, respectively, and that upregulation of miR-106a-5p,-107 was found for manic compared to euthymic patients. In two other studies using blood plasma,downregulation of miR-134 was observed i

关键词： biomarker bipolar disorder blood leukocytes blood plasma blood plasma extracellular vesicles/exosomes blood serum brain tissue brain tissue extracellular vesicles/exosomes lymphoblastoid cell lines microRNA neural progenitor cells whole blood

Autism spectrum disorder:difficulties in diagnosis and microRNA biomarkers

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Neural Regeneration Research 2025年第10期20卷 2776-2786页

We performed a PubMed search for microRNAs in autism spectrum disorder that could serve as diagnostic biomarkers in patients and selected 17 articles published from January 2008 to december 2023,of which 4 studies were performed with whole blood,4 with blood plasma,5 with blood serum,1 with serum neural cell adhesion molecule L1-captured extracellular vesicles,1 with blood cells,and 2 with peripheral blood mononuclear *** of the studies involved children and the study cohorts were largely *** of the studies had performed microRNA sequencing or quantitative polymerase chain reaction assays to measure microRNA *** five studies had used real-time polymerase chain reaction assay to validate microRNA expression in autism spectrum disorder subjects compared to *** microRNAs that were validated in these studies may be considered as potential candidate biomarkers for autism spectrum disorder and include miR-500a-5p,-197-5p,-424-5p,-664a-3p,-365a-3p,-619-5p,-664a-3p,-3135a,-328-3p,and-500a-5p in blood plasma and miR-151a-3p,-181b-5p,-320a,-328,-433,-489,-572,-663a,-101-3p,-106b-5p,-19b-3p,-195-5p,and-130a-3p in blood serum of children,and miR-15b-5p and-6126 in whole blood of *** important limitations were identified in the studies reviewed,and need to be taken into account in future *** studies are warranted with children and adults having different levels of autism spectrum disorder severity and consideration should be given to using animal models of autism spectrum disorder to investigate the effects of suppressing or overexpressing specific microRNAs as a novel therapy.

关键词： autism spectrum disorder biomarker blood cells blood plasma blood serum diagnosis microRNA peripheral blood mononuclear cells serum neural cell adhesion molecule L1-captured extracellular vesicles whole blood

MicroRNAs as potential biomarkers for diagnosis of post-traumatic stress disorder

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Neural Regeneration Research 2025年第7期20卷 1957-1970页

Post-traumatic stress disorder is a mental disorder caused by exposure to severe traumatic life ***,there are no validated biomarkers or laboratory tests that can distinguish between trauma survivors with and without post-traumatic stress *** addition,the heterogeneity of clinical presentations of post-traumatic stress disorder and the overlap of symptoms with other conditions can lead to misdiagnosis and inappropriate *** suggests that this condition is a multisystem disorder that affects many biological systems,raising the possibility that peripheral markers of disease may be used to diagnose post-traumatic stress *** performed a PubMed search for microRNAs(miRNAs)in post-traumatic stress disorder(PTSd)that could serve as diagnostic biomarkers and found 18 original research articles on studies performed with human patients and published January 2012 to december *** included four studies with whole blood,seven with peripheral blood mononuclear cells,four with plasma extracellular vesicles/exosomes,and one with serum *** of these studies had also used whole *** studies were excluded as they did not involve microRNA *** of the studies had collected samples from adult male veterans who had returned from deployment and been exposed to combat,and only two were from recently traumatized adult *** measuring miRNA expression levels,many of the studies had used microarray miRNA analysis,miRNA Seq analysis,or NanoString *** six studies had used real time polymerase chain reaction assay to determine/validate miRNA expression in PTSd subjects compared to *** miRNAs that were found/validated in these studies may be considered as potential candidate biomarkers for PTSd and include miR-3130-5p in whole blood;miR-193a-5p,-7113-5p,-125a,-181c,and-671-5p in peripheral blood mononuclear cells;miR-10b-5p,-203a-3p,-4488,-502-3p,-874-3p,-5100,and-7641 in plasma extracellular vesicles/

关键词： biomarker diagnosis microRNA peripheral blood mononuclear cells plasma extracellular vesicles/exosomes post-traumatic stress disorder serum exosomes whole blood whole plasma

Unveiling urbanization effects on trees outside forests along the urban-rural gradient in megacity bengaluru

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Forest Ecosystems 2025年第01期 56-65页

作者： Tao Jiang Maximilian Freudenberg Christoph Kleinn v.P.Tewari b.N.diwakara Nils N?lke Forest Inventory and Remote Sensing department Faculty of Forest Sciences and Forest Ecology University of G?ttingen Himalayan Forest Research Institute ICFRE Institute of Wood Science and Technology IWST

Rapid urbanization has caused significant changes along the urban-rural gradient, leading to a variety of landscapes that are mainly shaped by human activities. This dynamic interplay also influences the distribution and characteristics of trees outside forests(TOF). Understanding the pattern of these trees will support informed decision-making in urban planning, in conservation strategies, and altogether in sustainable land management practices in the urban context. In this study, we employed a deep learning-based object detection model and high resolution satellite imagery to identify 1.3 million trees with bounding boxes within a 250 km2research transect spanning the urban-rural gradient of bengaluru, a megacity in Southern India. Additionally, we developed an allometric equation to estimate diameter at breast height(dbH) from the tree crown diameter(Cd) derived from the detected bounding boxes. Our study focused on analyzing variations in tree density and tree size along this gradient. The findings revealed distinct patterns: the urban domain displayed larger tree crown diameters(mean:8.87 m) and dbH(mean: 43.78 cm) but having relatively low tree density(32 trees per hectare). Furthermore,with increasing distance from the city center, tree density increased, while the mean tree crown diameter and mean tree basal area decreased, showing clear differences of tree density and size between the urban and rural domains in bengaluru. This study offers an efficient methodology that helps generating instructive insights into the dynamics of TOF along the urban-rural gradient. This may inform urban planning and management strategies for enhancing green infrastructure and biodiversity conservation in rapidly urbanizing cities like bengaluru.

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Synthesis,characterization and application of PvA/ionic liquid mixed matrix membranes for pervaporation dehydration of isopropanol

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Chinese Journal of Chemical Engineering 2017年第10期25卷 1402-1411页

作者： Ganesh b.Thorat Smita Gupta Z.v.P.murthy department of Chemical Engineering Sardar Vallabhbhai National Institute of Technology Surat 395007 Gujarat India

In this study,polyvinyl alcohol(PvA)–ionic liquid(IL) membranes were prepared for the separation of isopropyl alcohol(IPA)–water azeotropic mixtures by ***-IL composite membranes were prepared by simple solvent evaporation method using four ILs,viz.,1-n-butyl-3-methylimidazolium chloride(bMIMCl),1-hexyl-3-methylimidazolium chloride(HMIMCl),1-hexyl-3-methylimidazolium tetra fluoroborate(HMIMbF4) and 1-octyl-3-methylimidazolium chloride(OMIMCl).Three ILs were used to study the effect of alkyl chain on the pervaporation *** study had focused on the effect feed water concentration from 10%–40%and effect of feed temperature from 50–80°*** properties of all the membranes were studied using Fourier transform infrared spectroscopy(FTIR),scanning electron microscopy(SEM) and contact angle *** Arrhenius activation energies for permeation were estimated to be in the range 4–12 kJ·mol-1 from the temperature dependent permeation values.

关键词： Composite membranes Ionic liquids dehydration Isopropanol Pervaporation

Unlocking hypoglycemia–associated brain microvascular dysfunction:critical insights from proteomic analysis

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Neural Regeneration Research 2025年第6期20卷 1707-1708页

作者： Siva S.v.P.Sakamuri Anil Sakamuri department of Chemistry Auburn University at MontgomeryMontgomeryALUSA vascular biology Center and department of Medicine Medical College of Georgia at Augusta UniversityAugustaGAUSA

Hypoglycemia-a critical complication linked to worsened brain function in diabetic subjects:Hypoglycemia is characterized by a decline in circulatory glucose levels below sta nda rd physiological *** hypoglycemia,classified as level 1 hypoglycemia,is defined by blood glucose levels below 70 mg/dL and can be effectively addressed through carbohydrate *** hypoglycemia,denoted by blood glucose levels less than 54 mg/dL,poses a life-threatening risk if left *** with type 1 and type 2 diabetes undergoing insulin treatment are particularly susceptible to hypoglycemia due to impaired counterregulatory mechanisms.

关键词： impaired intake critical

Cortical hem signaling center: functions, development, and potential implications for evolution and brain disorders

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Neural Regeneration Research 2025年第4期20卷 1079-1080页

作者： victor v.Chizhikov Igor Y.Iskusnykh department of Anatomy and Neurobiology University of Tennessee Health Science CenterMemphisTNUSA

development of the telencephalon relies upon several signaling centers-localized cellular populations that supply secreted factors to pattern the cortical *** such signaling center is the cortical hem,which arises during embryonic development at the telencephalic dorsal midline,adjacent to the choroid plexus and hippocampal primordium(Figure 1A).While the cortical hem has also been described in reptiles and birds,most of our knowledge about the developmental roles of the cortical hem is derived from the analysis in *** cortical hem produces several types of secreted molecules,including wingless-related integration site(Wnt)and bone morphogenetic(bmp)*** cortical hem is particularly important for the development of the hippocampus,which is involved in learning and memory,and the neocortex,which is the most complex brain region that mediates multiple types of behavior and higher cognitive functions(Mangale et al.,2008;dal-valle-Anton and borrell,2022).

关键词： epithelium Figure center