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Numerical modeling of external light gauge steel framed wall systems exposed to bushfire flame zone conditions

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Frontiers of Structural and Civil Engineering 2024年第9期18卷 1424-1444页

作者： sahani HENdAWITHARANA Anthony ARIYANAYAGAM Mahen MAHENdRAN Faculty of Engineering Queensland University of TechnologyBrisbaneQLD 4000Australia

Bushfire-related building losses cause adverse economic impacts to countries prone to *** materials and components play a vital role in reducing these ***,due to high costs of experimental studies and lack of numerical studies,the heat transfer behavior of building’s external components in bushfire-prone areas has not been adequately *** large-scale heat transfer models are developed using Computational Fluid dynamics(CFd)tools,and the availability of CFd models for heat transfer in building components improves the understanding of the behavior of systems and systems of ***,this paper uses a numerical modeling approach to investigate the bushfire/wildfire resistance of external Light gauge Steel Framed(LSF)wall *** full-scale and small-scale heat transfer models were developed for the LSF wall *** results of six internal and external LSF wall systems with varying plasterboard thickness and cladding material were used to validate the developed *** study was then extended to investigate the bushfire resistance of seven external wall systems under two different bushfire flame zone *** results illustrate the significant effects of fire curves,LSF wall components and configuration on the heat transfer across the *** have shown 1)the favorable performance of steel cladding and Autoclaved Aerated Concrete(AAC)panels when used on the external side of wall systems and 2)the adequacy of thin-walled steel studs’load-bearing capacity during bushfire *** study has shown that most of the investigated external LSF walls could be reused with cost-effective retrofitting such as replacing the Fire Side(FS)steel cladding after bushfire ***,this study has advanced the understanding of the behavior of external light steel framed walls under bushfire flame zone conditions.

关键词： bushfires flame zone external light gauge steel framed walls heat transfer analyses numerical models

Autism spectrum disorder:difficulties in diagnosis and microRNA biomarkers

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Neural Regeneration Research 2025年第10期20卷 2776-2786页

作者： Bridget Martinez Philip v.Peplow department of Pharmacology University of Nevada-RenoRenoNVUSA department of Medicine University of Nevada-RenoRenoNVUSA department of Anatomy University of OtagoDunedinNew Zealand

We performed a PubMed search for microRNAs in autism spectrum disorder that could serve as diagnostic biomarkers in patients and selected 17 articles published from January 2008 to december 2023,of which 4 studies were performed with whole blood,4 with blood plasma,5 with blood serum,1 with serum neural cell adhesion molecule L1-captured extracellular vesicles,1 with blood cells,and 2 with peripheral blood mononuclear *** of the studies involved children and the study cohorts were largely *** of the studies had performed microRNA sequencing or quantitative polymerase chain reaction assays to measure microRNA *** five studies had used real-time polymerase chain reaction assay to validate microRNA expression in autism spectrum disorder subjects compared to *** microRNAs that were validated in these studies may be considered as potential candidate biomarkers for autism spectrum disorder and include miR-500a-5p,-197-5p,-424-5p,-664a-3p,-365a-3p,-619-5p,-664a-3p,-3135a,-328-3p,and-500a-5p in blood plasma and miR-151a-3p,-181b-5p,-320a,-328,-433,-489,-572,-663a,-101-3p,-106b-5p,-19b-3p,-195-5p,and-130a-3p in blood serum of children,and miR-15b-5p and-6126 in whole blood of *** important limitations were identified in the studies reviewed,and need to be taken into account in future *** studies are warranted with children and adults having different levels of autism spectrum disorder severity and consideration should be given to using animal models of autism spectrum disorder to investigate the effects of suppressing or overexpressing specific microRNAs as a novel therapy.

关键词： autism spectrum disorder biomarker blood cells blood plasma blood serum diagnosis microRNA peripheral blood mononuclear cells serum neural cell adhesion molecule L1-captured extracellular vesicles whole blood

MicroRNAs as potential diagnostic biomarkers for bipolar disorder

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Neural Regeneration Research 2025年第6期20卷 1681-1695页

Abnormal expression of microRNAs is connected to brain development and disease and could provide novel biomarkers for the diagnosis and prognosis of bipolar disorder. We performed a PubMed search for microRNA biomarkers in bipolar disorder and found 18 original research articles on studies performed with human patients and published from January 2011 to June 2023. These studies included microRNA profiling in bloodand brain-based materials. From the studies that had validated the preliminary findings,potential candidate biomarkers for bipolar disorder in adults could be miR-140-3p,-30d-5p,-330-5p,-378a-5p,-21-3p,-330-3p,-345-5p in whole blood, miR-19b-3p,-1180-3p,-125a-5p, let-7e-5p in blood plasma, and miR-7-5p,-23b-5p,-142-3p,-221-5p,-370-3p in the blood serum. Two of the studies had investigated the changes in microRNA expression of patients with bipolar disorder receiving treatment. One showed a significant increase in plasma miR-134 compared to baseline after 4 weeks of treatment which included typical antipsychotics, atypical antipsychotics, and benzodiazepines. The other study had assessed the effects of prescribed medications which included neurotransmitter receptorsite binders(drug class B) and sedatives, hypnotics, anticonvulsants, and analgesics(drug class C) on microRNA results. The combined effects of the two drug classes increased the significance of the results for miR-219 and-29c with miR-30e-3p and-526b* acquiring significance. MicroRNAs were tested to see if they could serve as biomarkers of bipolar disorder at different clinical states of mania, depression, and euthymia. One study showed that upregulation in whole blood of miR-9-5p,-29a-3p,-106a-5p,-106b-5p,-107,-125a-3p,-125b-5p and of miR-107,-125a-3p occurred in manic and euthymic patients compared to controls, respectively, and that upregulation of miR-106a-5p,-107 was found for manic compared to euthymic patients. In two other studies using blood plasma,downregulation of miR-134 was observed i

关键词： biomarker bipolar disorder blood leukocytes blood plasma blood plasma extracellular vesicles/exosomes blood serum brain tissue brain tissue extracellular vesicles/exosomes lymphoblastoid cell lines microRNA neural progenitor cells whole blood

MicroRNAs as potential biomarkers for diagnosis of post-traumatic stress disorder

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Neural Regeneration Research 2025年第7期20卷 1957-1970页

Post-traumatic stress disorder is a mental disorder caused by exposure to severe traumatic life ***,there are no validated biomarkers or laboratory tests that can distinguish between trauma survivors with and without post-traumatic stress *** addition,the heterogeneity of clinical presentations of post-traumatic stress disorder and the overlap of symptoms with other conditions can lead to misdiagnosis and inappropriate *** suggests that this condition is a multisystem disorder that affects many biological systems,raising the possibility that peripheral markers of disease may be used to diagnose post-traumatic stress *** performed a PubMed search for microRNAs(miRNAs)in post-traumatic stress disorder(PTSd)that could serve as diagnostic biomarkers and found 18 original research articles on studies performed with human patients and published January 2012 to december *** included four studies with whole blood,seven with peripheral blood mononuclear cells,four with plasma extracellular vesicles/exosomes,and one with serum *** of these studies had also used whole *** studies were excluded as they did not involve microRNA *** of the studies had collected samples from adult male veterans who had returned from deployment and been exposed to combat,and only two were from recently traumatized adult *** measuring miRNA expression levels,many of the studies had used microarray miRNA analysis,miRNA Seq analysis,or NanoString *** six studies had used real time polymerase chain reaction assay to determine/validate miRNA expression in PTSd subjects compared to *** miRNAs that were found/validated in these studies may be considered as potential candidate biomarkers for PTSd and include miR-3130-5p in whole blood;miR-193a-5p,-7113-5p,-125a,-181c,and-671-5p in peripheral blood mononuclear cells;miR-10b-5p,-203a-3p,-4488,-502-3p,-874-3p,-5100,and-7641 in plasma extracellular vesicles/

关键词： biomarker diagnosis microRNA peripheral blood mononuclear cells plasma extracellular vesicles/exosomes post-traumatic stress disorder serum exosomes whole blood whole plasma

Effects of delay in immunological response of HIv infection

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International Journal of Biomathematics 2018年第6期11卷 1-29页

作者： Saroj Kumar sahani Yashi department of Mathematics South Asian University Akbar Bhawan Chankyapuri New Delhi 110021 India

In this paper, a human immunodeficiency virus （HIv） infection model with both the types of immune responses, the antibody and the killer cell immune responses has been introduced. The model has been made more logical by including two delays in the acti-vation of both the immune responses, along with the combination drug therapy. The inclusion of both the delayed immune responses provides a greater understanding of long-term dynamics of the disease. The dependence of the stability of the steady states of the model on the reproduction number R0 has been explored through stability theory. Moreover, the global stability analysis of the infection-free steady state and the infected steady state has been proved with respect to R0. The bifurcation analysis of the infected steady state with respect to both delays has been performed. Numerical simulations have been carried out to justify the results proved. This model is capable of explaining the long-term dynamics of HIv infection to a greater extent than that of the existing model as it captures some basic parameters involved in the system such as immunological delay and immune response. Similarly, the model also explains the basic understanding of the disease dynamics as a result of activation of the immune response toward the virus.

关键词： HIv humoral immunity immunological delay Hopf bifurcation globalstability.

A new protection scheme for Pv-wind based dC-ring microgrid by using modified multifractal detrended fluctuation analysis

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Protection and Control of Modern Power Systems 2022年第1期7卷 100-123页

作者： Kanche Anjaiah Pradipta Kishore dash Mrutyunjaya sahani department of Electrical Engineering Siksha‘O’Anusandhan Deemed to be UniversityBhubaneswarOdishaIndia Multidisciplinary Research Cell Siksha‘O’Anusandhan Deemed to be UniversityBhubaneswarOdishaIndia department of Electrical and Electronics Engineering Siksha‘O’Anusandhan Deemed to be UniversityBhubaneswarOdishaIndia

This paper presents fault detection,classification,and location for a Pv-Wind-based dC ring microgrid in the MATLAB/SIMULINK ***,dC fault signals are collected from local measurements to examine the outcomes of the proposed *** detection is carried out for all faults,(i.e.,cable and arc faults)under two cases of fault resistance and distance variation,with the assistance of primary and secondary detection techniques,***-order differential current derivatived2I3 dt2and sliding mode window-based Pearson’s correlation *** fault classification a novel approach using modified multifractal detrended fluctuation analysis(M-MFdFA)is *** advantage of this method is its ability to estimate the local trends of any order polynomial function with the help of polynomial and trigonometric *** also doesn’t require any signal processing algorithm for decomposition resulting and this results in a reduction of computational *** detected fault signals are directly passed through the M-MFdFA classifier for fault type *** enhance the performance of the proposed classifier,statistical data is obtained from the M-MFdFA feature vectors,and the obtained data is plotted in 2-d and 3-d scatter plots for better *** fault distance estimation is carried out for all types of faults in the dC ring bus microgrid with the assistance of recursive least squares with a forgetting factor(FF-RLS).To verify the performance and superiority of the proposed classifier,it is compared with existing classifiers in terms of features,classification accuracy(CA),and relative computational time(RCT).

关键词： dC ring microgrid differential current Fault resistance detection Classification Fault location estimation Multifractal detrended fluctuation analysis

Unlocking hypoglycemia–associated brain microvascular dysfunction:critical insights from proteomic analysis

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Neural Regeneration Research 2025年第6期20卷 1707-1708页

作者： Siva S.v.P.Sakamuri Anil Sakamuri department of Chemistry Auburn University at MontgomeryMontgomeryALUSA vascular Biology Center and department of Medicine Medical College of Georgia at Augusta UniversityAugustaGAUSA

Hypoglycemia-a critical complication linked to worsened brain function in diabetic subjects:Hypoglycemia is characterized by a decline in circulatory glucose levels below sta nda rd physiological *** hypoglycemia,classified as level 1 hypoglycemia,is defined by blood glucose levels below 70 mg/dL and can be effectively addressed through carbohydrate *** hypoglycemia,denoted by blood glucose levels less than 54 mg/dL,poses a life-threatening risk if left *** with type 1 and type 2 diabetes undergoing insulin treatment are particularly susceptible to hypoglycemia due to impaired counterregulatory mechanisms.

关键词： impaired intake critical

Cortical hem signaling center: functions, development, and potential implications for evolution and brain disorders

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Neural Regeneration Research 2025年第4期20卷 1079-1080页

作者： victor v.Chizhikov Igor Y.Iskusnykh department of Anatomy and Neurobiology University of Tennessee Health Science CenterMemphisTNUSA

development of the telencephalon relies upon several signaling centers-localized cellular populations that supply secreted factors to pattern the cortical *** such signaling center is the cortical hem,which arises during embryonic development at the telencephalic dorsal midline,adjacent to the choroid plexus and hippocampal primordium(Figure 1A).While the cortical hem has also been described in reptiles and birds,most of our knowledge about the developmental roles of the cortical hem is derived from the analysis in *** cortical hem produces several types of secreted molecules,including wingless-related integration site(Wnt)and bone morphogenetic(Bmp)*** cortical hem is particularly important for the development of the hippocampus,which is involved in learning and memory,and the neocortex,which is the most complex brain region that mediates multiple types of behavior and higher cognitive functions(Mangale et al.,2008;dal-valle-Anton and Borrell,2022).

关键词： epithelium Figure center

Biochemical dissection of STAT3 signaling in amyotrophic lateral sclerosis

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Neural Regeneration Research 2025年第11期20卷 3229-3230页

作者： Savina Apolloni Nadia d’Ambrosi department of Biology University of Rome Tor VergataRomeItaly

Amyotrophic lateral sclerosis(ALS)is a progressive neurodegenerative disease characterized by the loss of upper and lower motor neurons,clinically marked by muscle atrophy and *** the clinical course is highly variable,the average time from the onset of symptoms to the need for respiratory support or death is 3-5 *** is the most prevalent motor neuron disease in adults,occurring at a rate of 2 per 100,000 individuals and affecting 5.4 per 100,000 individuals overall.

关键词： STAT3 dissection sclerosis