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CNN-LSTM: A Novel Hybrid deep Neural Network Model for Brain Tumor Classification

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Intelligent Automation & Soft Computing 2023年第7期37卷 1129-1143页

作者： R.d.dhaniya K.M.umamaheswari department of Computer Science and Engineering SRM Institute of Science and TechnologyKattankulathur603202India department of Computing technologies SRM Institute of Science and TechnologyKattankulathur603202India

Current revelations in medical imaging have seen a slew of computer-aided diagnostic(CAd)tools for radiologists *** tumor classification is essential for radiologists to fully support and better interpret magnetic resonance imaging(MRI).In this work,we reported on new observations based on binary brain tumor categorization using HYBRId ***,the collected image is pre-processed and augmented using the following steps such as rotation,cropping,zooming,CLAHE(Contrast Limited Adaptive Histogram Equalization),and Random Rotation with panoramic stitching(RRPS).Then,a method called particle swarm optimization(PSO)is used to segment tumor regions in an MR *** that,a hybrid CNN-LSTM classifier is applied to classify an image as a tumor or *** this proposed hybrid model,the CNN classifier is used for generating the feature map and the LSTM classifier is used for the classification *** effectiveness of the proposed approach is analyzed based on the different metrics and outcomes compared to different methods.

关键词： Brain tumor segmentation particle swarm optimization CNN-LSTM convolution neural network

Characterisation, Luminescence and Antibacterial Properties of Stable AgNPs Synthesised from AgCl by Precipitation Method

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Journal of Materials Science & Technology 2015年第11期31卷 1125-1132页

作者： Arockiasamy Ajaypraveenkumar Johnson Henry Kannusamy Mohanraj Ganesan Sivakumar Sankaran umamaheswari department of Physics Manonmaniam Sundaranar University Centralised Instrumentation and Service Laboratory Department of Physics Annamalai University department of Biotechnology Manonmaniam Sundaranar University

Silver nanoparticles （AgNPs） were synthesised using equimolar concentrations of redtlcing agent vitamin C and AgCl precursor by simple precipitation method. The synthesised AgNPs were characterised by X-ray diffraction （XRd）, UV-Visible, photoluminescence and field emission scanning electron microscopy （FESEM） analysis. The formation of AgNPs was confirmed by the typical surface plasmon resonance band at 426 nm. The presence of elemental silver and pure crystalline face centre cubic （fcc） structure was confirmed by energy dispersive X-ray analysis and XRd analysis, respectively. The FESEM images showed the formation of spherical AgNPs for lower concentrations （0.1 and 0.3 mol/L） while spike and flower shaped particles were formed for higher concentration. Photoluminescence characteristic band was observed with no shift at 390 nm indicating the stable nature of AgNPs. The antibacterial property of the AgNPs was tested against gram negative bacteria Pseudomonas aeruginosa by using Cissus quadrangular as a control and the result showed that vitamin C reduced AgNPs have good antibacterial activity.

关键词： Silver nanoparticles Precipitation Rietveld refinement Photoluminescence spectroscopy Optical properties

Phytopharmacological potential of the natural gift Moringa oleifera Lam and its therapeutic application: An overview

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Asian Pacific Journal of Tropical Medicine 2019年第11期12卷 485-498页

作者： Sakthivel Lakshmana Prabu Appavoo umamaheswari Ayarivan Puratchikody department of Pharmaceutical Technology University College of Engineering(BIT Campus)Anna UniversityTiruchirappalli620024India

Traditionally,medicinal plants of family Moringaceae have been well-recognized due to their multipurpose utilization in various fields such as treatment of several diseases for they have a broad range of pharmacological activities,in wastewater treatment as well as food *** of this medicinal plants and its bioactivity study discloses the presence of several phytoconstituents and secondary metabolites like terpenes,flavonoids,steroids,phenolic compounds,tannins,carohydrates,flavonoids,vitamins and *** results of bioactivity study results revealed that different extracts such as aqueous,methanolic and ethanolic of Moringa oleifera showed notable therapeutic *** present review explore and focus on the phytochemical composition and various pharmacological activities like immunomodulator,antidiabetic,antiulcer,anthelmintic,anti-inflammatory,antipyretic,analgesic,antiepileptic,cardioprotective,lipid lowering,antihypertensive,hepatoprotective,anti-nephrotoxicity and anti-microbial activities to arouse public consciousness about the nutritional and medicinal value of this"miracle tree-Moringa oleifera"in favor of humanity.

关键词： Moringa oleifera Phytoconstituents Pharmacological activity

Identification of Potential Leptospira Phosphoheptose Isomerase Inhibitors Through Virtual High-Throughput Screening

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Genomics, Proteomics & Bioinformatics 2010年第4期8卷 246-255页

作者： Amineni umamaheswari dibyabhaba Pradhan Marisetty Hemanthkumar SVIMS Bioinformatics Centre SVIMS University Agricultural Research Station Perumallapalle

The life-threatening infections caused by Leptospira serovars demand the need for designing anti-leptospirosis drugs. The present study encompasses exploring inhibitors against phosphoheptose isomerase （GmhA） of Leptospira, which is vital for lipopolysaccharide （LPS） biosynthesis and is identified as a common drug target through the subtractive genomic approach. GmhA model was built in Modeller 9v7. Structural refinement and energy minimization of the predicted model was carried out using Maestro 9.0. The refined model reliability was assessed through Procheck, ProSA, ProQ and Profile 3d. The substrate-based virtual high-throughput screening （VHTS） in *** Meta-database tool generated an in-house library of 354 substrate structural analogs. Furthermore, structure-based VHTS from the in-house library with different conformations of each ligand provided 14 novel competitive inhibitors. The model together with insight gained from the VHTS would be a promising starting point for developing anti-leptospirosis competitive inhibitors targeting LPS biosynthesis pathway.

关键词： LPS biosynthesis Leptospira homology modeling virtual high-throughput screening GmhA inhibitors

Biochemical dissection of STAT3 signaling in amyotrophic lateral sclerosis

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Neural Regeneration Research 2025年第11期20卷 3229-3230页

作者： Savina Apolloni Nadia d’Ambrosi department of Biology University of Rome Tor VergataRomeItaly

Amyotrophic lateral sclerosis(ALS)is a progressive neurodegenerative disease characterized by the loss of upper and lower motor neurons,clinically marked by muscle atrophy and *** the clinical course is highly variable,the average time from the onset of symptoms to the need for respiratory support or death is 3-5 *** is the most prevalent motor neuron disease in adults,occurring at a rate of 2 per 100,000 individuals and affecting 5.4 per 100,000 individuals overall.

关键词： STAT3 dissection sclerosis

A perspective on toxicology of Conus venom peptides

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Asian Pacific Journal of Tropical Medicine 2015年第5期8卷 337-351页

作者： Palanisamy Satheesh Kumar dhanabalan Senthil Kumar Sundaresan umamaheswari department of Biological and Environmental Sciences University of Messina department of Zoology Kandaswami Kandar College department of Environmental Biotechnology Bharathidasan University

The evolutionarily unique and ecologically diverse family Conidae presents fundamental opportunities for marine pharmacology research and drug *** focus of this investigation is to summarize the worldwide distribution of Conus and their species diversity with special reference to the Indian *** addition,this study will contribute to understanding the structural properties of conotoxin and therapeutic application of Conus venom *** snails can inject a mix of various conotoxins and these venoms are their major weapon for prey capture,and may also have other biological purposes,and some of these conotoxins fatal to *** venoms contain a remarkable diversity of pharmacologically active small peptides;their targets are an iron channel and receptors in the neuromuscular *** divergence is pronounced in venom peptide genes,which is generally attributed to their species specific biotic *** is a notable interspecific divergence observed in venom peptide genes,which can be justified as of biotic interactions that stipulate species peculiar habitat and ecology of cone *** are several conopeptides used in clinical trials and one peptide(Ziconotide) has received FdA approval for treatment of *** perspective provides a comprehensive overview of the distribution of cone shells and focus on the molecular approach in documenting their taxonomy and diversity with special reference to geographic distribution of Indian cone snails,structure and properties of conopeptide and their pharmacological targets and future directions.

关键词： distribution Conus Conotoxin Peptide Toxicology Pharmacology

Anti-amyloid antibodies in Alzheimer’s disease: what did clinical trials teach us?

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Neural Regeneration Research 2025年第4期20卷 1092-1093页

作者： danko Jeremic Lydia Jiménez-díaz Juan d.Navarro-López NeuroPhysiology&Behavior Lab University of Castilla-La ManchaBiomedical Research Center(CRIB)School of Medicine of Ciudad RealCiudad RealSpain

Although many causes of Alzheimer’s disease(Ad)may exist,both the original amyloid cascade and tau hypotheses posit that abnormal misfolding and accumulation of amyloid-β(Aβ)and tau protein is the central event causing the ***,that conclusion could be only partly true,and there is conflicting evidence about the role of both proteins in Ad,being able to precede and influence one *** researchers argue that these proteins are mere executors rather than primary causes of ***,there have been continuing refinements of both hypotheses,with alternative explanations proposed.Aβand tau proteins may be independently involved in specific neurotoxic pathways;yet there may be other crucial processes going on in early ***,accumulating evidence suggests that Aβand tau act synergistically,rather than additively in disease onset(Jeremic et al.,2021,2023a).

关键词： amyloid Alzheimer additive

Remaking a connection:molecular players involved in post-injury synapse formation

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Neural Regeneration Research 2025年第6期20卷 1719-1720页

作者： diogo Tomé Ramiro d.Almeida iBiMEd-Institute of Biomedicine Department of Medical SciencesUniversity of AveiroAveiroPortugal CNC-Center for Neuroscience and Cell Biology University of CoimbraCoimbraPortugal

Functional recovery from central nervous system(CNS)trauma depends not only on axon regeneration or compensatory sprouting of uninjured fibers but also on the ability of newly grown axons to establish functional synapses with appropriate *** several studies have successfully promoted long-distance axonal regeneration in distinct CNS injury models,none of them have resulted in a viable therapeutic approach for patient recovery.A possible reason may be the lack of new synaptogenesis for reestablishing the circuitry lost after ***,we discuss how our understanding of the mechanisms that instruct synapse formation in the injured nervous system may contribute to the design of new strategies to promote functional restoration in traumatic CNS disorders.

关键词： viable injury instru

Performance prediction of switched reluctance generator with time average and small signal models

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Frontiers in Energy 2013年第1期7卷 56-68页

作者： Jyoti KOUJALAGI B. umamaheswari R. ARUMUGAM department of Electrical Engineering Dr. Ambedkar Institute of Technology Bangalore 560056 India department of Electrical Engineering CEG Campus Anna University Chennai 600025 India department of Electrical Engineering SSN Engineering of CollegeChennai 603110 India

This paper presents the complete mathematical model and predicts the performance of switched reluctance generator with time average and small signal models. The complete mathematical model is developed in three stages. First, a switching model is developed based on quasi-linear inductance profile. Next, based on the switching behaviour, a time average model is obtained to measure the difference between the excitation and generation time in each switching cycle. Finally, to track control voltage and current wave shapes, a small signal model is designed. The effectiveness of the complete multilevel model combining electrical machine, power converter, load and control with programming language is demonstrated through simulations. A PI controller is used for controlling the voltage of the generator. The results presented show that the controller exhibits accurate tracking control of load voltage under different operating conditions. This demonstrates that the proposed model is able to perform an accurate control of the generated output voltage even in transient situations. The simulation is performed to choose the control parameters and study the performance of switched reluctance generator prior to its actual implementation. Initial experimental results are presented using NI-data acquisition card to control the output power according to load requirements.

关键词： generator reluctance switching model small signal model time average model