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急性肺栓塞:薄层CT毛玻璃样改变与猪血流动力学之间的关系

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国际医学放射学杂志 2009年第3期 277-277页

作者： P.Thoma B.Rondelet C.Melot d.tack R.Naeije P.A.Gevenois 司徒卫军 departmentofRadiology HpitalErasmeUniversitéLibre de BruxellesRoute de Lennik8081070 BrusselsBelgium

目的研究急性肺栓塞(PE)与出现毛玻璃样改变的联系及这种改变的出现与实验动物的急性肺栓塞血流动力学之间的关系。方法此研究经动物保护委员会同意。5头猪经中央静脉导管注射血栓导致急性肺栓塞。在栓塞前及栓塞后行薄层CT扫描及血流... 详细信息

目的研究急性肺栓塞(PE)与出现毛玻璃样改变的联系及这种改变的出现与实验动物的急性肺栓塞血流动力学之间的关系。方法此研究经动物保护委员会同意。5头猪经中央静脉导管注射血栓导致急性肺栓塞。在栓塞前及栓塞后行薄层CT扫描及血流动力学测量,包括平均肺动脉压、体循环与肺循环心输出量、有效肺毛细血管压、右房压及闭塞肺动脉压。主观性地对毛玻璃改变程度及范围给予评分,测量每次扫描肺衰减值。

关键词：急性肺栓塞毛玻璃心输出量心脏功能试验薄层地层 CT

在CT上鉴别亚实性及实性肺结节:经验丰富的胸部放射学医师的观察者内及观察者间的一致性

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国际医学放射学杂志 2016年第3期 307-307页

作者： C.A.Ridge A.Yildirim M.Boiselle T.Franquet C.M.Schaefer-Prokopetal d.tack 陈思璇 department of Radiology Mater Misericordiae University Hospital

摘要目的对经验丰富的胸部放射学医师在CT上鉴别亚实性及实性肺结节的重复性及准确度进行量化。材料与方法Beth Israel deaconess医学中心的机构伦理委员会批准了这项多中心研究。选择6名在胸部放射学方面平均有21年(17～22年)经验的放... 详细信息

摘要目的对经验丰富的胸部放射学医师在CT上鉴别亚实性及实性肺结节的重复性及准确度进行量化。材料与方法Beth Israel deaconess医学中心的机构伦理委员会批准了这项多中心研究。选择6名在胸部放射学方面平均有21年(17～22年)经验的放射科医师;选择有10个实性和10个亚实性的结节影像以创建一个120个结节的数据;以该集合为

关键词：胸部放射实性肺结节医师 CT

A 75 kda glycoprotein isolated from Cudrania tricuspidata Bureau induces colonic epithelial proliferation and ameliorates mouse colitis induced by dextran sulfate sodium

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Chinese Journal of Natural Medicines 2021年第1期19卷 46-55页

作者： Park Jeong-Bae Kim do-Wan Lim Kye-tack Oh Sejong Lee Sei-Jung department of Pharmaceutical Engineering Daegu Haany UniversityGyeongsan 38610South Korea division of Animal Science Chonnam National UniversityGwangju 61186South Korea

Cudrania tricuspidata Bureau(CTB),a species of the Moraceae plant,has been used as a bruise recovery *** study aimed to determine whether the 75 kda phytoglycoprotein extracted from CTB has a regulatory effect on the proliferation of human colon epithelial cells and the pathological process of inflammatory bowel disease(IBd).We found that CTB glycoprotein significantly induces the proliferation of human colon epithelial HT-29 cells by activating protein kinase *** glycoprotein stimulated the phosphorylation of c-Jun N-terminal kinase and transcription factor nuclear factor-κB,which are responsible for the expression of cell-cycle-related proteins(CdK2,CdK4,cyclin d1 and cyclin E)during its promotion of cell *** colitis was induced in mice by adding dextran sulfate sodium to their drinking water at a concentration of 4%(W/V)for seven *** found that CTB glycoprotein ameliorates the pathological process of IBd and lowers the disease activity index score,which was composed of body weight change,diarrhea,and hematochezia in ICR mice treated with dextran sulfate ***,we suggest that CTB glycoprotein has the ability to prevent IBd by promoting cell proliferation signaling events via the activation of PKC,JNK and NF-κB in colon epithelial cells.

关键词： Cell cycle Cell proliferation Colon epithelial cells Cudrania tricuspidata Glycoprotein Inflammatory bowel disease Protein kinase C

Phosphorus Use Efficiency of Bio-Based Fertilizers:Bioavailability and Fractionation

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Pedosphere 2016年第3期26卷 310-325页

作者： Céline VANEECKHAUTE Joery JANdA Peter A.VANROLLEGHEM Filip M.G.tack Erik MEERS Laboratory for Analytical and Applied Ecochemistry Faculty of Bioscience EngineeringGhent University model EAU Département de Génie Civil et de Génie des EauxFaculté des Sciences et de GénieUniversité Laval

Although to date some technologies producing bio-based phosphorus(P) fertilizers have been proposed and implemented, the efficient use of the recovered products is still limited due to legislative constraints and lack of insights in the P release with time and in the corresponding mechanisms. The aim of this work was to evaluate the fertilizer performance in terms of P release and use efficiency of recovered struvite, FePO_4-sludge, digestate, and animal manure as compared to fossil reserve-based mineral triple superphosphate(TSP). First, product physicochemical characteristics and P fractions in the context of European fertilizer legislation were assessed. Next, a controlled greenhouse experiment was set up to evaluate plant reactions as well as changes of P availability in a sandy soil with high P status and a Rheinsand soil with low P status. Soil P fractions were determined in the extracts with water, ammonium lactate and CaCl_2, and in soil solution sampled with Rhizon soil moisture samplers. Based on all results, it is worth conducting long-term field trials to evaluate the P release effect of struvite and digestate as compared to animal manure and TSP on different soil types with varying P status. These products showed promise as sustainable substitutes for conventional P fertilizers and could contribute to a more efficient use of P in agriculture. A refined classification of P application standards/recommendations in terms of soil P status, soil texture, and fertilizer characteristics, next to the crop P demand, is recommended. Moreover, the additional use of Rhizon samplers for determination of direct available P, including dissolved organic P, is proposed for better understanding and categorization of different P fertilizers in environmental and fertilizer legislations.

关键词： chemical soil analysis digestate nutrient recovery Rhizon samplers struvite

Graphene Bridge Heterostructure devices for Negative differential Transconductance Circuit Applications

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Nano-Micro Letters 2023年第2期15卷 161-171页

作者： Minjong Lee Tae Wook Kim Chang Yong Park Kimoon Lee Takashi Taniguchi Kenji Watanabe Min‑gu Kim do Kyung Hwang Young tack Lee department of Electrical and Computer Engineering Inha UniversityIncheon 22212Republic of Korea department of Materials Science and Engineering The University of Texas at DallasRichardsonTX 75080USA Center for Opto‑Electronic Materials and devices Post‑Silicon Semiconductor InstituteKorea Institute of Science and Technology(KIST)Seoul 02792Republic of Korea department of Physics Kunsan National UniversityGunsan 54150Republic of Korea Advanced Materials Laboratory National Institute for Materials ScienceTsukuba 305‑0044Japan department of Information and Communication Engineering Inha UniversityIncheon 22212Republic of Korea division of Nanoscience and Technology KIST SchoolUniversity of Science and Technology(UST)Seoul 02792Republic of Korea department of Electronic Engineering Inha UniversityIncheon 22212Republic of Korea

Two-dimensional van der Waals(2d vdW)material-based heterostructure devices have been widely studied for high-end electronic applications owing to their heterojunction *** this study,we demonstrate graphene(Gr)-bridge heterostructure devices consisting of laterally series-connected ambipolar semiconductor/Gr-bridge/n-type molybdenum disulfide as a channel material for field-effect transistors(FET).Unlike conventional FET operation,our Gr-bridge devices exhibit nonclassical transfer characteristics(humped transfer curve),thus possessing a negative differential *** phenomena are interpreted as the operating behavior in two series-connected FETs,and they result from the gate-tunable contact capacity of the Gr-bridge ***-value logic inverters and frequency tripler circuits are successfully demonstrated using ambipolar semiconductors with narrow-and wide-bandgap materials as more advanced circuit applications based on non-classical transfer ***,we believe that our innovative and straightforward device structure engineering will be a promising technique for future multi-functional circuit applications of 2d nanoelectronics.

关键词： Graphene bridge Heterostructure device Non-classical transfer characteristics Multi-value logic inverter Frequency tripler

选择性5-羟色胺再摄取抑制剂西酞普兰在肠易激综合征中的交叉对照研究

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世界核心医学期刊文摘（胃肠病学分册） 2006年第12期2卷 39-40页

作者： tack J. Broekaert d. Fischler B. 廖新华 department of Internal Medicine Division of GastroenterologyUniversity Hospital GasthuisbergHerestraat 49B-3000 LeuvenBelgium Dr.

Introduction:Selective serotonin reuptake inhibitors(SSRIs) are frequently used in the treatment of irritable bowel syndrome(IBS) although evidence of their efficacy is ***:Twenty three non-depressed IBS patients were recruited from a tertiary care centre and included in a crossover trial comparing six weeks of treatment with the SSRI citalopram(20 mg for three weeks,40 mg for three weeks) with *** symptom severity was the primary outcome measure,and depression and anxiety scores were also *** effect of acute administration of citalopram on colonic sensitivity and on colonic response to feeding was investigated as a putative predictor of symptomatic response to the ***:After three and six weeks of treatment,citalopram significantly improved abdominal pain,bloating,impact of symptoms on daily life,and overall well being compared with *** was only a modest effect on stool *** in depression or anxiety scores were not related to symptom *** effect of acute administration of citalopram during a colonic barostat study did not predict clinical *** of the first treatment period as a double blind parallel arm study confirmed the benefit of citalopram over ***:The SSRI citalopram significantly improves IBS symptoms,including abdominal pain,compared with *** therapeutic effect is independent of effects on anxiety,depression,and colonic sensorimotor function.

关键词：肠易激综合征西酞普兰再摄取抑制剂色胺交叉对照 SSRI 安慰剂对照组腹胀症状抑郁型阶段

SOI-NMOS场效应晶体管的Kink特性分析

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电子学报 1990年第2期18卷 50-56页

作者：李秀琼 M.tack E.Simoen C.Claeys G.declerck 中国科学院微电子中心比利时大学微电子中心

本文研究了在室温(RT)、液氮温度(LN)和液氮温度(LHe)下的SOI-NMOS场效应晶体管的电流—电压特性。研究的器件制作在二氧化硅上的经激光退火后的多晶硅薄膜体上。结果表明室温下带有薄膜引出端的晶体管的I_d—V_d特性曲线的Kink形状和... 详细信息

本文研究了在室温(RT)、液氮温度(LN)和液氮温度(LHe)下的SOI-NMOS场效应晶体管的电流—电压特性。研究的器件制作在二氧化硅上的经激光退火后的多晶硅薄膜体上。结果表明室温下带有薄膜引出端的晶体管的I_d—V_d特性曲线的Kink形状和液氦下观测到的N-MOS场效应晶体管的Kink形状很类似。实验还表明Kink大小是液氮下比室温下大、液氦下比液氮下的大。应用电容效应,低温下载流子“冻结”机制和不同偏压下载流子产生和复合的物理过程分析可以相应地解释不同温度下Kink效应。

关键词：场效应晶体管 Kink特性 SOI-NMOS

Consumption of gluten with gluten-degrading enzyme by celiac patients: A pilot-study

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World Journal of Gastroenterology 2013年第35期19卷 5837-5847页

作者： Greetje J tack Jolanda MW van de Water Maaike J Bruins Engelina MC Kooy-Winkelaar Jeroen van Bergen Petra Bonnet Anita CE Vreugdenhil Ilma Korponay-Szabo Luppo Edens B Mary E von Blomberg Marco WJ Schreurs Chris J Mulder Frits Koning department of Gastroenterology and Hepatology VU University Medical Centre dSM Biotechnology Centre department of Immunohematology and Blood Transfusion Leiden University Medical Centre department of Pathology VU University Medical Centre department of Paediatrics University Hospital Maastricht department of Paediatrics University of Debrecen Paediatric Research Centre University of Tampere

AIM:To assesses the safety and efficacy of Aspergillus niger prolyl endoprotease(AN-PEP)to mitigate the im-munogenic effects of gluten in celiac ***:Patients with initial diagnosis of celiac disease as confirmed by positive serology with subtotal or total villous atrophy on duodenal biopsies who adhere to a strict gluten-free diet(GFd)resulting in normalised antibodies and mucosal healing classified as Marsh 0 orⅠwere *** a randomised double-blind placebo-controlled pilot study,patients consumed toast(approximately 7 g/d gluten)with AN-PEP for 2 wk(safety phase).After a 2-wk washout period with adherence of the usual GFd,14 patients were randomised to gluten intake with either AN-PEP or placebo for 2 wk(efficacy phase).Measurements at baseline included complaints,quality-of-life,serum antibodies,immunophenotyping of T-cells and duodenal mucosa ***,serum and quality of life questionnaires were collected during and after the safety,washout and efficacy *** biopsies were collected after the safety phase and after the efficacy phase.A change in histological evaluation according to the modified Marsh classification was the primary ***:In total,16 adults were enrolled in the *** serious adverse events occurred during the trial and no patients withdrew during the *** mean score for the gastrointestinal subcategory of the celiac disease quality(CdQ)was relatively high throughout the study,indicating that AN-PEP was well *** the efficacy phase,the CdQ scores of patients consuming gluten with placebo or gluten with AN-PEP did not significantly deteriorate and moreover no differences between the groups were *** the efficacy phase,neither the placebo nor the AN-PEP group developed significant antibody *** IgA-EM concentrations remained negative in both *** patients were excluded from entering the efficacy phase as their mucosa showed an increase oftwo Marsh steps a

关键词： Celiac disease Gluten Enzyme Prolyl endoprotease Aspergillus niger prolyl endoprotease Treatment Adverse events efficacy IgA-tTG intestinal deposits