检索结果-南通市图书馆

Biochemical dissection of StAt3 signaling in amyotrophic lateral sclerosis

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第11期20卷 3229-3230页

作者： Savina Apolloni Nadia d’Ambrosi department of Biology University of Rome Tor VergataRomeItaly

Amyotrophic lateral sclerosis(ALS)is a progressive neurodegenerative disease characterized by the loss of upper and lower motor neurons,clinically marked by muscle atrophy and *** the clinical course is highly variable,the average time from the onset of symptoms to the need for respiratory support or death is 3-5 *** is the most prevalent motor neuron disease in adults,occurring at a rate of 2 per 100,000 individuals and affecting 5.4 per 100,000 individuals overall.

关键词： StAt3 dissection sclerosis

Anti-amyloid antibodies in Alzheimer’s disease: what did clinical trials teach us?

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第4期20卷 1092-1093页

作者： danko Jeremic Lydia Jiménez-díaz Juan d.Navarro-López NeuroPhysiology&Behavior Lab University of Castilla-La ManchaBiomedical Research Center(CRIB)School of Medicine of Ciudad RealCiudad RealSpain

Although many causes of Alzheimer’s disease(Ad)may exist,both the original amyloid cascade and tau hypotheses posit that abnormal misfolding and accumulation of amyloid-β(Aβ)and tau protein is the central event causing the ***,that conclusion could be only partly true,and there is conflicting evidence about the role of both proteins in Ad,being able to precede and influence one *** researchers argue that these proteins are mere executors rather than primary causes of ***,there have been continuing refinements of both hypotheses,with alternative explanations proposed.Aβand tau proteins may be independently involved in specific neurotoxic pathways;yet there may be other crucial processes going on in early ***,accumulating evidence suggests that Aβand tau act synergistically,rather than additively in disease onset(Jeremic et al.,2021,2023a).

关键词： amyloid Alzheimer additive

Remaking a connection:molecular players involved in post-injury synapse formation

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第6期20卷 1719-1720页

作者： diogo tomé Ramiro d.Almeida iBiMEd-Institute of Biomedicine Department of Medical SciencesUniversity of AveiroAveiroPortugal CNC-Center for Neuroscience and Cell Biology University of CoimbraCoimbraPortugal

Functional recovery from central nervous system(CNS)trauma depends not only on axon regeneration or compensatory sprouting of uninjured fibers but also on the ability of newly grown axons to establish functional synapses with appropriate *** several studies have successfully promoted long-distance axonal regeneration in distinct CNS injury models,none of them have resulted in a viable therapeutic approach for patient recovery.A possible reason may be the lack of new synaptogenesis for reestablishing the circuitry lost after ***,we discuss how our understanding of the mechanisms that instruct synapse formation in the injured nervous system may contribute to the design of new strategies to promote functional restoration in traumatic CNS disorders.

关键词： viable injury instru

Water vapor δd dynamics over China derived from SCIAMACHY satellite measurements

在线全文

学校读者我要写书评

暂无评论

Science China Earth Sciences 2014年第4期57卷 813-823页

作者： LIU ZhongFang Kei YOSHIMURA casey d.KENNEdY WANG XinHui PANG ShuoGuang tianjin Key Laboratory of Water Resource and Environment Tianjin Normal University Atmosphere and Ocean Research Institute University of Tokyo United States department of Agriculture Agricultural Research ServicePasture Systems and Watershed Management Research UnitEast WarehamMA 02538USA

this study investigates water vapor isotopic patterns and controls over China using high-quality water vapor δd data retrieved from the Scanning Imaging Absorption Spectrometer for Atmospheric Chartography （SCIAMACHY） observations. the results show that water vapor δd values on both annual and seasonal time-scales broadly exhibit a continental effect, with values largely decreasing northwestward from coastal lowlands to high-elevation mountainous regions. However, region-specific analysis reveals spatially distinct patterns of water vapor dd between seasons. In the monsoon domain （e.g., China south of 35~N）, depletion in d in the summer and fall seasons is closely tied to monsoon moisture sources （the Indian and Pacific oceans） and subsequent amount effect, but higher 8d values in winter and spring are a result of isotopically-enriched conti- nental-sourced moisture proceeded by less rainout. In contrast, farther inland in China （non-monsoon domain）, moisture is de- rived overwhelmingly from the dry continental air masses and local evaporation, and 8d values are largely controlled by the temperature effect, exhibiting a seasonality with isotopically enriched summer and depleted winter/spring. the observation that the spatial pattern of water vapor δd is the opposite to that of precipitation δd in the summer season also suggests that partial evaporation of falling raindrops is a key driver of water vapor isotope in the non-monsoon domain. this study highlights the importance of non-Rayleigh factors in governing water vapor isotope, and provides constraints on precipitation isotope inter- pretation and modern isotope hydrological processes over China.

关键词： water vapor δd moisture sources evapotranspiration droplet evaporation China

Synchronous formation of the‘forearc’Bay of Islands ophiolite and its basal high-temperature metamorphic sole constrained by U-Pb zircon ages

在线全文

学校读者我要写书评

暂无评论

Geoscience Frontiers 2023年第6期14卷 234-272页

作者： Weiyao Yan John F.casey department of Earth and Atmospheric Sciences University of HoustonHoustonTXUSA

the welded metamorphic sole at the base of the Bay of Islands Ophiolite Complex(BOIC)in the Northern Appalachians of Newfoundland shows a typical inverted pressure-temperature(P-t)metamorphic gradient from Ht-MP granulite to Lt-LP greenschist *** incorporates mafic volcanic/plutonic protoliths mixed with pelagic,hemi-pelagic and coarser epiclastic sedimentary *** LA-ICP-MS U–Pb concordia ages,trace elements,and ti-in-zircon geothermometry for -250 zircon analyses from three metabasites of the upper Ht sole amphibolites with N-MORB-like protoliths are *** samples collected within meters of the ophiolite peridotite-sole contact of the Blow Me down Mountain and North Arm Mountain massifs yielded the oldest comparable concordia ages of 487.7±2.6 Ma and 489.1±3.1 Ma,respectively,that are both within error of the igneous age of 488.3±1.5 Ma of the directly overlying BOIC ophiolite,which formed at a supra-subduction zone(SSZ)forearc spreading center.A third slightly younger age of 484.2±2.4 Ma was obtained for an upper Ht amphibolite sample with similar phase assemblages but collected30 m below the peridotite contact of the table Mountain *** crystals analyzed have similar size and morphologies,subparallel rare earth element(REE)variation patterns,and steep heavy REE-enrichments((Lu/Gd)_(cn)>20),significant positive Ce anomalies(dominantly>5)and slight positive to dominantly negative Eu anomalies(1.2–0.4).Zircon shows th/U mean values of 0.37–0.48 with little to no rim to core *** ti-in-zircon mean crystallization temperatures range from764–787℃.these neocrystallized zircon crystals appear to be derived from thin leucosomes within the three *** other samples also from the upper Ht sole show evidence of inherited detrital zircon with core dates spanning the Cambrian Notre dame Arc through older Laurentian-like basement and rift age *** of the sole took place below a hot forearc asthenospheric wed

关键词： Ophiolite metamorphic sole U-Pb zircon ages Hot subduction interface Supra-subduction forearc spreading center Arc-continent collision taconic Orogeny

transport mechanism in chemically reactive hybrid nanofluid flow containing gyrotactic micro-organisms over a curved oscillatory surface

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Applied Mathematics and Mechanics(English Edition) 2025年第1期46卷 177-192页

作者： M.NAVEEd M.IMRAN t.ASGHAR Z.ABBAS department of Mathematics Division of Science and TechnologyUniversity of Education department of Mathematics The Islamia University of Bahawalpur

this paper examines the transport analysis, including both heat transfer and mass transfer, in hybrid nanofluid flow containing gyrotactic microorganisms towards a curved oscillatory surface. the influence of magnetic fields is also inspected in terms of their physical characteristics. to depict the phenomena of transport, modified versions of both Fick's and Fourier's laws are used. Additionally, the characteristics of both heterogeneous and homogeneous chemical reactions are also incorporated. Utilizing a curvilinear coordinate system, the flow problem is formulated as partial differential equations(PdEs)for momentum, concentration, microorganism field, and energy. An analytical solution to the obtained flow equations is achieved utilizing the homotopy analysis method(HAM).the effects of significant flow parameters on the pressure and microorganism fields, velocity, oscillation velocity, concentration, and temperature distributions are shown via graphs. Furthermore, the variations in skin friction, mass transfer rate, heat transfer rate, and local motile number due to different involved parameters are presented in tables and are analyzed in detail. Graphical results indicate that the curves of velocity and temperature fields are enhanced as the values of the solid volume fraction variables *** is also verified that the concentration rate field decreases as the values of the homogeneous reaction strength parameter and the radius of curvature parameter increase, and it increases with the Schmidt number and the heterogeneous reaction strength *** outcomes show a favorable response of the motile number to advanced values of the Peclet number, the Schmidt number, the microorganism difference parameter, and the bio-convective Lewis number.

关键词：

treating amyotrophic lateral sclerosis with allogeneic Schwann cell-derived exosomal vesicles: a case report

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2025年第4期20卷 1207-1216页

作者： Pascal J.Goldschmidt-Clermont Aisha Khan George Jimsheleishvili Patricia Graham Adriana Brooks Risset Silvera Alexander J.P.Goldschmidt damien d.Pearse W.dalton dietrich Allan d.Levi James d.Guest Miller School of Medicine University of MiamiMiamiFLUSA Stem Cell Institute Miller School of MedicineUniversity of MiamiMiamiFLUSA the Miami Project to Cure Paralysis Miller School of MedicineUniversity of MiamiMiamiFLUSA Alzady International LLC MiamiFLUSA Neurological Surgery Miller School of MedicineUniversity of MiamiMiamiFLUSA

Schwann cells are essential for the maintenance and function of motor neurons,axonal networks,and the neuromuscular *** amyotrophic lateral sclerosis,where motor neuron function is progressively lost,Schwann cell function may also be ***,important signaling and potential trophic activities of Schwann cell-derived exosomal vesicles have been *** case report describes the treatment of a patient with advanced amyotrophic lateral sclerosis using serial intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles,marking,to our knowledge,the first instance of such *** 81-year-old male patient presented with a 1.5-year history of rapidly progressive amyotrophic lateral *** initial diagnosis,the patient underwent a combination of generic riluzole,sodium phenylbutyrate for the treatment of amyotrophic lateral sclerosis,and *** patient volunteered to participate in an FdA-approved single-patient expanded access treatment and received weekly intravenous infusions of allogeneic Schwann cell-derived exosomal vesicles to potentially restore impaired Schwann cell and motor neuron *** confirmed that cultured Schwann cells obtained from the amyotrophic lateral sclerosis patient via sural nerve biopsy appeared impaired(senescent)and that exposure of the patient’s Schwann cells to allogeneic Schwann cell-derived exosomal vesicles,cultured expanded from a cadaver donor improved their growth capacity in *** a period of observation lasting 10 weeks,during which amyotrophic lateral sclerosis Functional Rating Scale-Revised and pulmonary function were regularly monitored,the patient received weekly consecutive infusions of 1.54×1012(×2),and then consecutive infusions of 7.5×1012(×6)allogeneic Schwann cell-derived exosomal vesicles diluted in 40 mL of dulbecco’s phosphate-buffered *** of the infusions were associated with adverse events such as infusion reactions(allergic or otherwise)or

关键词： allogeneic amyotrophic lateral sclerosis exosomes infusion neuromuscular junction Schwann cell

Combating CHK1 resistance in triple negative breast cancer:EGFR inhibition as potential combinational therapy

在线全文

学校读者我要写书评

暂无评论

Cancer drug Resistance 2022年第1期5卷 229-232页

作者： casey d.Stefanski Jenifer R.Prosperi department of Biological Sciences University of Notre DameNotre DameIN 46617USA department of Biochemistry and Molecular Biology Indiana University School of Medicine-South BendSouth BendIN 46617USA

triple negative breast cancer(tNBC)is marked by a lack of expression of the Estrogen Receptor,Progesterone Receptor,and human epidermal growth factor receptor ***,targeted therapies are being investigated based on the expression profiles of *** to the potential for acquired and intrinsic resistance,there is a need for combination therapy to overcome *** the article by Lee et al.,the authors identify that,while prexasertib(a CHK1 inhibitor)lacks efficacy alone,combination with an EGFR inhibitor provides synergistic anti-tumor *** in targeted therapy for tNBC will benefit the clinical landscape for this disease,with this study initiating a new avenue of investigation.

关键词： CHK1 tNBC EGFR chemoresistance

StRUCtURAL EVOLUtION IN BIORENEWABLE SOY BASEd POLYUREtHANES

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Chinese Journal of Polymer Science 2009年第4期27卷 447-454页

作者： deepa Puthanparambil casey Kimball Shaw Ling Hsu Polymer Science and Engineering department and Materials Research Science and Engineering Center University of MassachusettsAmherstMA 01003USA douglas McKinnon Hall Williston Northampton AcademyEasthamptonMA 01027USA Invited lecture presented at the International Symposium on Polymer Physics

Spectroscopic studies have revealed that the amount of polyureas formed and the kinetics of their formation in soy based polyurethane systems are considerably different from traditional systems employing ethylene oxide-propylene oxide (EO-PO) based *** aggregation of polyureas was characterized by the hydrogen bonds formed utilizing FtIR *** study offered the opportunity to assign the previously undefined infrared *** structural transformation is reflected in the segmental rel...

关键词： Spectroscopy Miscibility Polyurethanes